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1.
《Macromolecular bioscience》2018,18(7)
Strontium has a beneficial role on bone remodeling and is proposed for the treatment of pathologies associated to excessive bone resorption, such as osteoporosis. Herein, the possibility to utilize a biomimetic scaffold as strontium delivery system is explored. Porous 3D gelatin scaffolds containing about 30% of strontium substituted hydroxyapatite (SrHA) or pure hydroxyapatite (HA) are prepared by freeze‐drying. The scaffolds display a very high open porosity, with an interconnectivity of 100%. Reinforcement with further amount of gelatin provokes a modest decrease of the average pore size, without reducing interconnectivity. Moreover, reinforced scaffolds display reduced water uptake ability and increased values of mechanical parameters when compared to as‐prepared scaffolds. Strontium displays a sustained release in phosphate buffered saline: the quantities released after 14 d from as‐prepared and reinforced scaffolds are just 14 and 18% of the initial content, respectively. Coculture of osteoblasts and osteoclasts shows that SrHA‐containing scaffolds promote osteoblast viability and activity when compared to HA‐containing scaffolds. On the other hand, osteoclastogenesis and osteoclast differentiation are significantly inhibited on SrHA‐containing scaffolds, suggesting that these systems could be usefully applied for local delivery of strontium in loci characterized by excessive bone resorption. 相似文献
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以明胶为模板剂,制备出在明胶水溶液中稳定存在的HgS微晶.通过扫描电镜(SEM)图像表明,生长时间为2d的样品为微晶结构,生长15d的HgS微晶为针状,平均直径约87nm,长度约1.3μm.紫外可见吸收和荧光光谱的测试结果表明,所合成HgS具有量子限域效应.明胶分子的构象变化对HgS纳米颗粒的成核和形貌转化起到非常重要的作用. 相似文献
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双连续微乳模板合成羟基磷灰石仿生物骨材料的研究 总被引：5，自引：0，他引：5
为制备具有与天然生物骨磷灰石结构相似的羟基磷灰石（hydroxyapatites简称HAP或HA）材料,依据生物矿化的原理,通过以十六烷基三甲基溴化铵（CTAB）作为表面活性剂,正己醇为助表面活性剂,十六烷为油相和水作出的拟三元相图,找到体系所形成的双连续微乳液作为模板,控制矿化材料的成核和生长,并用SEM,TEM,XRD,IR等手段对合成的样品进行了形貌和结构的表征,并将其与共沉淀法制备的HAP在模拟体液中的溶解性进行了比较。结果表明：得到的矿化产物是具有棒状的六方晶体组成羟基磷灰石矿化材料,其结构参数a0=0.920,c0=0.688,与天然生物骨材料较相似,抗体液溶解性比共沉淀法制备的优越。 相似文献
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凝聚态化学是研究凝聚态材料的合成、组分、结构、性能、相互作用及相关化学反应等多个领域的一门学科。近年来对生物矿物这种特殊的天然凝聚态材料不断深入的探索,极大扩展了凝聚态化学原有的研究视野。这些生物矿物常通过非经典的方式,在温和而复杂的体内甚至体外环境中形成;它们具有长期进化筛选出的跨尺度多级组织结构,充分利用了材料微观形态和不同凝聚态材料间的表、界面相互作用,因此具有非常优异的性能。本文通过分析生物矿物形成和转化过程中涉及的几种特殊机制,阐明真实环境条件下凝聚态材料合成和凝聚态化学反应的一些新特征。同时,还将介绍由生物矿物相关研究推动的凝聚态化学的实际应用。最后,对该领域未来需要解决的问题和重要发展方向做出展望。 相似文献
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蛋白质糖基化分析对深入认识其生物功能和发现生物标志物意义重大。由于生物样品中糖肽的丰度低,糖肽的富集至关重要。该文合成了一种以色氨酸为功能基团的新型仿生聚合物材料(简称Poly-Trp),并用于糖肽的高选择性富集。扫描电子显微镜、热分析仪和红外光谱仪等表征证明Poly-Trp已成功合成。通过考察溶液条件变化对糖肽在Poly-Trp保留的影响,发现糖肽在Poly-Trp上的保留分别随着溶液中乙腈浓度的降低和酸度的升高而变弱。且Poly-Trp对牛胎球蛋白糖肽的富集选择性高于商品化ZIC-HILIC和氨基硅胶,能抵抗物质的量倍数为100的牛血清白蛋白的干扰。该研究中仿生聚合物材料的设计为糖肽富集材料提供了新思路和新方法。 相似文献
6.
