Diffusion of magnetic nanoparticles in a multi-site injection process within a biological tissue during magnetic fluid hyperthermia using lattice Boltzmann method

In this study the lattice Boltzmann model (LBM) has been used to simulate diffusion of magnetic nanoparticles (MNPs) injected at multiple sites inside a biological tissue during magnetic fluid hyperthermia (MFH). To validate the numerical results, diffusion in infinite one and two dimensional domains have been compared with the analytical solutions. Agreement were excellent. Also diffusion of a water based nanofluid containing magnetite MNPs (ferrofluid) for mono and multi-site injection in the tissue has been studied. Moreover, the effects of ferrofluid injection volume as well as infusion flow rate of ferrofluid on the distribution of MNPs have been investigated.     

Interstitial fluid flow: simulation of mechanical environment of cells in the interosseous membrane

In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues,while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity.On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array,we set up a porous media model simulating the flow field with FLUENT software,studied the shear stress on interstitial cells’ surface due to the interstitial fluid flow,and analyzed the effect of flow on protein space distribution around the cells.The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries.Interstitial fluid flow would induce shear stress on the membrane of interstitial cells,up to 30 Pa or so,which reaches or exceeds the threshold values of cells’ biological response observed in vitro.Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells.Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries,blood pressure and the permeability coefficient of capillary’s wall.The interstitial pressure and the interstitial porosity could also affect the shear stress on cells.In conclusion,numerical simulation provides an effective way for in vivo dynamic interstitial velocity research,helps to set up the vivid subtle interstitial flow environment of cells,and is beneficial to understanding the physiological functions of interstitial fluid flow.     

Numerical simulation of blood flow and interstitial fluid pressure in solid tumor microcirculation based on tumor-induced angiogenesis

A coupled intravascular–transvascular–interstitial fluid flow model is developed to study the distributions of blood flow and interstitial fluid pressure in solid tumor microcirculation based on a tumor-induced microvascular network. This is generated from a 2D nine-point discrete mathematical model of tumor angiogenesis and contains two parent vessels. Blood flow through the microvascular network and interstitial fluid flow in tumor tissues are performed by the extended Poiseuille’s law and Darcy’s law, respectively, transvascular flow is described by Starling’s law; effects of the vascular permeability and the interstitial hydraulic conductivity are also considered. The simulation results predict the heterogeneous blood supply, interstitial hypertension and low convection on the inside of the tumor, which are consistent with physiological observed facts. These results may provide beneficial information for anti-angiogenesis treatment of tumor and further clinical research. The project supported by the National Natural Science Foundation of China (10372026).     

MASS TRANSPORT IN SOLID TUMORS (Ⅰ)──FLUID DYNAMICS

A three-porous-medium model for transvascular exchange and extravascular transport of fluid and macromolecules in a spherical solid tumor is developed. The microvasculature, lymphatics, and tissue space are each treated as a porous medium with the flow of blood. lymph, and interstitial fluid obeying Darcy’s law and Starling’s assumption. In this part, the role of interstitial pressure and fluid convection are studited. The analytical soiutions are obtained for foe isolated tumor and the normal-tissue-surrounded tumor respectively. The calculated interstitial pressure profue are consistent with the experimental observation that the elevated interstitial pressure is a major barrier in the penetration of macromolecular drug into tumors. The factors which may reduce the interstitial pressure are analyzed in details.     

MASS TRANSPORT IN SOLID TUMORS (Ⅰ)──FLUID DYNAMICS

I.IntroductionCancerhasbeenthekillerinmanywesterncountriesonlysecondtothecardiovasculardiseaseformanyyears.Ditficultiesinearlydiagnosisisoneofthemajorobstaclesincancertreatment.However,recentlyitisreportedthatthetumorphysiologicalbarrier,whichpreventsdrugsfrompenetratingintothecoreoftumor,'mayconstituteanothermajorobstacleinkillingcancercallseffectivelyl'].Therefore,tostudythemasstransp.ortprocessintumorbecomesimportantinthatitmayprovidesomecriteriafordrugdesignanddrug-giningstrategies.Tradit…     

