Synthesis,Crystal Structure and Biological Activity of 8-（（4-（（2,3-diaminopyridin-4-yl）oxy）-3-fluorophenyl）-amino）-2-（4-fluorophenyl）-3-methyl-2,7-naphthyridin-1（2H）-one

The new title compound 8-((4-((2,3-diaminopyridin-4-yl)-oxy)-3-fluorophenyl)-amino)-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1(2H)-one(C26H20F2N6O2, Mr = 486.48) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 15.365(3), b = 13.144(2), c = 11.863(2), β= 108.882(3)°, Z = 4, V = 2267.0(7)3, Dc = 1.425 g/cm3, F(000) = 1008, μ = 0.105 mm-1, MoKa radiation(λ = 0.71073), R = 0.0480 and wR = 0.1294 for 3197 observed reflections with I 2σ(I). X-ray diffraction analysis reveals that the region C(substituents of 8-amino group and 3-methyl group on the 2,7-naphthyridin-1(2H)-one ring) of compound 6 are effectively planar. Intramolecular and intermolecular hydrogen bonds together with π···π interations are found in the structure. In addition, compound 6 shows potent c-Met and c-Kit kinase inhibition activities.     

Synthesis and Characterization of a New Pure Inorganic 2D Network Based on [H_2W_（12）O_（42）]~（10-）

An isopolytungstate(NH4)6Na4[H2W12O42]·14H2O(1) has been synthesized in an aqueous solution and characterized by elemental analysis,IR spectroscopy,TG analysis,X-ray powder diffraction(XRD) and single-crystal X-ray diffraction.The result indicates a degradation from nitrilotriacetic acid(NTA) to NH3.The electrochemical analysis and thermal stability of 1 were also studied.The crystal data are as follows:H54N6Na4O56W12(Mr = 3332.65),orthorhombic,Pbca,a = 14.1497(15),b = 15.9414(16),c = 22.931(2) ,Z = 4,V = 5172.4(9) 3,Dc = 4.280 Mg/m3,μ = 26.729 mm-1,F(000) = 5904,the final R = 0.0809 and wR = 0.2104 for 4565(Rint = 0.1351) independent reflections.The β-[H2W12O42]10-clusters are linked through {Na2(OH2)3} groups into a 2D layer and are further connected into a 3D framework via hydrogen bonding interactions.     

A One-dimensional Metallic Oxide Constructed from Molybdenum Clusters and Mn（Ⅱ）-[3-（2-pyridyl） pyrazole] Cationic Coordination Components

A new polyoxomolybdate compound [Mn II (L) 2 (Mo 8 O 26) 0.5 ] 2n (1,L=3-(2-pyridyl)pyrazole) has been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction,elemental analyses,TG and IR spectroscopy.The compound crystallizes in the triclinic system,space group P1 with a=10.063(4),b=11.554(5),c=11.554(5),α=88.89,β=74.839(4),γ=74.839(4)o,V=1249.8(9) 3,C 16 H 14 MnMo 4 N 6 O 13,M r=937.03,D c=2.490 g/cm 3,μ(MoKα)=2.521 mm 1,F(000)=898,Z=2,the final R=0.0390 and wR=0.0970 for 4000 observed reflections (I > 2σ(Ⅰ)).Single-crystal X-ray diffraction analysis results reveal that compound 1 owns a chain structure based on β-[Mo 8 O 26 ] 4anions,which are linked by Mn II (L) 2 units via the terminal oxygen atoms.     

A Novel Three-dimensional Extended Supramolecular Network Constructed from Octamolybdate Clusters and Morpholine Molecules： Nae（Hmorph）e[MosO26]·2H2O

A novel organic-inorganic hybrid, Na2(Hmorph)2[MosO26]·2H2O (1, Hmorph = morpholine), has been synthesized by convenient aqueous solution method and structurally characterized by single-crystal X-ray d...     

