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1.
Adil A. Gobouri Naif A. Alshanbari Mosselhi A. M. Mohamed 《Phosphorus, sulfur, and silicon and the related elements》2020,195(3):211-217
AbstractEthylcarboxylate and acetyl selenoloquinoline derivatives were prepared in a one pot synthesis via reaction of sodium hydrogen selenide and 2-chloro-3-cyano-4-methylquinoline followed by reactions with ethyl chloroacetate and chloro acetone respectively which used as precursors to synthesize many of tetra and pentacyclic systems. A new series of pyrimido [4′,5′:4,5]selenolo[2,3-b]quinoline, thiazino[2’,3’:4,5]selenolo[2,3-b]quinoline, oxazino[2',3':4,5]selenolo[3,2-b]quinoline, pyrido[2′,3′:4,5]selenolo[2,3-b]quinoline, pyrido[2′,3′:4,5]selenolo[2,3-b]quinoline-2-substituted selenyl and selenolo[2′,3′:5,6]pyrido[2″,3″:4,5]selenolo[2,3-b]quinoline derivatives were prepared. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectra confirmed the structures of the newly synthesized compounds. 相似文献
2.
Cemil Ibis Sibel Sahinler Ayla Elvira Babayeva 《Phosphorus, sulfur, and silicon and the related elements》2020,195(6):474-480
AbstractIn the present study, the reactions of 2,3-dichloro-1,4-naphthoquinone (DCNQ) with amino-1,2-propanediol and some thiols were investigated. Novel N-, N,S-, and S,O- substituted derivatives were obtained and the structures of all compounds were characterized by spectroscopic methods (FT-IR, 1H NMR, 13C NMR, Mass spectroscopy) and microanalysis. The absorption behaviors of novel compounds were also investigated with UV-Vis spectroscopy in different solvents, such as ethanol, tetrahydrofuran and chloroform. 相似文献
3.
Kishore Karumanchi Senthil Kumar Natarajan Sunil Gadde Ramadas Chavakula Raghu Babu Korupolu Kishore Babu Bonige 《合成通讯》2019,49(3):359-366
The present work describes the synthesis and characterization of four potential impurities of Vigabatrin (1) namely 2-(2-aminobut-3-enyl)malonic acid (2) (Vigabatrin USP impurity-E), 2-(2-oxo-5-vinylpyrrolidin-1-yl)acetic acid (3) (USP Tablets impurity), 4-aminohexanoic acid (4) and 2,2′-oxo-5,5′-bispyrrolidinyl ether (5). Compound 4 is a possible process related impurity of 1 where as compound 5 is a process related impurity of 5-ethoxy-2-pyrrolinone (16). All these impurities have a significant impact on the quality of the drug product. This work is extremely useful for generic pharmaceutical industry. 相似文献
4.
Mohamed Lahbib Mrad Souhir Belhajsalah Mohammed Said M. Abdelbaky Sergio García-Granda Khaled Essalah C. Ben Nasr 《Journal of Coordination Chemistry》2019,72(2):358-371
An investigation of the solid-state X-ray structure of the new organic–inorganic compound [C5H14N2]2PbCl6·3H2O shows a layered organization of the (PbCl6)4– anions, with (R2NH2)+ groups and water molecules developed in the [001] plane at x = (2n?+?1)/4. The crystal structure is stabilized by N???H···Cl, N???H···O, O???H···Cl, O???H···O, and C???H···Cl hydrogen bonds. The powder X-ray diffraction and X-ray photoelectron spectroscopic (XPS) analyses confirm the phase purity of the crystal sample. The intermolecular contacts are quantified using the Hirshfeld surfaces computational method. The major inter-contacts contributing to the Hirshfeld surfaces are H…Cl, H…H, and O…H. The vibrational modes were identified and assigned by IR and Raman spectroscopies. The optical properties were investigated by UV–visible and photoluminescence spectroscopic studies. The compound was characterized by thermal analysis to determine its thermal behavior with respect to the temperature. Finally, X-ray photoelectron spectroscopy analysis is reported for analyzing the surface chemistry of [C5H14N2]2PbCl6·3H2O. 相似文献
5.
