Extraction of the total alkaloids from the epigeal part of Aconitum orientale

The process of extracting the total alkaloids fromAconitum orientale with aqueous solutions of a number of electrolytes has been investigated. It has been established that it is most desirable to use 2% solutions of H₂SO₄ and 5% solutions of CH₃COOH. The optimum parameters of the process have been found, under which the degree of extraction of the total alkaloids averages 96%. I. G. Kutateladze Institute of Pharmacochemistry, Georgian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 816–821, November–December, 1991.     

Chromatopolarographic determination of the alkaloids from the seeds ofHaplophyllum perforatum

Summary 1. The polarographic behavior of haploperine, haplopine, haplophyllidine, and perforine in Britton-Robinson buffer solutions and in (C₂H₅)₄NOH solutions has been studied. Optimum conditions for their quantitative determination in solutions within the range of concentrations from 5×10^–4 to 1×10^–2 M have been found.2. A method for the separate quantitative determination of the alkaloids in the seeds ofH. perforatum has been developed.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 5, pp. 333–337, 1966     

Alkaloids ofAndrachne rotundifolia

Summary 1. The content of total alkaloids in the hypogeal parts ofAndrachne rotundifolia C. A. Mey. (family Euphorbicease) is 0.2–0.3% and in the epigeal parts 0.06–0.08%.The total alkaloids in both the hypogeal and the epigeal parts ofAndrachne rotundifolia consist of five or six non-phenolic bases.2. Three individual substances have been isolated: andrachnine C₁₁H₁₇NO₂, which is a new alkaloid; base (II), giving a perchlorate with mp 139°–140° C; and base (III) with mp 135°–136° C.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 257–260, 1966     

The polybuffer separation of the alkaloids of Vinca erecta

Summary By separating the total alkaloids ofV.erecta according to their basicities in an APS, in addition to bases known previously we have isolated ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (–)-1,2-dehydroaspidospermidine, and kopsanone. This is the first time that these alkaloids have been obtained from this plant. Thin-layer chromatography showed the presence of another 10–12 uncharacterized alkaloids.The region of the passage into the buffer solutions of some alkaloids has also been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 713–717, November–December, 1970.     

An investigation of the alkaloids of Ammothamnus lehmanni the structure of lehmannine

Summary 1. The qualitative and quantitative composition of the combined alkaloids from the leaves, stems, seeds, and roots ofAmmothamnus lehmanni Bge. according to its vegetation periods have been studied.2. It has been found that the young plant contains predominantly the N-oxide forms of the matrine alkaloids, and as the plant develops these are reduced to the free bases.3. A new base lehmannine, C₁₅H₂₂ON₂ has been isolated for which 12,13-dehydromatrine is proposed as the most probable structure.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 377–380, May–June, 1975.     

The structure of vinerine and vineridine

Summary 1. The epigeal part ofV. erecta gathered in the Tashkent Oblast in the early vegetation period contains a mixture of alkaloids (2.7%). Separation of the total alkaloids gave vincanine, vincanidine, vinervine, akuammine, kopsinine, pseudokopsinine, and the new bases vinerine and vineridine.2. The structure of vinerine has been established by a study of the IR, NMR, and mass spectra. Vineridine is isomeric with vinerine at C₃ and C₇.3. A new base, hydroxyindole reserpinine, has been obtained from reserpinine.Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 260–265, 1966     

Determination of the position of the acyl groups and the nature of some amino alcohols in native ester alkaloids of the genusVeratrum

Conclusions 1. On the basis of literature data on the structure of theVeratrum alkaloids, a definite law for the arrangement of the acyl radicals in these ester alkaloids and an interrelationship between the melting point and the structure of the substituent in the C₇ position, and between the melting point and the types of amino alcohols upon which the ester alkaloids are based, has been found.2. The features mentioned may be used in studying the structure of theVeratrum ester alkaloids according to a scheme which we propose.Khimiya Prirodnykh Soedinenii, Vol. 6, No. 4, pp. 440–443, 1970     

Investigation of Aconite alkaloids

Summary The composition of the alkaloids in plants of the genus Aconitum —A. kirinense,A. altaicum, A. coreanum, andA. nemorosum — has been studied. Four new alkaloids of composition C₂₆H₄₁O₈N·HNO₃, C₃₅H₄₁O₁₀N·HBr, C₂₀H₂₅O₃N, and C₂₃H₂₉O₆N have been isolated.Khimiya Prirodnykh Soedinenii, Vol. 1, No. 2, pp. 113–116, 1965.     

Alkaloids of Merendera iolantae

Summary The alkaloids ofMerendera iolantae E. Czerniak have been studied for the first time. The total alkaloids consist of tropolone compounds and bases without a tropolone ring. From this plant we isolated the known alkaloids colchicine, colchamine, -lumicolchicine, colchameine, and 2-demethylcolchiceine, and four new, nontropolone, bases — MI-1 (iolantamine), MI-2, MI-3, and MI-4. The presence of colchiceine, 3-demethylcolchamine, and two unknown bases with R _f 0.49 and 0.53 was shown by chromatographic methods.A developed formula has been put forward for iolantamine on the basis of its spectral characteristics.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 487–493, July–August, 1972.     

