共查询到20条相似文献,搜索用时 15 毫秒
1.
A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH50 values of 0.043 mg/mL, but saponins (2–10) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (2–10) resulted in its aglycones (2a–10a) correspondingly which showed anticomplement activity with the CH50 values of 0.049–0.156 mg/mL. 相似文献
2.
During investigation of cell suspension cultures of Brucea javanica (L.) Merr., the canthin-6-one alkaloid 5,11-dimethoxycanthin-6-one (1) was isolated. The structural determination is based on spectral analysis. Five other alkaloids, canthin-6-one-3-N-oxide (2), 11-hydroxycanthin-6-one (3), canthin-6-one (4), 5-methoxycanthin-6-one (5), and 11-methoxycanthin-6-one (6), were also identified. 相似文献
3.
Ming Zhao Sin Ting Lau Xiao Qi Zhang Wen Cai Ye Po Sing Leung Chun‐Tao Che Zhi‐Xiu Lin 《Helvetica chimica acta》2011,94(11):2099-2105
Bruceine K ( 1 ), a pentacyclic C20‐quassinoid bearing a unique 12,20‐epoxy moiety, and bruceine L ( 2 ), along with the ten known compounds (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosins A–C, luteoline, quercetine, bruceantinol, pinoresinol, and thevetiaflavone, were isolated from the ripe fruits of Brucea javanica. Bruceines K ( 1 ) and L ( 2 ) were determined to be (1β,2α,11β,12β,14ξ,15β)‐12,20‐epoxy‐1,2,11,13,14,15‐hexahydroxypicras‐3‐en‐16‐one and (1β,2α,11β,12β,15β)‐13,20‐epoxy‐1,2,11,12‐tetrahydroxy‐16‐oxo‐15‐(senecioyloxy)picras‐3‐en‐21‐oic acid methyl ester (senecioic acid=3‐methylbut‐2‐enoic acid), respectively, on the basis of NMR (1H‐ and 13C‐NMR, DEPT, 1H,1H‐COSY, NOESY, HMQC, and HMBC) and ESI‐MS data. Among the known compounds, (6S,7E)‐6,9,10‐trihydroxy‐ and (6S,7E)‐6,9‐dihydroxymegastigma‐4,7‐dien‐3‐one ( 3 and 4 , resp.), cleomiscosin C, luteoline, quercetine, and thevetiaflavone were isolated for the first time from the Brucea plants. 相似文献
4.
《Journal of carbohydrate chemistry》2012,31(9):552-565
AbstractJuniperus tibetica Kom., a common forest species in Tibet, has been traditionally used in Tibetan medicine to treat rheumatic arthritis. In order to investigate the effective substances of J. tibetuca, anticomplent assay-guided fractionation using gradient anion-exchange chromatography and gel permeation chromatography was applied to the crude polysaccharides of the twigs and leaves of J. tibetica and led to the isolation of a homogenous polysaccharide, YB-PS. It exhibited a robust anticomplement activity (CH50: 461?±?10?μg/mL) through the classical pathway of complement system activation by targeting complement components C1q, C3, C4 and C5. The structure of YB-PS was studied by monosaccharide composition and methylation analyses, 1?D, 2?D NMR data and scanning electron microscope. The results indicated that YB-PS was composed of Ara, Gal, and Glc with a molar ratio of 5.8:3.0:1.2. Its backbone was comprised of 1,3-linked α-Araf, 1,3,5-linked α-Araf, 1,2,4-linked α-Galp, and 1,3-linked α-Glcp with terminal α-Araf, β-Galp and 1,4-linked β-Galp as branches. YB-PS was found to have a sheet structure with smooth surface. This study provided scientific foundation for YB-PS as a potential complement inhibitor to treat diseases involved with excessive activation of the complement system. 相似文献
5.
Bo Kyeong Yoon Zheng Yi Lim Won-Yong Jeon Nam-Joon Cho Jeong Hoon Kim Joshua A. Jackman 《Molecules (Basel, Switzerland)》2020,25(22)
Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes. 相似文献
6.
