Polycationic glycosides

Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.     

Secondary-emission mass spectrometry of hederagenin glycosides and medicagenic acid glycosides

The secondary emission (SE) spectra of six glycosides of medicagenic acid (MA) and of hederagenin have been studied. The (M + H)⁺ ions were observed in the secondary ion spectra (LSIMS) of mono- and biosides of MA and also of a triand a tetraoside of hederagenin in a glycerol matrix. The (M + Na)⁺ ions were recorded in the spectra of tri- and tetraosides of MA. In the majority of cases processes involving the successive splitting out of the carbohydrate units were revealed. Positive- and negative-ion spectra have been obtained on the ionization by bombardment with fast atoms — FAB + and FAB – — of a trioside and a tetraoside of MA. The FAB – spectra are the most characteristic: They show intense peaks of the (M - H)^– ions and of the products of the sequential elimination of the sugar residues.Institute of the Chemistry of Plant Substances, Uzbekstan Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 98–102, January–February, 1992.     

Resolution of dianthrone glycosides and anthraquinone glycosides by thin-layer chromatography

Summary Existing TLC systems for the separation of dianthrone glycosides (sennosides) and anthraquinone glycosides were found unsatisfactory. Separation of these two groups of glycosides was achieved using a conventional TLC development tank and also in a modern VARIO-KS-Chamber at a relative humidity of 32%. The separation in a VARIO-KS-Chamber was superior.     

Discotic peracylated glycosides

Easily accessible peracylated glycosides show columnar discotic phases. The mesomorphic properties of the cellobiosides studied are interpreted as resulting from the polarity contrast between the sugar nucleus and the alkyl side chains.     

Triterpene glycosides ofGleditschia triacanthos

Chemistry of Natural Compounds -