共查询到20条相似文献,搜索用时 31 毫秒
1.
The reaction of partially hydrogenated 2-pyridinethiols with 1,3-dibromopropane gives substituted pyrido[2,1-b][1,3]thiazines.
The structure of 7,9-dicyano-6-oxo-3,4,6,7-tetrahydro-2H-spirocyclohexane-1′,8-pyrido[2,1-b][1,3]thiazine was solved by X-ray
diffraction structural analysis.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1428–1433, September, 2007. 相似文献
2.
7-Acetyl-8-aryl-2-(1-chloro-2-hydroxy-3-propyl)thio-9-cyano-6-methyl-1,4-dihydropyridines were obtained by treatment of 1,4-dihydropyridine-2(3H)-thiones
with epichlorohydrin in the presence of sodium bicarbonate. When treated with NaOMe, these compounds are readily intramolecularly
alkylated with formation of 7-acetyl-8-aryl-3-hydroxy-9-cyano-6-methyl-3,4-dihydro-2H,8H-pyrido[2,1-b]-[1,3]thiazines. We
have studied amination of 2-(1-chloro-2-hydroxy-3-propyl)thio-1,4-dihydropyridines and acylation of 3-hydroxy-3,4-dihydro-2H,8H-pyrido[2,1-b][1,3]thiazines.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1394–1399, September, 2005. 相似文献
3.
A. A. Shachkus Yu. A. Degutis A. G. Urbonavichyus 《Chemistry of Heterocyclic Compounds》1989,25(5):562-565
Reaction of 2,3,3-trimethyl-, 2,3,3,5- and 2,3,3,7-tetramethyl-3H-indoles with 4-nitro-2-chloromethylphenol has given the 5a,6-dihydro-12H-indolo-[2,1-b][1,3]-benzoxazines, which have been examined for ring-chain interconversion by NMR spectroscopy. Treatment of 5a,6-dihydro-12H-indolo[2,1-b][1,3]benzoxazines with either perchloric acid or potassium hydroxide results in opening of the dihydrooxazine ring with the formation of indole derivatives.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 672–676, May, 1989. 相似文献
4.
Three-component reactions of 3-substituted pyridines, dimethyl acetylenedicarboxylate (DMAD), and α-halo ketones led to regioselective and stereoselective synthesis of pyrido[2,1-b][1,3]oxazines in high to excellent yields under mild conditions. All the reactions gave the pyrido[2,1-b][1,3]oxazine derivatives without formation of any indolizine products. 相似文献
5.
Dingben Chen Jiashou Wu Jianguo Yang Ling Huang Yubo Xiang Weiliang Bao 《Tetrahedron letters》2012,53(52):7104-7107
An efficient cascade method has been developed for the synthesis of aza[2,1-b][1,3]-benzothiazinones from cyclic thiourea and methyl 2-iodobenzoate via the Cu(I)-catalyzed C–S coupling/amidation process. A number of aza[2,1-b][1,3]-benzothiazinones containing five, six, seven membered rings and different substituents were obtained in good yield. 相似文献
6.
The reaction of 4-methoxy-5-amino-6-mercaptopyrimidine with 2-oxo-1-chlorocyclopentyl(hexyl)glyoxalate esters gave derivatives of the previously unknown tetracyclic systems 1,2-dioxocyclopenta (hexa)[g]oxazolidino[3,2-f]pyrimido[4,5-b][1,4]thiazines, which are transformed by ammonium acetate into derivatives of 1,2-dioxocyclopenta(hexa) [g]imidazolidino[3,2-f]pyrimido[4,5-b]-[1,4] thiazines. Derivatives of the new tricyclic 1-oxazino [5,4-g]pyrimido[4,5-b][1,4]thiazine system were obrtained by reaction of 6-carbethoxy-7-acetylpyrimido [4,5-b] [1,4] thiazines with hydroxylamine. 相似文献
7.
Mohammad Mehdi Ghanbari 《Green Chemistry Letters and Reviews》2016,9(4):203-207
A simple and eco-friendly method for the synthesis of novel imidazo[2,1-b][1,3]thiazin derivatives has been developed via the one-pot, three-component and solvent-free reaction of thiohydantoins, aromatic aldehyde and 5,5-dimethylcyclohexane-1,3-dione in the presence of catalytic amount of p-toluene sulfonic acid, in good and excellent yields. 相似文献
8.
The reaction of 2,3-dibromo-1,4-naphthoquinone with 2-aminothiazole in MeONa/MeOH at 60oC for 3 h gave naphtho[2',3':4,5]imidazo[2,1-b][1,3]thiazole-5,10-dione
in 64% yield. The reaction of 2,3-dibromo-1,4-naphthoquinone with 2-aminobenzothiazole under the above-mentioned conditions
gave 2-(benzo[d]thiazol-2-ylamino)-3-bromonaphthalene-1,4-dione in 64% yield, which on treatment with Na/THF or NaN3/acetone under reflux conditions gave naphtho[2',3':4,5]imidazo[2,1-b][1,3]- benzothiazole-7,12-dione in 69 and 56% yields,
respectively. 相似文献
9.
