共查询到20条相似文献,搜索用时 15 毫秒
1.
Pei‐Pei Jin Xue‐Cheng Liu De‐Qi Liu Zhi‐Bin Huang Da‐Qing Shi 《Journal of heterocyclic chemistry》2015,52(6):1625-1630
A series of chromeno[4,3‐d]isoxazolo[5,4‐b]pyridin‐6‐one derivatives were easily and efficiently synthesized by the reaction of 3‐acyl‐2H‐chromen‐2‐ones with isoxazol‐5‐amine in acetic acid. Some synthesized compounds were evaluated for their antiproliferative properties in vitro against cancer cells, and these compounds were found to have some activities. 相似文献
2.
Saleh M. Al‐Mousawi Mohammad A. Mohammad Mohamad H. Elnagdi 《Journal of heterocyclic chemistry》2001,38(4):989-991
While 3(5)‐aminopyrazole reacts with enaminonitrile to yield pyrazolo[1,5‐a]pyrimidines, 3‐amino‐5‐pyrazolone reacts with the same reagents to yields pyrazolo[3,4‐b]pyridines. 相似文献
3.
Mahmoud A. Mohamed 《Journal of heterocyclic chemistry》2012,49(1):200-203
Cyclocondensation of cyanoacetamide and cyanothioacetamide with sodium salt of 3‐hydroxy‐1‐(pyridin‐3‐yl)prop‐2‐en‐1‐one gave 6‐oxo‐[2,3′]bipyridine 5a and 6‐thioxo‐[2,3′]bipyridine 5b derivatives, respectively. Compound 5b upon treatment with different methylenes 8 gave thieno[2,3‐b]pyridines 10 . Treatment of 5b with iodomethane gave bipyridine derivative 7 , which cyclocondensed with hydrazines 11 to give pyrazolo[3,4‐b]pyridines 13 . J. Heterocyclic Chem., (2012). 相似文献
4.
Improved and Efficient Synthesis of Chromeno[4,3‐d]pyrazolo [3,4‐b]pyridin‐6(3H)‐ones and Their Fluorescence Properties 下载免费PDF全文
Xue‐Cheng Liu Wei Lin Hui‐Yan Wang Zhi‐Bin Huang Da‐Qing Shi 《Journal of heterocyclic chemistry》2014,51(4):1036-1044
A series of chromeno[4,3‐d]pyrazolo[3,4‐b]pyridin‐6(3H)‐one derivatives was easily and efficiently synthesized by the reaction of 2H‐chromen‐2‐ones with pyrazol‐5‐amines catalyzed by CuCl2?2H2O in ethanol. This protocol has the advantages of mild reaction conditions, easy work‐up, and high yields. These compounds were showed to have high fluorescence quantum yields, which mentioned their value as luminescence or fluorescence probe. 相似文献
5.
Synthesis of the title compounds was achieved using the anils 2a , 2b , 2c , 2d , 2e and 5a , 5b , 5c derived from the 4‐aminopyrazole 1 as starting materials. These compounds were allowed to react with mercaptoacetic acid in boiling dry benzene to afford the corresponding thiazolidinones and spiro‐thiazolidinones 3a , 3b , 3c , 3d , 3e and 6a , 6b , 6c , respectively. Pictet—Spengler reaction of the 4‐aminopyrazole hydrochloride 7 with aromatic aldehydes and cyclic ketones resulted in the formation of new pyrazolo[4,3‐e]pyrrolo[1,2‐a]pyrazines 8a , 8b , 8c , 8d , 8e and 9a , 9b , respectively. Other derivatives of pyrazolo pyrrolopyrazines 10 and 11 were obtained via the reaction of the amino derivative 1 with 1,1′‐carbonyldiimidazol and CS2, respectively. J. Heterocyclic Chem., (2011). 相似文献
6.
Nalla Ram Reddy Ghanta Mahesh Reddy Padi Pratap Reddy 《Journal of heterocyclic chemistry》2005,42(4):675-678
A facile approach to pyrazolo[4,3‐e][1,4]diazepin‐5,8‐diones and pyrazolo[4,3‐e]pyrrolo[1,2‐a][1,4]‐diazepin‐5,10‐diones is reported. Strategy involved the utility of α‐amino acid as a three‐atom segment in the construction of diazepine skeleton on the preformed pyrazole ring. 相似文献
7.
A facile, solvent free, ecofriendly approach for the synthesis of 2‐amino‐3(ethylcarboxy)‐4,6‐disubsti‐tuted pyridine 4 and pyrazolo[3,4‐b]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure. The observed reaction rate enhancement and high yield of products are due to the neat reaction conditions coupled with microwaves (MWs). 相似文献
8.
Z. Arghiani S. M. Seyedi M. Bakavoli H. Eshghi 《Journal of heterocyclic chemistry》2015,52(4):1099-1107
A number of new [1,2,4]triazolo[4,3‐b]pyridazines were prepared by either cyclocondesation of substituted hydrazinopyridazines with orthoesters or oxidative cyclization of their hydrazone analogs in nitrobenzene as an oxidizing agent. A host of other new [1,2,4]triazolo[4,3‐b]pyridazine derivatives were synthesized by sequential treatment of the latter compounds with carbon disulfide and alkyl halides. 相似文献
9.
