闪光照相中散射分布均匀性的影响因素

为了在客体密度重建过程中采用迭代法扣除散射X射线的影响,提出了以散射分布均匀为主要目的的闪光照相系统设计思想。在介绍散射分布均匀性定义的基础上,分析了均匀扣除散射所带来的光程差。采用蒙特卡罗方法研究了系统放大倍数、照相距离以及后防护锥到图像接收系统的距离对散射分布均匀性的影响。结果表明：后防护锥到图像接收系统的距离是影响散射分布形状和散射照射量大小的一个主要因素;当后防护锥到图像接收系统的距离为55 cm左右时,散射分布均匀性近似最佳,而且照相距离越大,散射分布均匀性越好。这些研究结果可用于实际闪光照相系统的优化设计,在图像接收系统的响应范围内达到使散射分布均匀和降低光源模糊影响的目的。     

闪光照相中散射分布均匀性的影响因素

 为了在客体密度重建过程中采用迭代法扣除散射X射线的影响,提出了以散射分布均匀为主要目的的闪光照相系统设计思想。在介绍散射分布均匀性定义的基础上,分析了均匀扣除散射所带来的光程差。采用蒙特卡罗方法研究了系统放大倍数、照相距离以及后防护锥到图像接收系统的距离对散射分布均匀性的影响。结果表明：后防护锥到图像接收系统的距离是影响散射分布形状和散射照射量大小的一个主要因素;当后防护锥到图像接收系统的距离为55 cm左右时,散射分布均匀性近似最佳,而且照相距离越大,散射分布均匀性越好。这些研究结果可用于实际闪光照相系统的优化设计,在图像接收系统的响应范围内达到使散射分布均匀和降低光源模糊影响的目的。     

利用数值模拟测量闪光照相中H-D曲线

 在分析高能闪光照相中传统实验方法不足的基础上,提出了采用Monte Carlo模拟结果来建立底片光学密度与照射量之间的关系,并对一个球对称客体进行了实验照相。采用Monte Carlo方法分析了底片光学密度分布左右不对称的各种因素,认为底片光学密度分布左右不对称主要是照相器件几何对中不理想造成的,并说明了底片光学密度左右平均的合理性。在此基础上介绍了H-D曲线的生成方法,采用Silberstein理论得到了具有较高精度的H D曲线。这种结合Monte Carlo模拟的H-D曲线测量方法不但避免了照射量测量误差,而且还考虑了H-D曲线对X射线能谱的依赖关系,更能体现实际情况,具有较高的精度。可用于球对称客体或柱对称客体的辐射照相。     

利用数值模拟测量闪光照相中H-D曲线

在分析高能闪光照相中传统实验方法不足的基础上,提出了采用Monte Carlo模拟结果来建立底片光学密度与照射量之间的关系,并对一个球对称客体进行了实验照相。采用Monte Carlo方法分析了底片光学密度分布左右不对称的各种因素,认为底片光学密度分布左右不对称主要是照相器件几何对中不理想造成的,并说明了底片光学密度左右平均的合理性。在此基础上介绍了H-D曲线的生成方法,采用Silberstein理论得到了具有较高精度的H D曲线。这种结合Monte Carlo模拟的H-D曲线测量方法不但避免了照射量测量误差,而且还考虑了H-D曲线对X射线能谱的依赖关系,更能体现实际情况,具有较高的精度。可用于球对称客体或柱对称客体的辐射照相。     

模糊和散射对闪光照相边界检测的影响

借助蒙特卡罗方法模拟闪光照相过程,研究了模糊和散射因素对边界检测的影响。结果表明：模糊与边界退化量的变化关系依赖于相邻飞层的材料、密度和尺寸;相同客体结构下,模糊越大,边界退化量也越大;客体结构不同,相同模糊下的边界退化量也不同;散直比越大,散射对边界检测结果的影响也越大,当散直比大于50时,散射引起的边界检测误差超过1个像素。     

闪光照相中散射照射量的解析分析

 考虑了光子与物质的三种相互作用方式,用解析分析法确定光子在材料中能量的一次散射转化几率,并由此求得闪光照相系统中成像平面上的散射和最小直散比的表达式。用该公式求得的FTO客体的最小直散比约为1.0,与美国NIH实验结果0.5~1.5近似符合。     

闪光照相中散射照射量的解析分析

考虑了光子与物质的三种相互作用方式,用解析分析法确定光子在材料中能量的一次散射转化几率,并由此求得闪光照相系统中成像平面上的散射和最小直散比的表达式。用该公式求得的FTO客体的最小直散比约为1.0,与美国NIH实验结果0.5~1.5近似符合。     

