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1.
G. A. Gazieva Yu. V. Nelyubina A. N. Kravchenko K. A. Lysenko N. G. Kolotyrkina P. A. Belyakov A. A. Korlyukov O. V. Lebedev N. N. Makhova 《Russian Journal of Organic Chemistry》2009,45(2):248-255
Derivatives of a new heterocyclic system, 3,3′-bi(6,8-dialkyl-2,4-dioxa-7-thia-6,8-diazabicyclo[3.3.0]-octane-7,7-dioxides), were synthesized by condensation of 1,3-dialkylsulfamides with glyoxal (as a dihydrate trimer). Their structure was investigated by spectral methods, XRD, and X-ray phase analysis of one among these compounds. 相似文献
2.
1-Carbethoxy-2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1] nonan-9-ones (1, 2) were synthesized and their 1H and 13C NMR data are reported. Chemical shifts and spectral assignments for 2,4,6,8-tetrakis(4-chlorophenyl)-3,7-diazabicyclo[3.3.1]nonan-9-one (3), 2,4,6,8-tetraphenyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one (4) and 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonanes (5-7) are also included. 相似文献
3.
Kravchenko A. N. Maksareva E. Yu. Belyakov P. A. Sigachev A. S. Chegaev K. Yu. Lyssenko K. A. Lebedev O. V. Makhova N. N. 《Russian Chemical Bulletin》2003,52(1):192-197
New (1R*,5S*)-2-R-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-diones containing the terminal carboxy or hydroxy group in the substituent R were synthesized by cyclocondensation of 4,5-dihydroxyimidazolidin-2-one with 1-R-ureas. Single-crystal X-ray diffraction analysis showed that 2-carboxyethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione crystallizes as a racemate. 相似文献
4.
Miftakhov M. S. Ermolenko M. S. Gaisina I. N. Kuznetsov O. M. Selezneva N. K. Yusupov Z. A. Muslukhov R. R. 《Russian Chemical Bulletin》2001,50(6):1101-1106
Alkylation of (1R,2R,5R)-2-benzenesulfonyl-6,8-dioxa-bicyclo[3.2.1]octan-3-one, which is accessible from levoglucosan, afforded (1R,2R,5R)-2-benzenesylfonyl-2,4,4-trimethyl-6,8-dioxabicyclo[3.2.1]octan-3-one. This was further converted into (1S,2R,3S,5R)-2,4,4-trimethyl-6,8-dioxabicyclo[3.2.1]octan-3-ol representing the C9—C13 fragment of acutiphycin molecule. 相似文献
5.
G. A. Gazieva K. A. Lysenko A. N. Kravchenko O. V. Lebedev 《Russian Journal of Organic Chemistry》2007,43(11):1715-1718
Condensation of N,N′-dimethylsulfamide with glyoxal gave 2,4,6,8-tetramethyl-3,7-dithia-2,4,6,8-tetraazabicyclo[3.3.0]octane 3,3,7,7-tetraoxide, a sulfur-containing analog of 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione (Mebicar). The product structure was studied by X-ray analysis. 相似文献
6.
K. Yu. Chegaev A. N. Kravchenko O. V. Lebedev Yu. A. Strelenko P. A. Belyakov 《Chemistry of Heterocyclic Compounds》2002,38(10):1250-1252
N-Trimethylsilyl derivatives of 2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-diones have been prepared for the first time and the electrophilic substitution reaction of the trimethylsilyl group has been studied. 相似文献
7.
Barbara DeSantis AnnaLaura Iamiceli RinaldoMarini Bettolo LuisaMaria Migneco Rita Scarpelli Giorgio Cerichelli Giancarlo Fabrizi Doriano Lamba 《Helvetica chimica acta》1998,81(12):2375-2387
The factors responsible for the diastereoselective formation of the 6-endo-hydroxybicyclo[2.2.2]octan-2-one by acid-catalyzed intramolecular aldol reaction of 3-oxocyclohexaneacetaldehydes have been investigated. This study, carried out on (1SR,4RS,6RS)-6-hydroxybicyclo[2.2.2]octan-2-one 1a , (1SR,4RS,6SR)-6-hydroxybicyclo[2.2.2]octan-2-one 1b , and 3,3-(ethylenedioxy)cyclohexaneacetaldehyde 2a , allowed to demonstrate the absence of intramolecular H-bonding in 1a as a stabilizing factor, and to ascertain the presence of unfavorable steric interactions in 1b . 相似文献
8.
