Two new steroidal saponins from "Gualou-xiebai-baijiu-tang" consisting of Fructus trichosanthis and Bulbus allii macrostemi

Two new steroidal saponins were isolated from the Chinese folk medicine called Gualou-xiebai-baijiu-tang. The structures were determined to be spirost 25(27)-ene-2beta,3beta-diol-3-O-beta-D-glucopyranosyl(1-->2)-beta-D-galactopyranoside and 26-O-beta-D-glucopyranosyl-22alpha-hydroxy-5beta-furost-25(27)-ene-1beta,3beta,6beta,26-tetraol-3-O-beta-D-galactopyranoside, respectively, based on chemical evidences and spectral analysis.     

A New Triterpenoid Saponin from Anemone tomentosa

TherootsofAnemonetomentosa(Maxim.)PeiareusedasafolkmedicineforthetreatmentofdysenteriainChinal.Recently,twonewcoumarinsandnineknowncompoundswereisolatedfromtheethylacetateeXtractwhichexhibitedstrongantifeedantactivityagainstLeucaniaSeparataWailiee.Duringthefurtherinvestigationofthetitleplant,anewminorsaponin,tomentoside,togetherwithfourknownoneswasisolated.Tomentoside(5),amorphouspowder,[a]D-41.5(MeOH,c0.26).MolecularformulawasdeterminedasC,,H,,.O,.byHRFABMS,m/zf1497.7166([M-H]-),caf…     

A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

A new triterpenoid saponin with novel sugar moiety (1), a new trisaccharide derivative (2), as well as a known monosaccharide derivative (3), were isolated from the dried stem of Epigyhum aurilum. The structures of compounds 1 and 2 were determined by MS and NMR spectram analyses.     

Two New Oleanene-Type Triterpenoid Saponins from Pueraria peduncularis

Pueraria pedllncltlaris Grab. (Leguminosae) is a plant growing in the southwest of China.The plants of Pueraria DC. are important oriental crude drugs used as a perspiration,antipyretic and antispasmodic agents. Various isoflavonoids and triterpenoidsaponins"' have been discovered from them. Since P pedunculariS is toxic. it hasnever been used as a source for medicines. There are only scarce reports on its chemicalconstituents.In the preceding paper', we reported the isolation of a new …     

A New Triterpenoid Spaonin Isolated from the Seeds of Aesculus assamica Griff

The Aesculus genus consists of about thirty species distributed in Asia, Europe andAmerica. There are sixteen species distributed in China, and most of them are used asherbal medicines for the treatment of distention and pain in the chest and abdomen. Anu…     

A New Triterpenoid Saponin: Se-saponin A

In continuation of our studies on the constituents of Clerodendrum serratum var.amplexghlium Moldenke'-"', a new triterpenoid saponin, sc-saponin A (l), was isolated.To the best of our knowledge, it is the second instance oftriterpenoid saponin from theClerodendrum genus. This paper deals with the structural elucidation of the newcompound.Se-saponin A (l) an amorphous powder, gave positive Liebermann-Burchardreaction. It was deduced to have a molecular formula of C58H,,O,, by high resoluti…     

A Triterpenoid Saponin from Polycarpon prostratum

FromPo{1'cal'Ponproslraluln(Forssk.)Aschers.etSchwein.ExAscherswhichissaidtobetoxicandhasanti-inflammatoryandanodynicactivities',anewtriterpenoidsaponin.namedprostratosideA.wasisolated.ProstratosideA1.mpf250-252"C,[a]5'= 4.3(c0.88,MeOH).0.0018%yield.ItsHRFAB-MSgavea[M-1]'ionatm/zI117.>505,inagreementwiththemolecularformulaC..H,.O:.(cafed."l/zI117.5431).TheiRspectrumshowedabsorptionbandsat3371.1717.1646and1046cm-'.AcomparisonofIwith22a-hydroxy-saikogeninG=showedIwasverysimilarto22a-…     

A New Triterpenoid Saponin from Codonopsis lanceolata

A new triterpenoid saponin, named codonolaside (1) was isolated from the root of Codonopsis lanceolata.Its structure was determined by analysis of its spectral and chemical data.     

A New Taraxastane-type Triterpenoid from Potentilla multicaulis

The genus Potentilla (Rosaceae) consists of about 200 species distributed in many countries, among them about 90 species grow in China1. Some species of Potentilla plants have long been used as traditional Chinese medicinal herbs for anti-rheumatism, deto…     

A New Cyclopropyl‐Triterpenoid from Ochradenus arabicus

One new cyclopropyl‐triterpenoid ( 1 ), along with four known constituents including octacosan‐1‐ol ( 2 ), pentacosanoic acid ( 3 ), β‐sitosterol ( 4 ), and β‐sitosterol 3‐O‐β‐D ‐glucopyranoside ( 5 ) were isolated from the aerial parts of Ochradenus arabicus for the first time. These compounds were isolated by repeated column chromatography followed by further purification through recycling HPLC. The structure of the new secondary metabolite 1 was established on the basis of UV, IR, 1D‐ (¹H‐ and ¹³C‐) and 2D‐NMR (HMBC and HSQC), and MS spectral data. The molecular mass was determined by HR‐MS, and hence the molecular formula was deduced. The configurations of stereogenic centers in the molecule were assigned by NOESY experiments, along with biogenetic considerations. The structures of the known compounds were confirmed by comparison of their physical and spectroscopic data with those reported in literature.     

