A 1-D chain praseodymium complex with chelidamic acid: synthesis,structure, and optical properties

The title compound [Pr(C₇H₃NO₅)(C₇H₄NO₅)(H₂O)₂] _n · 1.25nH₂O (1) or [Pr(HChel)(H₂Chel)(H₂O)₂] _n · 1.25nH₂O, where H₃Chel is 4-hydroxypyridine-2,6-dicarboxylic (chelidamic) acid, was synthesized by reaction of chelidamic acid, PrCl₃ · 6H₂O and H₂O under hydrothermal conditions, and characterized by X-ray single-crystal diffraction. The crystal structure of 1 reveals that Pr is nine-coordinate with distorted tricapped trigonal prismatic coordination. Coordination polyhedra are interlinked into a 1-D chain, further linked by hydrogen bonds into a 3-D network. Fluorescence spectra exhibit strong green luminescence with maximum emission at 530 nm when excited with λ _ex = 475 nm, originating from π–π* of the ligand.     

The Synthesis of 1-Aryl-5-Fluorouracil

5-Fluorouracil (5-Fu,1)1 is an important antitumor drug. Some derivatives2,3 have shown better therapeutic efficacy than 5-Fu. In order to find much more better antitumor drugs of its derivatives, several attempts have been made and many different types of its derivatives have been prepared at N1, N3 position4~7. Moreover, several different ways have been used for alkylation of 5-Fu7~10. However, up to now, the arylation of 5-Fu at N1 or N3 position hasn't been reported, and the compound o…     

不同沉淀剂制备的Ag／TS－1催化丙烯直接气相氧化合成环氧丙烷

 在423K、常压固定床石英反应器中，以丙烯直接气相氧化为探针反应，考察了催化剂制备方法、沉淀剂的种类和浓度对制备的Ag／TS－1催化剂催化性能的影响，采用TEM，XRD和UV－Vis等表征手段对Ag／TS－1催化剂进行了分析．结果表明，沉积－沉淀法是最佳的催化剂制备方法，但浸渍法也可制得具有环氧丙烷选择性的催化剂．K2CO3是一种良好的沉淀剂．以K2CO3为沉淀剂，硅钛比为64的TS－1为载体制备的Ag／TS－1催化剂上的丙烯转化率为1．72％，环氧丙烷选择性为98．2％．少量单质银的存在有利于环氧丙烷的生成，除银粒子的分散状态外，银粒子与载体TS－1间的相互作用对提高催化剂的选择性具有决定性作用．     

蚜虫报警信息素EBF的合成

[反]－β－法尼烯（E－β－Farnesene,简称EBF）是许多蚜虫报警信息素的主要成份，可用于控制蚜虫危害，本文从起始原料的角度，着重从橙花叔醇，法尼醇，月桂烯和香叶基溴四类主要原料，总结了蚜虫报警信息素EBF的合成方法研究进展，并对各种方法进行了简要评述。     

A Novel and Convenient Synthesis of Coenzyme Q1

Abstract

A convenient and efficient synthetic route to Coenzyme Q₁ (6) starting from 3,4,5‐trimethoxytoluene (1) is described. The key features of this synthesis include the Diels–Alder reaction of 2,3‐dimethoxy‐l,4‐benzoquinone (3) with cyclopentadiene and the introduction of a C₅ side chain to 4,5‐dimethoxy‐2‐methyltricyclo[6.2.1.0^2,7]undeca‐4,9‐diene‐3,6‐dione (4) under mild conditions, (6) was obtained in overall 60% yield.     

立方介孔分子筛Zr-SBA-1的合成及表征

在强酸性条件下以十六烷基三甲基溴化铵为模板剂,TEOS为硅源,沿S X-I 途径合成了Zr含量为0.85~2.42%的介孔分子筛Zr-SBA-1.采用XRD、SEM、BET、DR UV-V is等技术对所合成的Zr-SBA-1的表征结果表明,所合成的Zr-SBA-1分子筛具有典型的立方相介孔结构SBA-1分子筛的特征,锆物种被成功引入分子筛骨架中.     

Synthesis,Crystal Structure and Fluorescence of A 1-D Polymeric Zinc(Ii) Complex with Pyrazine-2-Carboxylate as a Bridging Ligand

A one-dimensional chain complex {[Zn(pyz)(SCN)(H₂O)₂]·H₂O}_∞ (pyz = pyrazine-2-carboxylic anion) has been synthesized and its crystal structure determined by X-ray crystallography. The complex crystallizes in an orthorhombic system and the space group is P2 ₁2₁2₁ with a = 6.873(3), b = 9.847(4), c = 16.466(7) Å. The Zn(II) ion is located in a distorted octahedral environment with two oxygen atoms O(3) and O(4) from terminal ligands of two water molecules, another oxygen atom O(1) from the carboxylate group of pyz, and three nitrogen atoms, N(1), and N(2A) from two different pyz and N(3) from a terminal thiocyanate anion, in which a chelated five-membered ring is formed by coordination of O(1) and N(1) to the Zn(1) atom. Therefore, an infinite zigzag chain consisting of Zn(II) ions and pyz anions is constructed and the chains are linked together with hydrogen bonding from coordinated and uncoordinated water molecules. The fluorescence spectra for the bridging ligand Na(pyz) and the complex were measured at room temperature in aqueous solution and in the solid state.     

