心电图心率变异性参数与AMI患者心肌损伤的关系及联合预测预后分析

选取我院145例急性心肌梗死(AMI)患者作为研究对象,探究心电图心率变异性(HRV)参数与AMI患者心肌损伤的关系及联合预测预后的应用价值.结果 发现,年龄≥60岁、发病至就诊时间＞6h、吸烟史、高脂血症史、心肌损伤标志物(CK-MK、cTnI、NT-proBNP)水平升高、LF/HF升高,以及SDNN、SDANN、...     

超声检查在孕妇产前诊断中的应用价值

选择2460例孕妇为研究对象,探讨超声检查在孕妇产前诊断中的应用价值.孕妇20?28孕周时利用超声心电图对胎儿的先天性心脏病进行诊断,11?32孕周时利用超声对畸形胎儿进行检查,18?23孕周时对超声提示结构畸形的孕妇进行染色体侵入检查.结果发现,最终诊断出110例先天性心脏病胎儿,超声心电图检查共检出102例,诊断准...     

心电图结合中性粒细胞/淋巴细胞比值对急性前壁心肌梗死患者PCI术后预后的预测价值

本文分析心电图结合中性粒细胞/淋巴细胞比值(NLR)对急性前壁心肌梗死患者PCI术后预后的预测价值.选取行PCI术的急性前壁AMI患者180例,观察其心电图和NLR水平变化,并应用Cox回归分析心电图变化、NLR水平高低与预后的相关性.180例患者不良心血管事件发生率为17.78％;NLR水平＞3人数有113人;存在有...     

A Study on the Effect of Environmental and Genetic Factors on Postmenopausal Osteoporosis in Wenzhou Women

为探讨温州地区绝经后女性骨质疏松症( Postmenopausal osteoporosis,PMOP)与雌激素受体基因( Estrogen receptor,ERa)多态性及相关因素的关联性,将203例观察对象按骨质疏松症诊断标准分为骨量正常组、骨量减少组与PMOP组,分别检测各组观察对象的腰椎L1-4正位骨密度、Pvu Ⅱ、Xba Ⅰ基因型并调查其膳食行为与运动习惯等项目.结果显示:(1)年龄越大、文化程度越低、身材矮小及BMI低者、妊娠次数越多、产次越多者易罹患PMOP;经常饮用牛奶、豆浆、茶,经常食用水产品、豆类、肉类、蛋类、水果、坚果及每月运动次数较多者与高骨密度有关;在校正年龄、文化程度、BMI等干扰因素之后,饮茶、食用水果、坚果类的次数与BMD呈正相关.(2)该研究未发现Pvu Ⅱ与Xba Ⅰ基因型与PMOP间有关联.提示该地区膳食行为、环境因素与PMOP关系密切,但雌激素受体α多态性与骨密度间关系尚不明确,其对骨质疏松的预测价值尚待深入研究.     

瑞安市0～7岁健康儿童头发中微量元素分析

用火焰原子吸收法检测了瑞安市５５２例０￣７岁儿童头发中锌、铁铜、钙必需元素含量,并探讨了元素含量与年龄,性别的关系,结果显示,元素含量与性别差异无显著意义;锌,钙元素含量随着年龄增长有相似变化,新生儿发铁含量明显低于其他年龄组。提示,在不同年龄儿童之间头发中元素含量存在着一定差异。     

