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1.
From the endophytic strain Streptomyces sp. CS of Maytenus hookeri, five novel type III polyketides, compounds 1 – 5 , were isolated. Their structures were elucidated by spectroscopic analyses including 1D‐ and 2D‐NMR experiments, and by HR‐ESI‐MS. 相似文献
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Xiang LI Yi Nan ZHENG Wen Han LIN Isabel SATTLER 《中国化学快报》2006,17(11):1466-1468
A novel butanolide, named virginaebutanolide F (1), was isolated from the lyophilized culture broth of Slreptomyces sp., along with a known compound virginaebutanolide C (2). Their structures including the stereochemistry were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS and CD spectroscopic analysis. 相似文献
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对海洋放线菌Streptomyces sp.发酵液的提取物进行柱层析分离, 得到5个化合物. 经MS, NMR, 1H-1H COSY, HSQC和HMBC等数据鉴定, 其结构分别为3-氨基-丙酸对甲苯酯(1)、6-Amino-3-(4-hydroxybenzyl)-1,4-diazonane-2,5-dione(2)、正丁基-α-D-吡喃甘露糖苷(3)、大豆苷元(4)和1H-3-吲哚甲酸(5). 其中化合物1和2为新化合物, 细胞毒活性测试结果表明, 化合物1~4对人肝癌细胞(SMMC-7721)具有不同程度的生长抑制活性. 相似文献
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Zi Fei Xu Sheng Tao Bo Mei Jing Wang Jing Shi Rui Hua Jiao Yang Sun Qiang Xu Ren Xiang Tan Hui Ming Ge 《Chemical science》2020,11(34):9237
Nonribosomal peptides (NRPs) that are synthesized by modular megaenzymes known as nonribosomal peptide synthetases (NRPSs) are a rich source for drug discovery. By targeting an unusual NRPS architecture, we discovered an unusual biosynthetic gene cluster (bsm) from Streptomyces sp. 120454 and identified that it was responsible for the biosynthesis of a series of novel linear peptides, bosamycins. The bsm gene cluster contains a unique monomodular NRPS, BsmF, that contains a cytochrome P450 domain at the N-terminal. BsmF (P450 + A + T) can selectively activate tyrosine with its adenylation (A) domain, load it onto the thiolation (T) domain, and then hydroxylate tyrosine to form 5-OH tyrosine with the P450 domain. We demonstrated a NRPS assembly line for the formation of bosamycins by genetic and biochemical analysis and heterologous expression. Our work reveals a genome mining strategy targeting a unique NRPS domain for the discovery of novel NRPs.Genome mining targeting a unique NRPS domain led to the identification of a novel class of peptides named bosamycins. 相似文献
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Yong-Jun Jiang Li-She Gan Wan-Jing Ding Zhe Chen Zhong-Jun Ma 《Tetrahedron letters》2017,58(38):3747-3750
Two new gephyromycins (1–2), belonging to angucyclinones, were identified from Streptomyces sp. SS13I. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and the structure of 1 was further elucidated by X-ray diffraction data. The absolute configurations of compounds 1–2 were evidenced by ECD calculations. To our best knowledge, Compounds 1–2 were the second reported gephyromycin-type angucyclinones. Compound 2 exhibited significant cytotoxicity against PC3 cell lines with IC50 values of 1.38 ± 0.47 μM. 相似文献
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One new anthraquinone, 1,8-dihydroxy-2-ethyl-3-methylanthraquinone (1), together with two known compounds octadecanoic acid (2) and cholest-4-en-3-one (3) was isolated from marine actinomycete Streptomyces sp. FX-58. The structure of 1 was elucidated on the basis of spectroscopic methods, especially, the 2D-NMR spectral analysis. The cytotoxic activities of 1 were evaluated in vitro. 相似文献
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Ze Ping Xie Hong Yu Zhang Fu Chao Li Bing Liu Sheng Xiang Yang Hong Peng Wang Yang Pu Yi Chen Song Qin 《中国化学快报》2012,23(8):941-944
One new isobenzofuranone derivative,1,4-dimethoxy-3-(3R*-hydroxy-3R*-methyl-1-tetralone)-1(3H)-isobenzofuran(1),was isolated from the broth of marine Streptomyces sp.M268.The structure was elucidated by spectroscopy characteristics as well as comparison with the literature.Compound 1 exhibited cytotoxicities against human cancer cell,HL-60,A549,and BEL-7402. 相似文献
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M. P. Sobolevskaya S. Fotso U. Havash V. A. Denisenko E. Helmke N. G. Prokof'eva T. A. Kuznetsova H. Laatsch G. B. Elyakov 《Chemistry of Natural Compounds》2004,40(3):282-285
Sea isolate of Streptomyces sp. 6167 was found to produce four macrolide antibiotics feigrisolides A, B, and D, and dinactin. The chemical structures of the compounds were determined using 1D and 2D NMR spectrometry and electrospray mass spectrometry (ESMS). It was shown that the feigrisolides are cytotoxic to Ehrlich carcinoma tumor cells and to egg-cells of the sea urchin Strongylocentrotus intermedius and antimicrobial to the bacteria Bacillus cereus and Escherichia coli. 相似文献
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Zinad DS Shaaban KA Abdalla MA Islam MT Schüffler A Laatsch H 《Natural product communications》2011,6(1):45-48
Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3-methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 microg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against 相似文献
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Four new bisamides 1–4, and two new rhamnosides (5, 6), along with four known compounds 7–10, were isolated from a scale culture of the mangrove-derived actinomycete Streptomyces sp. SZ-A15. All structures were determined through analysis of the UV, IR, HRESIMS, 1D and 2D NMR spectra as well as by comparison with literature data. BRD4 inhibition of all isolated compounds was evaluated. As for the ability to inhibit protein BRD4, compound 9 exhibited moderate activity with the value of 78.4 ± 2.2% at 10 μM. 相似文献
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AbstractTwo diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0?μg/mL. 相似文献
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Xiu Chao XIE Wen Li MEI You Xing ZHAO Kui HONG Hao Fu DAI 《中国化学快报》2006,17(11):1463-1465
