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1.
V. S. Matiichuk M. A. Potopnyk N. D. Obushak 《Russian Journal of Organic Chemistry》2009,45(5):712-718
The reaction of ethyl 4-formyl-1-phenyl-1H-pyrazole-3-carboxylate with the malonic acid led to the formation (2E)-3-(3-ethoxycarbonyl-1-phenyl-1H-pyrazol-4-yl)propenic acid. In reactions of this acid chloride with 4-amino-5-aryl(hetaryl)-4H-1,2,4-triazole-3-thiols were obtained ethyl 4-[(E)-2-{3-aryl(hetaryl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl}ethenyl]-1-phenyl-1H-pyrazoe-3-carboxylates, with 5-aryltetrazoles, ethyl 4-[(E)-2-(5-aryl-1,3,4-oxadiazol-2-yl)-ethenyl]-1-phenyl-1H-pyrazole-3-carboxylates, with 1-(2-hydroxy-3,5-dimethylphenyl) followed by the Baker-Venkataraman rearrangement and the cyclization, ethyl 4-[(E)-2-(6,8-dimethyl-4-oxo-4Hchromen-2-yl)ethenyl]-1-phenyl-1H-pyrazole-3-carboxylate. 相似文献
2.
B. F. Kukharev V. K. Stankevich N. A. Lobanova G. R. Klimenko E. Kh. Sadykov 《Russian Journal of Organic Chemistry》2007,43(7):1027-1029
3-(4,5-Dihydro-1H-pyrazol-1-ylmethyl)oxazolidines and 3-(4,5-dihydro-1H-pyrazol-1-ylmethyl)perhydro-1,3-oxazines were synthesized in 54–85% yield by reactions of α-amino alcohols and 3-aminopropan-1-ol, respectively, with formaldehyde and 4,5-dihydro-1H-pyrazoles. 相似文献
3.
M. B. Bushuev A. V. Virovets E. V. Peresypkina D. Yu. Naumov A. S. Potapov A. I. Khlebnikov S. F. Vasilevsky L. G. Lavrenova 《Journal of Structural Chemistry》2005,46(6):1099-1103
A cobalt(II) iodide complex with bis(3,5-dimethyl-1H-pyrazol-1-yl)methane (L) CoLI2 has been synthesized, and its single crystals have been obtained. The complex compound was characterized by electron spectroscopy and X-ray diffraction analysis. The compound crystallizes in the monoclinic system (a = 8.4044(4) Å, b = 13.3120(5) Å, c = 14.5824(7) Å; β = 94.7290(10)°; V = 1625.92(13) Å3; Z = 4; ρcalc = 2.112 g/cm3; space group P21/m). The structure of the complex is molecular mononuclear. L is a cyclic bidentate ligand; the coordination polyhedron of cobalt is a CoN2I2 tetrahedron formed by the nitrogen atoms of the pyrazole fragments L and iodine atoms. The complex has π-π stacking interactions between the pyrazole rings of CoLI2 molecules, binding the molecules into infinite chains along the b axis. 相似文献
4.
O. S. Attaryan A. O. Balayan G. B. Asratyan 《Russian Journal of General Chemistry》2008,78(7):1425-1426
Noncatalytic hydrolysis of methyl 3-[2-(3-methyl-1H-pyrazol-1-y)ethylamino]-and methyl 3-[2-(5-methyl-1H-pyrazol-1-yl)ethylamino]propanoates at 200°C was performed. According to X-ray diffraction data, the resulting acids exist exclusively as salts. 相似文献
5.
T. M. Ivanova A. V. Naumkin R. V. Linko A. V. Petrov M. I. Bazanov K. M. Dyumaev 《Russian Journal of Inorganic Chemistry》2007,52(10):1527-1529
The electronic structures of complexes of cobalt(II) halides with 2-(1H-pyrazol-1-yl)-4(3H)-pyrimidinone have been studied by X-ray photoelectron spectroscopy. The Co2p 3/2 lines of cobalt atoms, N1s lines of nitrogen atoms, and O1s lines of oxygen atoms in the X-ray photoelectron spectra have been analyzed. Based on these data for the free and coordinated ligands, the atoms of the ligand coordinated to the central metal atom are determined. The coordinated organic compound serves as an electron-donating ligand. The results obtained are consistent with IR and UV-Vis spectroscopic data. 相似文献
6.
T. S. Khlebnikova Yu. A. Piven’ A. V. Baranovskii F. A. Lakhvich 《Russian Journal of Organic Chemistry》2012,48(3):411-418
3-Polyfluoroalkyl-6,6-dimethyl-7-(1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-ones were synthesized with high regioselectivity by 1,3-dipolar cycloaddition of terminal alkynes (phenylacetylene, hex-
1-yne, hept-1-yne, and but-3-yn-1-ol) to 7-azido-6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones which were prepared by bromination of 6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol- 4(5H)-ones with N-bromosuccinimide in anhydrous carbon tetrachloride, followed by treatment of the corresponding 7-bromo derivatives with sodium
azide. 相似文献
7.