Wei-Qun Yang Wei Tang Xiao-Jun Huang Jian-Guo Song Yue-Yue Li Yu Xiong Chun-Lin Fan Zhen-Long Wu Ying Wang Wen-Cai Ye 《Molecules (Basel, Switzerland)》2021,26(19)
A phytochemical investigation on the roots of medicinal plant Eurycoma longifolia resulted in the isolation of 10 new highly oxygenated C20 quassinoids longifolactones G‒P (1–10), along with four known ones (11–14). Their chemical structures and absolute configurations were unambiguously elucidated on the basis of comprehensive spectroscopic analysis and X-ray crystallographic data. Notably, compound 1 is a rare pentacyclic C20 quassinoid featuring a densely functionalized 2,5-dioxatricyclo[5.2.2.04,8]undecane core. Compound 4 represents the first example of quassinoids containing a 14,15-epoxy functionality, and 7 features an unusual α-oriented hydroxyl group at C-14. All isolated compounds were evaluated for their anti-proliferation activities on human leukemia cells. Among the isolates, compounds 5, 12, 13, and 14 potently inhibited the in vitro proliferation of K562 and HL-60 cells with IC50 values ranging from 2.90 to 8.20 μM. 相似文献
7.
Hui-Feng Huang Cai-Juan Zheng Guang-Ying Chen Wen-Qing Yin Xian Huang Zheng-Rong Mo 《中国化学快报》2016,27(10):1612-1616
Four new sesquiterpenoids,4,8-dioxo-6β-hydroxyl-7β,1 1-epoxycarabrane(1),4,8-dioxo-6β-hydroxyl-7,1 1-epoxycarabrane(2),wenyujinins Q and R(3-4),and nine known sesquiterpenoids(5-13) were isolated from the Curcuma wenyujin(C wenyujin) dreg.Their structures and relative configurations were elucidated using 1D,2D NMR,and HR-ESI-MS data.All the compounds were isolated for the first time from the C.wenyujin dreg and evaluated for their antibacterial and antifungal activities.Compounds 3,5-8 exhibited strong broad-spectrum antifungal activities against tested nine pathogenic fungi. 相似文献
8.
Dr. Xin Fang Ying Tong Di Yu Zhang Dr. Zhi Ping Xu Prof. Yang Lu Qian Qian Chen Prof. Qi Tai Zheng Prof. Dr. Xiao Jiang Hao 《Angewandte Chemie (International ed. in English)》2015,54(19):5592-5595
Perforalactone A ( 1 ), a new 20S quassinoid with a unique cagelike 2,4‐dioxaadamantane ring system and a migrated side chain, was isolated from the plant Harrisonia perforata together with two biosynthetically related new quassinoids. The structures of these natural products were elucidated by NMR spectroscopy, X‐ray diffraction analysis, computational modeling, and the CD excitation chirality method. The compounds exhibited notable biological properties, including insecticidal activity against Aphis medicaginis Koch and antagonist activity at the nicotinic acetylcholine receptor of Drosophila melanogaster. The structural features of these compounds may be related to their promising biological characteristics. Their biosynthesis and an alternative origin of quassinoid‐type natural products are also discussed. 相似文献
9.
Shanzhai Shang Jianlian Shi Jianguo Tang Juxing Jiang Wei Zhao Xudong Zheng 《Natural product research》2019,33(11):1577-1583
Three new isolates (1?3) including one new sterol and two new flavonoids together with three known sterols (4?6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. All compounds were evaluated for their anti-tobacco mosaic virus and cytotoxic activities. The results showed that compounds 2 and 3 exhibited high anti-TMV activity with inhibition rate of 34.2 and 33.4%, respectively, which were roughly equivalent to that of positive control. The cytotoxicities of compounds 1 and 4–6 against five human tumour cell lines were also tested, and tested compounds showed weak inhibitory activities against some tested human tumour cell lines. 相似文献
10.
Xiang Yuan Jianshuang Jiang Yanan Yang Xu Zhang Ziming Feng Peicheng Zhang 《中国化学快报》2022,33(6):2923-2927
Sophoralines A–C, three novel [2 + 2] cycloaddition dimers of matrine-based alkaloids with an unprecedented 6/6/6/6/4/6/6/6/6 nonacyclic skeleton containing 11 stereogenic centers, were isolated from Sophora alopecuroides. Their structures were determined by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemical calculations of electronic circular dichroism(ECD) spectra for 2 and 3. Moreover, 1 exhibi... 相似文献
11.
