共查询到20条相似文献,搜索用时 62 毫秒
1.
Pier Luigi Ferrarini Claudio Mori Giampaolo Primofiore 《Journal of heterocyclic chemistry》1986,23(2):501-504
Reaction of substituted 7-chloro-1,8-naphthyridines with N-carbethoxypiperazine gave in good yields the corresponding 7-(4-carbethoxypiperazin-1-yl)-1,8-naphthyridines V as potential antihypertensive agents. 相似文献
2.
<正>A novel tripodal receptor,1,3,5-tri((5,7-dimethyl-1,8-naphthyridin-2-yl-amino)methyl)-2,4,6-triethylbenzene(1) was synthesized from starting materials 2,6-diamino-pyridine(2) and 1,3,5-triethylbenzene(4) by three steps with an overall yield of 25%,and characterized by ESI-MS,FT-IR and ~1H NMR spectra.Additionally,its absorption and emission spectra were investigated. 相似文献
3.
A. Yu. Alekseeva I. N. Bardasov D. L. Mikhailov O. V. Ershov 《Russian Journal of Organic Chemistry》2017,53(8):1243-1248
Reactions of aromatic aldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and cyclic enhydrazinoketones led to the formation of N-substituted 5-aryl-2,4-diamino-6-oxo-5,6,7,8,9,10-hexahydrobenzo[b][1,8]- naphthyridine-3-carbonitriles 相似文献
4.
1,8-Naphthyridines (NAP) are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity against cowpea aphids (Aphis craccivora) with LC50 values ranging from 0.011 mmol/L to 0.067 mmol/L. The results indicated that 1,8- naphthyridine can be used as insecticidal structure for further modification. 相似文献
5.
Eva Eichler Clarence Stanley Rooney Haydn Windsor Richard Williams 《Journal of heterocyclic chemistry》1976,13(1):41-42
The synthesis of some 2-amino-1,8-naphthyridine derivatives substituted in the 5- and/or 7-positions with trifluoromethyl is described along with their conversions to the corresponding 1,8-naphthyridin-2(1H)ones. A modified procedure for oxidizing electron-deficient heterocyclic compounds to their N-oxides is presented. 相似文献
6.
Yoshiro Nishimura Akira Minamida Jun-Ichi Matsumoto 《Journal of heterocyclic chemistry》1988,25(2):479-485
A synthesis of 1,4-oxazine and pyrazine ring systems by an intramolecular cyclization of 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine and -quinoline derivatives having a nitrogen or oxygen nucleophilic site in the C-7 appendage was studied. The in vitro antibacterial activities of compounds prepared by this method were tested. 相似文献
7.
Váradi L Gray M Groundwater PW Hall AJ James AL Orenga S Perry JD Anderson RJ 《Organic & biomolecular chemistry》2012,10(13):2578-2589
Several novel fluorogenic N-aminoacylnaphthyridine substrates were synthesized in good yield and tested for their ability to detect pathogenic bacteria in agar-based cell culture. Simple 2-N-(β-alanyl)amino-5,7-dialkylnaphthyridine substrates were selectively hydrolysed by β-alanylaminopeptidase expressing bacteria, but were subject to diffusion in the agar medium. Diffusion was reduced in the 2-N-(β-alanyl)amino-7-alkylnaphthyridine substrates with longer alkyl chains, but inhibition of growth was increased. 2-N-(β-Alanyl)amino-7-octylnaphthyridine inhibited the growth of all species tested, except for strains resistant to colistin/polymyxin, providing a rationale for the development of substrates for the selective detection of drug resistant species in clinical samples. 相似文献
8.
Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands 总被引:1,自引:0,他引:1
Fu B Huang J Ren L Weng X Zhou Y Du Y Wu X Zhou X Yang G 《Chemical communications (Cambridge, England)》2007,(31):3264-3266
Water-soluble cationic corrole derivatives were designed and synthesized, and the first observation of their interactions with the telomeric G-quadruplex was made. 相似文献
9.
The pyrolysis of antipyrine 4dizaonium flouroborate gave an antipyrylazopyrazopyrazolone instead of the desired 4-fluoroantipyrine. This compound was formed by intermolecular and intramolecular coupling of the diazo compound at elevated temperatures. 相似文献
10.
D.M.W. Van Den Ham 《Journal of fluorine chemistry》1975,5(6):537-544
Hexachloro-1,8- and -2,7-naphthyridine have been prepared from 2,7-dichloro-1,8-naphthyridine and 1,3,6,8-tetrachloro-2,7- naphthyridine respectively. From these products and their starting materials a series of partially and totally fluorine substituted compounds have been derived. 相似文献
11.
Guleli Muge Erdem Safiye S. Ocal Nuket Erden Ihsan Sari Ozlem 《Research on Chemical Intermediates》2019,45(4):2119-2134
Research on Chemical Intermediates - An efficient and general method for the synthesis of substituted 3,4-dimethylisoxazolo[5,4-b]pyridine-5-carboxamide and benzo[b][1,8]naphthyridine-3-carboxamide... 相似文献
12.
13.