A New Triterpenoid Glycoside from Decaisnea Fargesii

Deculsnea./al..gesiiFranch.IsatraditionalChinesemedicinalplantwidely'distributedinChina.usedasananti-rheumaticandalltitussivedrugforalongtimeinChinesefolkmedicine'.Itsmethanolextractshowedantitunlouracidityif71)if)oagainstS:sl},HepaandEhrlichcellsanditsphytochemicalstudiesonsaponinshasreported'.Asacontinuationofthestudiesonthisplant,wepresentthespectralandchemicalevidenceofthestructureofanewdecaisosideF.Thedriedstems(2.23kg)werepercolated\vith95%EtOH.Afterremovalofthepercolatesb}evaporat…     

A New Triterpenoid Saponin from Aralia subcapitata

The plants of Aralia genus are used as folk medicines for rheumathism, hepatitis and bruise in China 1. Aralia subcapitata Hoo is distributed in Anhui Province of China and also used for the treatment of diabetes. Yang et al. 2 reported the isolation of four known triterpenoids from this plant. In this paper, we report the structural elucidation of a new triterpenoid saponin, subcapitatoside A, isolated from the roots of this plant. Figure 1: structure of compound 1 Subcapitatoside A (1), …     

降五环三萜──蓑衣莲酮的研究

从云南省玉溪地区产蓑衣莲的根部得到一种降五环三萜，经光谱分析及其衍生物的Ｘ射线衍射分析确定为新化合物蓑衣莲酮。     

Facile Synthesis of Several Oleanane-Type Triterpenoid Saponins

Facile synthesis of the natural oleanane-type triterpenoid saponin 1 isolated from Panax japonicus C. A. Meyer var major (Burk.) C. Y. Wu et K. M. Feng and its derivatives is reported. The glucuronide residue in saponins at a later stage via TEMPO-mediated oxidation of the primary-OH has been achieved. All structures of new compounds were established by means of ¹H NMR, ¹³C NMR, HRMS, and optical rotation.     

A New Triterpenoid from Doellingeria scaber

A new oleanane-type triterpene was isolated from the roots ofDoellingeria scaber. Itsstructure was identified as 3-oxo-16ct-hydroxy-olean-12-en-28-oic acid based on 1D and 2D NMRspectroscopy and X-ray analysis.     

A New Ursene Type Triterpenoid from Crepis napifera

A new triterpenoid, urs-20-en-3β-acetoxy-22α-ol, and three known compounds 3β-acetoxy-amyrin, 3β-acetoxy-lupeol, lupeol were isolated from the leaves of Crepis napifera (Franch.) Babc. Their structures were determined by means of spectroscopic studies.     

A New Triterpenoid Saponin from the Seeds of Vaccaria segetalis

A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis.On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as: olean-12-ene-23a ,28b -dioic acid 3b , 16a -dihydroxy-28-O-[b -D-glucopyranosyl-(1→ 3)]-b -D-glucopyra-nosyl-(1→ 2)-b -D-glucopyranosyl-(1→ 6)-b -D-gluco-pyranoside(1).     

A New Triterpenoid Saponin from the Seeds of Deccaria segetalis

The seeds of Vaccaria segetalis (Neck) Garcke, which is distributed all over China,except southern China, are used in Chinese folk medicine for promoting diuresis,activating blood circulation and relieving carbuncles 1. Previous studies on the seeds ofthis plant have led to the isolation of seven cyclic peptides 2-5 and several saponins 6-]o.We have repoyted the isolation and structural elucidation of Segetosides A, C-E from theseeds of Vaccaria segetalis I I-13. FuFther investigation of…     

A New Triterpenoid Oligoglycoside Escin IVe from the Seeds ofAesculus Chinensis

Inthecourseofourstudiesonnewbiologicallyactivesaponinsofnaturalmedicines,wehaveisolatedescinsla.fo.IVa.IVb,IVc,andIVdtyolnseedsof.4e'v"11/llSchinensisBee.(Hippocastanaceae),andsinglecrystalX-raydiffractionanalysiswasundertakenonescinla'.whichconfirmstheabsoluteconfigurationandsugarsequence.ThepresentpaperdescribesthestructuredeterminationofanewtriterpenoidsaponinnamedescinIVefromthesameplant.EscinIVe,whitepowder.Positive-modeTOF-MScm/zI111[M Na] ,coupledwitllNMRdata.correspondstoane…