14MeV中子照相中散射中子对成像影响的Monte Carlo模拟

依据实验参数，建立了14MeV快中子照相的物理模型，并利用Monte Carlo方法对照相过程进行了模拟. 分析了经聚乙烯样品散射的中子对快中子图像的影响随样品与探测器间距及样品参数的变化. 计算结果表明，样品与探测器的距离d<5cm时，样品中的散射中子对图像的影响强烈依赖于d，而当d>20cm时，样品散射中子对图像的影响可忽略；当样品密度为3—5g/cm³时散射中子对图像的影响相对最大；样品宽度越大，图像中的散射成分越多，当宽度在3cm以上时散射成分的强度趋于饱和. 关键词： 14MeV中子 快中子照相 散射中子 Monte Carlo模拟     

闪光照相中侧向散射的数值模拟

散射是闪光照相诊断技术中需要重点考虑的一个关键性问题,弄清散射的影响因素及其来源对于提高客体信息诊断精度具有十分重要的促进作用。针对法国实验客体照相系统,采用蒙特卡罗方法,系统研究了侧向散射的影响因素及其来源。结果表明:在没有侧向保护器的情况下,前保护器是侧向散射的主要来源,对任一点,前保护器的散射贡献均达到50%以上,并且侧向散射沿光轴方向呈递增或递减分布。在有侧向保护器情况下,侧向散射照射量有所减小,在与光轴垂直方向呈中间高两边低的单峰分布。增大侧向记录距离不一定带来侧向散射的降低。在适当的记录距离下,得到了较为均匀的散射分布。     

闪光照相中侧向散射的数值模拟

散射是闪光照相诊断技术中需要重点考虑的一个关键性问题,弄清散射的影响因素及其来源对于提高客体信息诊断精度具有十分重要的促进作用。针对法国实验客体照相系统,采用蒙特卡罗方法,系统研究了侧向散射的影响因素及其来源。结果表明：在没有侧向保护器的情况下,前保护器是侧向散射的主要来源,对任一点,前保护器的散射贡献均达到50%以上,并且侧向散射沿光轴方向呈递增或递减分布。在有侧向保护器情况下,侧向散射照射量有所减小,在与光轴垂直方向呈中间高两边低的单峰分布。增大侧向记录距离不一定带来侧向散射的降低。在适当的记录距离下,得到了较为均匀的散射分布。     

高能闪光照相中钨球散射规律研究

 用解析法和Monte Carlo法研究了钨球闪光X光照相的散射照射量空间分布随钨球半径、系统中元件构成以及保护器件与记录平面间距的变化规律。指出散射照射量的空间分布是不均匀的，它随球半径增加而变大；保护器件是散射照射量的主要来源，增加从保护器件到记录平面的距离，可以降低散射分布不均匀性，以及有效地减少散射。     

Investigation of scatter from out of the field of view and multiple scatter in PET using Monte Carlo simulations

In fully three-dimensional (3D) positron emission tomography (PET) imaging, the scatter fraction (SF) is about 40%-60%, which may degrade the imaging quality severely. Scatter correction is important for high quality image reconstruction. Model-based scatter correction has been proved to be accurate and available in clinical PET. However, it does not correct the scatter from out of the field of view (OFOV) and multiple scatters. In this study, we demonstrate the radial and axial distribution of scatters from OFOV when the source is located in different radial positions. In order to apply the above conclusions to different PET systems, we characterize the scatters from OFOV as a function of the ratio of the scanner diameter to the length of the axial field of view (AFOV) by modeling several typical whole-body and micro PET systems. The proportions of true events (S_0-0), single scatter of one photon (S_1-0) , single scatter of both photons (S_1-1) , double scatter of one photon (S_2-0) and multiple scatter (S_m) are also calculated and compared. Here the 3D-PET Monte Carlo simulations are performed with the Geant4 Application for Tomography Emission (GATE). In summary, the scatters from OFOV tend to be recorded on the lines of response (LOR) far away from the source. They have a much more serious impact on whole-body PET than micro PET depending on the ratio of scanner diameter to the length of AFOV. In whole-body PET, twice scatters including single scatter of both photons (S_1-1) and double scatter of one photon (S_2-0) add up to about 12% so that twice scatter correction must be taken into account to acquire a high quality reconstruction image.     