Synthesis of (±)-Lsodeoxypodophyllotoxin

A process for the synthesis of (±)-isodeoxypodophyllotoxin starting from ethyl 3,4-methylcnedioxy-benzoacetate and methyl 3,4,5-trimethoxycinnamate is described.     

Two solvent directed zinc(II) coordination polymers with 1-D single-zigzag chain and 1-D double-zigzag chains

Two coordination polymers, {[Zn(NiL)(DMA)(H₂O)₂] (DMA)(H₂O)} _n (1) (DMA?=?N,N-dimethylacetamide) and {[Zn₂(NiL)₂(DMF)(H₂O)₄]?·?3DMF} _n (2) (DMF?=?N,N-dimethylformamide), have been prepared by reactions of Zn(NO₃)₂?·?6H₂O and NiL in CH₂Cl₂-DMA–H₂O and CH₂Cl₂-DMF–H₂O, respectively. H₂L denotes dimethyl 5,6,7,8,15,16-hexahydro-6,7-dioxodibenzo-9,10-benzo-[1,4,8,11]tetraazacyclotetradecine-13,18-dicarboxylate. Single-crystal X-ray diffraction analyses reveal that coordination geometries around Ni(II) are identical with slightly distorted square planar and all Ni–N bonds are very short. Complex 1 shows 1-D zigzag chain structure, while 2 has 1-D double-zigzag chains. The chains, which are packed parallel in 1 and 2, are interconnected by lattice solvent through O–H···O and C–H···O hydrogen bonds to form 3-D supramolecular networks. We discuss solvent effects on assembly of the two coordination polymers. The results reveal that coordinated solvent has influence on the assembly procedure.     

A cyanide-bridged 1-D helical chain involving both four- and six-coordinate nickel(II)

A cyanide-bridged coordination polymer, {[Ni(tren)][Ni(CN)₄]} _n (tren?=?tris(2-aminoethyl)amine), has been synthesized by self-assembly of cis-[Ni(tren)]²⁺ and [Ni(CN)₄]^2? building blocks. In the molecular structure, the paramagnetic cis-[Ni(tren)]²⁺ cations are bridged by diamagnetic [Ni(CN)₄]^2? anions through two cis-cyanides to form a 1-D helical chain of {[Ni(tren)][Ni(CN)₄]} _n . The compound crystallizes with a centrosymmetrical space group, P2₁ /n, in which the helical chains are packed in alternating right- and left-handed chiralities with a helical pitch of 10.2566(3)?Å (equal to the length of the b-axis), leading to the formation of a racemic compound. The crystal packing is stabilized by moderately strong hydrogen-bonding between primary amines of tren and nitrogens of terminal cyanide.     

Al-TS-1的合成及催化氧化性能

系统研究了Al掺杂TS-1(Al-TS-1)分子筛的合成及其催化氧化性能,采用X射线衍射、紫外-可见光谱、电感耦合等离子体发射光谱、扫描电镜、²⁷Al和²⁹Si固体核磁共振等手段对Al-TS-1样品进行了表征.结果表明,在合成过程中,Al的引入会影响TS-1中骨架Ti的形成,但当Al含量低于一定值(Al/Si≤0.005)时,其影响很小.Al-TS-1中骨架Al和骨架Ti均不对其相应的酸催化和催化氧化作用产生影响.骨架Al抑制了Al-TS-1在碱性应用体系中的与Ti相邻Si的溶脱,从而保护了骨架Ti活性中心.     

用新方法催化合成6-乙酰基-1-甲基环己烯

室温下用HY沸石取代传统催化剂通过1-甲基环己烯与乙酐的酰基化反应合成了6-乙酰基-1-甲基环己烯，考察了HY沸石的SiO2／Al2O2摩尔比、用量和活化时间以及反应时间对该酰化反应的影响．当1-甲基环己烯／乙酐／HY沸石(SiO2／Al2O3摩尔比=29)=1mmol／10mmol／0．200g、反应温度25℃、反应时间3h时，所得酰化产品的产率为60％，HY沸石能够回收和重新使用，显示出与新鲜催化剂几乎相同的催化活性．     

Template-Free Synthesis of AlPO 4 -H1 by Microwave Heating

Microwave heating enhanced the crystallization of aluminophosphate gels, and AlPO 4 -H1 was successfully obtained without using organic template reagents in a short reaction time. The use of amorphous aluminum hydroxide as an aluminum source and the addition of hydrochloric acid were found to be essentially important to obtain AlPO 4 -H1 as a single phase. Nitrogen and water adsorption properties were studied by measuring the adsorption isotherms.     