Scaling Transformation for the Effect of Temperature-Dependent Fluid Viscosity with Thermophoresis Particle Deposition on MHD-Free Convective Heat and Mass Transfer Over a Porous Stretching Surface

This article concerns with a steady two-dimensional flow of an electrically conducting incompressible fluid over a vertical stretching sheet. The flow is permeated by a uniform transverse magnetic field. The fluid viscosity is assumed to vary as a linear function of temperature. A scaling group of transformations is applied to the governing equations. The system remains invariant due to some relations among the parameters of the transformations. After finding three absolute invariants, a third-order ordinary differential equation corresponding to the momentum equation, and two second-order ordinary differential equations corresponding to energy and diffusion equations are derived. The equations along with the boundary conditions are solved numerically. It is found that the decrease in the temperature-dependent fluid viscosity makes the velocity to decrease with the increasing distance of the stretching sheet. At a particular point of the sheet, the fluid velocity decreases with the decreasing viscosity but the temperature increases in this case. Impact of thermophoresis particle deposition in the presence of temperature-dependent fluid viscosity plays an important role on the concentration boundary layer. The results, thus, obtained are presented graphically and discussed.     

Influence of Hall current and Joule heating on entropy generation during electrokinetically induced thermoradiative transport of nanofluids in a porous microchannel

A comprehensive theoretical study of entropy generation during electrokinetically driven transport of a nanofluid is of prime concern in the paper. The flow is considered to take place on a wavy channel under the action of an external transverse magnetic field and an external pressure gradient. Navier slips at the walls of the channel and thermal radiation have been taken into account in the study. The theoretical study has been carried out by developing a mathematical model by taking into account the effects of Joule heating, viscous dissipation, and the transverse magnetic field on heat transfer during the electrokinetic transport of the fluid. The derived analytical expressions have been computed numerically by considering the nanofluid as a mixture of blood and ferromagnetic nanoparticles. Variations in velocity, streaming potential, temperature distribution, Nusselt number, and Bejan number associated with the electrokinetic flow in capillaries have been investigated by the parametric variation method. The results have been presented graphically. The present investigation reveals that streaming potential decreases due to the Hall effect, while for the cooling capacity of the microsystem,we find an opposite behavior due to the Hall effect. The study further reveals that the fluidic temperature is reduced due to increase in the Hall current, and thereby thermal irreversibility of the system is reduced significantly. The results presented here can be considered as the approximate estimates of blood flow dynamics in capillaries during chemotherapy in cancer treatment.     

Investigation of the effects of two parallel wires' non-uniform magnetic field on heat and biomagnetic fluid flow in an aneurysm

ABSTRACT

In this paper, effects of two wires magnetic field on heat transfer and biomagnetic fluid flow in an aneurysm have been investigated using the ferrohydrodynamics model. Using the finite volume method and the SIMPLE algorithm, the governing equations have been discretised. Simulations have been carried out for both conditions of wires in the same and opposite directions and different magnetic numbers of 41 and 82. Results show that the magnetic field causes a decrease in heat transfer of blood flow towards the walls. Moreover, major energy loss or pressure drop, arising from mean wall shear stress, decreases but local or minor energy loss, arising from aneurysm vortexes, increases. Furthermore, risk factors of aneurysm rupture is decreased under the effect of the magnetic field. The effective contact surface between drug-coated magnetic nanoparticles and the aneurysm tissue may increase and residence time of drug on the cells of the region would decrease.     

Mean-field hydrodynamics brownian dynamics simulations of stabilized colloidal liquids under shear

We extend a recently proposed mean-field hydrodynamics (MFH) discrete element simulation technique to consider the effects of a shear velocity profile on a model colloidal liquid containing monodisperse spherical particles in the non-newtonian shear thinning regime. The MFH method adapts Ermak's free draining brownian dynamics algorithm to include a local density approximation for the friction coefficient, semiempirically parametrized to reproduce the experimentally determined short-time diffusion coefficient. We have also generalized further the previous treatment to allow for a friction coefficient that is dependent on local density anisotropy. The behaviour of Ermak's equations of motion and also the “isotropic” and “anisotropic” MFH schemes with shear flow are compared. We show that, at equilibrium, the MFH approaches generate the same static averages as Ermak's method, and give good agreement with the Percus-Yevick prediction for hard-sphere structure factors using an r⁻³⁶ soft-sphere interaction. However, under shear, the three equations of motion give quite different rheological behaviour. The MFH methods produce higher viscosities, although the structures remain similar (e.g. all give a “string” phase) but at different shear rates. Variation in the specific details of the MFH equations of motion can promote or delay the development of long-range order with Péclet number.     

