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1.
设计合成了由1-丁基-3-甲基咪唑阳离子与咪唑阴离子搭配的[bmim]Im新型碱性离子液体并对其碱性进行研究.[bmim]Im离子液体的碱性与[bmim]OH的碱性接近且强于[bmim]OAc.在水溶液及室温条件下,2%的[bmim]Im离子液体对系列芳香醛与活泼的亚甲基化合物之间的Knoevenagel缩合反应具有较好的催化性能,目标产物的收率达到86%~95%,选择性为100%.同时,该催化剂体系具有良好的循环性能.  相似文献   

2.
Yetkin G 《催化学报》2007,28(6):489-491
在三乙胺存在下,在离子液体([bmim]I和[bmim]PF6)中进行了各种卤代烃对胺类化合物中氨基的选择性烷基化反应.反应在相对温和的条件下进行,转化率和选择性优异.离子液体可以回收并重复使用.  相似文献   

3.
碱性离子液体[bmim]OH在Knoevenagel反应和Perkin反应中的应用   总被引:4,自引:0,他引:4  
李娟  孙辉  蔡晓晨  戴立益 《有机化学》2007,27(10):1296-1299
以碱性离子液体[bmim]OH作为催化剂, 在无溶剂条件下, 催化Knoevenagel反应和Perkin反应两类缩合反应. 实验结果表明, 该离子液体对Knoevenagel反应具有很高的催化活性, 一系列的芳香醛和活泼亚甲基化合物在室温条件下10~30 min内顺利完成反应, 以85%~95%的高产率生成取代烯烃产物. 离子液体经简单处理后能多次循环使用. 此外, 初步探讨了该碱性离子液体在Perkin反应中的应用.  相似文献   

4.
以碱性离子液体[bmim]OH为溶剂和催化剂, 由芳香醛与2-硫代-4-噻唑酮在沸水浴中反应30~75 min, 以89%~ 96%的产率制备了5-芳亚甲基-2-硫代-4-噻唑酮. 结果表明该方法简便易行, 产率较高, 所使用的离子液体对环境友好, 并可循环使用. 产物结构经1H NMR和IR确证.  相似文献   

5.
李晓君  郭红云 《有机化学》2012,32(1):127-132
在碱性离子液体氢氧化1-丁基-3-甲基咪唑([bmim]OH)催化作用下,由芳香醛、丙二腈、苯甲酰乙酸乙酯和肼或苯肼"一锅法"合成了一系列1,4-二氢吡喃并[2,3-c]吡唑化合物.实验中考察了催化剂、反应温度、催化剂用量、溶剂对反应的影响,确定了最优反应条件,给出了可能的反应机理.此外催化剂可以方便地收回,且循环使用四次其催化活性并没有显著降低.目标产物经过了1H NMR,IR,MS和元素分析确证.合成方法条件温和、反应时间短、产率高且对环境友好.  相似文献   

6.
碱性离子液体催化甘油合成1,2-甘油碳酸酯(英)   总被引:3,自引:0,他引:3  
以离子液体为催化剂,在无溶剂体系中,考察了生物质平台化合物甘油转化1,2-甘油碳酸酯的反应.与酸性离子液体和常用无机碱性催化剂相比,碱性离子液体咪唑基1-丁基-3-甲基咪唑([Bmim]Im)、氢氧化1-丁基-3-甲基咪唑([Bmim]OH)、咪唑基1-烯丙基-3-甲基咪唑([Amim]Im)、氢氧化1-烯丙基-3-甲基咪唑([Amim]OH)在甘油与碳酸二甲酯的酯交换反应中表现出优异的活性.其中,以[Bmim]Im离子液体为催化剂时甘油转化率为98.4%和甘油碳酸酯选择性接近100%.另外,该离子液体可以回收重复利用3次后甘油转化率仍可达92%,甘油碳酸酯选择性可近100%.此碱性离子液体催化方法具有反应结果较好、产物分离简单、条件温和以及环境友好等特点.  相似文献   

