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1.
Synthesis of 1,5‐Benzodiazepine Derivatives Containing 1,2,3‐Triazole Moiety via 1,3‐Dipolar Cycloaddition Reaction 下载免费PDF全文
Zhi‐Qiang Dong Hai Shi Sen‐Lin Chen Hong‐Xiang Chen Wei‐Bin Jiang Fang‐Ming Liu Mei‐Lin Hong 《Journal of heterocyclic chemistry》2014,51(6):1844-1848
A series of 1,5‐benzodiazepine derivatives were synthesized by the reaction of 1,5‐benzodiazepine containing 1,2,3‐triazole moiety with benzohydroximinoyl chlorides at room temperature. The structural identities of these novel compounds were confirmed on the basis of IR, 1H NMR, mass spectral and elemental analysis data, and by X‐ray crystallographic analysis of a typical example of the new class of 1,5‐benzodiazepine analogs. 相似文献
2.
1,3‐Dipolar cycloaddition of α,β‐unsaturated ketones bearing 1,2,3‐triazole moiety with nitrile oxides and sydnones obtained a series of novel 3,4,5‐trisubstituted isoxazolines ( 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h ) and 1,3,4‐trisubstituted pyrazoles ( 7a , 7b , 7c , 7d , 7e , 7f , 7g , 7h ) with different active pharmacophores in a single molecular scaffold. The structure of the target compounds was confirmed on the basis of IR, 1H NMR, mass spectral, elemental analysis, and X‐ray crystallographic analysis. 相似文献
3.
Highly Efficient Ultrasonic‐Assisted CuCl‐Catalyzed 1,3‐Dipolar Cycloaddition Reactions in Water: Synthesis of Coumarin Derivatives Linked with 1,2,3‐Triazole Moiety 下载免费PDF全文
Xu Li Xiaolan Chen Yuqin Jiang Senshen Chen Lingbo Qu Zhibo Qu Jinwei Yuan Hanyu Shi 《Journal of heterocyclic chemistry》2016,53(5):1402-1411
By introducing ultrasound irradiation into “on water” CuCl‐catalyzed 1,3‐dipolar Huisgen cycloaddition, the reaction efficiencies were notably promoted toward a wide variety of applicable azides and alkynes at room temperature, and a series of coumarin derivatives linked with 1,2,3‐triazole moiety were synthesized using the optimized conditions. 相似文献
4.
Synthesis of Novel 1,2,4‐oxadiazoline Derivatives Containing Quinoline Moiety by 1,3‐Dipolar Cycloaddition 下载免费PDF全文
A series of novel 1,2,4‐oxadiazoline derivatives containing 2‐(1,2,4‐triazol‐1‐yl)quinoline were synthesized by the reaction of imines with benzohydroximinoyl chlorides in the presence of Et3N via 1,3‐diplolar cycloaddition reaction. The structures of the target compounds were confirmed by IR, 1H NMR, MS, elemental, and X‐ray crystallographic analysis. 相似文献
5.
Synthesis of New Bis‐1,2,4‐Oxadiazoline Derivatives via 1,3‐Dipolar Cycloaddition Reaction 下载免费PDF全文
A series of novel bis‐oxadiazoline derivatives 4 was synthesized via 1,3‐dipolar cycloaddition reaction of bis‐aldimines 3 , and nitrile oxides generated in situ from various benzohydroximinoyl chlorides in the presence of Et3N. The target products were confirmed by IR, 1H‐NMR, and mass spectrometry. 相似文献
6.
Synthesis and Characterization of Novel 1,2,4‐oxadiazoline Derivatives Containing Pyrazole Moiety by 1,3‐Dipolar Cycloaddition 下载免费PDF全文
Ting‐Hong Fei Ying‐Lei Zhou Le Huang Fang‐Ming Liu 《Journal of heterocyclic chemistry》2016,53(5):1640-1645
A series of novel pyrazolyl‐oxadiazoline derivatives bearing 1,2,4‐triazole moiety 4a , 4b , 4c , 4d , 4e , 4f , 4g , 4h , 4i , 4j , 4k , 4l , 4m , 4n , 4o , 4p were synthesized by schiff bases of 3‐methyl‐1‐phenyl?5‐(1,2,4‐triazole‐1‐yl)‐4‐formylpyrazole 3a , 3b , 3c , 3d and various benzohydroximinoyl chlorides in the presence of Et3N via 1,3‐dipolar cycloaddition reaction. The target products were confirmed by IR, 1H‐NMR, MS, elemental analysis. In addition, the structure of compound 4d was defined by X‐ray crystallography. 相似文献
7.