A. Mobinikhaledi N. Foroughifar M. Fallah 《Phosphorus, sulfur, and silicon and the related elements》2013,188(4):717-721
Benzoxazoles are of special interest because of having various types of biological properties such as antihistaminic, antihelmintic antifungal and antibacterial activities. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 Benzamide derivatives, as the possible metabolites of benzoxazoles, show various types of biological activities. 11 , 12 Some N-(2-hydroxyphenyl)- benzamides, which showed significant activity compared to phenylacetamides and furamides,11 have been synthesized by treating 2-aminophenol with carboxylic acid chlorides under weak basic solution. 11 , 12 However, synthesis and especially biological activity of N-(3-hydroxy-2-pyridyl)benzamides were not studied well. Owing to the versatility of benzamides we have extended the reaction of 2-amino-3-pyridinol with different carboxylic acid chlorides in order to preparation of some new benzamide derivatives containing a hydroxypyridyl ring. 相似文献
6.
ω‐Isonitrosoacetophenone 1, phenylglyoxime 2, chlorophenylglyoxime 1, dopaminophenylglyoxime 3 and [(salen/saloph)Fe]2O 4 have been synthesized as described in the literature procedure. [Fe(III)(salen/saloph)dopaminophenylglyoxime)] (starting complexes) have been synthesized from dopaminophenylglyoxime and tetradentate schiff bases which contain dinuclear Fe(III) oxygen‐bridges N,N′‐bis(salicylidene)ethylenediamine (salenH2) and bis(salicylidene)‐o‐phenylenediamine (salophH2). The new heterotrinuclear complexes have been obtained from starting complexes and Co(II), Ni(II), Cu(II) salts. Then, heterotrinuclear vic‐dioxime complexes containing BF2 + capped have been synthesized. The complexes have been characterized as low‐spin distorted octahedral Fe(III) bridged by o‐hydroxyphenolic groups. The o‐hydroxyphenolic groups play a role as bridges for weak antiferromagnetic intramolecular exchange. The structure of dioxime and its complexes were identified by using elemental analysis, ICP‐AES, 1H‐NMR and IR spectral data. 相似文献
7.
K. Boukallaba A. Elachqar A. El Hallaoui A. Alami S. El Hajji B. Labriti 《Phosphorus, sulfur, and silicon and the related elements》2013,188(4):819-823
α-heterocyclic α-aminophosphonates were obtained in good yields by N-of several nitrogen heterocycles with α-azido-α-aminophosphonate 1. 1 相似文献
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9.
《Journal of Coordination Chemistry》2012,65(10):1572-1583
Cobalt(II) chloro complexes were studied in aprotic solvents, namely, dimethylsulfoxide (DMSO), dimethylformamide (DMF), and propylene carbonate (PC). The measurements were performed spectrophotometrically in UV–visible–IR region at 25°C and at constant ionic strength: I = 1 mol L?1 in DMSO and DMF, and 0.1 mol L?1 in PC. Different models were tested and the model 1, 2, 3, 4, i.e., that of four mononuclear successive complexes was retained. Stability constants of the identified complexes were determined and they increase inversely with the Gutmann's donor number of the solvents. Calculated electronic spectra are reported and the effect of solvents on the spectral properties are discussed. The symmetry of tetrachlorocobaltate is strictly Td. 相似文献
10.
Sándor Kunsági-Máté Kornélia Szabó Előd L. Szabó István Bitter Géza Nagy László Kollár 《Supramolecular chemistry》2013,25(3):245-250
The π–π interaction-based inclusion complexation of calix[6]arene hexasulfonate as host with neutral aromatic guest molecules was studied in aqueous media. To vary the distribution of electron density on the guest's aromatic rings, the phenol parent compound was substituted in the para- or ortho- positions with CH3 group. To study the interaction between calixarene and the guests, PL, DSC and quantum-chemical methods were used. The results indicate 1:1 stoichiometry of the formed host-guest complexes. Although the enthalpy change during complex formation of calixarene with p- or o-cresol are the same, the Gibbs free energy change is significantly higher in the case of calixarene—o-cresol complexes. This property is due to the unexpected entropy change during the complex formation. Using molecular dynamic calculations, a guest-induced redistribution of the electron density on the calixarene rings, followed by the restructuring of the solvent molecules was identified as a background of this unexpected entropy change at molecular level. 相似文献
11.
