共查询到20条相似文献,搜索用时 46 毫秒
1.
Malley R Stack AM Husson RN Thompson CM Fleisher GR Saladino RA 《Journal of immune based therapies and vaccines》2004,2(1):2
Background
A recently licensed pneumococcal conjugate vaccine has been shown to be highly effective in the prevention of bacteremia in immunized children but the degree of protection against pneumonia has been difficult to determine. 相似文献2.
James B Whitney Saied Mirshahidi So-Yon Lim Lauren Goins Chris C Ibegbu Daniel C Anderson Richard B Raybourne Fred R Frankel Judy Lieberman Ruth M Ruprecht 《Journal of immune based therapies and vaccines》2011,9(1):2
Background
We have evaluated an attenuated Listeria monocytogenes (Lm) candidate vaccine vector in nonhuman primates using a delivery regimen relying solely on oral vaccination. We sought to determine the impact of prior Lm vector exposure on the development of new immune responses against HIV antigens. 相似文献3.
Rajpal S Kashyap Aliabbas A Husain Shweta H Morey Milind S Panchbhai Poonam S Deshpande Hemant J Purohit Girdhar M Taori Hatim F Daginawala 《Journal of immune based therapies and vaccines》2010,8(1):3
Background
Tuberculosis (TB) is one of the most prevalent cause of death due to a single pathogen. Bacillus Calmette Guérin (BCG) is the only vaccine available for clinical use that protects against miliary TB; however, this vaccine has shown variable levels of efficacy against pulmonary TB. In India, a single dose of BCG vaccine is given and there are few countries where repeated doses of BCG are given. The incidence of TB in India is very high inspite of primary vaccination in neonatal period and therefore requires consideration for repeated immunization. 相似文献4.
Background
Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection. 相似文献5.
Garry L Morefield Ralph F Tammariello Bret K Purcell Patricia L Worsham Jennifer Chapman Leonard A Smith Jason B Alarcon John A Mikszta Robert G Ulrich 《Journal of immune based therapies and vaccines》2008,6(1):5
Background
Combination vaccines reduce the total number of injections required for each component administered separately and generally provide the same level of disease protection. Yet, physical, chemical, and biological interactions between vaccine components are often detrimental to vaccine safety or efficacy. 相似文献6.
Nelson F Eng Srinivas Garlapati Volker Gerdts Lorne A Babiuk George K Mutwiri 《Journal of immune based therapies and vaccines》2010,8(1):4
Background
We previously demonstrated that polyphosphazenes, particularly PCEP, enhance immune responses in mice immunized subcutaneously and intranasally. The objective of the present study was to investigate the efficacy of polyphosphazenes as adjuvants when delivered through different routes of vaccine administration. 相似文献7.
Jonathan B Angel Curtis L Cooper Jennifer Clinch Charlene D Young Andreane Chenier Karl G Parato Michael Lautru Heather Davis Donald W Cameron 《Journal of immune based therapies and vaccines》2008,6(1):4
Background
Lack of adequate adjuvancy is a possible explanation for lack of vaccine immunogenecity. Immunostimulatory CpGs are potent vaccine adjuvants and may be an important component of the development vaccines, particularly those for which a cellular immune response is required for protection. We have previously demonstrated that CpG ODN co-administration with hepatitis B vaccine results in earlier, stronger and more sustained antibody responses to hepatitis B surface antigen in HIV infected individuals, and wished to determine if, in this population, helper T-cell responses were also enhanced. 相似文献8.
Jerome S Harms Marina A Durward Diogo M Magnani Gary A Splitter 《Journal of immune based therapies and vaccines》2009,7(1):1-14
Background
There is no safe, effective human vaccine against brucellosis. Live attenuated Brucella strains are widely used to vaccinate animals. However these live Brucella vaccines can cause disease and are unsafe for humans. Killed Brucella or subunit vaccines are not effective in eliciting long term protection. In this study, we evaluate an approach using a live, non-pathogenic bacteria (E. coli) genetically engineered to mimic the brucellae pathway of infection and present antigens for an appropriate cytolitic T cell response. 相似文献9.
Harm HogenEsch Anisa Dunham Bethany Hansen Kathleen Anderson Jean-Francois Maisonneuve Stanley L Hem 《Journal of immune based therapies and vaccines》2011,9(1):1-10
Background
Streptococcus pneumoniae causes widespread morbidity and mortality. Current vaccines contain free polysaccharides or protein-polysaccharide conjugates, and do not induce protection against serotypes that are not included in the vaccines. An affordable and broadly protective vaccine is very desirable. The goal of this study was to determine the optimal formulation of a killed whole cell pneumococcal vaccine with aluminum-containing adjuvants for intramuscular injection.Methods
Four aluminium-containing adjuvants were prepared with different levels of surface phosphate groups resulting in different adsorptive capacities and affinities for the vaccine antigens. Mice were immunized three times and the antigen-specific antibody titers and IL-17 responses in blood were analyzed.Results
Although all adjuvants induced significantly higher antibody titers than antigen without adjuvant, the vaccine containing aluminum phosphate adjuvant (AP) produced the highest antibody response when low doses of antigen were used. Aluminum hydroxide adjuvant (AH) induced an equal or better antibody response at high doses compared with AP. Vaccines formulated with AH, but not with AP, induced an IL-17 response. The vaccine formulated with AH was stable and retained full immunogenicity when stored at 4°C for 4 months.Conclusions
Antibodies are important for protection against systemic streptococcal disease and IL-17 is critical in the prevention of nasopharyngeal colonization by S. pneumoniae in the mouse model. The formulation of the whole killed bacterial cells with AH resulted in a stable vaccine that induced both antibodies and an IL-17 response. These experiments underscore the importance of formulation studies with aluminium containing adjuvants for the development of stable and effective vaccines. 相似文献10.
