共查询到20条相似文献,搜索用时 421 毫秒
1.
Background
Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) are implicated in the impaired learning and memory in lactational and adolescent rat hippocampus following developmental ID and hypothyroidism. 相似文献2.
Maria?Sol?Fusti?ana Pablo?Ariel Noel?Federman Ramiro?Freudenthal Arturo?Romano 《BMC neuroscience》2010,11(1):109
Background
Human β-amyloid, the main component in the neuritic plaques found in patients with Alzheimer's disease, is generated by cleavage of the β-amyloid precursor protein. Beyond the role in pathology, members of this protein family are synaptic proteins and have been associated with synaptogenesis, neuronal plasticity and memory, both in vertebrates and in invertebrates. Consolidation is necessary to convert a short-term labile memory to a long-term and stable form. During consolidation, gene expression and de novo protein synthesis are regulated in order to produce key proteins for the maintenance of plastic changes produced during the acquisition of new information. 相似文献3.
Background
Previous research has demonstrated a relationship between memory recall and P300 amplitude in list learning tasks, but the variables mediating this P300-recall relationship are not well understood. In the present study, subjects were required to recall items from lists consisting of 12 words, which were presented in front of pictures taken from the IAPS collection. One word per list is made distinct either by font color or by a highly arousing background IAPS picture. This isolation procedure was first used by von Restorff. Brain potentials were recorded during list presentation. 相似文献4.
Background
Following practice of skilled movements, changes continue to take place in the brain that both strengthen and modify memory for motor learning. These changes represent motor memory consolidation a process whereby new memories are transformed from a fragile to a more permanent, robust and stable state. In the present study, the neural correlates of motor memory consolidation were probed using repetitive transcranial magnetic stimulation (rTMS) to the dorsal premotor cortex (PMd). Participants engaged in four days of continuous tracking practice that immediately followed either excitatory 5 HZ, inhibitory 1 HZ or control, sham rTMS. A delayed retention test assessed motor learning of repeated and random sequences of continuous movement; no rTMS was applied at retention. 相似文献5.
I. Ya. Podol’skii E. V. Kondrat’eva I. V. Shcheglov M. A. Dumpis L. B. Piotrovskii 《Physics of the Solid State》2002,44(3):578-580
A microinjection of C60/poly-(N-vinyl-pyrrolidone) (C60/PVP) adduct into the dorsal hippocampus is shown to prevent the disturbance of spatial memory consolidation induced by the administration of a high dose of cycloheximide, which inhibits protein synthesis in the central nervous system by more than 90%. It is supposed that microinjections of the C60/PVP adduct into the hippocampus suppress the death of its neurons, which may be one of the essential factors that prevent the disturbance of long-term memory consolidation by protein-synthesis inhibition. Other mechanisms of the fullerene action are also possible; however, they remain as yet unknown. 相似文献
6.
Costas Papatheodoropoulos Evangelos Sotiriou Dimitrios Kotzadimitriou Panagiota Drimala 《BMC neuroscience》2007,8(1):60
Background
Many sedative agents, including anesthetics, produce explicit memory impairment by largely unknown mechanisms. Sharp-wave ripple (SPW-R) complexes are network activity thought to represent the neuronal substrate for information transfer from the hippocampal to neocortical circuits, contributing to the explicit memory consolidation. In this study we examined and compared the actions of two barbiturates with distinct amnesic actions, the general anesthetic thiopental and the anticonvulsant phenobarbital, on in vitro SPW-R activity. 相似文献7.
Kara L Kuntz-Melcavage Robert M Brucklacher Patricia S Grigson Willard M Freeman Kent E Vrana 《BMC neuroscience》2009,10(1):95
Background
A number of gene expression studies have investigated changes induced by drug exposure, but few reports describe changes that persist following relapse. In this study, genome-wide analysis of gene expression was conducted following an extinction session (90 min) in rats that expressed behavioral incubation of heroin-seeking and goal-directed behavior. As an important modulator of goal-directed behavior, the medial prefrontal cortex (mPFC) was the target of genomic analysis. Rats were trained to self-administer heroin during 3 h daily sessions for 14 d. Following the self-administration period, rats were reintroduced to the self-administration chambers for a 90-minute extinction session in which they could seek heroin, but received none. Extinction sessions were conducted on groups after either 1 d or 14 d of drug-free enforced abstinence to demonstrate behavioral incubation. 相似文献8.