12.
Three new triterpenoid saponins, named celosin E (1), celosin F (2) and celosin G (3), together with a known compound cristatain (4), were isolated from the seeds of Celosia argentea L. (Amaranthaceae). All the isolated compounds were obtained for the first time from this plant. The structures of new compounds were characterized on the basis of extensive NMR experiments and mass spectrometry data. The antitumor and anti-inflammatory activities of the four compounds were tested in vitro. 相似文献
13.
《Arabian Journal of Chemistry》2022,15(10):104155
Five new arylnaphthalide lignans (1 ? 4a/4b), together with five known analogues (5–9), were isolated from whole plants of Saussurea medusa. Compound 4 was characterized as an aryltetralin lignan with an unusual C-7′-C-9 oxygen bridge group, and a chiral HPLC analysis was carried out to afford one pair of enantiomers (4a/4b). Structures of the new compounds were elucidated by extensive spectroscopic and electronic circular dichroism (ECD) calculations. All compounds were firstly isolated from S. medusa, and compounds 1–5, 7 and 8 had never been obtained from the genus Saussurea previously. Furthermore, this is the first report of arylnaphthalide lignans isolated from S. medusa. anti-inflammatory activities of the compounds were evaluated by determining their inhibitory activities on the production of NO by LPS-stimulated RAW 264.7 cells. Compounds (?)-4a and 5 exerted the significant inhibition activities with IC50 values of 13.4 ± 1.5 and 15.7 ± 1.1 μM, respectively, which even exceeded the positive control quercetin (IC50 = 15.9 ± 1.2 μM). Compounds 2, (+)-4b, 6 and 9 exhibited moderate inhibitory activities with IC50 values ranging from 19.7 ± 1.9 to 47.4 ± 3.1 μM. Further analysis by molecular docking showed that almost all the active compounds could interact with the amino acid residues of iNOS proteins, which also supported their anti-inflammatory activities. 相似文献
14.
Jianhong Yang Wenyu Liu Shucai Li Haoyu Ye Huan Tang Lijuan Chen Aihua Peng 《Helvetica chimica acta》2014,97(2):278-282
A new coumarinolignan, cleomiscosin E ( 1 ), together with the known compound cleomiscosin A ( 2 ), has been isolated from the seeds of Brucea javanica (L.) Merr . Their structures were assigned on the basis of spectral studies. These two compounds exhibited potent anti‐inflammatory activities by inhibiting the nitric oxide (NO) production in lipopolysaccharide (LPS)‐activated RAW264.7 macrophages. 相似文献
15.
《Arabian Journal of Chemistry》2023,16(3):104528
Six previously undescribed sulfur-containing amides were isolated from the leaves of Glycosmis pentaphylla. Their structures were delineated by HRESIMS, 1D and 2D NMR, electronic circular dichroism (ECD) calculations, and DP4+ analyses based on gauge-independent atomic orbital (GIAO) NMR calculations. Compounds 1–4 belong to the type of methylsulfonylpropenoic acid amides. Through different cyclization pathways of geranyloxy, compounds 1 and 2 carry uncommon cyclohexane-1, 3-diol and cyclohex-3-en-1-ol moiety, respectively. Compound 3 is the oxidation product of the double bond Δ6′′(7′′) of geranyloxy. Compound 5 is elucidated as the type of methylsulfonylpropanoic acid amide. Compound 6 represents a rare sulfur-containing amide possessing a morpholin-3-one moiety. All isolated compounds were evaluated for their anti-inflammatory and anti-proliferative activities. Compound 4 significantly inhibited lipopolysaccharide-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells with the IC50 value of 0.55 µM. Moreover, compounds 3 and 4 exhibited different anti-proliferative activities against HepG-2 with IC50 values ??of 11.52 and 9.41 µM, respectively. 相似文献
16.
