共查询到20条相似文献,搜索用时 46 毫秒
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荧光/光声成像和光疗技术的生物医学应用引起了人们越来越多的关注, 然而很多荧光/光声造影剂存在生物相容性较差, 缺乏肿瘤靶向性, 信噪比较低, 功能单一等共性问题, 严重限制其诊疗应用. 透明质酸具有优异的生物相容性和主动肿瘤靶向性, 可被透明质酸酶降解, 并且易于化学修饰和实现多种超分子弱相互作用力协同工作. 因此, 人们将透明质酸与荧光/光声造影剂结合制备纳米材料, 使其在细胞乃至活体的标记性能和治疗效果获得了很大的改善. 本文综述了将两类物质结合制备纳米材料的方法, 着重阐述了纳米材料的结构与性能关系, 为其未来设计和开发提供了指导, 最后对存在的主要问题以及未来的重要研究方向进行了分析和展望. 相似文献
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光声位相理论及其在化学中的应用研究进展 总被引:2,自引:0,他引:2
光声位相作为光声光谱重要的一部分, 包含着很多有价值的信息, 对它的研究可以获得其它光谱甚至光声振幅谱都不能得到的信息。光声位相在测定样品的光学和热学性质、样品无辐射弛豫过程的研究以及深度剖面分析等方面显示了特有的能力。本文结合本实验室近几年的工作, 在光声光谱理论的基础上,对光声位相理论及其在化学中的应用作一综述。 相似文献
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肿瘤是由细胞、细胞外基质及微环境等多因素组成的复杂系统,不同因素在肿瘤的发生和发展中发挥关键作用.肿瘤细胞、细胞外基质及微环境的特异性分析对于肿瘤的精准诊断和靶向治疗至关重要.多肽探针具有特异性高、生物相容性好、组织穿透能力强和易于制备等优点,已被广泛用于肿瘤的特异性成像研究.本文综述了多肽探针对肿瘤细胞、免疫细胞等细胞靶点的特异性成像;并介绍了以胶原蛋白、纤维蛋白等外基质蛋白为靶点的肿瘤特异性多肽探针的成像研究.本文还总结了对肿瘤微环境中弱酸性、高酶活性等因素响应的肿瘤特异性多肽探针及其生物成像应用.最后,本文总结并讨论了肿瘤特异性多肽探针所面临的挑战与机遇,展望了其在肿瘤精准诊断和个性化治疗领域的前景. 相似文献
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利用双联传感器得到光声信号的叠加作用,可提高光声检测灵敏度或扣除溶液背景吸收。以亚硝基R盐测定钴为例,得到最低检测浓度为0.3ng/mL,相当于4.25×10~(-5)的吸收。 相似文献
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Dr. Jiaguo Huang Prof. Kanyi Pu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(29):11813-11827
Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep-tissue imaging are also discussed. 相似文献
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Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal‐to‐background ratio and shallow penetration depth, which limits its ability in deep‐tissue in vivo imaging. Second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near‐infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep‐tissue imaging are also discussed. 相似文献
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Dr. Qing Li Shenhua Li Dr. Shasha He Wan Chen Penghui Cheng Dr. Yan Zhang Prof. Qingqing Miao Prof. Kanyi Pu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(18):7084-7089
Discriminative detection of invasive and noninvasive breast cancers is crucial for their effective treatment and prognosis. However, activatable probes able to do so in vivo are rare. Herein, we report an activatable polymeric reporter (P-Dex) that specifically turns on near-infrared (NIR) fluorescent and photoacoustic (PA) signals in response to the urokinase-type plasminogen activator (uPA) overexpressed in invasive breast cancer. P-Dex has a renal-clearable dextran backbone that is linked with a NIR dye caged with an uPA-cleavable peptide substrate. Such a molecular design allows P-Dex to passively target tumors, activate NIR fluorescence and PA signals to effectively distinguish invasive MDA-MB-231 breast cancer from noninvasive MCF-7 breast cancer, and ultimately undergo renal clearance to minimize the toxicity potential. Thus, this polymeric reporter holds great promise for the early detection of malignant breast cancer. 相似文献
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Qing Li Shenhua Li Shasha He Wan Chen Penghui Cheng Yan Zhang Qingqing Miao Kanyi Pu 《Angewandte Chemie (International ed. in English)》2020,59(18):7018-7023
Discriminative detection of invasive and noninvasive breast cancers is crucial for their effective treatment and prognosis. However, activatable probes able to do so in vivo are rare. Herein, we report an activatable polymeric reporter (P‐Dex) that specifically turns on near‐infrared (NIR) fluorescent and photoacoustic (PA) signals in response to the urokinase‐type plasminogen activator (uPA) overexpressed in invasive breast cancer. P‐Dex has a renal‐clearable dextran backbone that is linked with a NIR dye caged with an uPA‐cleavable peptide substrate. Such a molecular design allows P‐Dex to passively target tumors, activate NIR fluorescence and PA signals to effectively distinguish invasive MDA‐MB‐231 breast cancer from noninvasive MCF‐7 breast cancer, and ultimately undergo renal clearance to minimize the toxicity potential. Thus, this polymeric reporter holds great promise for the early detection of malignant breast cancer. 相似文献