I. V. Taidakov B. E. Zaitsev A. N. Lobanov A. G. Vitukhnovskii Z. A. Starikova 《Russian Journal of Coordination Chemistry》2012,38(4):300-304
The reaction of Tb(NO3)3 · 6H2O with 1,3-bis(1,3-dimethyl-1H-pyrazol-4-yl)-1,3-propanedi-one (HL) and 1,10-phenanthroline (Phen) in the presence of NaOH in a water-alcohol medium afforded the neutral complex [Tb(L)3(Phen)] (I). The unstable adduct [Tb(L)3(Phen)] · 0.4 MeCN (II), whose structure is studied by X-ray diffraction analysis, is obtained from an acetonitrile solution. The crystals of compound II at 100 K are triclinic, a = 11.2508(13), b = 11.4246(14), c = 22.486(3) Å, α = 96.522(2)°, β = 91.578(2)°, γ = 110.073(2)°, V = 2690.3(5) Å3, space group P \(\bar 1\), Z= 2, R = 0.0433. The complex is characterized by the green luminescence (λexc = 380 nm, λem = 550 nm). 相似文献
8.
9.
E. I. Mikhed’kina O. S. Bylina I. I. Mel’nik D. T. Kozhich 《Russian Journal of Organic Chemistry》2009,45(4):564-571
Ethyl 4-[(E)-1-chloro-3-oxoprop-1-en-1-yl]-3,5-dimethyl-1H-pyrrole-2-carboxylate reacted with substituted hydrazines in different solvents to give mixtures of regioisomeric 3- and 5-substituted pyrazoles. Conditions were found for selective formation of 1-aryl(alkyl)-5-(5-ethoxycarbonyl-2,4-dimethyl-1H-pyrrol-3-yl)-1H-pyrazoles. 相似文献
10.
D. Ashok M. Ziauddin B. Vijaya Lakshmi M. Sarasija 《Russian Journal of General Chemistry》2016,86(7):1753-1757
Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains. 相似文献
11.
E. A. Nudnova A. S. Potapov A. I. Khlebnikov V. D. Ogorodnikov 《Russian Journal of Organic Chemistry》2007,43(11):1698-1702
New approaches have been proposed for the synthesis of compounds containing two bis(1H-pyrazol-1-yl)methane fragments. Nucleophilic replacement of the halogen atoms in appropriate tetrabromo derivatives by pyrazoles in the superbasic system KOH-DMSO gave ditopic chelating ligands: 1,1,2,2-tetrakis(1H-pyrazol-1-yl)ethane, 1,4-bis[bis(1H-pyrazol-1-yl)methyl]benzene, and 1,4-bis[bis(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzene. 1,4-Bis[bis(1H-pyrazol-1-yl)methyl]benzene was also synthesized by reaction of 1H-pyrazole with terephthalaldehyde in the presence of thionyl chloride. 1,1,2,2-Tetrakis(1H-pyrazol-1-yl)ethane was converted into the corresponding tetraiodo and tetranitro derivatives. 相似文献
12.
A series of new (E)-1-{2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones (3a–3i) has been synthesized via copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction (CuAAC) of benzyl azide with substituted (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-[2-(prop-2-ynyloxy)phenyl]prop-2-en-1-ones (2a–2i). The synthesized compounds have been characterized by their IR, lH, 13C NMR spectra, and mass spectroscopy data. All the compounds have been screened for antimicrobial activity. 相似文献
13.
N-Allyl-5-amino-1H-pyrazole-4-carboxamides in reactions with polyphosphoric acid, with N-halosuccinimides in chloroform, and with (chlorosulfanyl)benzenes in nitromethane in the presence of lithium perchlorate underwent cyclization involving the N-allylamide fragment to give 4-[5-methyl(halomethyl)-4,5-dihydrooxazol-2-yl]-1H-pyrazol-5-amines and 2-(5-amino-1H-pyrazol-4-yl)-5-[(arylsulfanyl)methyl]-4,5-dihydro-1,3-oxazolium perchlorates, respectively. Analogous reactions of N-propargyl-5-amino-1H-pyrazole-4-carboxamides with polyphosphoric acid afforded 4-(5-methyloxazol-2-yl)-1H-pyrazol-5-amines, and with (chlorosulfanyl) benzenes, 2-(5-amino-1H-pyrazol-4-yl)-5-[(arylsulfanyl)methylidene]-4,5-dihydro-1,3-oxazolium perchlorates. 相似文献
14.