Fanfoni L Meduri A Zangrando E Castillon S Felluga F Milani B 《Molecules (Basel, Switzerland)》2011,16(2):1804-1824
Two new chiral, enantiomerically pure, hybrid P-N ligands, namely (2R,5S)-2-phenyl-3-(2-pyridyl)-1,3-diaza-2-phosphanicyclo[3,3,0]octan-4-one (1) and (2R,5S)-2-phenyl-3-(2-pyridyl)-1,3-diaza-2-phosphanicyclo[3,3,0]octane (2), have been synthesized starting from L-proline. The two ligands differ in the presence or not of a carbonyl group in the diazaphosphane ring. Their coordination chemistry towards Pd(II) was studied by reacting them with [Pd(CH?)Cl(cod)]. A different behaviour was observed: ligand 2 shows the expected bidentate chelating behaviour leading to the mononuclear Pd-complex, while ligand 1 acts as a terdentate ligand giving a dinuclear species. The corresponding cationic derivatives were obtained from the palladium neutral complexes, both as mono- and dinuclear derivatives, and tested as precatalysts for styrene dimerization, yielding E-1,3-diphenyl-1-butene regio- and stereoselectively as the sole product. A detailed analysis of the catalytic behaviour is reported. 相似文献
9.
This paper reports our recent efforts to develop novel tricycles based on 4H-benzo[1,4]thiazin-3-one ( 2) and 1,1-dioxo-1,4-dihydro-2H-1lambda(6)-benzo[1,4]thiazin-3-one (3) using 1,5-difluoro-2,4-dinitrobenzene (1). All of these tricycles integrate two privileged structures into one skeleton, including 3,8-dihydro-5-thia-1,3,8-triaza-cyclopenta[b]naphthalene-7-one (4, 10, 12), 5,5-dioxo-3,5,6,8-tetrahydro-5lambda(6)-thia-1,3,8-triaza-cyclopenta[b]naphthalene-7-one (5, 11), 3,8-dihydro-5-thia-1,2,3,8-tetraaza-cyclopenta[b]naphthalene-7-one (6), 5,5-dioxo-3,5,6,8-tetrahydro-5lambda(6)-thia-1,2,3,8-tetraaza-cyclopenta[b]naphthalene-7-one (7), 3,8-dihydro-1H-5-thia-1,3,8-triaza-cyclopenta[b]naphthalene-2,7-dione (8), and 5,5-dioxo-3,5,6,8-tetrahydro-1H-5lambda(6)-thia-1,3,8-triaza-cyclopenta[b]naphthalene-2,7-dione (9). A typical library of scaffold 5 was synthesized in a parallel solution-phase manner and analyzed by HPLC-UV-MS or HPLC-UV-ELSD method. 相似文献
10.
S. D. Mikhno T. M. Filippova T. N. Polyanskaya S. I. Peretokina I. G. Suchkova V. M. Berezovskii 《Chemistry of Heterocyclic Compounds》1978,14(12):1315-1319
It is shown that acrolein adds to the 4 position (rather than to the 2 position) of 4-benzamido-3-oxothiophan under the influence of catalysts with basic character; the aldehyde group of the intermediate compound reacts with the amino group (if the reaction is carried out in chloroform) to give 6-benzoyl-7-hydroxy-2-thia-6-azaspiro[4.4]nonan-4-one or (if the reaction is carried out in a mixture of alcohol and chloroform) 1-benzamido-4-hydroxy-6-thiabicyclo-[3.2.1]octan-8-one as a result of intramolecular aldol condensation.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1620–1624, December, 1978. 相似文献
11.
