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1.
A new method for the synthesis of propargylated aromatic compounds is developed. The reaction was carried out at room temperature in the presence of a catalytic amount of FeCl3 in acetonitrile, high product yields were obtained with excellent regioselectivity and the reaction proceeded smoothly without exclusion of moisture or air. 相似文献
2.
A facile, efficient and environmentally benign procedure for the synthesis of diarylmethanes via the reaction of arenes with trioxane catalyzed by InCl3·4H2O was developed. The reactions of aromatic compounds bearing electron-donating group proceeded smoothly affording the corresponding diarylmethanes in good to excellent yields. 相似文献
3.
Zirconyl chloride was found to be an efficient catalyst for the cycloaddition reaction of aziridines with CO2, thus leading to the preferential formation of 5-aryl-2-oxazolidinones under solvent-free conditions. The methodology could be extended to various substituted aziridines with high conversion and chemo-, regio-, and stereoselectivity. Furthermore, the catalyst could be reused over five times without significant loss in activity. Interestingly, the recovered catalyst showed higher activity in comparison with the fresh catalyst, presumably due to its morphological variation. The use of this cheap and moisture stable catalyst make this protocol practical, environmentally benign, and economically attractive. 相似文献
4.
J.S. Yadav B.V. Subba Reddy N. Sivasankar Reddy K.V. Purnima B. Jagadeesh 《Tetrahedron letters》2010,51(2):244-7511
Indoles undergo smooth alkylation with α- and β-pinenes in the presence of 20 mol % of anhydrous FeCl3 under mild reaction conditions to produce a wide range of the corresponding 3-alkylated indoles in excellent yields with high trans-selectivity. This is the first example of alkylation of indoles with mono-terpenes. 相似文献
5.
Indoles undergo smooth alkylation at the 3-position with 1,3-dicarbonyl compounds in the presence of 20 mol % of FeCl3 under mild reaction conditions to produce a wide range of 3-substituted indoles in excellent yields and with high E-selectivity. 相似文献
6.
Monoterpenes such as α-pinene, β-pinene, limonene and isolimonene undergo smooth hydroalkoxylation in the presence of 20 mol % of FeCl3 under mild reaction conditions to produce a wide range of the corresponding ethers in excellent yields and with high selectivity. 相似文献
7.
Surisa Tuengpanya Chayamon Chantana Uthaiwan Sirion Wipada Siritanyong Klaokwan Srisook Jaray Jaratjaroonphong 《Tetrahedron》2018,74(33):4373-4380
A convenient, practical and highly efficient one-pot method has been developed for the synthesis of triaryl- and triheteroarylmethane derivatives by Bi(OTf)3-catalyzed Friedel-Crafts alkylation of trialkyl orthoformates in combination with a wide variety of arenes/heteroarenes at room temperature under solvent-free conditions and in an air atmosphere. The methodology offers an operational simplicity, high atom economy and environmentally benign procedure. Furthermore, selected compound 3k showed promising anti-inflammatory activity with inhibition nitric oxide and did not exhibit significant cytotoxic effects on macrophage cells. 相似文献
8.
Claudio C. Silveira Samuel R. Mendes Lucas Wolf Guilherme M. Martins 《Tetrahedron letters》2010,51(15):2014-3697
Anhydrous CeCl3 was successfully used as a catalyst for the synthesis of several 3-sulfenyl indoles in good to excellent yields through the reaction of indole with N-(alkylthio) and N-(arylthio)phthalimides in DMF. 相似文献
9.
Farhad Shirini Somayeh Akbari-DadamahalehAli Mohammad-Khah 《Comptes Rendus Chimie》2013,16(10):945-955
Rice-husk-supported FeCl3 nano-particles (FeCl3–RiH) were prepared and used as an environmentally friendly catalyst in the synthesis of β-amino carbonyl compounds, 1,8-dioxo-octahydro xanthenes, and bis-indolyl methanes from simple and readily available precursor molecules. 相似文献
10.
A mild, efficient and chemoselective method has been developed for the direct transformation of tert-butyldimethylsilyl and tetrahydropyranyl protected alcohols into the corresponding acetates with acetic anhydride and zirconium(IV) chloride as the catalyst in acetonitrile, in a one-pot reaction with high yields and short reaction times. This method has been applied to a variety of substrates. 相似文献
11.
FeCl3·6H2O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines was further exploited. Both 1-aryl- and 1-alkyl- or 1-alkenyl-benzazepines underwent this reaction smoothly. The rearrangement products were used to prepare a series of novel derivatives containing both tetrahydroisoquinoline (THIQ) and tetrahydropyrimidin-4(1H)-one scaffolds through a Mannich-type process. 相似文献
12.