Background
Infections with respiratory viruses can activate the innate immune response - an important host defence mechanism in the early stage of viral infection. Interferon (IFN) release, triggered by virus infection, is an important factor in establishing an antiviral state, where IFN activation occurs prior to the onset of the adaptive immune response. 相似文献11.
Curtis L Cooper Navneet K Ahluwalia Susan M Efler Jörg Vollmer Arthur M Krieg Heather L Davis 《Journal of immune based therapies and vaccines》2008,6(1):3
Background
Chronic hepatitis C virus (HCV) infection results from weak or absent T cell responses. Pegylated-interferon-alpha (IFN-α) and ribavirin, the standard of care for chronic HCV, have numerous immune effects but are not potent T cell activators. A potent immune activator such as TLR9 agonist CpG oligodeoxynucleotide (CpG) may complement current treatment approaches. 相似文献12.
Kenneth H Huang Marie-Pierre Boisvert Famane Chung Maude Loignon Don Zarowny Lise Cyr Emil Toma Nicole F Bernard 《Journal of immune based therapies and vaccines》2006,4(1):7-12
Background
Despite the benefits of highly active antitretroviral therapy (HAART) for suppressing viral replication in HIV infection, virus persists and rebounds during treatment interruption (TI). This study explored whether HAART intensification with Remune™ vaccination before TI can boost HIV-1-specific immunity, leading to improved control of viremia off HAART. 相似文献13.
Background
The mammalian homologue of Seven in Absentia (Siah) can act in the ubiquitin/proteasome pathway. Recent work has shown that Siah can bind group I metabotropic glutamate receptors (mGluRs), but the functional consequences of this interaction are unknown. 相似文献14.
Graphical Abstract
相似文献15.
So-Yon Lim Adam Bauermeister Richard A Kjonaas Swapan K Ghosh 《Journal of immune based therapies and vaccines》2006,4(1):5-10
Background
Adjuvants are known to significantly enhance vaccine efficacy. However, commercial adjuvants often have limited use because of toxicity in humans. The objective of this study was to determine the comparative effectiveness of a diterpene alcohol, phyto l and its hydrogenated derivative PHIS-01, relative to incomplete Freund's adjuvant (IFA), a commonly used adjuvant in augmenting protective immunity in mice against E. coli and S. aureus, and in terms of inflammatory cytokines. 相似文献16.
Wen Ji Yuan Takao Yasuhara Tetsuro Shingo Kenichiro Muraoka Takashi Agari Masahiro Kameda Takashi Uozumi Naoki Tajiri Takamasa Morimoto Meng Jing Tanefumi Baba Feifei Wang Hanbai Leung Toshihiro Matsui Yasuyuki Miyoshi Isao Date 《BMC neuroscience》2008,9(1):1-11
Background
A recent human clinical trial of an Alzheimer's disease (AD) vaccine using amyloid beta (Aβ) 1–42 plus QS-21 adjuvant produced some positive results, but was halted due to meningoencephalitis in some participants. The development of a vaccine with mutant Aβ peptides that avoids the use of an adjuvant may result in an effective and safer human vaccine.Results
All peptides tested showed high antibody responses, were long-lasting, and demonstrated good memory response. Epitope mapping indicated that peptide mutation did not lead to epitope switching. Mutant peptides induced different inflammation responses as evidenced by cytokine profiles. Ig isotyping indicated that adjuvant-free vaccination with peptides drove an adequate Th2 response. All anti-sera from vaccinated mice cross-reacted with human Aβ in APP/PS1 transgenic mouse brain tissue.Conclusion
Our study demonstrated that an adjuvant-free vaccine with different Aβ peptides can be an effective and safe vaccination approach against AD. This study represents the first report of adjuvant-free vaccines utilizing Aβ peptides carrying diverse mutations in the T-cell epitope. These largely positive results provide encouragement for the future of the development of human vaccinations for AD. 相似文献17.
Graphical abstract
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Graphical Abstract
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Graphical abstract
相似文献20.
Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor
Maddalena M Lino Catherine Vaillant Slobodanka Orolicki Melanie Sticker Mirna Kvajo Denis Monard 《BMC neuroscience》2010,11(1):70