Synthesis,structure and cytotoxicity of new 2‐[(3‐aminopropyl)dimethylsilyl]‐5‐furfural diethylacetals and 2‐[(3‐aminopropyl)dimethylsilyl]‐5‐phenylfurans

Novel 2‐[(3‐aminopropyl)dimethylsilyl]‐5‐furfural diethylacetals and 2‐[(3‐aminopropyl)di‐methylsilyl]‐5‐phenylfurans have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N‐allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and nature of organic substituent at the furan ring on the cytotoxicity of the new compounds have been studied. Copyright © 2013 John Wiley & Sons, Ltd.     

Three‐Step Synthesis of 3‐Aryl‐2‐sulfanylthieno[2,3‐b]‐, ‐[2,3‐c]‐, or ‐[3,2‐c]pyridines from the Corresponding Aryl(halopyridinyl)methanones

A convenient three‐step procedure for the synthesis of three types of 3‐aryl‐2‐sulfanylthienopyridines 4, 8 , and 12 has been developed. The first step of the synthesis of thieno[2,3‐b]pyridine derivatives 4 is the replacement of the halo with a (sulfanylmethyl)sulfanyl group in aryl(2‐halopyridin‐3‐yl)methanones 1 by successive treatment with Na₂S?9 H₂O and chloromethyl sulfides to give aryl{2‐[(sulfanylmethyl)sulfanyl]pyridin‐3‐yl}methanones 2 . In the second step, these were treated with LDA (LiNⁱPr₂) to give 3‐aryl‐2,3‐dihydro‐2‐sulfanylthieno[2,3‐b]pyridin‐3‐ols 3 , which were dehydrated in the last step with SOCl₂ in the presence of pyridine to give the desired products. Similarly, thieno[2,3‐c]pyridine and thieno[3,2‐c]pyridine derivatives, 8 and 12 , respectively, can be prepared from aryl(3‐chloropyridin‐4‐yl)methanones 5 and aryl(4‐chloropyridin‐3‐yl)methanones 9 , respectively.     

Darstellung und Kristallstruktur eines Ditelluridovanadium(IV)‐Komplexes: [(μ‐η1‐Te2)(μ‐NtBu)2V2Cp2]

Synthesis and Crystal Structure of a Ditelluridovanadium(IV) Complex: [(μ‐η¹‐Te₂)(μ‐N^tBu)₂V₂Cp₂] [(μ‐η¹‐Te₂)(μ‐N^tBu)₂V₂Cp₂] ( 2 ) is formed from [^tBuN = VCp(PMe₃)₂] ( 1 ) upon reaction with elemental tellurium. 1 and 2 are characterized by spectroscopic methods (MS; ¹H, ¹³C, ⁵¹V NMR), in addition 2 by single crystal X‐ray diffraction. The crystal structure indicates a folded cyclodivanadazen ring bridged by a bidentated ditellurido ligand, the first example of this structure type.