Natan Roberto de Barros Mohammad Ali Darabi Xin Ma Sibel Emir Diltemiz Menekse Ermis Alireza Hassani Najafabadi Sara Nadine Ethan A. Banton Kalpana Mandal Reza Abbasgholizadeh Natashya Falcone João F. Mano Rohollah Nasiri Rondinelli Donizetti Herculano Yangzhi Zhu Serge Ostrovidov Junmin Lee Han-Jun Kim Vahid Hosseini Mehmet R. Dokmeci Samad Ahadian Ali Khademhosseini 《Macromolecular bioscience》2023,23(12):2370037
Several microfabrication technologies have been used to engineer native-like skeletal muscle tissues. However, the successful development of muscle remains a significant challenge in the tissue engineering field. Muscle tissue engineering aims to combine muscle precursor cells aligned within a highly organized 3D structure and biological factors crucial to support cell differentiation and maturation into functional myotubes and myofibers. In this study, the use of 3D bioprinting is proposed for the fabrication of muscle tissues using gelatin methacryloyl (GelMA) incorporating sustained insulin-like growth factor-1 (IGF-1)-releasing microparticles and myoblast cells. This study hypothesizes that functional and mature myotubes will be obtained more efficiently using a bioink that can release IGF-1 sustainably for in vitro muscle engineering. Synthesized microfluidic-assisted polymeric microparticles demonstrate successful adsorption of IGF-1 and sustained release of IGF-1 at physiological pH for at least 21 days. Incorporating the IGF-1-releasing microparticles in the GelMA bioink assisted in promoting the alignment of myoblasts and differentiation into myotubes. Furthermore, the myotubes show spontaneous contraction in the muscle constructs bioprinted with IGF-1-releasing bioink. The proposed bioprinting strategy aims to improve the development of new therapies applied to the regeneration and maturation of muscle tissues. 相似文献
7.
Taotao Liu Wenxian Weng Yuzhuo Zhang Xiaoting Sun Huazhe Yang 《Molecules (Basel, Switzerland)》2020,25(22)
In recent years, the microfluidic technique has been widely used in the field of tissue engineering. Possessing the advantages of large-scale integration and flexible manipulation, microfluidic devices may serve as the production line of building blocks and the microenvironment simulator in tissue engineering. Additionally, in microfluidic technique-assisted tissue engineering, various biomaterials are desired to fabricate the tissue mimicking or repairing structures (i.e., particles, fibers, and scaffolds). Among the materials, gelatin methacrylate (GelMA)-based hydrogels have shown great potential due to their biocompatibility and mechanical tenability. In this work, applications of GelMA hydrogels in microfluidic technique-assisted tissue engineering are reviewed mainly from two viewpoints: Serving as raw materials for microfluidic fabrication of building blocks in tissue engineering and the simulation units in microfluidic chip-based microenvironment-mimicking devices. In addition, challenges and outlooks of the exploration of GelMA hydrogels in tissue engineering applications are proposed. 相似文献
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Dr. Feng Dang Dr. Yuya Oaki Takao Kokubu Dr. Eiji Hosono Dr. Haoshen Zhou Prof. Dr. Hiroaki Imai 《化学:亚洲杂志》2013,8(4):760-764
Nanoporous MnO frameworks with highly dispersed Co nanoparticles were produced from MnCO3 precursors prepared in a gel matrix. The MnO frameworks that contain 20 mol % Co exhibited excellent cycle performance as an anode material for Li‐ion batteries. The solid–electrolyte interphase (SEI) formed in the frameworks through the electrochemical reaction mediates the active materials, such as MnO, Mn, and Li2O, during the conversion reaction in the charge–discharge cycle. The Co nanoparticles and SEI provide the electron and Li‐ion conductive networks, respectively. The ternary nanocomposites of the MnO framework, metallic Co nanoparticles, and embedded SEI are categorized as durable anode materials for Li‐ion batteries. 相似文献
10.