7.
郭红云  田金金 《有机化学》2011,31(11):1901-1904
在水相中碱性离子液体[bmim][OH]催化作用下,由苊醌、丙二腈/氰乙酸乙酯和β-二酮三组分“一锅法”合成了一系列螺杂环化合物,产物的结构通过1H NMR,IR和MS表征.该方法条件温和,操作简单,后处理方便,反应时间短,对环境友好,且催化剂廉价易得.  相似文献   

8.
离子液体[bmim]Cl-CrCl2促进的Reformatsky反应研究   总被引:7,自引:0,他引:7  
刘长春  袁加程  谭佩毅  金德宽 《有机化学》2009,29(10):1650-1653
用无水氯化铬(CrCl2)和氯化1-丁基-3-甲基咪唑([bmim]Cl)制备了离子液体[bmim]Cl-CrCl2, 考察了CrCl2与[bmim]Cl物质的量比以及离子液体与底物物质的量比对Reformatsky反应的影响, 研究了[bmim]Cl-CrCl2促进不同底物发生的Reformatsky反应. 结果表明, 离子液体[bmim]Cl-CrCl2不仅能促进醛、酮与α-溴代酸酯的反应, 以极好的产率得到β-羟基酸酯; 而且能较好地诱导α-溴代苯乙酮与醛、酮的反应, 以较高的产率得到β-羟基酮. 该离子液体经处理后可以重复使用, 是一种Reformatsky反应的绿色化学方法.  相似文献   

9.
在离子液体[bmim+][BF4-]中高产率的合成了一系列13-芳基-5,7,12,14-四氢二苯并[b, i]氧杂蒽-5,7,12,14(13H)-四酮类化合物。该反应操作步骤简单,离子液体易于与产物分离,并且离子液体可以循环使用。  相似文献   

10.
以碱性离子液体为催化剂, 构建了一种新型、高效的合成三羟甲基丙烷(TMP)的方法. 系统考察了催化剂类型、催化剂用量、反应温度、反应时间、甲醛与正丁醛用量比等因素对三羟甲基丙烷分离收率的影响. 研究结果表明: 碱性离子液体的催化性能与其碱强度息息相关, 碱性越强、催化活性越高. 最优条件下, 经离子液体[bmim]OH催化后, 可得到84%的TMP分离收率, 这一结果优于传统的有机无机碱催化体系且成功规避了传统碱催化合成TMP过程中繁琐的除盐过程、降低了过程能耗. 此外, 离子液体催化剂和未反应的丁醛均表现了良好的重复使用性能.  相似文献   

11.
以三乙烯二胺(DABCO)为原料,通过两步法制备了新型离子液体[DABCO-PDO][BF4]催化剂,并用于催化环亚氨类与丙烯酸酯类、丙烯腈等α,β-不饱和烯类化合物之间的Michael加成反应;考察了催化剂的循环使用性能,讨论了可能的反应机理及催化剂具有高效催化活性的原因.结果表明,在催化剂用量为反应原料的20mol%,反应温度为25℃,反应时间为5h的条件下加成产物的收率为85%以上,催化剂循环使用6次后仍保持82%的催化活性.  相似文献   

12.
Jian-Ming Xu 《Tetrahedron》2007,63(4):986-990
A fast and green protocol for the Michael addition of N-heterocycles to α,β-unsaturated compounds at room temperature was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, as a catalyst and a reaction medium. The reactions were performed at room temperature with good yields in short reaction times (0.5-3 h). This strategy is quite general and it works with a broad range of N-heterocycles, including five-membered N-heterocycles, pyrimidines and purines. The recovered ionic liquid could be reused for several cycles with consistent activity.  相似文献   