Cyclization of 5‐cyano‐1,6‐dihydro‐4‐methyl‐2‐phenyl‐6‐thioxopyrimidine 4 with excess of 85% hydrazine hydrate afforded the 3‐amino‐4‐methyl‐6‐phenylpyrazolo[3,4‐d]pyrimidine 5 , which can react with appropriate Mannich base derivatives 13a‐c and chalcones 27a,b to yield the corresponding 6,8‐disubstituted 7,8‐dihydropyrimido[2,3:4,3]pyrazolo[1,5‐a]pyrimidines 15a‐c and 30a,b , respectively. On the other hand, the 6,7,8‐trisubstituted pyrimido[2,3:4,3]pyrazolo[1,5‐a]pyrimidine derivatives 8a‐g, 20a‐e, 36 and 38 were obtained by treatment of compound 5 with appropriate 1,3‐diketones 6a‐g , 3‐dimethylamino‐1‐(substituted)prop‐2‐enones 18a‐e , 3‐aminocrotononitrile 3 , and ethoxymethylenemalononitrile 37 under acidic condition, respectively. 相似文献
10.
An efficient two respectively three steps procedure for the synthesis of cycloalkyl[b]thieno[3,2‐e]‐pyridine amines was developed and in general good to very good yields were obtained. 相似文献
11.
Novel spiro[pyrazolo[3,4‐b]pyridine‐4,3′‐indoline] derivatives were prepared by the three‐component reaction of isatins 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine and Meldrum's acid in the presence of a catalytic amount of melamine trisulfonic acid. This protocol provides a simple one‐step procedure with the advantages of easy work‐up, mild reaction conditions and environmentally benign. 相似文献
12.
《Journal of heterocyclic chemistry》2017,54(4):2434-2439
A domino three‐component strategy with high efficiency for the synthesis of spiro[indoline‐3,4′‐pyrazolo[3,4‐b ]pyridines] from easily available isatins, pyrazol‐5‐amines and β‐ketonitriles under microwave heating. During reaction process, HOAc plays dual roles as reaction media as well as a Brønsted acid‐promoter. Flexible structural modification, broad functional group compatibility and mild reaction conditions make this strategy a useful and attractive process of library generation for drug discovery. 相似文献
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14.
Chebolu Naga Sesha Sai Pavan Kumar Ejjirothu Srihari Mettu Ravinder Koochana Pranay Kumar U. S. N. Murthy Vaidya Jayathirtha Rao 《Journal of heterocyclic chemistry》2013,50(Z1):E131-E135
Several new thieno[2,3‐b]pyridine and thieno[2,3‐b]quinoline derivatives are synthesized in an efficient manner catalyzed by DBU as a base. Simple workup procedure, good yields, and mild reaction conditions are the salient features of this method. All the synthesized compounds are screened for antimicrobial activity against several organisms. 相似文献
15.
Jairo Quiroga Débora Cobo Braulio Insuasty Rodrigo Abonía Silvia Cruz Manuel Nogueras Justo Cobo 《Journal of heterocyclic chemistry》2008,45(1):155-159
New fused indeno[1,2‐b]pyridine derivatives have been prepared in a multicomponent reaction from benzaldehydes, indanedione and the appropriate aminoheteroaryl compound. The simple methodology permitted the syntheses of a series of indeno[1,2‐b]pyrazolo[4,3‐e]pyridines 4 from 5‐aminopyrazol 1 and modulated by the corresponding benzaldehyde 2 . 相似文献
16.
《Journal of heterocyclic chemistry》2017,54(5):2929-2934
Two series of furo[3,2‐f ]quinoline‐2‐carboxylate were obtained via a three‐component reaction of aldehydes, 5‐aminobenzofuran‐2‐carboxylate, and 4‐hydroxy‐2H‐chromen‐2‐one or cyclopentane‐1,3‐dione in DMF under catalyst‐free condition in high yields. This one‐pot three‐component reaction provided an efficient method for the synthesis of fused polycyclic heterocycles for bioactive screening. 相似文献
17.
A mild and efficient method for the synthesis of 10‐aryl‐6,7,8,10‐tetrahydrocyclopenta[b]pyrazolo[4,3‐f]quinolin‐9(3H)‐one derivatives is described in high yields at 50°C in ionic liquids. The method involves a three‐component reaction of aromatic aldehyde 1H‐indazol‐5‐amine and cyclopentane‐1,3‐dione. 相似文献
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19.
Dhananjay B. Kendre Raghunath B. Toche Madhukar N. Jachak 《Journal of heterocyclic chemistry》2008,45(5):1281-1286
Synthesis of novel pyrazolo[3,4‐b]pyridines has been achieved successfully by sequence of Gould ‐ Jacobs reaction between 5‐aminopyrazole and diethylethoxymethylenemalonate in good yield. Further the pyrazolo[3,4‐b]pyridines were converted into succinimidoyl active esters which are then replaced by biological samples such as amino acids and carbohydrate in slightly aqueous medium. 相似文献