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微型全化学分析系统 总被引:2,自引:0,他引:2
赵国城 《理化检验(化学分册)》2004,40(6):362-363
微型全化学分析系统,是微芯片的概念,来自计算机芯片的发展,至今不过几年时间,但进展神速,国外迄今已有近百家公司从事微芯片相关工艺、设备及检测手段和软件的发展。 相似文献
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微全分析系统专用微型电源的研制 总被引:1,自引:0,他引:1
芯片毛细管电泳(Chip-CE)是当前微全分析系统(μ-TAS)中最活跃的领域和发展前沿.Chip-CE包括微芯片、高压电源和检测器等3个主要部分. 相似文献
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微型全化学分析系统及技术进展 总被引:9,自引:0,他引:9
对微型全化学分析系统(μ-TAS)的发展现状及其应用领域进行了综述,对μ-TAS在毛细管电泳微型化、DNA及生化分析、组合化学研究等领域的应用研究作了重点介绍. 相似文献
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这次会议的正式名称为"第五届微型化学分析与生物分析国际会议",由美国加利福尼亚洲分离科学学会主办,于2001年10月21日~25日在Monterey会议中心召开. 相似文献
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微分析系统对苯二酚抑制化学发光的研究 总被引:1,自引:0,他引:1
在自行设计和制作的有机玻璃 (PMMA)微流控芯片上 ,以流动注射方式进样 ,利用对苯二酚对Luminol H2 O2 Co2 +体系化学发光 (CL)的强抑制作用 ,建立了间接测定对苯二酚含量的微型全化学分析系统 ( μ TAS)。对影响化学发光反应的各因素进行优化 ,对芯片结构的设计和反应过程进行探讨 ,设计并制作出适合该反应体系的芯片。在合成水样对苯二酚的测定中 ,化学发光强度的变化与对苯二酚的浓度在 1 .0× 1 0 - 7~ 2 .0× 1 0 - 8mol/L范围内成良好线性关系 ,检出限达 2 .0× 1 0 - 9mol/L。 相似文献
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Micro-separation toward systems biology 总被引:1,自引:0,他引:1
Current biology is experiencing transformation in logic or philosophy that forces us to reevaluate the concept of cell, tissue or entire organism as a collection of individual components. Systems biology that aims at understanding biological system at the systems level is an emerging research area, which involves interdisciplinary collaborations of life sciences, computational and mathematical sciences, systems engineering, and analytical technology, etc. For analytical chemistry, developing innovative methods to meet the requirement of systems biology represents new challenges as also opportunities and responsibility. In this review, systems biology-oriented micro-separation technologies are introduced for comprehensive profiling of genome, proteome and metabolome, characterization of biomolecules interaction and single cell analysis such as capillary electrophoresis, ultra-thin layer gel electrophoresis, micro-column liquid chromatography, and their multidimensional combinations, parallel integrations, microfabricated formats, and nano technology involvement. Future challenges and directions are also suggested. 相似文献
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We described a simple and quick miniaturized sequencing gel system for DNA analysis. Two major modifications were made to the previously reported miniaturized DNA sequencing gel system to achieve high-resolution hydroxyl radical cleavage analysis: including formamide in the miniaturized gel and providing uniform heating during electrophoresis. Our method enables one to reduce the cost for chemicals and to significantly reduce electrophoresis time. Furthermore, minimal gel handling simplifies the entire process. We show that the resolution of DNA fragments obtained by hydroxyl radical cleavage for the miniaturized gel is similar to that of a large conventional sequencing gel. 相似文献
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A novel miniaturized capillary electrophoresis (CE)-amperometric detection system has been fabricated by integrating a self-positioning electrode system and a 10-cm piece of fused silica capillary on a Plexiglas base plate. The self-positioning electrode system was composed of a disc working electrode positioned opposite the outlet of the capillary, with an Ag/AgCl reference electrode, a platinum auxiliary electrode, and a platinum grounding electrode accommodated in a rectangular detection cell on the plate. The platinum wire, close to the inlet of capillary, served as a contact to the high-voltage power supply. Alternate placement of the capillary inlet in vials containing sample or buffer solutions permits volume-defined electrokinetic sample introduction in a horizontal arrangement. Performance of this unique system was demonstrated by separating sugars, amino acids, and two phenols used in the pharmaceutical industry. The factors influencing the analytical performance of the new microsystem for the separation of p-aminophenol and acetaminophen have been characterized and optimized. The two analytes could be separated on baseline within 160s in 50mM acetate buffer (pH 5.0). Responses for p-aminophenol and acetaminophen were linear over the range of 10 to 1000µM with detection limits (S/N=3) of 2.1 and 2.9µM. 相似文献
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M. H. Hashmi Maqbool Ahmad Shahid N. A. Chughtai Mushtaq Ahmad Rana 《Mikrochimica acta》1968,56(6):1143-1153
Summary An all glass nichrome wire ring chamber for the separation and identification of 46 metal ions from a single drop of test solution is described. Before analysis, the cations are separated into 6 groups by liquid-liquid extraction. The total analysis takes about 1 hour and the method holds an excellent promise for the identification of airborne particulates and trace elements from blood, bone, tissues, food materials, etc.
Zusammenfassung Die Trennung und Identifizierung von 46 Metallionen in einem Tropfen Probelösung mit Hilfe eines aus Glas und Nichromdraht gefertigten Gerätes wurde beschrieben. Vor der Analyse werden die Kationen durch flüssig-flüssig-Extraktion in sechs Gruppen aufgeteilt. Die Analyse selbst dauert etwal Stunde und ist besonders geeignet für Luftverunreinigungen und Spurenelemente in Blut, Knochen, Gewebe, Lebensmitteln u. dgl.相似文献