13.
Ranu BC  Banerjee S 《Organic letters》2005,7(14):3049-3052
[reaction: see text] A task-specific ionic liquid, [bmIm]OH, has been introduced as a catalyst and as a reaction medium in Michael addition. Very interestingly, although the addition to alpha,beta-unsaturated ketones proceeds in the usual way, giving the monoaddition products, this ionic liquid always drives the reaction of open-chain 1,3-dicarbonyl compounds with alpha,beta-unsaturated esters and nitriles toward bis-addition to produce exclusively bis-adducts in one stroke.  相似文献   

14.
A clean and efficient Michael addition reaction on chalcones using phosphonium ionic liquid catalyst (PhosIL-Cl) is described. The method provides several advantages, such as simple workup, environmental friendliness, mild conditions, and excellent yields. In addition, the ionic liquid was chosen as a green solvent, recovered, and reused several times in subsequent reactions.  相似文献   

15.
以BrΦnsted酸性离子液体[HSO3-bpy][HSO4]为催化剂, 将吲哚或取代吲哚与α,β-不饱和酮在乙腈中于80 ℃下反应3 h, 以92%~98%的产率制备了一系列的β-吲哚酮. 该方法简便易行且产率高. 催化剂离子液体对环境友好, 并可循环使用.  相似文献   

16.
The iron containing ionic liquid 1-butyl-3-methylimidazolium tetrachloroferrate ([C4mim]Cl/FeCl3; = 0.5) proved to be an efficient catalyst for the solvent-free metal catalyzed Michael addition of β-keto esters and enones. Due to the ionic structure of the catalyst, a significant acceleration of the reaction rate was observed under microwave conditions. Furthermore, recycling of the ionic liquid catalyst could be performed after simply distilling off the products.  相似文献   

17.
A dabco-based basic ionic liquid,1-butyl-4-aza-1-azaniabicyclo[2.2.2]octane hydroxide,has been developed as a catalyst for a convenient and rapid method for the Michael addition of active methylene compounds to a b-unsaturated carboxylic esters and nitriles.The method is very simple,and the yields are very high.The catalyst can be recycled several times without much loss of activity.  相似文献   

18.
A basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide ([bmIm]OH), has been introduced as a catalyst and reaction medium for the Markovnikov addition of N-heterocycles to vinyl esters under mild conditions. The evidence for the role of this basic ionic liquid [bmIm]OH in promoting the Markovnikov addition has been given. On the basis of the evidence, a mechanism was postulated.  相似文献   

19.
The Michael addition of indoles to electron‐deficient nitroolefins was effectively catalyzed by an ionic liquid‐coordinated ytterbium(III) sulfonate catalyst. The recycling procedure of the catalyst was very simple without extraction with water, and the catalyst was reused for five times without any loss of its catalytic activity. Furthermore, to demonstrate the application of this methodology, the Pictet‐Spengler reaction was chosen and successfully carried out in the mixture of Br?nsted‐acidic ionic liquid and [bmim]BF4.  相似文献   

20.
By performing density functional theory calculations, we have investigated the Michael addition of acetylacetone to methyl vinyl ketone in the absence and presence of the ionic liquid 1‐butyl‐3‐methylimidazolium hydroxide ([bmIm]OH). In the absence of ionic liquids, acetylacetone is firstly tautomerized to enol form and then takes place Michael addition to methyl vinyl ketone. As in the catalyzed Michael addition reaction, a bmIm+‐OH? ion pair is introduced into the reaction system to model the effect of the ionic liquid environment on the reactivity. The calculated results show that the anion enhances nucleophilic ability of acetylacetone since the OH? anion captures a proton to form an acetylacetone anion‐H2O complex, and the cation improves the electrophilic ability of methyl vinyl ketone by forming intermolecular hydrogen‐bonds. Both the remarkable effects of the cation and anion on the reactivity of reactants promote this reaction, which take place more easily compared with uncatalyzed reaction. The calculated results show that the main product of the Michael addition is in its ketone form. Our study provides a detailed reaction mechanism of Michael addition catalyzed by basic ionic liquid [bmIm]OH and clearly reveal the catalytic role of ionic liquid in important chemical reaction. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010  相似文献   

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