Exact solutions for the incompressible viscous magnetohydrodynamic fluid of a rotating disk flow

The main interest of the present investigation is to generate exact solutions to the steady Navier-Stokes equations for the incompressible Newtonian viscous electrically conducting fluid flow motion due to a disk rotating with a constant angular speed. For an external uniform magnetic field applied perpendicular to the plane of the disk, the governing equations allow an exact solution to develop taking into account of the rotational non-axisymmetric stationary conducting flow.Making use of the analytic solution, exact formulas for the angular velocity components as well as for the wall shear stresses are extracted. It is proved analytically that for the specific flow the properly defined thicknesses decay as the magnetic field strength increases in magnitude. Interaction of the resolved flow field with the surrounding temperature is further analyzed via the energy equation. The temperature field is shown to accord with the dissipation and the Joule heating. According to Fourier's heat law, a constant heat transfer from the disk to the fluid occurs, though decreases for small magnetic fields because of the dominance of Joule heating, it eventually increases for growing magnetic field parameters.     

Fluid flow and fluid shear stress in canaliculi induced by external mechanical loading and blood pressure oscillation

The paper studies the problem of fluid flow and fluid shear stress in canaliculi when the osteon is subject to external mechanical loading and blood pressure oscillation. The single osteon is modeled as a saturated poroelastic cylinder. Solid skeleton is regarded as a poroelastic transversely isotropic material. To get near-realistic results, both the interstitial fluid and the solid matrix are regarded as compressible. Blood pressure oscillation in the Haverian canal is considered. Using the poroelasticity theory, an analytical solution of the pore fluid pressure is obtained. Assuming the fluid in canaliculi is incompressible, analytical solutions of fluid flow velocity and fluid shear stress with the Navier-Stokes equations of incompressible fluid are obtained. The effect of various parameters on the fluid flow velocity and fluid shear stress is studied.     

Rotational flow of Oldroyd-B nanofluid subject to Cattaneo-Christov double diffusion theory

A nanofluid is composed of a base fluid component and nanoparticles, in which the nanoparticles are dispersed in the base fluid. The addition of nanoparticles into a base fluid can remarkably improve the thermal conductivity of the nanofluid, and such an increment of thermal conductivity can play an important role in improving the heat transfer rate of the base fluid. Further, the dynamics of non-Newtonian fluids along with nanoparticles is quite interesting with numerous industrial applications. The present predominately predictive modeling studies the flow of the viscoelastic Oldroyd-B fluid over a rotating disk in the presence of nanoparticles. A progressive amendment in the heat and concentration equations is made by exploiting the Cattaneo-Christov heat and mass flux expressions. The characteristic of the Lorentz force due to the magnetic field applied normal to the disk is studied. The Buongiorno model together with the Cattaneo-Christov theory is implemented in the Oldroyd-B nanofluid flow to investigate the heat and mass transport mechanism. This theory predicts the characteristics of the fluid thermal and solutal relaxation time on the boundary layer flow. The von K′arm′an similarity functions are utilized to convert the partial differential equations(PDEs) into ordinary differential equations(ODEs). A homotopic approach for obtaining the analytical solutions to the governing nonlinear problem is carried out. The graphical results are obtained for the velocity field, temperature, and concentration distributions. Comparisons are made for a limiting case between the numerical and analytical solutions, and the results are found in good agreement. The results reveal that the thermal and solutal relaxation time parameters diminish the temperature and concentration distributions, respectively. The axial flow decreases in the downward direction for higher values of the retardation time parameter. The impact of the thermophoresis parameter boosts the temperature distribution.     