A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as (1α,4aα,5α, 7β, 8aβ)-5, 8a-dimethyl-decahydronaphthalene -1, 4a, 7-triol on the basis of spectroscopic data. 相似文献
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Luciana A. I. de Azeredo Leda R. Castilho Selma G. F. Leite Rosalie R. R. Coelho Denise M. G. Freire 《Applied biochemistry and biotechnology》2003,108(1-3):749-755
Streptomyces are important microorganisms because of their capacity to produce numerous bioactive molecules. In the present work protease
production, by Streptomyces sp. 594 isolated from a Brazilian Cerrado soil, was maximized by optimizing a low-cost culture medium composition (casitone
and sugarcane molasses) using statistical experimental design. The final protease activity (56 U/mL) was 2.8-fold and 58-fold
higher than that obtained in the beginning of this study, and in a previous work, using an actinomycete selection medium,
respectively. Protease production, not growth associated, appeared to be modulated by an inducer system, whereby the C/N ratio
seemed to play a significant role. 相似文献
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Neaumycin, a new 30-membered macrolide featuring an internal diester bridge, a molecular architecture that is unprecedented among known macrolide natural products, was isolated from a soil actinomycete strain Streptomyces sp. NEAU-x211. The structure of neaumycin was elucidated on the basis of comprehensive mass and NMR spectroscopic interpretation, including the relative stereochemistry of four independent coupling systems. 相似文献
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Shinji Kishimoto Yuta Tsunematsu Shinichi Nishimura Yutaka Hayashi Akira Hattori Hideaki Kakeya 《Tetrahedron》2012,68(27-28):5572-5578
Tumescenamide C, a new cyclic lipodepsipeptide, was isolated from a culture broth of an actinomycete Streptomyces sp. KUSC_F05. Tumescenamide C was a congener of tumescenamides A and B, representing a sixteen-membered ring system, consisting of two proteinogenic and three non-proteinogenic amino acids, to which a methyl-branched fatty acid was attached. The planar structure was determined by spectroscopic analysis, while its absolute stereochemistry was determined by chemical degradation and asymmetric synthesis. Tumescenamide C exhibited antimicrobial activity with high selectivity against Streptomyces species. 相似文献
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Samar M. Abdelrahman Noura S. Dosoky Amro M. Hanora Nicole B. Lopanik 《Molecules (Basel, Switzerland)》2022,27(14)
Antibiotic-resistant bacteria are the primary source of one of the growing public health problems that requires global attention, indicating an urgent need for new antibiotics. Marine ecosystems are characterized by high biodiversity and are considered one of the essential sources of bioactive chemical compounds. Bacterial associates of marine invertebrates are commonly a source of active medicinal and natural products and are important sources for drug discovery. Hence, marine invertebrate-associated microbiomes are a fruitful resource for excavating novel genes and bioactive compounds. In a previous study, we isolated Streptomyces sp. SCSIO 001680, coded as strain 63, from the Red Sea nudibranch Chromodoris quadricolor, which exhibited antimicrobial and antitumor activity. In addition, this isolate harbors several natural product biosynthetic gene clusters, suggesting it has the potential to produce bioactive natural products. The present study aimed to investigate the metabolic profile of the isolated Streptomyces sp. SCSIO 001680 (strain 63) and to predict their potential role in the host’s survival. The crude metabolic extracts of strain 63 cultivated in two different media were characterized by ultra-high-performance liquid chromatography and high-resolution mass spectrometry. The metabolomics approach provided us with characteristic chemical fingerprints of the cellular processes and the relative abundance of specific compounds. The Global Products Social Molecular Networking database was used to identify the metabolites. While 434 metabolites were detected in the extracts, only a few compounds were identified based on the standards and the public spectral libraries, including desferrioxamines, marineosin A, and bisucaberin, halichoblelide, alternarin A, pachastrelloside A, streptodepsipeptide P1 1B, didemnaketal F, and alexandrolide. This finding suggests that this strain harbors several novel compounds. In addition, the metabolism of the microbiome of marine invertebrates remains poorly represented. Thus, our data constitute a valuable complement to the study of metabolism in the host microbiome. 相似文献
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Vera A. Alferova Maxim V. Shuvalov Roman A. Novikov Alexey S. Trenin Lubov G. Dezhenkova Elena G. Gladkikh Olda A. Lapchinskaya Valeriya V. Kulyaeva Olga P. Bychkova Elena P. Mirchink Pavel N. Solyev Gulnara Kh. Kudryakova Vladimir A. Korshun Anton P. Tyurin 《Tetrahedron letters》2019,60(21):1448-1451
Three natural glycosylated macrolide compounds, known irumamycin 1 and X-14952B 2, as well as new isoirumamycin 3, were isolated from ethyl acetate mycelium extract of Streptomyces sp. INA-Ac-5812. Structures of the compounds were elucidated using 1D and 2D NMR. Isoirumamycin 3 was found to be an isomer of irumamycin with an 18-membered macrolactone ring instead of 20-membered macrolide in irumamycin. A previously unknown stereo configuration of irumamycin epoxide (C23, C24) and hemiketal (C3, C7) fragments was deduced from NMR data (ROESY/NOESY and HSQMBC). Cytotoxic, antifungal and antibacterial activities were studied for all isolated compounds. Comparison of the collected data showed crucial importance of 20-membered macrolactone ring for antimicrobial properties of this antibiotic family. 相似文献