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isothiocyanates catalyzed by silver triflate are described; they provide an efficient and practical route for the synthesis of 2,4-dihydro-1 H-benzo[ d][1,3]thiazines. 相似文献
10.
Lipunova G. N. Nosova E. V. Mokrushina G. A. Ogloblina E. G. Aleksandrov G. G. Charushin V. N. 《Russian Journal of Organic Chemistry》2003,39(2):248-256
The heating of derivatives of benzimidazole-2-thione and imidazolidine-2-thione with tetra(penta)fluorobenzoyl chlorides in toluene or pyridine gave rise to fluorocontaining derivatives of imidazo[2,1-b][1,3]benzothiazine. The latter were studied in reactions of nucleophilic substitution of fluorine for amino groups. 相似文献
11.
Robabeh Baharfar Seyed Meysam BaghbanianSeyed Mohammad Vahdat 《Tetrahedron letters》2011,52(45):6018-6020
The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedicarboxylates, was trapped by thiouracils to yield a ketenimine intermediate, which cyclized and then rearranged to afford pyrimido[2,1-b][1,3]thiazines in good yields. 相似文献
12.
Qiuping Ding Xianjin Liu Jinsheng Yu Qiulan Zhang Dan Wang Banpeng Cao Yiyuan Peng 《Tetrahedron》2012,68(21):3937-3941
Tandem addition-cyclization reactions of various 2-alkynylbenzenamines with CS2 lead to the formation of 2-mercapto-4-benzylidene-4H-benzo[d][1,3]thiazines under mild conditions. The reactions showed moderate to excellent yields and were highly regiospecific, and only the six-membered ring was generated via 6-exo-dig S-cyclization. The reaction can be transferred to highly functionalized 4-benzylidene-4H-benzo[d][1,3]thiazines via CuI-catalyzed crossing-coupling and reductive coupling reactions. 相似文献
13.
Benzo[4,5]imidazo[2,1-b]pyrimido[5,4-f][1,3,4]thiadiazepines representing a new heterocyclic system were prepared by cyclocondensation reaction of l-aminobenzimidazol-2-thione with 6-chloropyrimidine-5-carbaldehydes. 4-Dimethylamino derivative of this tetraheterocyclic system possessed anti-HIV activity. 相似文献
14.
Shan-Shan Gong Chun-Hong Zheng Zhen-Zhen Chen Dong-Zhao Yang Mei Chi Shou-Zhi Pu Qi Sun 《Molecules (Basel, Switzerland)》2021,26(17)
A bisthienylethene-dipyrimido[2,1-b][1,3]benzothiazole (BTE-2PBT) triad has been designed and synthesized based on our recent discovery of PBTs as atypical propeller-shaped novel AIEgens. The triad not only maintains the photochromic properties of BTE moiety in solution, film, and solid state but also exhibits remarkable AIE properties. Moreover, the fluorescence of BTE-2PBT PMMA film could be modulated with high contrast by alternate UV and visible light irradiation. Photoerasing, rewriting, and non-destructive readout of fluorescent images on BTE-2PBT PMMA film well demonstrate its potential application as optical memory media. 相似文献
15.
Aamal A. Al-Mutairi Hend N. Hafez Abdel-Rhaman B. A. El-Gazzar Marwa Y. A. Mohamed 《Molecules (Basel, Switzerland)》2022,27(4)
In our attempt towards the synthesis and development of effective antimicrobial, anticancer and antioxidant agents, a novel series of 2,3-dihydropyrido[2,3-d]pyrimidin-4-one 7a–e and pyrrolo[2,1-b][1,3]benzothiazoles 9a–e were synthesized. The synthesis of 2-(1,3-benzo thiazol-2-yl)-3-(aryl)prop-2-enenitrile (5a–e) as the key intermediate was accomplished by a microwave efficient method. Via a new variety oriented synthetic microwave pathway, these highly functionalized building blocks allowed access to numerous fused heteroaromatic such as 7-amino-6-(1,3-benzo thiazol-2-yl)-5-(aryl)-2-thioxo-2,3dihydropyrido [2,3-d]pyrimidin-4(1H)-one 7a–e and 1-amino-2-(aryl)pyrrolo[2,1-b][1,3]benzothiazole-3-carbonitrile derivatives 9a–e in order to study their antimicrobial and anticancer activity. The present investigation offers effective and rapid new procedures for the synthesis of the newly polycondensed heterocyclic ring systems. All the newly synthesized compounds were evaluated for antimicrobial, anticancer and antioxidant activity. Compounds 7a,d, and 9a,d showed higher antimicrobial activity than cefotaxime and fluconazole while the remaining compounds exhibited good to moderate activity against bacteria and fungi. An anticancer evaluation of the newly synthesized compounds against the three tumor cell lines (lung cell NCI-H460, liver cancer HepG2 and colon cancer HCT-116) exhibited that compounds 7a, d, and 9a,d have higher cytotoxicity against the three human cell lines compared to doxorubicin as a reference drug. These compounds also exhibited higher antioxidant activity and a great ability to protect DNA from damage induced by bleomycin. 相似文献
16.
