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Dmitriy E. Siyutkin 《Tetrahedron》2009,65(7):1366-1979
New chiral ionic liquids bearing proline, serine or threonine moieties were synthesized. Compounds that contain 1-dodecylimidazolium or 4-(5-n-nonyl)-pyridinium cations and NTf2 or PF6 anions efficiently catalyze the asymmetric aldol reaction between aldehydes and ketones in the presence of water to generate aldols with high distereo- (up to 98:2) and enantioselectivity (up to >99% ee). 4-Hydroxyproline modified by the 4-(5-n-nonyl)-pyridinium hexafluorophosphate moiety retains its activity and selectivity over at least eight reaction cycles. 相似文献