A series of new dispiropyrrolidine derivatives were synthesized via the three‐component 1,3‐dipolar cycloaddition reaction of azomethine ylides generated in situ by the decarboxylative condensation of acenaphthenequinone and sarcosine or l ‐thioproline with 5‐benzylidene‐1,3‐dimethylpyrimidine‐2,4,6‐trione. The structures of the products were identified by IR, 1H‐NMR, and HRMS spectra. 相似文献
8.
《Journal of heterocyclic chemistry》2017,54(6):3554-3564
A series of diverse heterocycles containing spirooxindole, isoxazoline/triazole, and isoxazole rings has been synthesized via an efficient three‐component reaction of (E )‐2‐(1‐propargyl‐2‐oxoindoline‐3‐ylidene)acetophenones 1 , arylnitrile oxides 2 , and arylazides 3 using Cu(I) as catalyst. The regiochemistry and stereochemistry of cycloadducts 4a and 5a have been confirmed by X‐ray diffraction studies. The heterocycles were screened against Gram‐positive and Gram‐negative bacteria and fungi. Several compounds exhibit moderate to excellent activities comparable to those of established standard drugs. 相似文献
9.
Synthesis and Antifungal Activity of Novel 1,2,4‐Triazole Derivatives Containing 1,2,3‐Thiadiazole Moiety 下载免费PDF全文
Cheng‐Xia Tan Yan‐Xia Shi Jian‐Quan Weng Xing‐Hai Liu Wei‐Guang Zhao Bao‐Ju Li 《Journal of heterocyclic chemistry》2014,51(3):690-694
Starting from carbonic acid diethyl ester, a series of 1,2,4‐triazole derivatives containing 1,2,3‐thiadiazole were synthesized. Reactions were performed by microwave irradiation or ultrasonic irradiation as well as by conventional heating. The structure of title compounds was characterized by 1H‐NMR, MS, and elemental analyses. The fungicidal activities of these compounds were tested in vivo. Most of title compounds exhibited good antifungal activity against Pseudoperonospora cubensis. Some of title compounds displayed moderate antifungal activities against Fusarium oxysporum, Pseudoperonospora cubensis, Sphaerotheca fuligenea, Corynespora cassiicola, and Xanthomonas axonopodis. 相似文献
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11.
《Journal of heterocyclic chemistry》2017,54(1):517-523
A series of novel substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives contain quinoline ring 5a , 5b , 5c , 5d , 5e , 5f , 5g , 5h , 5i , 5j , 5k , 5l were synthesized by the reaction of benzothiazepines 4a , 4b , 4c and substituted‐benzohydroximinoyl chlorides through the 1,3‐dipolar cycloaddition reaction in the presence of Et3N at room temperature. The structures of the obtained adducts were elucidated by MS, IR, 1H NMR, and elemental analyses. In addition, the structures of 5e were further confirmed by X‐ray single crystal diffraction study. 相似文献
12.
An Efficient Protocol for the Synthesis of Novel 1,2,3‐Triazole Substituted 4H‐Chromene Derivatives 下载免费PDF全文
P. Sambasiva Rao G. Malla Reddy C. Kurumurthy B. Veeraswamy G. Santhosh Kumar P. Shanthan Rao B. Narsaiah 《Journal of heterocyclic chemistry》2014,51(Z1):E318-E322
A facile and an efficient protocol has been developed for the synthesis of novel 1,2,3‐triazole substituted 4H‐chromene derivatives 4 in single pot by multicomponent reaction of 1,3‐cyclohexanedione, malononitrile and 1‐substituted 1,2,3‐triazole‐5‐aldehyde using potassium carbonate as catalyst. 相似文献
13.