Hamid Saeidian Seyed Esmaeil Hosseini 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):587-592
AbstractIsopropyl methylphosphonoselenofluoridate (sarin-Se) was synthesized in order to determine its analytical data and to compare them as well as its reactivity parameters with those of sarin. After synthesis, sarin-Se was characterized using 1H, 13?C and 31P NMR spectroscopy and high resolution mass spectrometry (HRMS). 1H and 13?C NMR chemical shifts were also calculated using density functional theory (DFT) and compared with experimental data, showing a close agreement. Electrophilicity indices of sarin and sarin-Se were calculated at B3LYP/6-31++G (2d, 2p) level of theory. HOMO-LUMO analysis provides a basis to explain electrophilic nature of sarin-Se and sarin, which are almost similar. Based on calculated data, 31P NMR chemical shift and the reactivity of sarin-Se towards some enzymes such as acetylcholinesterase and albumin were explained. 相似文献
12.
Sulekh Chandra Monika Tyagi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):778-789
A series of metal complexes of Pd(II), Pt(II), Rh(III), Ir(III), and Ru(III) with thiosemicarbazone and semicarbazone of 2-acetyl thiophene have been synthesized. Their structures were determined on the basis of elemental analyses; molar conductance; magnetic susceptibility measurements; and IR, 1 H NMR, and electronic spectral studies. On the basis of molar conductance, the complexes may be formulated as [M(L)2]Cl2 and [M′(L)2Cl2]Cl [where M = Pd(II), Pt(II) and M′ = Rh(III), Ir(III), and Ru(III)] due to their 1:2 and 1:1 electrolytic nature. On the basis of IR, 1 H NMR, and electronic spectral studies, an octahedral geometry has been assigned for Rh(III), Ir(III), and Ru(III), while square planar geometry has been assigned for the Pd(II) and Pt(II) complexes. The synthesized ligands and their complexes have been screened for bactericidal activity against several bacterial species (i.e., B. macerans, A. aureus, E. coli), and it is shown that the metal complexes act as more active antimicrobial agents than the uncomplexed ligands from which they derive. 相似文献
13.
《合成通讯》2013,43(18):2903-2910
ABSTRACT A reinvestigation of the recently described method of synthesis of highly substituted 1,6-naphthyridines was carried out. It was found out that the reaction of chalcones with malononitrile catalysed by pyrrolidine afforded the mixture of four products both when thermal as well as microwave heating was used. The claimed[1] 1,6-naphthyridines formation were exceptions. 相似文献
14.
《Green Chemistry Letters and Reviews》2013,6(3):475-479
Abstract 2,10-Dichloro-12-trichloromethyl-6-substituted xanthato-12H-dibenzo[d,g] [1,3,2] dioxaphosphocin-6-sulfides (2a–l) with the eight-membered phosphorus and oxygen heterocyclic ring were synthesized by reacting equimolar quantities of alcohols, carbon disulfide, and 2,6,10-trichloromethyl-12H-dibenzo[d,g][1,3,2] dioxaphosphocin-6-sulfide 1 in the presence of dimethylaminopyridine (DMAP). The structures of the products were confirmed by IR, 1H, 13C, 31P-NMR, and mass spectral analyses. 相似文献
15.
Yann Vaugeois Ahmed Mazzah Roger Jaeger Jean Habimana 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1819-1840
Condensation reactions of 1,1,3,3,3 pentamethyldisiloxane-ol (MDH), in toluene catalysed by two[9.5pc] types of phosphonitrilic catalyst bearing a phosphazene ─N═PCl3, were studied using sampling and gas chromatographic analysis method. The condensation kinetics reactions were compared for both phosphazene compounds. The process is selective, leading to linear decamethyltetrasiloxane MD2M, (where D denotes the dimethylsiloxane unit and M denotes the trimethyloxysilane unit) as almost the exclusive primary product. The mechanisms of the MDH condensation are discussed using the 31 P NMR sampling technique. 相似文献
16.