Monte Carlo simulation of electron avalanches and avalanche size distributions in methane

The simulation of electron avalanches and avalanche size distributions in methane is presented in this paper. A model for electron transport under the influence of a constant electric field based on the Monte Carlo method is described in detail. The model is verified and then used to simulate the avalanche development, to calculate the number of electrons in the avalanche (avalanche size), and to determine the avalanche size distribution. The simulated avalanche size distributions in methane are compared with the experimental results, and a good agreement is observed. The influence of inter‐electrode distance, pressure, and reduced electric field on the shape of the avalanche size distribution is discussed. The assumption from the literature that for a constant reduced electric field the shape of the reduced avalanche size distribution is independent of the mean size of the avalanche is confirmed for a wide range of experimental conditions. The simulations have shown that avalanche size distributions depend only on the reduced electric field, confirming the similarity principle.     

DNA condensation and size effects of DNA condensation agent

Based on the model of the strong correlation of counterions condensed on DNA molecule, by tailoring interaction potential, interduplex spacing and correlation spacing between condensed counterions on DNA molecule and interduplex spacing fluctuation strength, toroidal configuration, rod-like configuration and two-hole configurations are possible. The size effects of counterion structure on the toroidal structure can be detected by this model. The autocorrelation function of the tangent vectors is found as an effective way to detect the structure of toroidal conformations and the generic pathway of the process of DNA condensation. The generic pathway of all of the configurations involves an initial nucleation loop, and the next part of the DNA chain is folded on the top of the initial nucleation loop with different manners, in agreement with the recent experimental results.     

晶粒棱长、尺寸与拓扑学特征之间关系的Monte Carlo仿真研究

采用Potts模型Monte Carlo方法研究了晶粒棱长、尺寸与拓扑学特征之间的统计关系.结果表明,晶粒棱长与晶粒面数之间呈线性统计关系,并且平均N面体晶粒模型和Poisson-Voronoi组织均支持该结论.不同时刻的晶粒长大仿真数据表明,在准稳态晶粒长大阶段晶粒棱长的分布具有自相似性.个体晶粒的平均棱长随晶粒面数（或晶粒尺寸）的增加而逐渐增大,这说明一些理论模型中采用的“不同面数的晶粒平均棱长均相等”的假设具有局限性.仿真数据和纯铁实验数据均表明,晶粒尺寸与晶粒面数之间的统计关系表现为一条单调递增的凸曲线. 关键词： 晶粒棱长 晶粒尺寸 拓扑学 Monte Carlo仿真     

An effective scatter correction method based on single scatter simulation for a 3D whole-body PET scanner

Hamamatsu SHR74000 is a newly designed full three-dimensional (3D) whole body positron emission tomography (PET) scanner with small crystal size and large field of view (FOV). With the improvement of sensitivity, the scatter events increase significantly at the same time, especially for large objects. Monte Carlo simulations help us to understand the scatter phenomena and provide good references for scatter correction. In this paper, we introduce an effective scatter correction method based on single scatter simulation for the new PET scanner, which accounts for the full 3D scatter correction. With the results from Monte Carlo simulations, we implement a new scale method with special concentration on scatter events from outside the axial FOV and multiple scatter events. The effects of scatter correction are investigated and evaluated by phantom experiments; the results show good improvements in quantitative accuracy and contrast of the images, even for large objects.     

质子照相中基于能量损失的密度重建

提出了一种质子能量在中高能时利用能量损失进行密度重建的方法,并利用Bethe-Bolch公式给出了利用能量损失进行密度重建的方程及条件.针对1.6 GeV的质子能量,通过定量计算常见材料的阻止本领,得出质子能量在1.45–1.6 GeV范围内时,材料的阻止本领的变化率小于1%,可近似为常数.最后,通过理论计算和Geant 4模拟,得出质子能量在1.6 GeV时,可以对面密度为113 g/cm²的缩比法国实验客体进行密度重建.     

蒙特卡罗方法在X光源尺寸测量中的应用

 利用蒙特卡罗方法对两种X光源尺寸测量方法狭缝法和刃边法进行了模拟,比较了在不同实验布局条件下的模拟结果,指出X射线的强穿透性对成像具有较大的影响,使狭缝像的底部展宽,影响对光源特性的判断,同时使刃边法的测量精度在一定程度上受对中精度的制约。为减小其影响,在保证不降低图像接收范围、图像对比度以及测量精度的基础上,设计了新的狭缝法实验测量布局,同时建议用ROLLBAR法代替刃边法进行测量。