Takuya Hashimoto 《Journal of organometallic chemistry》2011,696(1):99-105
Hydroarylation of propiolic acids with various arenes in TFA proceeded efficiently in the presence of FeCl3/AgOTf catalyst system. In the case of electron-rich arenes, the iron-catalyzed hydroarylation gave cinnamic acids in moderate to high yields. The hydroarylation of phenylacetylene was observed but the catalyst was not effective under the same conditions. 相似文献
13.
Hiroyuki ShinoharaMotohiro Sonoda Shingo AtobeHaruna Masuno Akiya Ogawa 《Tetrahedron letters》2011,52(47):6238-6241
IrCl3·3H2O or FeCl3-catalyzed convenient synthesis of 3-hydroxyphthalates has been achieved by a Diels-Alder reaction of furans with dimethyl acetylenedicarboxylate, followed by ring-opening aromatization reaction of the Diels-Alder adducts, 7-oxabicyclo[2.2.1]hepta-2,5-diene derivatives. In addition, 7-azabicyclo[2.2.1]hepta-2,5-diene derivative, derived from N-Boc-pyrrole and dimethyl acetylenedicarboxylate, also converted into 3-aminophthalate derivative. 相似文献
14.
Jaray Jaratjaroonphong Supaporn Sathalalai Vichai Reutrakul 《Tetrahedron letters》2009,50(44):6012-3245
Iodine is shown to be an efficient catalyst for the Friedel-Crafts alkylation of arenes with a wide variety of aldehydes in toluene under ‘open-flask’ and mild conditions. In the presence of 10 mol % of iodine, the reaction of arenes with aromatic aldehydes gives the corresponding triarylmethane derivatives (TRAMs), regioselectively, in good to excellent yields. On the other hand, a series of diarylalkane derivatives is synthesized smoothly by the reaction with aliphatic aldehydes. 相似文献
15.
Gnanamani Shanthi 《Tetrahedron letters》2007,48(38):6785-6789
A simple and convenient method for the synthesis of new 2-aminochromenes and indolyl chromenes via an indium trichloride catalyzed, three-component reaction in aqueous media is described. 相似文献
16.
Under ‘open-flask’ and mild conditions, arenes condense smoothly with aromatic aldehydes in the presence of catalytic amount of FeCl3. The reaction tolerated a variety of substitutions and functional groups. This method provides a facile and direct access to symmetrical and unsymmetrical triarylmethane derivatives. 相似文献
17.
[Co(η2-CO3)(NH3)4](NO3)·0.5H2O and [(NH3)3Co(μ-OH)2(μ-CO3)Co(NH3)3][NO3]2·H2O were prepared by prolonged aerial oxidation of a solution of Co(NO3)2·6H2O and ammonium carbonate in aqueous ammonia. The formation of these side products highlights the richness of the chemistry of these systems and the possibility of by products if methods are not strictly adhered to. The X-ray crystal structures of [Co(η2-CO3)(NH3)4][NO3]·0.5H2O and [(NH3)3Co(μ-OH)2(μ-CO3)Co(NH3)3][NO3]2·H2O reveal a monomeric octahedral cobalt center with η2-bound CO32− in the former, while the latter consists of a dimeric array where the two cobalt centers are bridged by two OH− and one μ2-CO32− groups with three terminal NH3 ligands for each Co center. In both complexes extensive hydrogen bonding interactions are evident. 相似文献
18.
Claudio C. Silveira Samuel R. Mendes Lucas Wolf Guilherme M. Martins 《Tetrahedron letters》2010,51(34):4560-4562
Anhydrous CeCl3 was successfully used as catalyst for the synthesis of several 3-propargyl indoles in good yields through the reaction of indole with propargyl alcohols in nitromethane. 相似文献
19.
Glycerin and CeCl3·7H2O were successfully used in recyclable catalytic system for the synthesis of several bis(indolyl)methanes in good to excellent yields through the reaction of indoles with aldehydes. The method is applicable to aliphatic and aromatic aldehydes, and the mixture of glycerin and CeCl3·7H2O can be reused up to five times without special treatment and with comparable yields. 相似文献
20.
B. Sunil Kumar P. S. Kumar N. Srinivasulu B. Rajitha Y. Thirupathi Reddy P. Narsimha Reddy R. H. Udupi 《Chemistry of Heterocyclic Compounds》2006,42(2):172-175
Good yields of substituted coumarins were obtained by a synthetic method involving the Pechmann reaction using vanadium(III)chloride
(VCl3) reagent to effect this condensation under solvent-free conditions.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 197–200, February, 2006. 相似文献