Expedient Synthesis of Novel Ferrocenyl Spiropyrrolidines Through 1,3‐Dipolar Cycloaddition Reaction 下载免费PDF全文
The synthesis of novel ferrocenyl spiropyrrolidines through the cycloaddition of azomethine ylides generated by a decarboxylative route from sarcosine and diketones with the dipolarophile, Knoevenagel adduct of ferrocene carbaldehyde is described. The regiochemistry and stereochemistry of the cycloadducts were confirmed by X‐ray analysis of one of the synthesized cycloadducts. 相似文献
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15.
A series of spiro[indoline‐3,2′‐[1,3,4]oxadiazol]‐2‐ones were prepared from the reaction of isatin derivatives and hydrazonoyl chlorides through the 1,3‐dipolar cycloaddition reaction. This method has some important aspects, such as mild reaction condition, easy purification, and high yield of products. Also, the synthesis of spiro[acenaphthylene‐1,2′‐[1,3,4]oxadiazol]‐2‐one and spiro[[1,3,4]oxadiazole‐2,9′‐phenanthren]‐10′‐one were studied under the same condition. The structures were confirmed spectroscopically (IR, 1H‐ and 13C‐NMR, and EI‐MS) and by elemental analyses. A plausible mechanism for this reaction is proposed. 相似文献
16.
A. Sudheer Kumar Vikas D. Ghule S. Subrahmanyam Prof. Dr. Akhila K. Sahoo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(2):509-518
Various thermally stable energetic polynitro‐aryl‐1,2,3‐triazoles have been synthesized through Cu‐catalyzed [3+2] cycloaddition reactions between their corresponding azides and alkynes, followed by nitration. These compounds were characterized by analytical and spectroscopic methods and the solid‐state structures of most of these compounds have been determined by using X‐ray diffraction techniques. Most of the polynitro‐bearing triazole derivatives decomposed within the range 142–319 °C and their heats of formation and crystal densities were determined from computational studies. By using the Kamlet–Jacobs empirical relation, their detonation velocities and pressures were calculated from their heats of formation and crystal densities. Most of these newly synthesized compounds exhibited high positive heats of formation, good thermal stabilities, reasonable densities, and acceptable detonation properties that were comparable to those of TNT. 相似文献
17.
Li Xiaofang Liu Bin Liu Haochong Yu Xianyong Yi Pinggui 《Journal of heterocyclic chemistry》2012,49(5):1050-1053
The 1,3‐dipolar cycloaddition of azomethine ylide generated in situ from isatin and sarcosine to 5‐arylmethylidene thiazolo[3,2‐b][1,2,4]triazol‐6(5H)‐ones afforded novel 1′‐methyl‐4′‐aryldispiro[indole‐3,2′‐pyrrolidine‐3′,5″‐[1,3]thiazolo[3,2‐b][1,2,4]triazole]‐2,6″ (1H)‐diones in moderate yields. The structures of all the products were characterized thoroughly by NMR, infrared spectroscopy (IR), mass spectroscopy (MS) elemental analysis together with X‐ray crystallographic analysis. 相似文献
18.
Xiaofang Li Haochong Liu Bin Liu Aiting Zheng Guobin Li Xianyong Yu Pinggui Yi 《中国化学》2011,29(4):741-744
The 1,3‐dipolar cycloaddition reactions of nitrilimine with thiazolo[3,2‐a]pyrimidine derivatives was investigated. Bis‐cycloadducts were obtained through a domino 1,3‐dipolar cycloaddition/ring‐opening/ring‐opening/1,3‐dipolar cycloaddition processes. The structures of the products were characterized thoroughly by NMR, IR, MS, elemental analysis together with X‐ray crystallographic analysis. 相似文献
19.
Serkan Yavuz Hamdi Özkan Gülçin Tok Ali Dişli 《Journal of heterocyclic chemistry》2013,50(6):1437-1440
The substituted pyrolidine derivatives with high stereoselectivity were obtained through cycloaddition reaction in the presence of a Lewis acid namely diethylzinc by solvent‐free grinding method. 相似文献