Elena Belgodere Ricardo Bossio Roberto Cencioni Stefano Marcaccini Roberto Pepino 《Journal of heterocyclic chemistry》1984,21(4):1241-1241
Reaction between 2-chloronicotinic acid chloride and 2-mercaptobenzimidazole afforded 5H-5-oxobenzimidazo[2,1-b]pyrido[3,2-e][1,3]thiazine, a novel heterocyclic ring system. The assigned structure was confirmed by means of mass spectrometry. 相似文献
17.
Richa Gupta Ram Pal Chaudhary 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):735-742
Abstract 8-Methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione, obtained by the condensation of 2-benzylidene-6-methoxy-3,4-dihydronapthalene-1(2H)-one with thiourea, on reaction with chloroacetic acid and 3-chloropropanoic acid in the presence of the ionic liquid N-methylpyridinium tosylate furnishes 3-methoxy-7-phenyl-7,10-dihydro-5H- benzo[h]thiazolo[2,3-b]quinazoline-9(6H)-one and 3-methoxy-7-phenyl-5,6,10,11-tetrahydro- benzo[h][1,3]thiazino[2,3-b]quinazoline-9(7H)-one. Further, condensation of the thione with 1,2-dibromoethane and 1,3-dibromopropane yields 3-methoxy-7-phenyl-6,7,9,10-tetrahydro-5 H-benzo[h]thiazolo[2,3-b]quinazoline and 3-methoxy-7-phenyl-5,6,7,9,10,11-hexahydrobenzo [h][1,3]thiazino[2,3-b]quinazoline respectively. Arylidene derivatives have been obtained by two routes. The structures of the cyclized compounds have been established on the basis of elemental analysis and spectroscopic data. The synthesized compounds were screened for antimicrobial activity. Some of the compounds showed promising antimicrobial activities. 相似文献
18.
García Ruano JL Fraile A Martín MR González G Fajardo C 《The Journal of organic chemistry》2008,73(21):8484-8490
1,3-Dipolar reactions of thiazolium azomethine ylides to enantiopure cyclic and acyclic vinyl sulfoxides provide an efficient access to polyfunctionalized pyrrolo[2,1-b][1,3]thiazoles in a highly regio- and stereoselective manner. Regioselectivity can be inverted by modifying the position of the sulfinyl group at the double bond of the sulfinylfuranones. The sulfoxide is the main controller of the endo selectivity of these processes as well as of the pi-facial selectivity in reactions of (Z)-3-p-tolylsulfinylacrylonitriles. In contrast, the pi-facial selectivity in reactions of 5-alkoxy-3-p-tolylsulfinyl furan-2(5H)-ones is mainly controlled by the configuration at C-5, affording the anti adducts with respect to the alkoxy group as the major or exclusive adducts. 相似文献
19.
Butani S. C. Vekariya M. K. Dholaria P. V. Kapadiya K. M. Desai N. D. 《Russian Journal of Organic Chemistry》2022,58(6):878-883
Russian Journal of Organic Chemistry - A series of 6-aryl-2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)imidazo[2,1-b][1,3,4]thiadiazoles were synthesized through a two-step procedure. The structure... 相似文献
20.
Kumar Parvin 《中国化学》2010,28(2):250-254
Synthesis of bis‐1,3‐{6′‐arylimidazo[2,1‐b][1,3,4]thiadiazol‐2‐yl}‐1,2,2‐trimethylcyclopentane ( 3 ), bis‐1,3‐{thiadiazolo[2′,3′:2,1]imidazo[4,5‐b]quinoxalinyl}‐1,2,2‐trimethylcyclopentane ( 5 ) has been achieved by the reaction of bis‐(5′‐amino‐1′,3′,4′‐thiadiazolyl)‐1,2,2‐trimethylcyclopentane with α‐haloketones, 2,3‐dichloroquinoxaline respectively. Bromination of compound 3 furnished bis‐1,3‐{5′‐bromo‐6′‐arylimidazo[2,1‐b][1,3,4]thiadiazol‐2‐yl}‐1,2,2‐trimethylcyclopentane ( 4 ). The structural assignment of these compounds was supported by IR, 1H NMR and elemental analysis data. The antimicrobial, anti‐inflammatory and antifungal activities of some of the compounds have also been evaluated. 相似文献