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The new title compound (2E,6E)-2,6-bis(2,3-dimethoxybenzylidene)cyclohexanone (C 24 H 26 O 5,M r=394.45) has been synthesized,and its crystal structure was studied.The title compound crystallizes in the orthorhombic system,space group Pca2 1 with a=17.536(2),b=14.8515(16),c=8.0512(9),V=2096.8(4) 3,Z=4,D c=1.250 g/cm 3,λ=0.71073,μ=0.087 mm-1 and F(000)=840.The structure was solved by direct methods and refined to R=0.0533 and wR=0.1248 from 2727 observed reflections (I > 2σ(Ⅰ)).The title molecules are connected through hydrogen bonds to generate a 3-D supramolecule.The preliminary biological tests showed definitely biological activity for the title compound. 相似文献
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Rogoza A. V. Furin G. G. Bagryanskaya I. Yu. Gatilov Yu. V. 《Russian Chemical Bulletin》2001,50(8):1446-1448
The reaction of benzimidazoline-2-thione with perfluoro-2-methylpent-2-ene in the presence of triethylamine afforded (2E)-2-(tetrafluoroethylidene)-3,3-bis(trifluoromethyl)-2,3-dihydrothiazolo[3,2-a]benzimidazole whose structure was confirmed by X-ray diffraction analysis. The reaction pathways are discussed. 相似文献
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A. V. Fokin A. N. Voronkov I. A. Timofeenko Yu. M. Kosyrev 《Russian Chemical Bulletin》1973,22(9):2098-2099
Conclusions A method was developed for the preparation of 5,5-bis(difluoroamino)-2-hexanone by the acid hydrolysis of the sodium salt of 2-nitro-5,5-bis(difluoroamino)hexane.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2145–2146, September, 1973. 相似文献
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The 1,3-bis(2-benzimidazyl)-2-thiapropane (TP2) and 1,5-bis(2-benzimidazyl)-3-thiapentane (TP3) ligands form 5-coordinate square pyramidal monometallic complexes with PdCl2. In both complexes the ligands act as chelating tridentate, through two of the nitrogen atoms in the imidazole ring and the sulphur atom of the bridging group. The ligands and complexes were characterised by analytical data and by modern spectroscopic methods such as FT-Raman, i.r., 1H and 13C-n.m.r. spectra. 相似文献
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Bromination of 3-phenylthio-2-sulfolene (2) with N-bromosuccinimide gave 2-bromo-3-phenylthio-2-sulfolene (3) which was converted mainly to 2,3-bis(phenylthio)-2-sulfolene (4) by treatment with sodium phenylthiolate. Thermal desulfonylation of 4 at different temperatures in the presence of a base (DBU) yielded stereoselectively the (Z)- and (E)-1,2-bis(phenylthio)-1,3-butadiene (6). These two geometric isomers could be thermally interconverted. The Diels-Alder reactions of 6 were also investigated. Only the (Z)-diene 6a could undergo the Diels-Alder reaction; the (E)-diene 6b was in situ converted to the Z isomer before undergoing (he Diels-Alder reaction. The reaction of 6a with N-phenylmaleimide gave the cycloaddition product 7 with complete endo selectivity, but under daylight or during chromatography it readily underwent a thioallylic rearrangement to yield 8 with inversion of configuration. The cycloaddition of 6a with methyl acrylate proceeded regiospecifically, but generating a mixture of endo and exo isomers. The endo/exo ratio could be increased by using ZnCl2 as the catalyst. 相似文献
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Lei Gao Qian Liu Sumei Ren Shengbiao Wan Tao Jiang Iris L. K. Wong 《Journal of carbohydrate chemistry》2013,32(8):620-633
A novel series of methoxy or benzyloxy substituted (E,E)-4,6-bis(styryl)-2-O-glucopyranosyl-pyrimidines as curcuminoid analogs were synthesized in four steps with total yields of 21.5% to 33.9%. A549 and HL60 cells were employed for the anticancer activity testing. The results demonstrated that 5a, 5c, and 5e have some inhibitory activity against the HL-60 cell line. Unfortunately, no compound displayed inhibitory activity against A549 except for 5c. MDR reversal activity results demonstrated that compounds 4a (RF = 12.3) and 4b (RF = 18.5) showed strong reversal activity to the P-gp-mediated LCC6MDR cells compared to verapamil (RF = 3.2) and no cytotoxicity to cancer or normal cell lines even at a high concentrations (100 μM). 相似文献
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Conclusions 1,2-Bis(B-amino-o-carboranyl)ethane and 1,4-bis(B-amino-o-carboranyl)benzene were synthesized.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1669–1670, July, 1976. 相似文献
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