Shou Wen Jin Bin Liu Wan Zhi Chen 《中国化学快报》2007,18(4):383-386
An efficient route to synthesize the heteroaryl-substituted 1,8-naphthyridine derivatives was described.Eight 2-heteroaryl-and 2,7-diheteroaryl-1,8-naphthyridine derivatives were obtained through palladium-catalyzed C-N-coupling reactions of chloro-naphthyridines with imidazole,benzimidazole,morpholine,3,5-dimethylpyrazole,and phthalimide in moderate to good yields. 相似文献
14.
15.
Pier Luigi Ferrarini Claudio Mori Stefania Belfiore 《Journal of heterocyclic chemistry》1996,33(4):1185-1189
We report a selective acetylation of compounds 2 in 1-, 4- or 1,4-position. The treatment of 2 with acetic anhydride gave the compounds 3 and with acetyl chloride the compounds 4 . The 1-acetyl derivatives were obtained starting from 5 via the oxime derivatives 6, 7 and 8 . Tests on phytoiatric antimycotic activity and on reactivation of phosphylated acetylcholinesterase and inhibition of acetylcholinesterase were performed. 相似文献
16.
E. Sh. Kagan V. I. Mikhailov V. D. Sholle B. V. Rozynov É. G. Rozantsev 《Russian Chemical Bulletin》1977,26(12):2612-2614
Conclusions Some stable nitroxyl radicals of the 2,2,6,6-tetramethylpiperidine series, namely 2-aryl(heteryl)-5-oxyl-5,5,7,7-tetramethyl-5,6,7,8 -tetrahydro-1,6-naphthyridines, were obtained.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2822–2825, December, 1977. 相似文献
17.
HU Quan ZHANG KeJun JIN HuiLe CHEN XiAn HU MaoLin & WANG Shun Nanomaterials Chemistry 《中国科学:化学(英文版)》2012,(7):1356-1364
The interaction of double-stranded(ds) and G-quadruplex(G4) DNA with sulfonyl 5-fluorouracil derivatives(5-fluoro-1-(arylsulfonyl) pyrimidine-2,4(1H,3H)-diones) was investigated in this research,in which Au electrodes modified with ds-DNA or G4-DNAs were used as a working electrode.The investigation showed that the binding affinity with G4-DNA was significantly increased when 5-fluorouracil(5-FU) was modified with arylsulfonyl groups.The presence of strong electron-withdrawing groups on benzene sulfonyl 5-FU greatly enhanced the binding selectivity(k G4-DNA /k ds-DNA).Such results provided new insights into the potential connections between the chemical structure of drug candidates and their anticancer activities. 相似文献
18.
电化学法研究苯磺酰类5-氟尿嘧啶衍生物与双链和G-四链DNA的相互作用 总被引:1,自引:0,他引:1
本文以自组装法制得的双链DNA(ds.DNA)和G-四链体DNA(G4-DNA)修饰的金电极为工作电极,以Fe(CN)63-/4-为电活性指示剂,采用循环伏安法和微分脉冲伏安法研究了非电活性苯磺酰类5-氟尿嘧啶衍生物与ds-DNA和G4.DNA的相互作用.实验结果表明:苯磺酰类5-氟尿嘧啶与ds-DNA或G4.DNA的结合常数与苯环上邻、对位取代基的得失电子能力密切相关,强吸电子基团取代有利于苯磺酰类5-氟尿嘧啶选择性结合G-四链体DNA. 相似文献
19.
Chang YH Liu ZY Liu YH Peng SM Chen JT Liu ST 《Dalton transactions (Cambridge, England : 2003)》2011,40(2):489-494
Palladium complexes containing 2,7-bis(mesitylimidazolylidenyl)naphthyridine (NHC-NP) have been synthesized and characterized. Reaction of [{Ag(3)(NHC-NP)(2)}(PF(6))(3)] with [Pd(PhCN)(2)Cl(2)] provided an unusual dipalladium complex bridged by two NHC-NP units, forming a 20-membered dinuclear metallacycle [{Pd(2)(NHC-NP)(2)Cl(2)}(PF(6))] (2) in high yield. Treatment of 2 with KI in acetone yielded a neutral species [Pd(2)(NHC-NP)I(4)] (3). Meanwhile, the pyridinyl N-heterocyclic carbene (NHC-Py) precursor, 1-(2-pyridinyl)-3-mesitylimidazolium chloride, reacted with Pd(2)(dba)(3) directly to form the mononuclear palladium complex [Pd(NHC-Py)Cl(2)] (4). These complexes were characterized by elemental analyses as well as NMR spectroscopy, and the structures of 3 and 4 were further identified by X-ray diffraction analysis. The use of these palladium complexes for Suzuki-Miyaura and Kumada-Corriu coupling reactions has been examined. There is no significant difference in catalytic activities between 2 and 4 in Suzuki-Miyaura coupling reactions. However, the catalytic activity of 2 in the Kumada-Corriu coupling of ArBr with cyclohexylmagnesium bromide is quite different from that of 4. Thus complex 2 is active for the cross coupling, but complex 4 is active for the reduction of aryl halides. 相似文献
20.
Persianova I. V. Sheinker Yu. N. Titkova R. M. Elina A. S. 《Chemistry of Heterocyclic Compounds》1977,13(7):781-784
The direction of protonation (1-N or 5-N) or 2-, 2,3-, and 2,6-substituted derivatives of 1,5-naphthyridine was determined on the basis of the basicity constants.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 965–968, July, 1977. 相似文献