R. Nurdinov É. É. Liepin'sh I. B. Mazheika I. Ya. Kalvin'sh 《Chemistry of Heterocyclic Compounds》1993,29(10):1215-1221
By the interaction of hydrazides of L-proline, L-thioproline, pipecolic acid, and tetrahydro-1,4-thiazine-3-carboxylic acid with an excess of a carbonyl compound, through a stage of hydrazone formation, the following compounds have been obtained: 2,3-substituted 1,3-diazabicyclo[3.3.0]octan-4-ones; 7,8-substituted 7-thia-1,7-diazabicyclo[3.3.0]octan-6-ones; and 8,9-substituted diazabicyclo[4.3.0]nonan-7-ones. Preferential translinkage of the rings is characteristic for these heterocycles in solutions; if the substitution is asymmetric, the E-isomers are predominant.For Communication 1 see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1415–1421, October, 1993. 相似文献
12.
Novel sulfur-containing spiro compounds such as 7,11-diaryl-9-thia-2,4-diazaspiro [5,5] undecane-1,3,5-trione 9,9-dioxides ( 2 ), 6,10-diaryl-8-thia-2,3-diazas-piro[4,5]decane-1,4-dione-8,8-dioxides ( 3 ) and 6,10-diaryl-2-oxo-8-thia-3-azaspiro [4,5] decane-1,4-dione-8,8-dioxides ( 5 ) have been prepared by the condensation of 4-dimethoxycarbonyl/diethoxycarbonyl-3,5-diaryl-1-thiane 1,1-dioxides ( 1 ) with urea, hydrazine hydrate, and hydroxylamine hydrochloride, respectively. The N-substituted derivatives ( 4 and 6 ) of 3 and 5 have also been prepared by acylation and nitrosation. The structures of 2, 3 , and 5 were established by IR, 1H NMR, and 13C NMR spectral studies, respectively. 相似文献
13.
[reaction:see text] The substituted cyclopentanic structures, 6-benzyloxymethyl-7-hydroxy-2-oxabicyclo [3.3.0]octan-3-one (1), a Corey lactone derivative, and 6-exo-benzyloxymethyl-2-oxabicyclo[3.3. 0]oct-7-en-3-one (2), have been obtained stereoselectively through the bicyclo[3.2.0]hept-3-en-6-one approach via 5-benzyloxymethyl-3-hydroxy-6-heptenoic acid, easily accessible from the inexpensive monoprotected cis-2-butene-1,4-diol. 相似文献
14.
2,6-Diaryl-3,7-dioxabicyclo[3,3,0]octan-8-one structures are assigned to two lignans isolated from Aegilops ovata L., by comparing their spectroscopic data to a synthetically prepared novel 2,4- and 2,6-diaryl monoepoxylignanolide. The possibility of differentiating between these two structural types is discussed and an X-ray analysis of the 2,4-diaryl lignan is presented. 相似文献
15.
T. V. Ternikova G. V. Pokhvisneva G. A. Smirnov S. V. Nikitin P. B. Gordeev O. A. Luk’yanov 《Russian Chemical Bulletin》2016,65(12):2873-2878
Synthetic procedures to access new potential NO donors that can generate NO in living systems, 3,3-bis(2-hydroxyethyl) and 3,3,3’-tris(2-hydroxyethyl) derivatives of 1,1’-[methylenebis(oxy)]bis(3,3-dialkyltriaz-1-ene 2-oxides), were elaborated. 3,3-Bis(2-acetoxyethyl)-1(chloromethoxy)triaz-1-ene 2-oxide reacts with 1-hydroxytriaz-1-ene 2-oxide sodium salts to give a series of alkylated 3,3-bis(2-acetoxyethyl) derivatives. Deacetylation of the latter produces 3-(2-hydroxyethyl)-11,11-dialkyl-6,8-dioxa-3,4,5,9,10,11-hexaazaundeca-4,9-dien-1-ol 4,10-dioxides and 11-alkyl-3-(2-hydroxyethyl)-6,8-dioxa-3,4,5,9,10,11-hexaazatrideca-4,9-diene-1,13-diol 4,10-dioxides. 相似文献
16.