TiO_2-water nanofluid in a porous channel under the effects of an inclined magnetic field and variable thermal conductivity

The TiO_2-water based nanofluid flow in a channel bounded by two porous plates under an oblique magnetic field and variable thermal conductivity is formulated as a boundary-value problem(BVP). The BVP is analytically solved with the homotopy analysis method(HAM). The result shows that the concentration of the nanoparticles is independent of the volume fraction of TiO_2 nanoparticles, the magnetic field intensity, and the angle. It is inversely proportional to the mass diffusivity. The fluid speed decreases whereas the temperature increases when the volume fraction of the TiO_2 nanoparticles increases. This confirms the fact that the occurrence of the TiO_2 nanoparticles results in the increase in the thermal transfer rate. The fluid speed decreases and the temperature increases for both the pure water and the nanofluid when the magnetic field intensity and angle increase. The maximum velocity does not exist at the middle of the symmetric channel, which is in contrast to the plane-Poiseuille flow, but it deviates a little bit towards the lower plate, which absorbs the fluid with a very low suction velocity. If this suction velocity is increased, the temperature in the vicinity of the lower plate will be increased.An explicit expression for the friction factor-Reynolds number is then developed. It is shown that the Hartmann number of the nanofluid is smaller than that of pure water,while the Nusselt number of the nanofluid is larger than that of pure water. However,both the parameters increase if the magnetic field intensity increases.     

A three-dimensional non-linear constitutive law for magnetorheological fluids, with applications

In this paper we first summarize the magnetic and mechanical balance equations for magnetorheological fluids undergoing steady motion in the presence of a magnetic field. A general three-dimensional non-linear constitutive law for such a fluid is given for the case in which the magnetic induction vector is used as the independent magnetic variable. The equations are needed for the analysis of boundary-value problems involving fluids with dispersed micron-sized ferrous particles subjected to a time-independent magnetic field. For illustration, the equations are applied, in the case of an incompressible fluid, to the solution of some basic problems. We consider unidirectional flow in a region confined by two infinite parallel plates with a magnetic field applied perpendicular to the plates. Next, we examine two problems involving a circular cylindrical geometry with the fluid occupying the region between two concentric cylinders: axial flow subjected to an axial magnetic field and circumferential flow with a circumferential field. After making some simplifying assumptions on the constitutive law and choosing material parameters, numerical solutions for the velocity profiles are illustrated.     

Melting effect and Cattaneo-Christov heat flux in fourth-grade material flow through a Darcy-Forchheimer porous medium

The melting phenomenon in two-dimensional (2D) flow of fourth-grade material over a stretching surface is explored. The flow is created via a stretching surface. A Darcy-Forchheimer (D-F) porous medium is considered in the flow field. The heat transport is examined with the existence of the Cattaneo-Christov (C-C) heat flux. The fourth-grade material is electrically conducting subject to an applied magnetic field. The governing partial differential equations (PDEs) are reduced into ordinary differential equations (ODEs) by appropriate transformations. The solutions are constructed analytically through the optimal homotopy analysis method (OHAM). The fluid velocity, temperature, and skin friction are examined under the effects of various involved parameters. The fluid velocity increases with higher material parameters and velocity ratio parameter while decreases with higher magnetic parameter, porosity parameter, and Forchheimer number. The fluid temperature is reduced with higher melting parameter while boosts against higher Prandtl number, magnetic parameter, and thermal relaxation parameter. Furthermore, the skin friction coefficient decreases against higher melting and velocity ratio parameters while increases against higher material parameters, thermal relaxation parameter, and Forchheimer number.

     

Steady mixed convection stagnation-point flow of upper convected Maxwell fluids with magnetic field

The steady MHD mixed convection flow of a viscoelastic fluid in the vicinity of two-dimensional stagnation point with magnetic field has been investigated under the assumption that the fluid obeys the upper-convected Maxwell (UCM) model. Boundary layer theory is used to simplify the equations of motion, induced magnetic field and energy which results in three coupled non-linear ordinary differential equations which are well-posed. These equations have been solved by using finite difference method. The results indicate the reduction in the surface velocity gradient, surface heat transfer and displacement thickness with the increase in the elasticity number. These trends are opposite to those reported in the literature for a second-grade fluid. The surface velocity gradient and heat transfer are enhanced by the magnetic and buoyancy parameters. The surface heat transfer increases with the Prandtl number, but the surface velocity gradient decreases.     

