一种新的六氢喹啉衍生物的NMR研究

应用¹H NMR,¹³C NMR,DEPT,¹H-¹H COSY,HSQC,HMBC等多种NMR实验测试分析方法,确证了一种新的六氢喹啉衍生物2,7,7-三甲基-4-(4-羟基-3-甲氧基）苯基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸甲酯的结构,并对它的¹H、¹³C信号进行了归属.     

土大黄苷的NMR研究

土大黄苷,3-羟基-5-[2-（3-羟基-4-甲氧苯基）乙烯基]苯-β-D-葡萄糖苷是从植物中提取分离的单体化合物,应用1D NOE 和2D NMR（¹H-¹H COSY、HMQC、HMBC）等技术相结合的方法对土大黄苷的¹H和¹³C NMR信号进行了准确归属,并对文献中错误的碳氢数据做了纠正和讨论.     

氟代四氢小檗碱的波谱特征与结构解析

对四氢小檗碱的氟取代衍生物（化合物1）的一维、二维核磁共振谱（¹H NMR、¹³C NMR、¹H-¹H COSY、HSQC、HMBC）以及质谱进行了解析和报道,对其所有的NMR谱信号进行了归属,确证了氟取代的位置为12位. 同时讨论了质谱的主要碎片离子的可能的裂解方式. 通过多种波谱技术确证了化合物1的结构.     

α-山竹黄酮的NMR研究

应用一维¹H NMR、¹³C NMR、DEPT、二维HMBC、HSQC、¹H-¹H COSY、ROESY对1, 3, 6-三羟基-7-甲氧基-2, 8双(3-甲基-2-丁烯)-9-口山酮（α-mangostin、α-MAG）的¹H、¹³C原子进行了指认归属.     

人参茎叶中一个新天然产物的结构研究

采用多种色谱方法从人参茎叶中分离得到一个新天然产物-达玛烷型三萜皂苷元dammar 20(22), 24-diene-3β,6α,12β-triol,并利用质谱、核磁共振谱和化学方法对此化合物进行了结构解析. 通过2D NMR（HMQC、HMBC）进行了¹H和¹³C NMR信号全归属,并纠正了文献中的个别化学位移的信号指认错误.     

新药替尼泊苷的碳氢NMR信号全归属

替尼泊苷是从北美鬼臼或西藏鬼臼提取到的鬼臼树脂,经化学成分分离得到鬼臼毒素通过半合成方法获得的衍生物,是一种周期特异性细胞毒药物.作为一种抗肿瘤药物,替尼泊苷已逐渐成为治疗颅内恶性肿瘤的主要化疗药物.本文应用1D NMR和2D NMR实验技术（COSY,NOESY,TOCOSY,gHSQC,gHMBC）研究了其结构,并对其¹H NMR、¹³C NMR谱信号进行了全归属.     

环维黄杨星D 13C 和1H 化学位移的全归属

环维黄杨星D为自黄杨木中提取精制的有效生物碱,临床上已长期用于心血管疾病的治疗. 本文用制备高效液相色谱提取、分离并纯化环维黄杨星D,用1D, 2D NMR技术 （COSY, DEPT, HMQC 和 HMBC）对其结构进行研究,并且首次对环维黄杨星D的¹H NMR 和¹³C NMR 信号进行了全归属,同时通过NMR数据确证了环维黄杨星D的结构.     

双分子缬氨酸氢膦烷构型的确定

以缬氨酸为原料,和三氯化磷反应合成了双分子缬氨酸氢膦烷．采用¹H NMR、¹³C NMR、¹H-¹H COSY、DEPT和HSQC等技术确证了目标化合物的结构;对其¹H NMR和¹³C NMR信号进行了归属,同时利用IR和ESI-MS验证了其结构．³¹P NMR显示所得产物为缬氨酸氢膦烷的一对非对映异构体,利用NOESY技术对分离得到的其中一种异构体绝对构型进行了确定,该结果得到了X-射线单晶衍射的验证．     

头孢菌素类化合物的核磁共振谱研究

应用¹H NMR、¹³C NMR和DEPT135°技术以及¹H-¹H COSY、HMBC、HMQC二维核磁共振技术，对头孢菌素类抗生素头孢替坦二钠、头孢曲松钠及头孢噻肟钠的质子信号和碳信号进行了全归属，并指出其核磁共振谱特征.     

