多层膜磁性微泡的非线性声振动特性

超顺磁性氧化铁纳米粒子与造影剂微泡结合形成磁性微泡,用于产生多模态造影剂,以增强医学超声和磁共振成像.将装载有纳米磁性颗粒的微泡包膜层看作由磁流体膜与磷脂膜组合而成的双层膜结构,同时考虑磁性纳米颗粒体积分数a对膜密度及黏度的影响,从气泡动力学基本理论出发,构建多层膜结构磁性微泡非线性动力学方程.数值分析了驱动声压和频率等声场参数、颗粒体积分数、膜层厚度以及表面张力等膜壳参数对微泡声动力学行为的影响.结果表明,当磁性颗粒体积分数较小且a≤0.1时,磁性微泡声响应特性与普通包膜微泡相似,微泡的声频响应与其初始尺寸和驱动压有关;当驱动声场频率f为磁性微泡共振频率f0的2倍(f=2f0)时,微泡振动失稳临界声压最低;磁性颗粒的存在抑制了泡的膨胀和收缩但抑制效果非常有限;磁性微泡外膜层材料的表面张力参数K及膜层厚度d也会影响微泡的振动,当表面张力参数及膜厚取值分别为0.2—0.4 N/m及50—150 nm时,可观察到气泡存在不稳定振动响应区.     

Nonlinear response of ultrasound contrast agent microbubbles:From fundamentals to applications

Modelling and biomedical applications of ultrasound contrast agent(UCA) microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including(i) the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry;(ii) a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size;(iii) the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and(iv) the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures.     

Radiation-induced resistance oscillation and instability in GaAS/AlGaAS heterostructure under transverse magnetic fields

This paper studies dynamics of a modulation-doped GaAs/AlGaAs heterostructure under transverse magnetic fields and microwave radiations. It finds that negative differential conductivity, due to the real-space electron transfer and delayed dielectric relaxation of the interface potential barrier, can lead to complex behaviours when a relatively small magnetic field is applied. Quasiperiodicity, frequency-locking and the routes from period-doubling to chaos are found. Under a large magnetic field, however, two time-independent homogeneous steady states exist; and the longitudinal resistance of the system shows an interesting oscillation with period tuned by the ratio of microwave radiation frequency w to the cyclotron frequency Wc and local minima at ω/ωc = integer ＋ 1/4.     

基于微泡共振的快速微流体声学混合方法研究

微流体在生物医学、化学工程等领域应用广泛,并具有重大意义.在预处理中,液体混合也是关键且最为必要的前序.为了提高微流控腔道内液体混合的效率,本文提出基于单微泡振动的声学混合器,通过微泡共振,产生声微流,声微流形成的剪切力将在流体中产生微扰动,实现液体的混合.设计了底面直径为40μm的微孔结构,由于液体表面张力作用形成微泡,在共振频率为165 kHz的压电换能器激励下,气泡发生共振产生声微流.通过对压电换能器输入不同能量,获取混合液体的最优参数,可在37.5 ms内实现混合效果,混合均匀度达到92.7%.本文设计的单微泡振动混合器结构简单、混合效率高、混合时间短、输入能量低,可为生物化学等方面的研究提供强有力的技术支撑.     

超声造影剂微泡非线性动力学响应的机理及相关应用

随着生命科学及现代医学的发展, 一体化无创精准诊疗已经日益成为人们关注的焦点问题, 而关于超声造影剂微泡的非线性效应的相关机理、动力学建模及其在超声医学领域中的应用研究也得到了极大的推动. 本文对下列课题进行了总结和讨论, 包括: 1)基于Mie散射技术和流式细胞仪对造影剂微泡参数进行定征的一体化解决方案; 2)通过对微泡包膜的黏弹特性进行非线性修正, 构建新的包膜微泡动力学模型; 3)探索造影剂惯性空化阈值与其包膜参数之间的相关性; 以及4)研究超声联合造影剂微泡促进基因/药物转染效率并有效降低其生物毒性的相关机理.     

