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R. Sh. Kuryazov N. S. Mukhamedov Kh. M. Shakhidoyatov 《Chemistry of Heterocyclic Compounds》2008,44(3):324-329
Treatment of quinazoline-2,4-dione and its symmetrical 1,3-dialkyl derivatives with chlorosulfonic acid gave the corresponding
6-chlorosulfonylquinazoline-2,4-diones. Reaction of the compounds obtained with nucleophilic agents (water, ammonia, aliphatic
and cyclic amines) gave the corresponding free 2,4-dioxoquinazoline-6-sulfonic acids, 6-sulfamidoquinazoline-2,4-diones, and
2,4-dioxoquinazoline-6-sulfonic acid amides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 420–427, March 2008. 相似文献
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Andre Rosowsky Katherine K. N. Chen Marilyn E. Nadel Nicholas Papathanasopoulos Edward J. Modest 《Journal of heterocyclic chemistry》1972,9(2):275-283
Twenty-one 1,3-diaminobenzo[f]quinazolines ( 2 , R = H, alkyl, halogen, methoxy) were synthesized as planar tricyclic analogs of the antimalarial agent pyrimethamine ( 1 ). The synthetic methods included i) condensation of 1-cyano-2-naphthylamines with cyanamide in the presence of pyridine hydrochloride, ii) cyclization of N1,N5-bis(2-naphthyl)biguanide hydrochlorides in diphenyl ether at 250°, iii) reaction of 2-naphthylamine hydrochlorides with excess sodium dicyanamide in boiling 1-octanol, and iv) selenium dioxide dehydrogenation of 1,3-diamino-5,6-dihydrobenzo[f]quinazolines. A number of new 2-naphthols and 2-naphthylamines were synthesized as intermediates. Substituent effects on the ultraviolet absorption spectra of 1,3-diamino-benzo[f]quinazolines were investigated and found to be additive. These compounds are of interest as inhibitors of dihydrofolate reductase and as potential antimalarial and antitumor agents. 相似文献
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A method for the synthesis of benzo[b]selenophenes was perfected. 3-Oxo-2,3-dihydrobenzo[b]selenophene and 2-methyl-3-oxo-2,3-dihydrobenzo[b]selenophene exist only in the keto form. 3-Methylbenzo[b]selenophene was obtained by the reaction of 3-oxo-2,3-dihydrobenzo[b]selenophene with methylmagnesium iodide. Metallation of benzo[b]selenophene with butyllithium proceeds at the 2 position of the selenophene ring.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1475–1480, November, 1970. 相似文献
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1,2,5-Trimethyl-4-ethoxycarbonylmethyl-4-hydroxypiperidine was obtained by the Reformatsky reaction between 1,2,5-trimethyl-4-piperidone and ethyl bromoacetate. Homologs were obtained from the same piperidone and ethyl -bromo--alkylacetates. Some further reactions of these hydroxypiperidines were studied. 相似文献
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Tino Rossi Daniele Andreotti Bruno Tamburini Carla Marchioro 《Journal of heterocyclic chemistry》1994,31(4):909-915
The synthesis of a series of 6,6-disubstituted penems starting from penicillanate 5a is described. These penems were isolated and characterized as their pivaloyloxy methyl ester. 相似文献
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Andre Rosowsky Katherine K. N. Chen Nickolas Papathanasopoulos Edward J. Modest 《Journal of heterocyclic chemistry》1972,9(2):263-273
Eighteen new 1,3-diamino-5,6-dihydrobenzo[f] quinazolines ( 6 , R. = alkyl, Cl, MeO) were synthesized via the condensation of appropriate 2-tetralones with cyanoguanidine under fusion conditions. Methods were developed for the preparation of a number of heretofore undescribed 2-tetralones as precursors. The final products can be viewed as conformationally rigid analogs of pyrimethamine ( 2 ), and are of interest as inhibitors of dihydrofolate reductase and as potential antimalarial and antitumor agents. 相似文献
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Conclusions Homologs of p-phenoxystyrene that had not been described in the literature have been synthesized: -methyl-p-phenoxystyrene, -ethyl-p-phenoxystyrene, ,-dimethyl-p-phenoxystyrene, -methyl-p-phenoxystyrene, and ,-dimethyl-p-phenoxy styrene. 相似文献
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Conclusions 1-(5-Methylfuryl)-3-aminoalkanes on vapor phase hydrogenation over Pt/C at 220–270° are converted into pyrrole and pyrrolidine homologs in 60–70% yield.Translated from. Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 210–213, January, 1968. 相似文献