急性脑梗死患者心电图特征与病情分型及其预后状况的关系

为探讨急性脑梗死患者心电图特征与病情分型及其预后状况的关系,选择2016年1月~2019年6月期间本院神经内科住院部收治的急性脑梗死患者110例作为研究对象,全部患者采用心电图检查。急性脑梗死患者心电图异常率为72.73%,其中缺血性ST-T改变占45.00%,窦性心动过速和室性早搏各占11.25%,心房颤动占7.50%,房性早搏和左心室肥厚各占6.25%。轻型组心电图异常率为52.63%,明显低于中型组的82.22%和重型组的85.19%,比较差异具有统计学意义(P<0.05)。大梗死灶组、小梗死灶组心电图异常率分别为88.89%和79.41%,明显高于腔隙性脑梗死组的41.94%,比较差异具有统计学意义(P<0.05)。心电图异常组死亡率明显高于心电图正常组,比较差异具有统计学意义(P<0.05)。提示急性脑梗死患者心电图异常主要表现为缺血性ST-T改变、窦性心动过速、室性早搏、心房颤动、房性早搏和左心室肥厚等,其异常率对病情分型及其预后状况具有重要的评估价值。     

SMI技术检测颈动脉斑块内新生血管的应用

探讨颈动脉粥样硬化斑块患者采用超声超微血管成像(SMI)技术检测斑块内新生血管形成的临床价值.选取经彩色多普勒颈动脉超声检查确诊的100例颈动脉粥样硬化患者作为研究对象,所有纳入对象均接受SMI、超声造影(CEUS)检查,以CEUS检查结果作为判断标准,计算SMI检测结果与CEUS结果的一致性.颈动脉彩色多普勒超声检出...     

颈动脉超声筛查脑卒中高危人群颈动脉易损斑块与ACR、ALBU的相关性研究

本研究探讨颈动脉超声筛查脑卒中高危人群颈动脉易损斑块与尿微量白蛋白/肌酐(ACR)、尿微量白蛋白(ALBU)的相关性.选取307例脑卒中高危患者,根据颈动脉超声检查将其分为:无颈动脉斑块组112例、颈动脉稳定斑块组45例和颈动脉易损斑块组150例.研究发现,各组年龄≥60岁占比、有脑卒中家族史占比以及颈动脉内中膜厚度(...     

儿童末梢血微量元素的检测及应用价值评定

目的探讨儿童末梢血微量元素检测的应用价值。方法选取华林街社区卫生服务中心接受健康体检的儿童388例作为研究对象,采集其末梢血进行微量元素测定,按照受检儿童的年龄将其分为3组,分别记为Ⅰ组(1~3岁、141例)、Ⅱ组(4~6岁、149例)、Ⅲ组(6岁、98例),通过比较各组儿童中不同微量元素的检测结果,计算不同年龄段儿童元素缺乏或者超量的发生率。结果分别对各组儿童Ca、Fe、Zn、Mg、Cu、Pb的检测结果进行分析,可见均无Mg、Cu缺乏或超标的现象,而儿童缺Ca率为6.4%,4~6岁儿童缺Ca率最高(11.4%);缺Fe率为25.0%,缺Zn率为24.2%,均为1~3岁儿童缺乏率最高,Pb超标率为10.8%,随年龄增长,发生率不断升高,各年龄段儿童发生率比较有统计学差异(P0.05)。结论通过检测儿童末梢血中微量元素的含量有利于指导家长调整日常膳食结构,保证儿童饮食结构的合理、营养平衡,促进儿童生长发育。     

韶关市学龄前儿童血铅与身高体质量关系的初步研究

为探讨韶关市学龄前儿童血铅水平及其对儿童身高、体质量的影响，随机抽取1128名2～6岁儿童为调查对象，测定其身高、体质量，并分别换算成z标准分；采指端末梢血20止，用钨舟原子吸收光谱法，测定血铅水平。结果显示，2～6岁1128名儿童均值97．9μg/L，几何均值82．1μg/L，铅中毒率39．89％，血铅水平及铅中毒率，男、女童无显著差异；血铅值与身高呈显著性负相关，随着年龄的增加，其相关系数减少；在6岁前，血铅值与体质量呈显著性负相关；高血铅组（≥100μg／L）女童体质量、身高z分显著低于低血铅组；男童体质量Z分显著低于低血铅组。提示年龄越小，铅暴露对儿童身高、体质量发育的损害越大；其中对女童的影响较明显。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.