脉冲强磁场技术发展现状与趋势

脉冲强磁场是现代科学研究的重要工具,因其可以较容易地实现50 T以上磁场,因而在最近20年快速发展。最高磁场强度已经由70 T左右发展到目前的100 T,磁场波形也由以前单一的短脉冲发展到现在的长脉冲、平顶脉冲、长短合成脉冲等多种波形。随着电源与控制技术的发展,脉冲强磁场技术也在一定时间内实现了高稳定度磁场,拓宽了脉冲强磁场的实用范围;同时,脉冲磁体技术发展催生出能快速冷却的、具有高重频和异形结构的脉冲磁体,以满足X射线实验、中子实验和太赫兹实验要求。文章详细介绍了脉冲强磁场技术的发展现状与发展趋势,还介绍了武汉国家脉冲强磁场科学中心的磁场技术。     

强磁场下的科学研究

文章介绍了强磁场在半导体物理、低维物理、高温超导体、重费米子、磁学、原子分子物理、化学、有机化合物、材料科学、微重力、核磁共振等领域中的重要作用.     

脉冲磁场下金属熔体凝固流场的数值模拟

用ANSYS55有限元数值模拟软件对铝合金熔体凝固过程中的流场作了数值模拟，模拟结果和实验现象相符合.通过数值模拟发现，用数值模拟的方法不仅可以初步了解凝固过程中熔体的流动状态，而且可以了解凝固组织细化和产生缺陷的原因.因此，是一个值得注意的研究方向，有较大的实用价值.     

Nonlinear oscillation and acoustic scattering of bubbles

The scattered acoustic pressure and scattered cross section of bubbles is studied using the scattered theory of bubbles. The nonlinear oscillations of bubbles and the scattering acoustic fields of a spherical bubble cluster are numerically simulated based on the bubble dynamic and fluid dynamic. The influences of the interaction between bubbles on scattering acoustic field of bubbles are researched. The results of numerical simulation show that the oscillation phases of bubbles are delayed to a certain extent at different positions in the bubble cluster, but the radii of bubbles during oscillation do not differ too much at different positions. Furthermore, directivity of the acoustic scattering of bubbles is obvious. The scattered acoustic pressures of bubbles are different at the different positions inside and outside of the bubble cluster. The scattering acoustic fields of a spherical bubble cluster depend on the driving pressure amplitude, driving frequency, the equilibrium radii of bubbles, bubble number and the radius of the spherical bubble cluster. These theoretical predictions provide a further understanding of physics behind ultrasonic technique and should be useful for guiding ultrasonic application.     

SNO results and neutrino magnetic moment solution to the solar neutrino problem

We have analysed the solar neutrino data obtained from chlorine, gallium and Super-Kamiokande (SK) experiments (1258 days) and also the new results that came from Sudbury Neutrino Observatory (SNO) charge current (CC) and elastic scattering (ES) experiments considering that the solar neutrino deficit is due to the interaction of neutrino transition magnetic moment with the solar magnetic field. We have also analysed the moments of the spectrum of scattered electrons at SK. Another new feature in the analysis is that for the global analysis, we have replaced the spectrum by its centroid.     

螺旋线行波管返波自激振荡的研究

在2维小信号模型的基础上,分析了均匀和周期永久聚焦磁场对抑制返波自激振荡的影响。研究结果表明：改变聚焦磁场的幅值或周期来增加起振长度是可能的, 而且不会改变基波的互作用条件。与此同时,对起振长度、初始非同步速度参量随皮尔斯增益参量、空间电荷参量、损耗参量等的变化,以及在超宽带行波管中当存在两个或多个角向非对称空间谐波时,起振长度、初始非同步速度参量随周期永久聚焦磁场的变化进行了研究。优化设计聚焦磁场、电子注和螺旋线慢波系统的参量可以对螺旋线行波管的稳定性分析提供必要的依据。     

螺旋线行波管返波自激振荡的研究

 在2维小信号模型的基础上，分析了均匀和周期永久聚焦磁场对抑制返波自激振荡的影响。研究结果表明：改变聚焦磁场的幅值或周期来增加起振长度是可能的， 而且不会改变基波的互作用条件。与此同时，对起振长度、初始非同步速度参量随皮尔斯增益参量、空间电荷参量、损耗参量等的变化，以及在超宽带行波管中当存在两个或多个角向非对称空间谐波时,起振长度、初始非同步速度参量随周期永久聚焦磁场的变化进行了研究。优化设计聚焦磁场、电子注和螺旋线慢波系统的参量可以对螺旋线行波管的稳定性分析提供必要的依据。     

超声造影剂微气泡的包膜黏弹特性的定量表征研究

包膜黏弹特性显著影响微气泡超声造影剂的诊断及治疗应用效果. 本文结合原子力显微镜技术及声衰减特性测量提出了一种对微气泡造影剂包膜黏弹特性定量表征的新方法. 首先采用原子力显微镜技术进行机械特性分析得到包膜微气泡的有效硬度及体弹性模量; 然后测量声衰减特性, 基于微气泡动力学理论, 计算包膜微气泡的体黏度系数. 为验证方法的有效性, 实验制备了直径为1-5 μm的白蛋白包膜微气泡造影剂, 原子力显微镜测量的有效硬度和体弹性模量分别为0.149±0.012 N/m和8.31±0.667 MPa, 并与粒径无关. 声衰减特性测量和动力学理论拟合的包膜微气泡的体黏度系数为0.374±0.003 Pa·s. 该方法可推广至其他种类包膜微气泡的黏弹特性表征, 对超声造影剂的制备及其诊断和治疗应用有积极意义.     