TiO<Subscript>2</Subscript>-water nanofluid in a porous channel under the effects of an inclined magnetic field and variable thermal conductivity

The TiO₂-water based nanofluid flow in a channel bounded by two porous plates under an oblique magnetic field and variable thermal conductivity is formulated as a boundary-value problem (BVP). The BVP is analytically solved with the homotopy analysis method (HAM). The result shows that the concentration of the nanoparticles is independent of the volume fraction of TiO₂ nanoparticles, the magnetic field intensity, and the angle. It is inversely proportional to the mass diffusivity. The fluid speed decreases whereas the temperature increases when the volume fraction of the TiO₂ nanoparticles increases. This confirms the fact that the occurrence of the TiO₂ nanoparticles results in the increase in the thermal transfer rate. The fluid speed decreases and the temperature increases for both the pure water and the nanofluid when the magnetic field intensity and angle increase. The maximum velocity does not exist at the middle of the symmetric channel, which is in contrast to the plane-Poiseuille flow, but it deviates a little bit towards the lower plate, which absorbs the fluid with a very low suction velocity. If this suction velocity is increased, the temperature in the vicinity of the lower plate will be increased. An explicit expression for the friction factor-Reynolds number is then developed. It is shown that the Hartmann number of the nanofluid is smaller than that of pure water, while the Nusselt number of the nanofluid is larger than that of pure water. However, both the parameters increase if the magnetic field intensity increases.     

An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC)

The articular cartilage (AC) can be seen as a biphasic poroelastic material. The cartilage deformation under compression mainly leads to an interstitial fluid flow in the porous solid phase. In this paper, an analytical poroelastic model for the AC under laboratorial mechanical testing is developed. The solutions of interstitial fluid pressure and velocity are obtained. The results show the following facts. (i) Both the pressure and fluid velocity amplitudes are proportional to the strain loading amplitude. (ii) Both the amplitudes of pore fluid pressure and velocity in the AC depend more on the loading amplitude than on the frequency. Thus, in order to obtain the considerable fluid stimulus for the AC cell responses, the most effective way is to increase the loading amplitude rather than the frequency. (iii) Both the interstitial fluid pressure and velocity are strongly affected by permeability variations. This model can be used in experimental tests of the parameters of AC or other poroelastic materials, and in research of mechanotransduction and injury mechanism involved interstitial fluid flow.     

Transient flow of magnetized Maxwell nanofluid: Buongiorno model perspective of Cattaneo-Christov theory

The present research article is devoted to studying the characteristics of Cattaneo-Christov heat and mass fluxes in the Maxwell nanofluid flow caused by a stretching sheet with the magnetic field properties. The Maxwell nanofluid is investigated with the impact of the Lorentz force to examine the consequence of a magnetic field on the flow characteristics and the transport of energy. The heat and mass transport mechanisms in the current physical model are analyzed with the modified versions of Fourier’s and Fick’s laws, respectively. Additionally, the well-known Buongiorno model for the nanofluids is first introduced together with the Cattaneo-Christov heat and mass fluxes during the transient motion of the Maxwell fluid. The governing partial differential equations (PDEs) for the flow and energy transport phenomena are obtained by using the Maxwell model and the Cattaneo-Christov theory in addition to the laws of conservation. Appropriate transformations are used to convert the PDEs into a system of nonlinear ordinary differential equations (ODEs). The homotopic solution methodology is applied to the nonlinear differential system for an analytic solution. The results for the time relaxation parameter in the flow, thermal energy, and mass transport equations are discussed graphically. It is noted that higher values of the thermal and solutal relaxation time parameters in the Cattaneo-Christov heat and mass fluxes decline the thermal and concentration fields of the nanofluid. Further, larger values of the thermophoretic force enhance the heat and mass transport in the nanoliquid. Moreover, the Brownian motion of the nanoparticles declines the concentration field and increases the temperature field. The validation of the results is assured with the help of numerical tabular data for the surface velocity gradient.