The structure of sophorbenzamine

Summary A new base with the composition C₂₂H₂₆N₂O has been isolated fromG. pachycarpa and has been called sophorbenzamine.On the basis of UV, IR, mass, and CMR spectra, and also the results of a chemical investigation, sophorbenzamine has been assigned to the quinolizidine alkaloids of the matrine series and a most probable formula has been proposed for it.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 71–74, January–February, 1976.     

Vinervine — A new alkaloid from the aboveground part of Vinca erecta RGL. ET schmalh

Summary From the aboveground part ofV. erecta gathered in the Shargun' settlement in the Surkhan-Darya region 1% of total alkaloids was isolated, and in the separation of these the bases vincanidine and a new phenolic base vinervine (C₂₀H₂₂O₃N₂) were obtained. Vinervine is an alkaloid of the 2-methyleneindoline group.Translated from Izvestiya Akademii Nauk SSSR, Khimicheskaya, No. 12, pp. 2152–2155, December, 1965     

Alkaloids ofNuphar luteum

Summary 1. The dry rhizomes ofNuphar luteum L. have yielded three sulfur-containing alkaloids: two — thiobinupharidine and neothiobinupharidine — were known substances, the third with composition C₃₀H₄₂O₄N₂S being new and having been given the name of nuphleine.2. A possible structure has been proposed for nuphleine.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 2, pp. 178–182, 1967     

Alkaloids of Gentiana olivieri

Summary The separation of the chloroform fraction of the combined alkaloids ofG. olivieri according to basicities (pH 6.0 and 4.0) has yielded gentioflavine, gentiananine, and the new base oliveramine, C₂₀H₂₀N₂O₄. On the basis of its UV, IR, NMR, and mass spectra structure (I) has been put forward as the most probable for it.Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 64–67, January–February, 1973.     

The structure of pediculidine

Summary A new alkaloid pediculidine, C₁₀H₉NO, mp 74–75°C, has been isolated from the ethereal fraction of the combined alkaloids ofP. olgae. Structure (I) has been proposed for the new alkaloid on the basis of its UV, IR, NMR, and mass spectra.Order of the Red Banner of Labor Institute of the Chemistry of Plant Substances of the Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 304–306, May–June, 1971.     

Alkaloids ofStephania hernandifolia. III

Summary 1. A new alkaloid hernandoline with the composition C₂₀H₂₅O₅N has been isolated from the herbStephania herandifolia Walp.2. The Hofmann degradation of the methiodide of the O-methyl ether of hernandoline has given a des base acetolysis of which led to the formation of a dimethoxydiacetoxyphenanthrene.3. It has been suggested that hernandoline is similar to alkaloids related to sinomenine and hasubanonine.Khimiya Prirodnykh Soedinenii, Vol. 3, No. 2, pp. 106–108, 1967     

A study of the alkaloids of plants of the genusStephania

Summary Four alkaloids have been isolated from the tubers ofStephania glabra (Roxb.) Miers. (synonymSt. rotunda Lour.) collected in the Democratic Republic of Vietnam:l-tetrahydropalmatine and three previously undescribed bases (A -C₁₉H₁₈O₂N, C - C₂₀H₂₅O₄N, and D -C₂₁H₂₅O₄N).Khimiya Prirodnykh Soedinenii, Vol. 1, No. 6, pp. 392–394, 1965.The substances in this paper are denoted by letters. The novelty of these substances has not been established, which contradicts the rules of this journal. The paper is printed as an exception (Editiorial Board).     

Alkaloids of the epigeal part of Aconitum talassicum. Structure of actaline

The epigeal part ofAconitum talassicum M. Pop. has yielded, in addition to five alkaloids known previously, kobusine, pseudokobusine, and the new alkaloid actaline. The structure of the latter has been established on the basis of an x-ray structural analysis. Actaline is the first C₂₀ diterpene alkaloid with a lycoctonine skeleton.Institute of the Chemistry of Plant Substances, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, Vol. 1, pp. 39–44, January–February, 1989.     

A new acid from the oil of the seeds of Sambucus nigra

Summary A new keto hydroxy acid (I) C₁₈H₃₀O₆ has been isolated from the fatty oil of the seeds ofSambucus nigra in an amount of 2% of the total fatty acids. A study of its chemical properties and spectral characteristics has shown that it is probably 11-hydroxy-9,15,16-trioxooctadeconoic acid, and that it consists of a keto-enol mixture containing about 30% of the two equiprobable tautomers (II and III); it has been given the name of caprifolonic acid.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 3–8, January–February, 1972.