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S.K. Agarwal R.P. Rastogi H. Van Koningsveld K. Goubitz G.J. Olthof 《Tetrahedron》1980,36(10):1435-1438
A novel natural product, microphyllone, has been isolated from Ehretia microphylla2 together with baurenol and ursolic acid. Spectroscopic techniques, derivative formation and finally X-ray diffraction have been utilized in the structure elucidation of microphyllone. The structure appears to be 4a, 5, 8,8a - tetrahydro -11,14- dihydroxy-7-methyl-4a-(3-methyl-2-butenyl)-5, 8a-o-benzeno-1, 4-naphthoquinone. 相似文献
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Yoshihisa Kurasawa Yumiko Kamigaki Ho Sik Kim Keiko Yonekura Atsushi Takada Yoshihisa Okamoto 《Journal of heterocyclic chemistry》1989,26(3):869-870
Dihydropyrazolo[5, 1-c][1, 2, 4]triazines 6, 7 and 8 were found to predominate as the 4, 6-dihydro tautomeric form in solution by the measurement of ID NOE different spectra. 相似文献
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As 1-aryl-5-methyl-4-substituted-1,2,3-triazoles often exhibit broad spectrum biological actions, we have synthesized many heterocyclic and condensed heterocyclic compounds which contained 1-aryl-5-methyl-1,2,3-triazol-4-yl functional groups and screened their antibacterical activities[1,2]. Our further work testified that it was necessary to go on studying such kind of compounds. In order to improve the soluble of these compounds, we chose aniline and p-toluidime as starting materials to synthesize 1-aryl-5-methyl-4-substituted-1,2,3-triazoles 1a-b, 2a-b, 3a-b, 4a-b, 5a, These new compounds all have active reaction groups such as SH, NH2 as well as OH. So they might react with ω-substituted-ω-bromo-acetophenone and 6a-b, 7a-b, 8a-b, 9a were obtained. They are all soluble in hot alcohol. Under similar conditions it is difficult to let 4a-b react completely with ω-substituted-ω-bromo-acetophenone. We only observed a little new compounds by TLC. By Mannich reaction, 1a-b also could react with formaldelyde and p-toluidime and l0a-b were isolated. The evaluation of the biological activity is in progress. 相似文献
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The title pyrazoles (2)-(8) were obtained by the condensation of 3-methyl-1-phenyl-2-pyrazoline-5-one (1) with carbon disulfide and primary alkyl halides, in the presence of n-butyllithium. 相似文献
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Pyun DK Kim BJ Jung HJ Kim JH Lee JS Lee WK Lee CH 《Chemical & pharmaceutical bulletin》2002,50(3):415-418
A new series of 1beta-methylcarbapenems 1a-d bearing 5-methyl-4-mercaptopyrrolidinone rings has been prepared and evaluated for in vitro antibacterial activity and pharmacokinetic parameters. Most compounds showed excellent antibacterial activity and high stability to dehydropeptidase-1. We have synthesized optically active 5-methyl-4-hydroxypyrrolidinones from enantiomerically pure aziridine esters. 相似文献
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3-正丙基-4-氨基-5-酰胺基-1-甲基吡唑的合成 总被引:2,自引:0,他引:2
以2-戊酮为起始原料,经Claisen缩合、环化、甲基化、皂化、硝化、酰胺化和还原反应,制得目标化合物。总收率比文献报道值提高一倍,达46.8%。 相似文献
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Deok-Heon Kweon Young-Jin Kang Hyun-A Chung Yong-Jin Yoon 《Journal of heterocyclic chemistry》1998,35(4):819-826
In order to confirm the regiochemistry for the functionalization of 1-(1,1-dibromo-2-oxopropyl)-4,5-dihalopyridazin-6-ones, the dehalogenation of 1-methyl-5-halo-4-substituted-pyridazin-6-ones using Pd/C and hydrogen was carried out. The results of the title reaction are reported. 相似文献
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V. G. Vinokurov D. A. Zykov Z. D. Kirsanova S. G. Rozenberg V. S. Troitskaya L. A. Krasnykh V. A. Zagorevskii N. V. Klimova B. M. Pyatin 《Chemistry of Heterocyclic Compounds》1991,27(3):288-291
The tautomerism of 1-phenyl-3-methyl-4-benzyl-5-pyrazolone —a side product in the reaction of acetoacetic ester with benzaldehyde phenylhydrazone — was studied by IR and PMR spectroscopy, and its thermodynamic characteristics were determined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 355–359, March, 1991. 相似文献
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N-Methylation at the pyrazole ring by sequential treatment of 5-tributylstannyl-4-trifluoromethylpyrazole with LDA and iodomethane regioselectively provided the title compound in high yield. The addition reaction of 5-lithiated-4-trifluoromethylpyrazole with a wide range of electrophiles allowed easy and high-yielding introduction of substituents on position 5. 相似文献
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Viveka Shivapura Vasantha Gowda Dinesha Naveen Shivalingegowda Lokanath Neratur Krishnappagowda Nagaraja Gundibasappa Karikannar 《Research on Chemical Intermediates》2016,42(5):4497-4511
Research on Chemical Intermediates - The present research work has focused on combined experimental and theoretical studies of one of the biologically important pyrazole-4-carboxylic acid... 相似文献
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K. I. Matveev E. G. Zhizhina V. F. Odyakov V. N. Parmon 《Russian Chemical Bulletin》1994,43(7):1142-1145
2-Methyl-1-naphthol is oxidized into 2-methyl-1,4-naphthoquinone (menadione) by air in the presence of vanadomolybdophosphoric heteropolyacids and their salts. The reaction proceeds in a biphasic system, and the yield of menadione is up to 85 %. The influence of the composition of the heteropolyacids on the rate and the selectivity of the reaction was studied, and the reaction mechanism was proposed.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1208–1211, July, 1994. 相似文献
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The title compound 3 was obtained during the rearrangement of isoxazol-5-yl hydrazine 1 to 1-aminopyrazolone 2 at 115°. X-ray analysis of the corresponding benzylidene derivative allowed us to achieve the structure assignment. 相似文献
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