Two new steroidal glycosides from the root of Cynanchum auriculatum

Two new steroidal glycosides named cyanoauriculoside A(1) and B(2),have been isolated from the roots of Cynanchumauriculatum Royle ex Wight.The structure of cyanoauriculoside A(1) was determined to be 20-O-acetyl-penupogenin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopy-ranosyl-(1→4)-β-D-cymaropyranoside.Cyanoauriculoside B(2) was characterized as 20-O-acetylpenupogenin-3-O-β-D-gluco-pyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.The structures of these compounds were elucidated based on the chemical and spectroscopic evidence.     

A novel phenylpropanoid glycosides and a new derivation of phenolic glycoside from Paris Polyphylla var. yunnanensis

A novel phenylpropanoid glycosides 1, named parispolyside F, and a novel derivation of phenolic glycoside 2, named parispolyside G, as well as two known flavonoid glycosides were isolated from the rhizome of Paris polyphylla var. yunnanensis. Their structures were elucidated by spectroscopic methods.     

Two New Octahydronaphthalene Derivatives from Trichoderma spirale,an Endophytic Fungus Derived from Aquilaria sinensis

Two new octahydronaphthalene derivatives, trichodermic acid A ( 1 ) and trichodermic acid B ( 2 ), along with a known analog, trichodermic acid ( 3 ), and a known modified dipeptide, trichodermamide A ( 4 ), were isolated from the extract of Trichoderma spirale, an endophytic fungus present in the medicinal plant Aquilaria sinensis. The structures of these compounds were established by extensive analysis of their spectroscopic data including 1D‐ and 2D‐NMR and MS data.     

Five new benzophenone glycosides from the leaves of Aquilaria sinensis(Lour.) Gilg

Phytochemical investigation on the ethanol extract from the leaves of Aquitaria sinensis led to the isolation of five new benzophenone glycosides,aquilarinensides A-E(1-5).Their structures were elucidated by a combination of 1D and 2D NMR,HRMS,and chemical analysis.     

小红参中蒽醌苷的分离和鉴定

云南普米族常用活血药茜草科小红参(Rubia yunnanensis)的根部水溶性部分曾用于治疗心绞痛。王淑仙等发现,它对小鼠能明     

A New Isofuranonaphthalenone and Benzopyrans from the Endophytic Fungus Nodulisporium sp. A4 from Aquilaria sinensis

A new isofuranonaphthalenone, (7R*,8S*)‐3,6,7,8‐tetrahydro‐4,7,8‐trihydroxynaphtho[2,3‐c]furan‐5(1H)‐one ( 1 ), and a new benzopyran, (2R*,4R*)‐3,4‐dihydro‐4‐methoxy‐2‐methyl‐2H‐1‐benzopyran‐5‐ol ( 2 ), together with four known related analogs, 3 – 6 , were isolated from the culture of Nodulisporium sp. A4, an endophytic fungus from the stem of Aquilaria sinensis (Lour.) Gilg . The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. The isolated compounds 1 – 6 were evaluated for their cytotoxic activities against the NCI‐H460 and SF‐268 tumor cell lines.     

Three new secoiridoid glycosides from the rhizomes and roots of Gentiana scabra and their anti-inflammatory activities

Three new (1–3) and 17 known (4–20) iridoid and secoiridoid glycosides were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their chemical structures were elucidated from 1D and 2D NMR, IR absorption, and HR-ESI-MS spectra, as well as comparisons of these data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 6, 10 and 20 exhibited significant inhibitory effects on LPS-induced IL-12 p40 and IL-6 production with IC₅₀ values of 1.62–14.29 μM. Compound 10 also showed a strong inhibitory effect on the LPS-stimulated production of TNF-α with an IC₅₀ value of 10.45 μM.     

Two new diarylheptanoids from the pericarps of Juglans regia L.

Two new cyclic diarylheptanoids juglanin A （1） and juglanin B （2） were isolated from the pericarps of Juglans regia L. Their structures were elucidated by various spectroscopic methods including 2D NMR techniques （COSY, HMQC, HMBC, NOESY） and HR-ESIMS.     

Scyphiphorins A and B,Two New Iridoid Glycosides from the Stem Bark of a Chinese Mangrove Scyphiphora hydrophyllacea

Two new iridoid glycosides, named scyphiphorins A ( 1 ) and B ( 2 ), together with four known compounds, geniposidic acid (=(1S,4aS,7aS)‐1‐(β‐D ‐glucopyranosyloxy)‐1,4a,5,7a‐tetrahydro‐7‐(hydroxymethyl)cyclopenta[c]pyran‐4‐carboxylic acid; 3 ), 4‐(4‐hydroxy‐3‐methoxybenzyl)butan‐2‐one, oleanolic acid (=(3β)‐3‐hydroxyolean‐12‐en‐28‐oic acid), and stigmasterol β‐D ‐glucoside (=(3β,22E)‐stigmasta‐5,22‐dien‐3‐yl β‐D ‐glucopyranoside), were isolated for the first time from the stem bark of a Chinese mangrove, Scyphiphora hydrophyllacea Gaertn . f. The structures of compounds 1 and 2 were determined as 10‐O‐benzoylgeniposidic acid and 10‐O‐[(2E,6R)‐8‐hydroxy‐2,6‐dimethyl‐1‐oxooct‐2‐en‐1‐yl]geniposidic acid, respectively, on the basis of spectroscopic data and chemical methods, including 2D NMR techniques.     

