共查询到20条相似文献,搜索用时 156 毫秒
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光化学反应是以洁净、节能、节约为目标的化学合成方法,它为有机合成化学提供了新途径、新方法和新技术,是合成化学中最活跃、最有生命力的研究领域之一,深入研究光化学反应必将为现代有机合成的发展注入新的活力.本论文重点研究了具有应用价值的烯烃光敏氧化、脱肟成酮光敏氧化及汉斯酯1,4二氢吡啶衍生物芳香化等光化学反应,取得了一系列重要的研究结果. 相似文献
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固相有机合成研究进展 总被引:4,自引:0,他引:4
组合化学技术给固相有机合成带来了新的发展契机,同时也提出了新的发展要求。目前这一研究领域发展迅速,应用范围不断扩大,技术日臻完善。本文综述了近期固相有机合成研究方面的最新进展。 相似文献
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微波在有机合成化学中的应用及进展 总被引:31,自引:4,他引:27
简述了微波有机合成的机理和特点,介绍了近年来微波辐射技术在有机合成中的应用,展望了微波促进有机合成化学的发展方向。参考文献30篇。 相似文献
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现代合成化学的发展十分迅速,据统计,世界上每天合成的新化合物有上千个之多,而其中绝大多数是新的有机化合物。新的有机合成反应及合成方法更是层出不穷。有机合成不仅是一门科学,从某种意义上说也是一门艺术。本书著者H.O.House就是当代一位著名的有机合成艺术家,尤其在活泼氢和羰基化合物等领域,他更有许多突出的研究成果。正因为如 相似文献
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绿色化学与有机合成及有机合成中的原子经济性 总被引:28,自引:0,他引:28
本文概述了有机合成和绿色化学的关系, 并介绍了原子经济性的概念及其在有机合成中的重要性。对21 世纪的化学发展提出了希望。 相似文献
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《Mendeleev Communications》2021,31(6):769-780
The synthesis of the desired chemical compound is the main task of synthetic organic chemistry. The predictions of reaction conditions and some important quantitative characteristics of chemical reactions as yield and reaction rate can substantially help in the development of optimal synthetic routes and assessment of synthesis cost. Theoretical assessment of these parameters can be performed with the help of modern machine-learning approaches, which use available experimental data to develop predictive models called quantitative or qualitative structure–reactivity relationship (QSRR) modelling. In the article, we review the state-of-the-art in the QSRR area and give our opinion on emerging trends in this field. 相似文献
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Duarte B. Clemente Dr. Jaime A. S. Coelho 《European journal of organic chemistry》2023,26(17):e202300193
Total synthesis of natural products is an important discipline of organic chemistry that has enabled the development of new synthetic methods and strategies for the preparation and study of the structure and reactivity of complex naturally occurring products. In this review we summarize the synthetic strategies developed in Portugal by several research groups for the synthesis of bioactive natural products including alkaloids, cyclitols, fatty alcohols, phenylpropanoic acids, γ-butyrolactones, xanthones and nucleosides. 相似文献
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Navjeet Kaur 《合成通讯》2018,48(13):1588-1613
The investigation for replacement of organic solvents in organic synthesis is a growing area of interest due to increasing environmental issues. The use of ionic liquid salts as solvents and catalysts in organic reactions has gained extensive interest. Ionic liquids provided a new environmentally benign and improved alternative to traditional methods in modern synthetic chemistry. The aim of present review is to focus on the applications of ionic liquids for the synthesis of O-heterocycles. 相似文献
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《Chemical record (New York, N.Y.)》2018,18(3):266-281
Fluorine‐containing organic molecules have generated increasing impact in drug research over the past decade. Their preparation and development of novel synthetic methods towards new types of fluorinated molecules among them of β‐amino acid derivatives has received large interest. Our research group have designed various highly selective and stereocontrolled methods for the construction of fluorine‐containing cyclic β‐amino acid derivatives. The synthetic approaches developed for the synthesis of various pharmacologically interesting cyclic β‐amino acid derivatives as monomers with multiple stereogenic centers might be valuable protocols for the access of other classes of organic compounds. 相似文献
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Navjeet Kaur 《合成通讯》2019,49(8):987-1030
The investigation of facial synthetic methods for chemical synthesis is a growing area of interest due to increasing environmental issues. The use of catalysts in organic reactions has gained extensive interest. Metal and nonmetal catalysts provided a new improved alternative to traditional methods in modern synthetic chemistry. The aim of the present review is to focus on the applications of metals and nonmetals for the synthesis of seven-membered N-heterocycles. 相似文献
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Dr. Shuya Liu Zhiguo Zhao Prof. Dr. Yao Wang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(10):2423-2441
N-Heterocycles have been found in a large number of natural products, drug molecules, and bioactive compounds, and they thereby play a vital role in diverse research disciplines including drug discovery, organic synthesis, chemical biology, and material science. To this end, the development of new methods and strategies for the construction of N-heterocyclic frameworks is arguably one of the most dynamic and significant research areas in organic synthesis. One of these powerful approaches to the synthesis of N-heterocycles is to establish cyclization reactions based on the transformation of tertiary amines, which has emerged as an attractive research topic. In this Minireview, the significant achievements in the construction of N-heterocycles through cyclization of tertiary amines are highlighted and a comprehensive overview of the rational design, development, and application of these synthetic methods is presented. 相似文献
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Navjeet Kaur 《合成通讯》2019,49(13):1679-1707
The investigation for replacement of organic solvents in chemical synthesis is a growing area of interest due to increasing environmental issues. The use of ionic liquid salts as solvents and catalysts in organic reactions has gained extensive interest. Ionic liquids provided a new environmentally benign and improved alternative to traditional methods in modern synthetic chemistry. The aim of present review is to focus on the applications of ionic liquids for the synthesis of fused six-membered oxygen heterocycles. 相似文献
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Hexamethylenetetramine is a versatile reagent in organic synthesis. It plays a major role in modern organic synthesis. This review focuses on hexamine reagent for its significant role in organic synthesis during the past decades and is able to provide a valuable perspective from synthetic point of view. 相似文献
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Horst Knig 《Angewandte Chemie (International ed. in English)》1980,19(10):749-761
Dissatisfaction with empirical methods, high expectations of the public, poorly harmonized international regulations, and rising costs have induced pharmaceutical research to search for new approaches. As a consequence, the medicinal chemist's professional activity is in a state of change. His synthetic strategy is being increasingly influenced by the reasoning of molecular biology. Novel classes of biologically active compounds demand the development of new synthetic methods beyond the scope of modern preparative organic chemistry: enzymes and microorganisms, cell cultures, and genetic engineering are harnessed to supply highly complex structures. Major efforts are devoted to the development of reliable structure-activity relationships to rationalize his work. Thus the field of medicinal chemistry stretches from physical and physical organic chemistry far into the realm of biosciences, and the interdisciplinary character of this research is rapidly increasing. The author endeavors to convey an impression of this complex subject with the aid of selected examples. 相似文献