《Journal of Coordination Chemistry》2012,65(5):825-832
A dicopper complex of p-tert-butylcalix8arene bearing eight salicylaldehyde acylhydrazone domains was prepared and its single crystal structure determined, in which only four acylhydrazone domains act as monoanionic tridentate planar chelators to coordinate to two copper ions. 相似文献
17.
《Journal of Coordination Chemistry》2012,65(10):1621-1636
AbstractThe synthesis and spectral characterizations of [CdLCl2] (1) and [CdL(NO3)2(H2O)] (2) pincer complexes of the s-triazine core ligand (L), 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine), are presented. Complexes 1 and 2 have five- and eight-coordinated Cd(II) ions, respectively, where L acts as a neutral tridentate N-chelate. The coordination sphere is completed by two coordinated Cl– anions in 1 and with one water molecule and two bidentate nitrate anions in 2. The neutral complex units of 1 and 2 are packed by the polar Cl…H and O…H hydrogen bonds, respectively. Using Hirshfeld analysis, the percentages of these contacts are 24.5% and ~36.8%, respectively. Both complexes showed some anion-π stacking interactions. Thermogravimetric analysis showed that 1 is thermally more stable than 2. The orbital-orbital interactions included in the Cd-Cl, Cd-O, and Cd-N coordinate bonds were analyzed using DFT calculations. The calculated NMR results correlated very well with the experimental data. 相似文献
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19.
Anna Kovářová Vladimíra Novotná Milada Glogarová Miroslaw Salamonczyk Damian Pociecha 《Liquid crystals》2013,40(12):1501-1513
New liquid crystalline (LC) compounds containing the [2]benzothiophene chromophore unit have been synthesised and their mesomorphic properties studied. Mesomorphic and fluorescent properties have been modified by various chemical moieties. Among others, terminal fluoroalkyl and/or chiral chains were introduced to stabilise mesophases and support the formation of polar phases. In spite of the bent shape due to the central 1,3-diphenylbenzo[c]thiophene unit, all compounds exhibit phases typical for the rod-like LC: nematic, smectic A and smectic C or their chiral analogues using the chiral (S)-C2H5CH(CH3)(CH2)6CO or (S)-C10H21OCH(CH3)CO chain. The orientational order in the nematic phase was studied by polarised infrared measurements. The fluorescent properties of the studied compounds have been measured and their parameters established. 相似文献
20.
Maher A. El-Hashash Eman A. El-Bordany Magda I. Marzouk Tarek M. S. Nawar 《合成通讯》2016,46(24):2009-2021
As a part of ongoing studies in the synthesis of a variety of heterocycles of biological importance, we report here an efficient and convenient method for the synthesis of novel compounds from 6-iodo-2-isopropyl-4H-3,1-benzoxazin-4-one 1 as building block. The reaction of benzoxazinone 1 with various reagents such as diethylmalonate, sodium azide, and phosphorus pentasulfide yielded the compounds 2–5. The behavior of benzothiazin-4-thione 5 toward formamide and hydrazine hydrate was investigated, forming the compounds 6 and 7. The reaction of quinazolinone derivative 8 with β-D-glucose pentaacetate, ethyl 2-methyl-5-((1S,2R,3R)-1,2,3,4-tetrahydroxybutyl)furan-3-carboxylate, epichlorohydrin and benzenesulphonyl chloride afforded quinazolinone derivatives 9, 10, 12, and 13 respectively. The reaction of quinazolinone derivative 10 with acetic anhydride resulted in formation of the acylated compound 11. The behavior of quinazolinylacetohydrazide derivative 14 toward carbon electrophiles[16] has been investigated by its reaction with ethyl benzoylacetate, potassium thiocyanate, and phenyl isothiocyanate, affording the quinazolinone derivatives 15, 16, and 18, respectively. Treatment of compound 16 with sodium hydroxide followed by hydrochloric acid yielded the mercapto-triazole derivative 17. The structures of the newly synthesized compounds were confirmed by elemental analysis, infrared (IR), 1H NMR, 13C NMR, and mass spectra. The antimicrobial activities of some of the synthesized compounds were preliminarily evaluated. 相似文献