共查询到20条相似文献,搜索用时 15 毫秒
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Alfonso G. Rubia Mateo M. Salgado Carlos T. Nieto Alejandro Manchado David Díez Francisca Sanz Narciso M. Garrido 《Tetrahedron: Asymmetry》2017,28(10):1394-1400
The asymmetric synthesis of methyl (E)-4-((1R,2S,3R)-3-amino-2-((E)-2-methoxycarbonyl-eten-1-yl)cyclohexyl)but-2-enoate 14 has been achieved from dimethyl (2E,7E)-nona-2,7-dienedioate 2. A key step is the asymmetric synthesis of 1-hydroxyoctahydro-1H-isochromene derivative 5 whose X-ray analysis corroborated the stereochemistry of the new stereocenters. The asymmetric synthesis of the isochromenyl acetate derivative 11 shows the potential of this methodology for fused cyclohexanic system heterocyclic synthesis. 相似文献
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化合物(4 aR,7R)-1-丁基-4 a-甲基-7-(1-甲基-1-羟乙基)-2(1H)-八氢萘酮是合成AF-5的重要中间体,传统方法是在强碱叔丁醇钾的作用下对化合物(4 aR,7R)-4 a-甲基-7-(1-甲基-1-羟乙基)-2(1H)-八氢萘酮进行烷基化反应而得到的.为了使操作更方便、安全,适合大量制备,并提高收率,作者探索了多种碱性条件,并选择氢氧化钾的叔丁醇溶液代替叔丁醇钾,最终使该步烷基化反应可以工业化. 相似文献
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《Tetrahedron letters》1987,28(13):1413-1416
Using carbon radicals generated by photolysis of N-hydroxy-2-thio-pyridone esters (mixed anhydrides) the chiral centre of L-aspartic acid has been easily incorporated into the perhydroindole structure of the title compounds. 相似文献
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ShengBiao ZongRuGUO 《中国化学快报》2002,13(5):412-415
A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1,3-dihydrogen-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-ones,as farnesyltransferase(Ftase) inhibitors,were synthesized. The preparation of the key intermediate,7-amino-3-methoxycabonylpropoxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,was improved. 相似文献
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《Mendeleev Communications》2020,30(1):10-11
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《Tetrahedron letters》1987,28(39):4601-4604
Enantiospecific syntheses of (6R,7S,8aR)-dihydroxyindolizidine (1) and (6R,7R,8S,8aR)-trihydroxyindolizidine (2) from readily available methyl 2-azido-4,6-O-benzylidene-2-deoxy-α-D-altropyranoside (5) are described. 相似文献