新型介孔分子筛Sn-SBA-1的合成与表征

在强酸性条件下沿“S X-I ”路线合成了具有立方结构(空间点群为Pm3n)的含Sn介孔分子筛SBA-1,并通过多种手段对其进行表征:XRD显示合成的介孔材料具有良好有序的立方结构,N2吸脱附测得样品有大的孔径(≈2nm)和比表面积(>1100m2g-1),UV-vis和FT-IR证明杂原子Sn替代S i进入分子筛骨架,并且以高分散四面体配位形式存在于分子筛骨架中,SEM则确定合成出来的材料为球形颗粒,粒径在2-4μm之间.     

以钛酸四丁酯和四氯化钛混合物作钛源合成钛硅分子筛TS—1

以四丙基溴化铵（TPABr)作模板剂、氨水作碱源,以四氯化钛部分取代钛酸四丁酯作钛源,成功地合作了钛硅分子筛TS－1。用XRD、IR、UV－Vis等手段进行表征的结果显示,样品呈现MFI拓扑结构特征。同经典合成体系的TS－1相对比,在紫外谱图上,样品中未出现锐钛矿TiO2的特征吸收,证明混合钛源更有利于钛原子进入分子筛骨架内,合成的分子筛样品在丙烯环氧化反应中也表现出了优异的催化性能。     

Applications of Nanomaterials in Microbial Fuel Cells: A Review

Microbial fuel cells (MFCs) are an environmentally friendly technology and a source of renewable energy. It is used to generate electrical energy from organic waste using bacteria, which is an effective technology in wastewater treatment. The anode and the cathode electrodes and proton exchange membranes (PEM) are important components affecting the performance and operation of MFC. Conventional materials used in the manufacture of electrodes and membranes are insufficient to improve the efficiency of MFC. The use of nanomaterials in the manufacture of the anode had a prominent effect in improving the performance in terms of increasing the surface area, increasing the transfer of electrons from the anode to the cathode, biocompatibility, and biofilm formation and improving the oxidation reactions of organic waste using bacteria. The use of nanomaterials in the manufacture of the cathode also showed the improvement of cathode reactions or oxygen reduction reactions (ORR). The PEM has a prominent role in separating the anode and the cathode in the MFC, transferring protons from the anode chamber to the cathode chamber while preventing the transfer of oxygen. Nanomaterials have been used in the manufacture of membrane components, which led to improving the chemical and physical properties of the membranes and increasing the transfer rates of protons, thus improving the performance and efficiency of MFC in generating electrical energy and improving wastewater treatment.     

钛硅分子筛（TS－1）的合成、结构表征及催化性能研究

在不同条件下成功地合成了钛硅分子筛ＴＳ－１，并利用ＩＣＰ－ＡＥＳ、ＸＲＤ、ＦＴ－ＩＲ、ＴＭＥ等手段对所获得的分子筛进行了表征，研究发现，ＴＳ－１分子筛中骨架钛与非骨架锐钛矿的相对含量、晶体结构、晶体粒子的大小、形貌特征等属性与分子筛的合成方法密切相关。并通过氯丙烯环氧化反应研究了获得的ＴＳ－１分子筛的催化活性与合成方法及其结构之间的相互关系。     

混合二烃基二氯化锡与水杨醛缩苯胺类Schiff碱1∶1配合物的合成和表征

由混合二烃基二氯化锡（ＲＲ＇ＳｎＣｌ＿２）与水杨醛缩苯胺类Ｓｃｈｉｆｆ碱（２－ＨＯＣ＿６Ｈ＿４ＣＨ＝ＮＡｒ）反应，合成了１４种新的有机锡配合物。经元素分析、ＩＲ、ＮＭＲ和ＴＧ－ＤＳＣ测定，确定配合物的组成是有机锡与Ｓｃｈｉｆｆ碱的１：１配合物，配体以酚羟基氧原子与锡原子配位，摩尔电导率测定表明配合物均为非电解质。     

Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency

Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.     

Carbon Nanomaterials for Targeted Cancer Therapy Drugs: A Critical Review

Cancer represents one of the main causes of human death in developed countries. Most current therapies, unfortunately, carry a number of side effects, such as toxicity and damage to healthy cells, as well as the risk of resistance and recurrence. Therefore, cancer research is trying to develop therapeutic procedures with minimal negative consequences. The use of nanomaterial‐based systems appears to be one of them. In recent years, great progress has been made in the field using nanomaterials with high potential in biomedical applications. Carbon nanomaterials, thanks to their unique physicochemical properties, are gaining more and more popularity in cancer therapy. They are valued especially for their ability to deliver drugs or small therapeutic molecules to these cells. Through surface functionalization, they can specifically target tumor tissues, increasing the therapeutic potential and significantly reducing the adverse effects of therapy. Their potential future use could, therefore, be as vehicles for drug delivery. This review presents the latest findings of research studies using carbon nanomaterials in the treatment of various types of cancer. To carry out this study, different databases such as Web of Science, PubMed, MEDLINE and Google Scholar were employed. The findings of research studies chosen from more than 2000 viewed scientific publications from the last 15 years were compared.