Under eons of evolutionary and environmental pressure, biological systems have developed strong and lightweight peptide-based polymeric materials by using the 20 naturally occurring amino acids as principal monomeric units. These materials outperform their man-made counterparts in the following ways: 1) multifunctionality/tunability, 2) adaptability/stimuli-responsiveness, 3) synthesis and processing under ambient and aqueous conditions, and 4) recyclability and biodegradability. The universal design strategy that affords these advanced properties involves \"bottom-up\" synthesis and modular, hierarchical organization both within and across multiple length-scales. The field of \"biomimicry\"-elucidating and co-opting nature's basic material design principles and molecular building blocks-is rapidly evolving. This Review describes what has been discovered about the structure and molecular mechanisms of natural polymeric materials, as well as the progress towards synthetic \"mimics\" of these remarkable systems. 相似文献
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Valtchev V Smaihi M Faust AC Vidal L 《Angewandte Chemie (International ed. in English)》2003,42(24):2782-2785
12.
Meifang Fu Dr. Anhe Wang Dr. Xiaoming Zhang Prof. Dr. Luru Dai Prof. Dr. Junbai Li 《Angewandte Chemie (International ed. in English)》2016,55(3):908-911
Biological organic–inorganic hybrid materials often achieve excellent properties and provide inspiration for the design of advanced materials. The organic phase plays a key role in determining the properties of biogenic materials, and the spatial arrangement of organic and inorganic phases provides direct evidence for interaction between the two phases. Super‐resolution fluorescence microscopy was used to visualize the gelatin distribution in two different crystalline polymorphs of calcium carbonate (vaterite and calcite) and to investigate the process by which gelatin is excluded from the crystals. The results demonstrated that gelatin is distributed through vaterite microspheres in the form of nanoparticles, whereas it tends to accumulate on the edges of the calcite rhombohedra. 相似文献
13.
Botterhuis NE Sun Q Magusin PC van Santen RA Sommerdijk NA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(5):1448-1456
Herein we report the synthesis and characterization of hollow silica spheres with a narrow size distribution, uniform wall thickness, and a worm-like pore structure. The formation of these spheres was monitored by confocal laser scanning microscopy and dynamic light scattering. A model for the molecular build-up of these silica hollow spheres is derived from these data in combination with studies of the as-made particles by transmission electron microscopy, scanning electron microscopy, pore size analysis, thermogravimetric analysis, and solid-state nuclear magnetic resonance. We further demonstrate that these spheres can be used for the encapsulation and subsequent release of different dye molecules. 相似文献
14.
Structured color in nature is controlled by nano‐ and micro‐structured interfaces giving rise to a photonic bandgap. This study presents a biomimetic optical material based on polymeric inverse opals that respond to enzyme activity. Polymer colloids provide a template in which acryloyl‐functionalized poly(ethylene glycol) is integrated; dissolution of the colloids leads to a hydrogel inverse opal that can be lithographically patterned using transfer printing. Incorporating enzyme substrates within the voids provides a material that responds to the presence of proteases through a shift in the optical properties. 相似文献
15.
海洋中的贻贝依靠丝足(Byssus)与足盘(Plaque)可以在潮湿及水下环境中快速而牢固地黏附于各种固体表面。贻贝强健的足部具有沟渠状的生理结构,通过类似于“注塑生产”的生理过程,它们可以生成丝足与足盘。贻贝将液态的蛋白质挤压到沟渠里,只需几秒钟时间,这些蛋白质就能形成一条条发丝一样纤细的丝足。每条丝足的末端都有一个黏性足盘,足盘可以牢牢地黏附在岩石及固体表面。丝足及足盘由多种黏附蛋白(Mfps)组成,且几乎每种黏附蛋白都含有L-3,4-二羟基苯丙氨酸(DOPA)成分。在过去的数十年间,科研人员基本揭示了贻贝黏附蛋白的结构及其黏附机理。DOPA的儿茶酚基团,通过氧化交联、金属螯合、氢键、静电作用、疏水作用、π-π作用、阳离子-π作用等各种共价和非共价相互作用,实现强大的界面黏接。基于贻贝黏附蛋白的结构及其黏附机理,通过使用DOPA及其类似物修饰的聚合物体系,人们得到了多种具有优秀机械性能和功能化的新型仿生多巴类水下胶黏剂。本综述首先介绍了贻贝黏附蛋白的组成特点及其黏附机理;随后分别介绍了凝聚层类胶黏剂、水凝胶类胶黏剂、智能型水下胶黏剂的结构特点及黏附机理;最后讨论了目前仿生水下胶黏剂存在的问题及未来发展前景。 相似文献
16.