Wenping Huang Zhiqi Wen Mengmeng Wang Bubin Xu Bin Zhou Xiaojing Li 《Biomedical chromatography : BMC》2020,34(2):e4736
Chimonanthus nitens Oliv. leaf (CNOL), as a traditional Chinese medicine, has been widely used for the treatment of influenza and colds over a long history. However, the mechanism of colds related to the effects of CNOL have been little studied. In this study, the anticomplement and antitussive activities of different polarity extracts of CNOL were evaluated. Ethyl acetate extract (EAE) among different extracts not only significantly decreased cough times by 21–58% (P < 0.01), but also had anticomplement effects demonstrated by the CH50 values of 0.100 mg/ml. A total of 28 constituents (10 coumarins, 13 flavonoids and five phenolics) were identified in EAE based on the ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry technique. Eight compounds in EAE were evaluated by an ammonia-induced cough model to reveal the antitussive mechanisms and classical anticomplement pathway. The results indicated that the antitussive effects of scopoletin, kaempferol-3-O-rutinoside and kaempferol may depend on central mechanisms and that flavonoids such as compounds of kaempferol-3-O-rutinoside and kaempferol have better anticomplementary activity than coumarins like compounds of scopolin, scopoletin and isofraxidin. Taken together, kaempferol-3-O-rutinoside and kaempferol could be important chemical markers in the present study that might be used to evaluate the quality and biological activity of CNOL. 相似文献
17.
A new flavone glycoside, eupatilin 7-O-β-d-glucopyranoside (1) and a new flavone, 5,6,2′,4′-tetrahydroxy-7,5′-dimethoxyflavone (2), were isolated from Artemisia argyi. Their structures were unambiguously elucidated by extensive spectroscopic analysis. Both flavonoids were evaluated for in vitro anticoagulation activities. Compound 1 significantly extended thrombin time. Compound 2 had obvious effect in increasing prothrombin time. 相似文献
18.
Yukun Jiao Yiting Yang Lishuang Zhou Daofeng Chen Yan Lu 《Molecules (Basel, Switzerland)》2022,27(14)
Two novel natural flavonoid substituted polysaccharides (MBAP-1 and MBAP-2) were obtained from Tamarix chinensis Lour. and characterized by HPGPC, methylation, ultra-high-performance liquid chromatography-ion trap tandem mass spectrometry (UPLC-IT-MSn), and NMR analysis. The results showed that MBAP-1 was a homogenous heteropolysaccharide with a backbone of 4)-β-d-Glcp-(1→ and →3,4,6)-β-d-Glcp-(1→. MBAP-2 was also a homogenous polysaccharide which possessed a backbone of →3)-α-d-Glcp-(1→, →4)-β-d-Glcp-(1→ and →3,4)-β-d-Glcp-2-OMe-(1→. Both the two polysaccharides were substituted by quercetin and exhibited anticomplement activities in vitro. However, MBAP-1 (CH50: 0.075 ± 0.004 mg/mL) was more potent than MBAP-2 (CH50: 0.249 ± 0.006 mg/mL) and its reduced product, MBAP-1R (CH50: 0.207 ± 0.008 mg/mL), indicating that multiple monosaccharides and uronic acids might contribute to the anticomplement activity of the flavonoid substituted polysaccharides of T. chinensis. Furthermore, the antioxidant activity of MBAP-1 was also more potent than that of MBAP-2. In conclusion, these two flavonoid substituted polysaccharides from T. chinensis were found to be potential oxidant and complement inhibitors. 相似文献
19.
AbstractA novel aromatic compound, grandiuvarone B (5-acetoxy-3-benzoyloxymethyl-5H-oxepin-4-one), along with a known compound grandiuvarone A (5-acetoxy-6-benzoyloxymethyl-5H-oxepin-4-one) were isolated from methanol extracts of Desmos chinensis leaves. Their structures were determined by various spectroscopic techniques including nuclear magnetic resonance (NMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). Grandiuvarone A and grandiuvarone B are isomers and the S configuration of grandiuvarone B was reported for the first time. We then determined their antifungal activity against Aspergillus flavus. Results revealed that grandiuvarone B exhibited better antifungal activity against A. flavus, with MIC values of 0.01?mg/mL compared to grandiuvarone A (MIC values of 0.02?mg/mL). In the presence of each active compound at 160?μg/g of aquafeed, A. flavus growth was completely inhibited. Grandiuvarone B also showed antibacterial activity against the plant pathogen Ralstonia solanacearum. 相似文献