Mark T McAuley Rose Anne Kenny Thomas BL Kirkwood Darren J Wilkinson Janette JL Jones Veronica M Miller 《BMC neuroscience》2009,10(1):26
Background
The hippocampus is essential for declarative memory synthesis and is a core pathological substrate for Alzheimer's disease (AD), the most common aging-related dementing disease. Acute increases in plasma cortisol are associated with transient hippocampal inhibition and retrograde amnesia, while chronic cortisol elevation is associated with hippocampal atrophy. Thus, cortisol levels could be monitored and managed in older people, to decrease their risk of AD type hippocampal dysfunction. We generated an in silicomodel of the chronic effects of elevated plasma cortisol on hippocampal activity and atrophy, using the systems biology mark-up language (SBML). We further challenged the model with biologically based interventions to ascertain if cortisol associated hippocampal dysfunction could be abrogated. 相似文献9.
Dipesh Chaudhury Dawn H Loh Joanna M Dragich Arkady Hagopian Christopher S Colwell 《BMC neuroscience》2008,9(1):63
Background
The neuropeptide vasoactive intestinal peptide (VIP) is widely distributed in the adult central nervous system where this peptide functions to regulate synaptic transmission and neural excitability. The expression of VIP and its receptors in brain regions implicated in learning and memory functions, including the hippocampus, cortex, and amygdala, raise the possibility that this peptide may function to modulate learned behaviors. Among other actions, the loss of VIP has a profound effect on circadian timing and may specifically influence the temporal regulation of learning and memory functions. 相似文献10.
Koji Inui Tomokazu Urakawa Koya Yamashiro Naofumi Otsuru Yasuyuki Takeshima Makoto Nishihara Eishi Motomura Tetsuo Kida Ryusuke Kakigi 《BMC neuroscience》2010,11(1):135
Background
The rapid detection of sensory change is important to survival. The process should relate closely to memory since it requires that the brain separate a new stimulus from an ongoing background or past event. Given that sensory memory monitors current sensory status and works to pick-up changes in real-time, any change detected by this system should evoke a change-related cortical response. To test this hypothesis, we examined whether the single presentation of a sound is enough to elicit a change-related cortical response, and therefore, shape a memory trace enough to separate a subsequent stimulus. 相似文献11.
Background
C57BL/6 mice show a relationship during aging between NMDA receptor expression and spatial reference memory performance in a 12-day task. The present study was designed to determine if age-related deficits could be detected with a shorter testing protocol and whether these deficits showed a relationship with NMDA receptors. Mice were trained in a reference memory task for two days in a Morris water maze. Cued testing was performed either after or prior to reference memory testing. Crude synaptosomes were prepared from prefrontal/frontal cortex and hippocampus of the mice that underwent reference memory testing first. NMDA receptor subunit and syntaxin proteins were analyzed with Western blotting. 相似文献12.
Andreas?Lüthi Martin?A?Wikstr?m Mary?J?Palmer Paul?Matthews Tim?A?Benke John?TR?Isaac Graham?L?Collingridge
Background
Knowledge of how synapses alter their efficiency of communication is central to the understanding of learning and memory. The most extensively studied forms of synaptic plasticity are long-term potentiation (LTP) and its counterpart long-term depression (LTD) of AMPA receptor-mediated synaptic transmission. In the CA1 region of the hippocampus, it has been shown that LTP often involves a rapid increase in the unitary conductance of AMPA receptor channels. However, LTP can also occur in the absence of any alteration in AMPA receptor unitary conductance. In the present study we have used whole-cell dendritic recording, failures analysis and non-stationary fluctuation analysis to investigate the mechanism of depotentiation of LTP. 相似文献13.