Jason R. McKee Johannes Huokuna Lahja Martikainen Mikko Karesoja Dr. Antti Nykänen Dr. Eero Kontturi Prof. Heikki Tenhu Prof. Janne Ruokolainen Prof. Olli Ikkala 《Angewandte Chemie (International ed. in English)》2014,53(20):5049-5053
Even though nanocomposites have provided a plethora of routes to increase stiffness and strength, achieving increased toughness with suppressed catastrophic crack growth has remained more challenging. Inspired by the concepts of mechanically excellent natural nanomaterials, one‐component nanocomposites were fabricated involving reinforcing colloidal nanorod cores with polymeric grafts containing supramolecular binding units. The concept is based on mechanically strong native cellulose nanocrystals (CNC) grafted with glassy polymethacrylate polymers, with side chains that contain 2‐ureido‐4[1H]‐pyrimidone (UPy) pendant groups. The interdigitation of the grafts and the ensuing UPy hydrogen bonds bind the nanocomposite network together. Under stress, UPy groups act as sacrificial bonds: simultaneously providing adhesion between the CNCs while allowing them to first orient and then gradually slide past each other, thus dissipating fracture energy. We propose that this architecture involving supramolecular binding units within side chains of polymer grafts attached to colloidal reinforcements opens generic approaches for tough nanocomposites. 相似文献
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Qurat Ul Ain;Mahira Zeeshan;Danish Mazhar;Ahmed Zeb;Iqra Afzal;Hameed Ullah;Hussain Ali;Abbas Rahdar;Ana M. Díez-Pascual; 《Macromolecular bioscience》2024,24(2):2300336
Biomaterials such as nanohydroxyapatite and gelatin are widely explored to improve damaged joint architecture associated with rheumatoid arthritis (RA). Besides joint damage, RA is associated with inflammation of joints and cartilage, which potentiates the need for both bone nucleation and therapeutic intervention. For such purpose, a modified nanoprecipitation method is used herein to fabricate tofacitinib (Tofa)-loaded nanohydroxyapatite (nHA) embedded gelatin (GLT) nanoparticles (NPs) (Tofa-nHA-GLT NPs). The quality by design (QbD) approach is chosen to assess the key parameters that determine the efficiency of the NPs, and are further optimized via Box–Behnken design of experiment. The particle size, polydispersity, zeta potential, and encapsulation efficiency (EE) of the prepared NPs are found to be 269 nm, 0.18, −20.5 mV, and 90.7%, respectively. Furthermore, the NPs have improved stability, skin permeability, and a sustained drug release pattern at pH 6.5 (arthritic joint pH). Moreover, rhodamine-B loaded nHA-GLT NPs demonstrates considerably higher cellular uptake by the murine-derived macrophages than free rhodamine-B solution. In vitro, cell-based experiments confirm the good cell biocompatibility with insignificant toxicity. Thus, QbD-based approach has successfully led to the development of Tofa-nHA-GLT NPs with the potential to target inflamed arthritic joint. 相似文献
19.
甲基丙烯酰胺基明胶(GelMA)水凝胶的制备及其在生物医学领域的应用是最近十几年的研究热点。GelMA水凝胶因其独特的光致交联特性,可以加工成不同形貌的水凝胶支架材料,同时,因其具有可控的力学性能、降解性能,以及优秀的生物相容性,已成为具有广泛应用前景的生物高分子聚合物材料。本文主要介绍了GelMA水凝胶在止血材料、创伤敷料、组织工程支架、药物控释、骨缺损修复等领域的研究进展。 相似文献
20.
Fei Wang Lvye Dou Jianwu Dai Yuyao Li Liqian Huang Yang Si Jianyong Yu Bin Ding 《Angewandte Chemie (International ed. in English)》2020,59(21):8285-8292
Resilient and compressible three‐dimensional nanomaterials comprising polymers, carbon, and metals have been prepared in diverse forms. However, the creation of thermostable elastic ceramic aerogels remains an enormous challenge. We demonstrate an in situ synthesis strategy to develop biomimetic silica nanofibrous (SNF) aerogels with superelasticity by integrating flexible electrospun silica nanofibers and rubber‐like Si?O?Si bonding networks. The stable bonding structure among nanofibers is in situ constructed along with a fibrous freeze‐shaping process. The resultant SNF aerogels exhibit integrated properties of ultralow density (>0.25 mg cm?3), temperature‐invariant superelasticity up to 1100 °C, and robust fatigue resistance over one million compressions. The ceramic nature also endows the aerogels with fire resistance and ultralow thermal conductivity. The successful synthesis of the SNF aerogels opens new pathways for the design of superelastic ceramic aerogels in a structurally adaptive and scalable form. 相似文献