阿普唑仑的波谱学数据和结构确证

阿普唑仑是一种临床上广泛应用的具有抗抑郁作用的药物. 本文对阿普唑仑进行了¹H、¹³C NMR检测,通过DEPT和¹H-¹H COSY、¹³C-¹H HSQC、¹³C-¹H HMBC等2D NMR技术对该化合物的¹H、¹³C NMR谱的信号进行了全归属,通过量子化学计算和NMR数据证实了化合物中亚甲基上2个氢的磁不等价性. 讨论了红外吸收光谱的特征峰,并对阿普唑仑的TOF MS的裂解途径进行了分析.      

克林霉素磷酸酯的波谱学研究

克林霉素磷酸酯是临床上广泛使用的一种抗菌类药物. 本文对克林霉素磷酸酯进行了¹H、¹³C、³¹P NMR检测,通过DEPT、¹H-¹H COSY、¹³C-¹H HSQC、¹³C-¹H HMBC等2D NMR技术对该化合物的¹H、¹³C谱的信号进行了全归属,并结合量子化学计算和NOESY谱证实了化合物的立体结构. 另外,对克林霉素磷酸酯的飞行时间质谱(TOF-MS)的裂解途径进行了分析.     

THE MEASUREMENT OF THE EXCITATION FUNCTIONS OF ISOTOPES OF Fr AND At,PRODUCED IN THE BOMBARDMENT OF 12C ON 209Bi

Excitation functions for Fr and At isotopes produced in ¹²C on ²⁰⁹Bi had been measured in the energy range 60—72 MeV. It was quite obvious that ²¹³Fr and ²¹⁴Fr were formed by the reactions ²⁰⁹Bi (¹²C,4n) ²¹⁷Ac and ²⁰⁹Bi (¹²C,3n) ²¹⁸Ac following the a decay of the Ac isotopes respectively, and ^214mFr was produced probably by compound nucleus evaporation of neutrons and an α particle, i.e. (¹²C, α 3n). ²¹¹At was mainly contributed by a multi-nucleon transfer reaction （e.g. ⁸Be transfer）. The experimental data for neutron evaporation reaction were fitted by the Jackson formula.     

β-Delayed Proton Decays of 133Sm and 149Yb

¹³³Sm was produced via fusion evaporation in the reaction ⁴⁰Ca+⁹⁶Ru. Its β-delayed proton decay was studied by means of “p-γ” coincidence in combination with a He-jet tape transport system, including half-lives, proton energy spectra, γ-transitions following the proton emissions, and the branching ratios to the low-lying states in the grand-daughter nuclei. The possible spins and parities of ¹³³Sm were extracted by fitting the experimental data with a statistical model calculation. The configuration-constrained nuclear potential energy surfaces of ¹³³Sm were calculated by using the Woods-Saxon Strutinsky method. Comparing the experimental and calculated results, the spins and parities of ¹³³Sm were assigned to be 5/2⁺ and 1/2^－, which is reconciled with our published simple (EC+β⁺) decay scheme of ¹³³Sm in 2001. In addition, our experimental data on the beta-delayed proton decay of ¹⁴⁹Yb reported in Eur. Phys. J., 2001, A12: 1—4 was also analyzed by using the same method. The spin and parity of ¹⁴⁹Yb was assigned to be 1/2^－.     