A. V. Ziminov V. K. Mal’tsev A. A. Sherstyuk Yu. A. Vikent’eva N. S. Seravin S. M. Ramsh 《Russian Journal of General Chemistry》2018,88(8):1648-1656
Tetracationic metal phthalocyanines were synthesized by the quaternization of the Cs-regioisomers of tetrasubstituted zinc and magnesium phthalocyanines containing 3,5-dimethylpyrazole fragments. The individuality of the synthesized compounds was confirmed by HPLC?mass spectrometry. The aggregation of the cationic metal phthalocyanines in water and aqueous-organic media, as well as in the presence of Triton X- 100 was studied. The dependence of the dimerization constant on the polarity of mixed solvents was determined. 相似文献
15.
I. B. Rozentsveig B. A. Shainyan E. V. Kondrashov E. V. Rudyakova G. N. Rozentsveig K. A. Chernyshev G. G. Levkovskaya 《Russian Journal of Organic Chemistry》2008,44(9):1332-1337
N-(2,2,2-Trichloroethylidene)arenesulfonamides react with 1H-pyrrole and 1-methyl-1H-pyrrole to give the corresponding N-[2,2,2-trichloro-1-(1H-pyrrol-2-yl)ethyl]arenesulfonamides. The reaction of N-(2,2,2-trichloroethylidene)trifluoromethanesulfonamide with pyrrole leads to a mixture of 2-mono-and 2,5-disubstituted pyrroles, whereas in the reaction with 1-methyl-1H-pyrrole only the 2-substituted compound is formed. N-(2,2-Dichloro-2-phenylethylidene)-4-methylbenzenesulfonamide reacts with 1H-pyrrole to form N-[2,2-dichloro-2-phenyl-1-(1H-pyrrol-2-yl)ethyl]-4-methylbenzenesulfonamide, and its reaction with 1-methyl-1H-pyrrole gives a mixture of 2-and 3-monosubstituted derivatives. The results of quantum-chemical calculations of the initial reactants and products indicate that the process is orbital-controlled. A good agreement is observed between the experimental data and theoretical conclusions concerning the dependence of the reaction regioselectivity on the nature of substituents in the electrophile molecule. 相似文献
16.
B. I. Buzykin E. V. Mironova A. T. Gubaidullin I. A. Litvinov V. N. Nabiullin 《Russian Journal of General Chemistry》2008,78(4):634-648
Compounds capable of tautomerism: sulfanyl-1,2,4-triazole, its C-phenyl derivative, and the crystal hydrate of the latter, were studied by single crystal X-ray diffraction. In the crystals they exist in the form of 3-R-1(H),4(H)-4,5-dihydro-1,2,4-triazole-5-thione with a considerable contribution of the bipolar structure. Published data on the tautomerism of sulfanyl-1,2,4-triazoles and their N-substituted analogs and on the correlation between the spectral characteristics and structures of sulfanyl-1,2,4-triazoles capable of tautomerism are discussed. 相似文献
17.
The structure of 9-(5,5-dimethyl-2,4,5,6-tetrahydro-1H-phenalen-2-yl)-5,5,9-trimethyl-5,6,8,9-tetrahydrocyclopenta[а]phenalen-10(4H)-one was determined by X-ray crystallography. The intermolecular interaction energies were calculated by the atom-atomic approach for the crystal structure. The character of the crystal structure and the structural subclass were established. 相似文献
18.
A. R. Kaliev V. Yu. Serykh G. G. Levkovskaya V. I. Potkin S. K. Petkevich I. B. Rozentsveig 《Russian Journal of Organic Chemistry》2016,52(11):1670-1673
2-Amino-4-R-6H-1,3-thiazine-6-thiones and 2-amino-4-phenyl-6H-1,3-thiazin-6-one react with highly electrophilic N-arylsulfonylimines of chloral and phenyldichloroacetic aldehyde at the exocyclic amino group affording in good yields products of nucleophilic addition to the azomethine group of imines: N-[2-polychloro-1-(6-thioxo-4-R-6H-1,3-thiazin-2-ylamino)ethyl]- or -[2-polychloro-1-(6-oxo-4-phenyl-6H-1,3-thiazin-2-ylamino)ethyl]arenesulfonamides. 相似文献
19.
A. O. Kharaneko 《Russian Journal of Organic Chemistry》2017,53(5):738-745
A strategy was developed for the synthesis of 7,8,9-trimethyl-1-phenyl-3H-pyrrolo[2,1-d][1,2,5]-triazepin-4(5H)-one, reactions of its functionalization at the С4 atom and aza rings fusion at the С4?N3 bond were explored. The formation mechanism of the pyrrolo-1,2,5-triazepinone scaffold was suggested. 相似文献