Two new polyacetylene glycosides from the roots of Codonopsis tangshen Oliv.

Two new polyacetylene glycosides, tangshenyne A (1) and tangshenyne B (2), along with six known polyacetylenes were isolated from an 85% MeOH extract of the roots of Codonopsis tangshen Oliv. The chemical structures of the new compounds were determined on the basis of extensive spectroscopic analyses, including UV, IR, 1D and 2D NMR (¹H–¹H COSY, HSQC and HMBC) and HR-ESI-MS.     

Panaxfuraynes A and B, two new tetrahydrofuranic polyacetylene glycosides from Panax ginseng C. A. Meyer

Panaxfurayne A (1), a tetrahydrofuranic polyacetylene glycoside, was isolated from the roots of Panax ginseng C. A. Meyer (Araliaceae) together with panaxfurayne B (2) as a geometric isomer of 1. The chemical structures of these two compounds were ascertained by UV, Mass, 1D, and 2D NMR experiments. During these experiments, these tetrahydrofuranic polyacetylene compounds proved to be of biogenetically novel type.     

Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii

The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1-3 are the second three examples of the sesqui-neolignans that contain a variety of non-aromatic rings, and their plausible biosynthetic routes from chavicol are proposed. Among the isolated sesqui-neolignans, isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 μM in the primary cultured rat cortical neurons.     

Two Novel Abietane Diterpenoids from Illicium wardii A.C.Sm.

Two novel abietane diterpenoids, wardinols A and B ( 1 and 2 , resp.), together with five known diterpenoids, 3 – 7 , were isolated from the fruits of Illicium wardii A.C.Sm . Their structures were elucidated on the basis of intensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectroscopy. Wardinol A ( 1 ) is a rare 9,10‐epoxy‐9,10‐secoabietane diterpenoid. All of the isolated compounds were evaluated for their cytotoxicities against three human tumor cell lines, A549, HCT116, and CCRF‐CEM.     

New C27 Steroidal Bisdesmosides from the Fresh Stems of Dracaena cambodiana

Two new steroidal bisdesmosides, cambodracanosides A and B ( 1 and 2 , resp.), were isolated from the fresh stems of Dracaena cambodiana, together with seven known glycosides. The structures of the new saponins were elucidated on the basis of detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and acidic hydrolysis.     

Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina

Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC₅₀ values of 37.58 ± 2.45 μM, 80.6 ± 5.82 μM and 125.65 ± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 ± 14.14% at a concentration of 31.85 μM.     

Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana

Two new diacetylene glycosides: bhutkesoside A (1) and B (2), along with 10 known compounds, i.e. falcarindiol (3), chlorogenic acid (4), 5-O-p-coumaroyl-quinic acid (5), 3,5-di-O-caffeoyl-quinic acid (6), 4-hydroxy-7-methoxy-phenylethanol (7), ferulic acid (8), dehydrodiconiferyl alcohol-4-O-β-d-glucopyranoside (9), 5,7-dihydroxy-2-methylchromone-7-O-rutinoside (10), schumanniofioside B (11) and marmesinin (12) were isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov (Apiaceae), commonly known as ‘Bhutkesh’ in Nepal. The structures were determined on the basis of spectroscopic data. Compounds 4 and 6 showed potent antioxidant activity on DPPH free radical scavenging assay.     

Two New Neolignans from the Stems of Syringa pinnatifolia Hemsl. var. alashanensis

Two new neolignans, syripinnalignins A and B ( 1 and 2 , resp.), were isolated from the 95% EtOH extract of the stem of Syringa pinnatifolia Hemsl . var. alashanensis. The structures of 1 and 2 were elucidated by spectroscopic methods, including UV, IR, HR‐ESI‐MS, and extensive 1D‐ and 2D‐NMR techniques.     

8-O-4’ Neolignan glycosides from the aerial parts of Matteuccia struthiopteris

Two new 8-O-4’ neolignan glycosides, named matteustruthiosides A(1) and B(2) were isolated from the aerial parts of Matteuccia struthiopteris. Their chemical structures were characterized on the basis of various spectroscopic techniques. The absolute configurations of them were determined by experimental circular dichroism(CD) spectra. Compounds 1 and 2 were inactive against influenza A(H1N1) virus in vitro.     

The absolute stereostructures of cyanogenic glycosides, hydracyanosides A, B, and C, from the leaves and stems of Hydrangea macrophylla

Three new cyanogenic glycosides named hydracyanosides A (1), B (2), and C (3) were isolated from the leaves and/or stems of Hydrangea macrophylla in China. The absolute stereostructures of hydracyanosides were characterized on the basis of chemical and physiochemical evidence including single crystal X-ray crystallographic analysis. To the best of our knowledge, this is the first scientific report of cyanogenic glycosides from Hydrangea plants.     

黄褐毛忍冬中主皂苷成分的结构解析

报道了黄褐毛忍冬中的两个皂苷主成分, 其中化合物1为新化合物, 并对另一个含量最高的皂苷结构进行了修正.