Background
Cholinergic neuronal dysfunction of the basal forebrain is observed in patients with Alzheimer's disease and dementia, and has been linked to decreased neurogenesis in the hippocampus, a region involved in learning and memory. Running is a robust inducer of adult hippocampal neurogenesis. This study aims to address the effect of running on hippocampal neurogenesis in lesioned mice, where septohippocampal cholinergic neurones have been selectively eliminated in the medial septum and diagonal band of Broca of the basal forebrain by infusion of mu-p75-saporin immunotoxin. 相似文献14.
Kimmo A Michelsen Daniël LA van den Hove Christoph Schmitz Olivier Segers Jos Prickaerts Harry WM Steinbusch 《BMC neuroscience》2007,8(1):107
Background
Both prenatal stress (PS) and postnatal chronic mild stress (CMS) are associated with behavioral and mood disturbances in humans and rodents. The aim of this study was to reveal putative PS- and/or CMS-related changes in basal spine morphology and density of pyramidal neurons in the rat medial prefrontal cortex (mPFC). 相似文献15.
He-Ping Tian Bao-Sheng Huang Jie Zhao Xiao-Han Hu Jun Guo Li-Xin Li 《BMC neuroscience》2009,10(1):139
Background
Neurogenesis in the adult mammalian hippocampus may contribute to repairing the brain after injury. However, Molecular mechanisms that regulate neuronal cell proliferation in the dentate gyrus (DG) following ischemic stroke insult are poorly understood. This study was designed to investigate the potential regulatory capacity of non-receptor tyrosine kinase Src on ischemia-stimulated cell proliferation in the adult DG and its underlying mechanism. 相似文献16.
Rodrigo S Chaves Thaiany Q Melo Stephanie A Martins Merari FR Ferrari 《BMC neuroscience》2010,11(1):144
Background
Protein aggregates containing alpha-synuclein, beta-amyloid and hyperphosphorylated tau are commonly found during neurodegenerative processes which is often accompanied by the impairment of mitochondrial complex I respiratory chain and dysfunction of cellular systems of protein degradation. In view of this, we aimed to develop an in vitro model to study protein aggregation associated to neurodegenerative diseases using cultured cells from hippocampus, locus coeruleus and substantia nigra of newborn Lewis rats exposed to 0.5, 1, 10 and 25 nM of rotenone, which is an agricultural pesticide, for 48 hours. 相似文献17.
Laurence Borgs Pierre Beukelaers Renaud Vandenbosch Laurent Nguyen Gustave Moonen Pierre Maquet Urs Albrecht Shibeshih Belachew Brigitte Malgrange 《BMC neuroscience》2009,10(1):30
Background
Newborn granule neurons are generated from proliferating neural stem/progenitor cells and integrated into mature synaptic networks in the adult dentate gyrus of the hippocampus. Since light/dark variations of the mitotic index and DNA synthesis occur in many tissues, we wanted to unravel the role of the clock-controlled Period2 gene (mPer2) in timing cell cycle kinetics and neurogenesis in the adult DG. 相似文献18.
Background
The matrix-like organization of the hippocampus, with its several inputs and outputs, has given rise to several theories related to hippocampal information processing. Single-cell electrophysiological studies and studies of lesions or genetically altered animals using recognition memory tasks such as delayed non-matching-to-sample (DNMS) tasks support the theories. However, a complete understanding of hippocampal function necessitates knowledge of the encoding of information by multiple neurons in a single trial. The role of neuronal ensembles in the hippocampal CA1 for a DNMS task was assessed quantitatively in this study using multi-neuronal recordings and an artificial neural network classifier as a decoder. 相似文献19.
Hana?Munakata Yukiko?Nakamura Kazumasa?Matsumoto-Miyai Kouichi?Itoh Hironobu?Yamasaki Sadao?Shiosaka
Background
The importance of L1 expression in the matured brain is suggested by physiological and behavioral studies showing that L1 is related to hippocampal plasticity and fear conditioning. The distribution of L1 in mouse brain might provide a basis for understanding its role in the brain. 相似文献20.
S?ren Diegelmann Vanessa Nieratschker Ursula Werner Jürgen Hoppe Troy Zars Erich Buchner 《BMC neuroscience》2006,7(1):76