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Tatsuya Nakamura Dr. Hisashi Matsushita Dr. Fuminori Sugihara Prof. Yoshichika Yoshioka Dr. Shin Mizukami Prof. Kazuya Kikuchi 《Angewandte Chemie (International ed. in English)》2015,54(3):1007-1010
19F magnetic resonance imaging (MRI) probes that can detect biological phenomena such as cell dynamics, ion concentrations, and enzymatic activity have attracted significant attention. Although perfluorocarbon (PFC) encapsulated nanoparticles are of interest in molecular imaging owing to their high sensitivity, activatable PFC nanoparticles have not been developed. In this study, we showed for the first time that the paramagnetic relaxation enhancement (PRE) effect can efficiently decrease the 19F NMR/MRI signals of PFCs in silica nanoparticles. On the basis of the PRE effect, we developed a reduction‐responsive PFC‐encapsulated nanoparticle probe, FLAME‐SS‐Gd3+ (FSG). This is the first example of an activatable PFC‐encapsulated nanoparticle that can be used for in vivo imaging. Calculations revealed that the ratio of fluorine atoms to Gd3+ complexes per nanoparticle was more than approximately 5.0×102, resulting in the high signal augmentation. 相似文献
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树状大分子是一类高度支化的单分散性大分子,具有精确可控的分子结构.本文在树状大分子结构特点的基础上,阐述了以树状大分子为载体的新型纳米CT成像造影剂的合成及其在CT成像中的应用,并对树状大分子在CT成像中的发展趋势和应用领域进行了展望. 相似文献
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波长位于1000~1700 nm之间的近红外窗口,通常被称为第二近红外(NIR-Ⅱ)窗口,在生物成像方面(荧光成像、光声成像等),该窗口展现出强大的吸引力。相比在可见光(400~700 nm)区域和第一近红外(NIR-Ⅰ,700~900 nm)窗口的传统成像,NIR-Ⅱ生物成像提供了分辨率高和穿透深度深等优点。但是,目前大多数“always-on”探针,并不能实现更高的信噪比。肿瘤微环境响应型智能药物的成像只在肿瘤中触发,可以克服这一局限性。因此,应充分结合肿瘤微环境和NIR-Ⅱ智能响应探针,充分发挥两者的优势,提高肿瘤的精准诊断。本文从不同的病理参数综述了可激活的NIR-Ⅱ荧光探针在生物成像中的最新研究进展,并对这一新兴的领域所面临的机遇和挑战提出看法。 相似文献
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Dipanjan Pan Dr. Manojit Pramanik Angana Senpan Dr. Xinmai Yang Kwang H. Song Mike J. Scott Huiying Zhang Patrick J. Gaffney Dr. Samuel A. Wickline Prof. Lihong V. Wang Prof. Gregory M. Lanza Prof. 《Angewandte Chemie (International ed. in English)》2009,48(23):4170-4173
Spotting clots : Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin‐targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near‐IR wavelength window, indicating their potential for diagnostic imaging.
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Dr. Lorena García-Hevia Dr. Manuel Bañobre-López Dr. Juan Gallo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(2):431-441
Manganese-based nanostructured contrast agents (CAs) entered the field of medical diagnosis through magnetic resonance imaging (MRI) some years ago. Although some of these Mn-based CAs behave as classic T1 contrast enhancers in the same way as clinical Gd-based molecules do, a new type of Mn nanomaterials have been developed to improve MRI sensitivity and potentially gather new functional information from tissues by using traditional T1 contrast enhanced MRI. These nanomaterials have been designed to respond to biological environments, mainly to pH and redox potential variations. In many cases, the differences in signal generation in these responsive Mn-based nanostructures come from intrinsic changes in the magnetic properties of Mn cations depending on their oxidation state. In other cases, no changes in the nature of Mn take place, but rather the nanomaterial as a whole responds to the change in the environment through different mechanisms, including changes in integrity and hydration state. This review focusses on the chemistry and MR performance of these responsive Mn-based nanomaterials. 相似文献