New Neutron-Rich Nuclide 185Hf

New neutron-rich nuclide ¹⁸⁵Hf has been identified for the first time.The ¹⁸⁵Hf was produced via the ¹⁸⁶W(n,2p)¹⁸⁵Hf reaction by 14MeV neutron irradiation of natural metallic tungsten powder and separated by radiochemical methods.The identification of ¹⁸⁵Hf was based on the observation of decay γ-ray of its daughter ¹⁸⁵Ta.A half-life of 3.5±0.6min was determined for ¹⁸⁵Hf by fitting the measured growth and decay curve of the 177.59keV γ-ray which is the strongest decay γ-ray of ¹⁸⁵Ta.In addition,a new γ-ray of 164.5±0.5keV was found and assigned to ¹⁸⁵Hf.     

(EC+β+) Decay of 130Pm and 128Pr

¹³⁰Pm and ¹²⁸ Pr were produced by irradiation of ⁹⁶Ru with 171MeV ³⁶Ar beam,and a He-jet recoil tape transport system transported radioactivities to shielded reigon. Based on X-γ-t and γ-γ-t coincidence measurements ,the (EC+β⁺)decay scheme of ¹³⁰Pm was proposed for the first time and the (EC+β⁺)decay scheme of ¹²⁸Pr was revised.     

Identification of a 9/2-[505] isomer in the neutron-rich 193Os nucleus

The neutron rich nucleus ¹⁹³Os was produced in the ¹⁹²Os(⁷Li, ⁶Li)¹⁹³Os reaction. An isomeric state based on the 9/2^-[505] Nilsson orbital was identified in the present work. The half-life of the isomeric state was extracted and discussed in terms of the K quantum number. A level scheme built on the isomeric state was proposed based on the experimental data.     

(EC+β+) decay of 130Pm and 128Pr

¹³⁰Pm and ¹²⁸Pr were produced by irradiation of ⁹⁶Ru with ³⁶Ar, and studied using a He-jet recoil tape transport system. Based on X-% and %-% coincidence measurements, the (EC+ # ⁺) decay scheme of ¹³⁰Pm was proposed for the first time and the (EC+ # ⁺) decay scheme of ¹²⁸Pr was revised.     

First Observation for Isotope 265Bh(Z=107)

New isotope ²⁶⁵Bh(Z=107) was produced in bombardment of an ²⁴³Am target with 135MeV ²⁶Mg ions at HIRFL. Identification was made by observation of correlated α particle decays between the new isotope ²⁶⁵Bh and its ²⁶¹Db and ²⁵⁷Lr daughters with four pairs of detectors. A total of 8 correlated decay events of ²⁶⁵Bh and 4 decay events of ²⁶⁴Bh were identified. ²⁶⁵Bh decays with a 0.94+0.70-0.31s half-life by emission of α particle with an average energy of (9.24±0.05)MeV.     

一种新型的喹啉-4-氨基磷酸酯衍生物的波谱学研究

以2-苯基-4-喹啉酮为原料,通过磷酰化反应将磷酰氮芥引入到2-苯基-4-喹啉酮中,合成了一种新型的喹啉-4-氨基磷酸酯衍生物. 应用DEPT、¹H-¹H COSY、¹³C-¹H HSQC、¹³C-¹H HMBC等2D NMR核磁共振技术,对该化合物的¹H、¹³C NMR谱的信号进行了全归属;通过飞行时间质谱(TOF-MS)对这种新型的喹啉-4-氨基磷酸酯衍生物的裂解途径进行了分析.     

(EC/β+) Decay of 130Nd and 140Tb

Isotopes,¹³⁰Nd and ¹⁴⁰Tb were produced using enriched targets ⁹⁶Ru and ¹⁰⁶Cd, respectively,bombarded by ³⁶Ar ion beam. The two nuclides were identified and studied by a He-jet tape transport system in combination with "X-γ" and "γ-γ" coincidence measure- ments. The half-life of ¹³⁰Nd was determined to be (13±2)s. The EC/β⁺ decay scheme of 130Nd was proposed for the first time, and the spins and parties of the ground-state and observed low-lying states in the daughter nucleus ¹³⁰Pr were speculated tentatively. The previous simple EC/β⁺ decay scheme of ¹⁴⁰Tb was revised, and the spin-parity of its groundstate was assigned to be 7⁺.