é. B. Shamuratov A. S. Batsanov Yu. T. Struchkov A. Yu. Tsivadze M. G. Tsintsadze L. I. Khmel'nitskii Yu. A. Simonov A. A. Dvorkin O. V. Lebedev T. B. Markova 《Chemistry of Heterocyclic Compounds》1991,27(7):745-749
Isomeric 2,6- and 2,8-diethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-diones were obtained by the reaction of glyoxal with ethylurea, and their crystal structures and IR, Raman, and PMR spectra were studied.Translated from Khimiya Geterotsikiicheskikh Soedinenii, No. 7, pp. 937–941, July, 1991. 相似文献
17.
HU Rong-zu YANG De-suo ZHAO Feng-qi CHEN Pei LUO Yang CHEN San-ping ZHAO Hong-an SONG Ji-rong GAO Sheng-li SHI Qi-zhen 《高等学校化学研究》2004,20(6)
Introduction 2,6-Dinitro-4,8-bis(2,2,2-trinitroethyl)-2,4,6,8-tetraazabicyclo[3.3.1] nonane-3,7-dionel is a typical cyclourea nitramine. Its crystal density is 1.94 g/cm3. The detonation velocity corresponding to ρ=1.920 g/cm3 is about 8957 m/s. It has the potential application as high explosive due to the above-mentioned high performance. Its preparation[1], properties[1] and hydrolytic behavior[2] have been reported. In the present paper, we report its kinetic parameters and mechanism of the exothermic first-stage decomposition reaction studied with DSC, TG-DTG and IR. 相似文献
18.
Panshina S. Yu. Ponomarenko O. V. Bakibaev A. A. Malkov V. S. 《Russian Journal of Organic Chemistry》2020,56(12):2067-2073
Russian Journal of Organic Chemistry - A new method has been developed for the synthesis of 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione in 62% yield using etidronic acid... 相似文献
19.
Bruce R. Bailey III K. Darrell Berlin Douglas R. Powell Dick Van der Helm 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):121-133
Abstract A series of N-alkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones and derivatives have been prepared from the reaction of an appropriate 4-thianone, an aldehyde and an amine in a Mannich type condensation. Reduction of the ketones via Wolff-Kishner conditions produced bicyclic systems with the methylene bridging group. Addition of Grignard reagents to the ketones did yield the expected alcohols. Conformational analysis of the systems was performed via diagnosis of the 1H and 13C NMR spectra. A single crystal X-ray diffraction analysis of 2,2,4,4-tetramethyl-6,8-diphenyl-3-thia-7-azabicyclo[3.3.1]nonan-9-one was accomplished and revealed a boat conformer for the nitrogen-containing ring and a chair conformer for the sulfur-containing ring. The ketone crystallized in the triclinic space group P1 (Z=2) with a=6.216 (3), b=10.507 (5), c=15.335 (6) Å, α=86.64 (4), β=86.66 (4), and γ=98.51 (5)° [Vol=986.55 Å3]. 相似文献
20.
Syroeshkina Yu. S. Petukhova V. Yu. Kachala V. V. Nelyubina Yu. V. Makhova N. N. 《Russian Chemical Bulletin》2010,59(7):1433-1441
A reaction of aryl ketenes with 1-arylmethylidenepyrazolidin-1-azomethine imines, generated by the diaziridine ring opening
in 6-aryl-1,5-diazabicyclo[3.1.0]hexanes catalyzed with Et2O·BF3, leads to 1,2-bis(phenylacetyl)pyrazolidine, 2-arylacetyl-1-arylidenepyrazolidin-1-ium
chlorides, or a representative of 1,5-diazabicyclo[3.3.0]octan-2-ones, viz., 4-(4-eth-oxyphenyl)-3,3-diphenyl-1,5-diazabicyclo[3.3.0]octan-2-one, depending on the reaction conditions and the structure
of the starting compounds. A mechanism suggested earlier for the transformation of 1,5-diazabicyclo[3.1.0]hexanes in the reaction
with ketenes was confirmed. 相似文献