强磁场环境下铁素体钢矩形流体通道内磁场分布研究

用Ansys静磁模块数值模拟了在外加强磁场环境下铁素体矩形通道管中心磁感应强度分布.与文献结果、解析解及实验数据的对比表明,模拟结果与它们基本一致.进一步的数值模拟还表明,铁素体矩形管对其内部的整体磁场分布影响较大,不同区域内产生不同程度的磁力线扭曲及非均匀的磁感应强度分布效应.该分布可能对管道内磁流体动力学效应产生较...     

Evidence of anisotropic Landau level splitting in topological semimetal ZrSiS under high magnetic fields

Magneto-transport study has been performed in topological semimetal ZrSiS single crystals under high pulsed magnetic fields. Obvious dependence of Landau level splitting on temperature and angular was investigated. The strong three-dimensional anisotropic nature of Landau level splitting under high pulsed magnetic fields was revealed by the angular dependent measurements, in which the orbital contribution is more dominant than Zeeman splitting. Our studies provide more insights into the physical properties of topological semimetals ZrSiS and shed light on future spintronic applications of ZrSiS.     

Photoluminescence of n-doped double quantum well—electron subbands under influence of in-plane magnetic fields

We report on photoluminescence (PL) measurements of a GaAs/AlGaAs double quantum well (DQW) in high magnetic fields. Measurements were carried out on a selectively contacted symmetric p-δn-DQW-δn-p structure, which allows a variation of the electron density in DQW by a p–n bias and simultaneously a tilting of DQW, when a p–p bias is applied. Attention was paid to phenomena in in-plane magnetic fields, theoretically studied by Huang and Lyo (HL), [Phys. Rev. B 59, (1999) 7600]. In this paper, we compare our results for both symmetric and asymmetric DQWs with the theoretical model made by HL. Whereas the spectra from a symmetric DQW fully confirmed the theoretical predictions, the results gained from DQW with an electric-field-induced asymmetry did not allow a proper study of anticipated effects. The reasons for that are discussed.     

电子成像均匀约束磁场的产生及测试分析

为增加离子与原子碰撞成像系统中探测电子的立体角，设计了一约束电子的复合型亥姆霍兹线圈装置.对复合型亥姆霍兹线圈的磁场分布进行了理论计算和分析，并对制作的复合型亥姆赫兹线圈产生的磁场进行了实验测量，得出磁场的均匀性好于±0.6%. 关键词： 亥姆霍兹线圈 磁场分布 磁场均匀性     

Eigen spectra and wave functions of the massless Dirac fermions under the nonuniform magnetic fields in graphene

In this research, firstly, by using the new form of Dirac-Weyl equation and the series method with submitting more suitable details, the energy spectrum and wave functions of the massless Dirac fermions are calculated under the inhomogeneous and q-deformed spatially magnetic fields. Although, we discussed about the results of the energy levels, further, we obtained the wave function as the Hessenberg determinant with calculating the elements of it as exact. On the other hand, by using the Mellin-Barnes integral representation and Hurwitz zeta function, we have achieved the thermodynamic physical quantities of the Dirac-Weyl fermions in the absence of a magnetic field for inside of the graphene quantum dot. Finally, our numerical results for the wave functions and probability densities are presented too.     

Nonlinear Rayleigh–Taylor instability of two superposed magnetic fluids under parallel rotation and a normal magnetic field

The Rayleigh–Taylor instability (RTI) of a ferrofluid has been the subject of recent research, because of its implications on the stability of stellar and planetary interiors. This paper analyzes the effects of rotation and magnetic field on nonlinear RTI of two superposed ferrofluids. It is considered that the system is subjected to uniform parallel rotation and normal magnetic field. Surface tension acts at the interface. The method of multiple scales is utilized to obtain the solutions and dispersion relations are obtained for the nonlinear problem of RTI of magnetic fluids. Finally the stability of the problem is discussed.