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ZHAI Xin ZHAO Yan-fang WANG Jia HONG Wei HUANG Liang GONG Ping 《高等学校化学研究》2006,22(4):459-464
IntroductionOxazolidinones, exemplified by linezolid, are anovel class of totally synthetic antibacterial agents withactivities against a variety of clinically important sus-ceptible and resistant Gram-positive pathogenic bacteriasuch as methicillin-resis… 相似文献
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A series of 6,7-dimethoxyquinazoline derivatives connected by diaryl urea scaffolds was designed, synthesized and their in vitro antitumor activities were evaluated. Most of them showed an excellent potency against the four tested cancer cell lines as compared with sorafenib. Particularly, a promising compound 20 was identified, which showed the most potent antitumor activities with IC50 values of 0.08, 0.09, 0.16 and 0.19 μmol/L against H460, HT-29, MKN-45 and MDA-MB-231 cell lines, respectively. The structure-activity relationship(SAR) analysis indicated that compounds with dimethylamino or diethylamino group at the C4 position of 6,7-dimethoxyquinazoline moiety exhibited superior activities than compounds bearing morpholino groups. 相似文献
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查尔酮是一类具有多种生物活性的1,3-二苯基丙烯酮化合物.以4-氟苯乙酮和2-噻吩甲醛为原料出发,经取代、Aldol反应和衍生化,合成得到16个未见文献报道的含哌嗪片段的噻吩查尔酮衍生物.以氧氟沙星、左氧氟沙星、莫西沙星作阳性对照,采用K-B纸片扩散法测试了目标化合物对金黄色葡萄球菌(Staphylococcus aureus Rosenbach)、大肠埃希菌(Escherichia coli)和枯草芽孢杆菌(Bacillus subtilis)的抑菌活性.结果表明,(E)-1-[4-(4-肉桂酸甲酯甲基哌嗪基)苯基]-3-(噻吩-2-基)丙-2-烯酮(4b)和(E)-1-{4-[4-(2-氧亚基苯乙基)哌嗪基]苯基}-3-(噻吩-2-基)丙-2-烯酮(4e)对枯草芽孢杆菌高度敏感,且最低抑菌浓度为4.0μg/m L. 相似文献
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以海洋来源青霉真菌Penicillim grisefulvum为研究对象,采用硅胶、C18柱和Sephadex LH-20凝胶柱层析等手段,从中分离获得3个桔霉素类化合物:7-methyl-penicitrinone A(1),citrinin(2)和penicitrinone A(3),其中化合物1为新化合物.通过一维核磁共振谱(1D NMR)、二维核磁共振谱(2D NMR)和高分辨质谱(HR-ESI-MS)对化合物1的平面结构和相对构型进行确定,并运用电子圆二色光谱(ECD)和量子化学计算方法确定了其绝对构型.抗菌活性测试结果表明,化合物1对副溶血性弧菌(Vibrio parahemolyticus)表现出了较强的抑制活性(MIC=0.8μmol/L),高于阳性对照药物环丙沙星的活性(MIC=1.3μmol/L). 相似文献
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TIAN Ye YU Simiao CAI Lude GONG Guowei WU Guodong QI Hongxia ZHAO Yanfang QIN Mingze 《高等学校化学研究》2019,35(1):41-46
A novel series of diaryl biuret derivatives containing a tetrazole moiety was designed and synthesized.All the target compounds were evaluated for their in vitro antitumor activity against HT-29,HepG2,MCF-7 and A549 cells by MTT assay.Most of them exhibited obvious antitumor activity,and four of them(4a,4c,4h and 7a)were superior to sorafenib in general.Among them,Compound 4h displayed more potent activity than sorafenib in all tested cancer cells.Compound 4c exhibited the most outstanding activity in inhibition of growth of HepG2 cells(IC50=0.55 μmol/L).Further,they both revealed favorable metabolic stability in in vitro assay.Compounds 4c and 4h are promising candidates for further development. 相似文献
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In order to develop novel spirocyclic tetronic acid lead compounds, a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed. The structures of 16 target compounds were characterized by 1H NMR spectra, 13C NMR spectra and high-resolution mass spectrometer(HRMS). Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilaparvata lugens at 100 mg/L. In particular, compound 6k showed the similar activity(LC50=6.87 mg/L) against A. fabae as the spirotetramat(LC50=4.56 mg/L) and had better effects(LC50=1.64 mg/L) against N. lugens in comparison with spirotetramat(LC50=7.90 mg/L). The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests. 相似文献
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A series of new sulfonylureas incorporating 1,2,4-triazolinone moiety was synthesized, which were further bio-assayed for the herbicidal activity against four herbs, representative of monocotyledons and dicotyledons. Some of them exhibited high potency to inhibit the growth of dicotyledons(Bassica napus and Amaranthus retroflexus) in the pot experiment. Compounds 9a and 9b also displayed an excellent herbicidal activity against Bassica napus at a concentration of 15 g/hectare, which were comparable with commercial triasulfuron. 相似文献
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以2-氨基-4,5-二甲氧基苯甲酸(2)和环酮(环戊酮、环己酮)为原料,在三氯氧磷作用下“一锅法”合成6,7-二甲氧基喹啉中间体(3),再与4-氨基哌啶或4-异丙基-1-氨基环己烷(4)发生Buchwald-Hartwig偶联反应,得到含有4-氨基哌啶或4-异丙基-1-氨基环己烷片段的6,7-二甲氧基喹啉衍生物(1a~1f),产物及中间体结构通过1H NMR、13C NMR、MS及元素分析进行表征。初步抗肿瘤活性测试表明,所合成化合物对HepG2、MCF-7、PC3和HeLa均有明显的抑制活性,尤其是化合物1b展现出较强的MCF-7抑制活性(IC50 =11.2μmol/L),甚至强于当前乳腺癌的一线治疗药物4-羟基他莫昔芬(IC50 =15.1μmol/L);此外,标题化合物对正常的乳腺上皮细胞MCF-10A没有毒性。 相似文献
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Synthesis,Characterization and Antibacterial Activity of New 5-Aryl Pyrazole Oxime Ester Derivatives
Eleven new 1-{5-[4-(benzyloxy)phenyl]-3-methyl-4,5-dihydropyrazol-l-yl} oxime ester dcrivatives were synthesized and characterized by elemental analysis, HRMS, ^1H NMR data. All the compounds were screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results indicate that compounds 8c and 8f possess potent activity with the minimum inhibitory concentrations(MIC) of 1.562--3.125 ug/mL against all the four bacteria. Compounds 8c, 8e and 8f show moderate inhibition against the DNA gyrase(IC50=1.9--2.5 ug/mL). On the basis of the biological activities, structure-activity relationship was discussed. 相似文献
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Microwave-Assisted Solid-Phase Synthesis of Cephalosporin Derivatives with Antibacterial Activity 总被引:1,自引:0,他引:1
Mazaahir Kidwai Preeti Misra Kumar R. Bhushan Rajendra K. Saxena Meena Singh 《Monatshefte für Chemie / Chemical Monthly》2000,131(9):937-943
Summary. The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation
afforded the N-acylated cephalosporin analogues in satisfactory yield. All compounds were tested for their antibacterial activity;
some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs.
Received February 23, 2000. Accepted March 28, 2000 相似文献
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利用中间体衍生化方法, 将噻吩环引入到双酰胺类化合物中, 合成了一系列取代噻吩双酰胺类化合物1~3; 目标化合物的结构经核磁共振波谱、 红外光谱及元素分析确认. 生物活性测试结果表明, 化合物1在600 mg/L剂量下对小菜蛾具有良好的杀虫效果, 致死率均为100%, 其中化合物1a和1e在20 mg/L剂量下对小菜蛾的致死率仍达到60%以上; 改变双酰胺结构中的吡唑环得到化合物2和3, 其杀虫活性消失, 说明该类化合物中吡唑环结构对杀虫活性具有关键作用. 相似文献
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Nuray Ulusoy Öznur Ateş Ömer Küçükbasmacı Muammer Kiraz Yıldız Yeğenoğlu 《Monatshefte für Chemie / Chemical Monthly》2003,134(3):465-474
Summary. Some novel 4-[[2-[[5-(2-furanyl)-4-alkyl/aryl-4H-1,2,4-triazol-3-yl]thio]-acetyl/propionyl]-amino]-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazoles were synthesized and evaluated for in vitro antibacterial activity against Staphylococcus aureus ATCC 29213, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, and Enterococcus faecalis ATCC 29212 and antifungal activity against Candida albicans ATCC 10231, Candida parapsilosis ATCC 22019, Candida krusei ATCC 6258, Candida parapsilosis, Trichophyton mentagrophytes var. erinacei NCPF 375, Microsporum gypseum NCPF 580, and Trichophyton rubrum using the microbroth dilution method. All of the compounds were found to be ineffective against the above bacteria within
the applied MIC ranges. On the other hand, they were effective against fungi to different degrees. Three compounds showed
high activity against C. parapsilosis and T. mentagrophytes var. erinacei NCPF 375 (MIC = 8 μg cm−3). The in vitro antimycobacterial activity of the new compounds was also investigated against Mycobacterium tuberculosis H37RV (ATCC 27294) in BACTEC 12B medium using a broth microdilution assay, the Microplate Alamar Blue Assay (MABA). Compounds
exhibiting fluorescence were tested in the BACTEC 460 radiometric system. The most active compound was found with 66% inhibition
at >6.25 μg cm−3.
Corresponding author. E-mail: nurayulusoy@yahoo.com
Received July 24, 2002; accepted August 26, 2002 相似文献
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Lei Liu Hui-zhu Yuan Zhao-hai Qin Xiao-jing Yan Yu-mei Xiao Nan Li 《Phosphorus, sulfur, and silicon and the related elements》2013,188(8):1790-1800
Abstract A series of novel 1,3-thiazoline derivatives containing a 5- or 6-position halogenated indole moiety were synthesized via a one-pot and three-step reaction. Their structures were confirmed by spectroscopic methods. The fungicidal activities of all the title compounds were evaluated. Most of them exhibited moderate to high activity against eight plant pathogens at the concentration of 50 ug/mL. Generally the fungicidal activity of fluorinated indolyl thiazolines was higher than that of chlorinated indolyl thiazoline derivatives. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT 相似文献
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Synthesis and Insecticidal Activity of New Quinoline Derivatives Containing Perfluoropropanyl Moiety
Long Cheng Peng‐Peng Cai Rui‐Rui Zhang Liang Han Cheng‐Xia Tan Jian‐Quan Weng Tian‐Ming Xu Xing‐Hai Liu 《Journal of heterocyclic chemistry》2019,56(4):1312-1317
A series of new quinoline derivatives containing perfluoropropanyl moiety were designed and synthesized. Their structures were confirmed by 1H‐NMR, MS, and elemental analysis. The bioassay results showed that compound 4e exhibited good insecticidal activity against Plutella xylostella and Mythimna separata at 100 mg/L. 相似文献