A 3D Supramolecular Pd（Ⅱ） Complex via Hydrogen-bonding and Weak M…M Interactions

The reaction of 2,4,6-tris（2-pyridyl）-1,3,5-triazine （tptz） and K2PdCl4 in THF/H2O （10：1） results in the hydrolysis of tptz to bis（2-pyridylcarbonyl）amide anion （bpca）, and affords complex Pd（bpca）Cl 1, which is the first example of Pd（Ⅱ）-promoted hydrolysis of ligands. Crystal data for 1： orthorhombic, space group Pbcn, a = 12.0136（17）, b = 14.180（2）, c = 6.9747（11）A, V= 1188.2（3） A3, Z = 4, Mr = 368.06, Dc = 2.058 g/cm3, F（000） = 720,μ = 1.786 mm^-1, λ（MoKα） = 0.71073 A, T= 293（2） K, 2θmax = 54.9°, GOOF = 1.085, the final R= 0.0647 and wR = 0.1051 for 1234 observed reflections with I 〉 2σ（I） （refinement on F2）. Complex 1 is connected through hydrogen bonding to give a 2D network. And weak Pd...Pd interactions are also found between adjacent molecules with the distance of 3.6074（5） A, so the complex is further extended into a 3D supramolecular structure. Thermal gravity analysis （TGA） shows that 1 exhibits high thermal stability below 310℃. X-ray powder diffraction （XRD） and UV/Vis spectrum of 1 are also discussed.     

A 3-fold Interpenetrated lvt Cd(Ⅱ) Network Constructed from 4-[(3-pyridyl)methylamino]benzoate Acid

A new three-dimensional(3D) coordination polymer, [Cd(L)2H2O]n·5nH2O 1 with 4-[(3-pyridyl)methylamino]benzoate acid(HL), has been synthesized by slow evaporation solvent at room temperature, and structurally characterized by elemental analysis, IR spectrum, thermal analysis, fluorescence spectrum and single-crystal X-ray diffraction. Compound 1 crystallizes in the tetragonal system, space group I-4, with a = 20.7937(16), c = 13.515(2), V = 5843.5(11) 3, C26H34CdN4O10, Mr = 674.97, Dc = 1.534 g/cm3, μ(MoKα) = 0.808 mm-1, F(000) = 2768, Z = 8, the final R = 0.0276 and wR = 0.0691 for 5323 observed reflections(I 2σ(I)). The result of thermal analysis shows that 1 is stable under 290 ℃. Moreover, it exhibits blue photoluminescence at room temperature.     

Synthesis,Crystal Structure and Antiproliferative Activity of 2-（（（5-（（（5,7-Dimethyl-[1,2,4]triazolo-[1,5-a]pyrimidin-2-yl）thio）methyl）-4-phenyl-4H-1,2,4-triazol-3-yl）thio）methyl）-4Hchromen-4-one Methanol Solvate

The novel crystal of the title compound 2-(((5-(((5,7-dimethyl-[1,2,4]triazolo-[1, 5-a]-pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)methyl)-4H-chromen-4-one methanol solvate(C27H25N7O3S2, Mr = 559.66) has been prepared and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monocline system, space group P21/c with a = 11.9879(9), b = 14.0743(10), c = 15.9706(11), β = 98.509(2)°, V = 2664.9(3)3, Z = 4, Dc = 1.395 g/cm3, F(000) = 1168, μ = 0.116 mm-1, MoKa radiation(λ = 0.71073), R = 0.0652, and wR = 0.1425 for 5220 observed reflections with I 2σ(I). X-ray diffraction analyses reveal that the molecule adopts a C-shape. The planes of the benzopyrone and triazolopyrimidine were nearly parallel to each other, with a dihedral angle of 1.21(3)°. Intramolecular and intermolecular hydrogen bonds together with π-π interations are found to exist in the structure. The results of MTT assay indicate that the title compound displays excellent antiproliferative activity against two human cancer cell lines.     

A New Three—dimensional Network Constructed by Heptamolybdate,SodiumIons and Hexamethylene Tetramine Cations via Hydrogen Bonds

1 INTRODUCTION The role played by CH…O hydrogen bonds in determining molecular conformation and crystal packing, in molecular recognition processes, in the stabilization of inclusion complexes, and possibly in the activity of biological macromolecules has been well established[1,2]. According to Desirajus structural setting for C-H贩稯 hydrogen bonds, the D (to define the C贩稯 contact distances) values within the range of 3.00~4.00 and the angles of CH…O with 150≤≤180 are stru…     

Synthesis,Structure and Thermal Property of a Cobalt Supramolecular Complex Containing N-[（4-Carboxyphenyl）-sulfonyl]glycine

Utilizing N-[(4-carboxyphenyl)-sulfonyl]glycine (abbreviated as cbsglyH3),a new cobalt complex [Co(cbsglyH)(bipy)2]3H2O (bipy = 2,2'-bipyridine) has been synthesized under mild conditions and characterized by IR,elemental analysis,thermogravimetric analysis and X-ray diffraction analysis. It crystallizes in the monoclinic system,space group C2/c with a = 34.978(3),b = 12.0437(11),c = 20.0041(19) ,β = 122.2990(10)°,V = 7123.0(11) 3,Z = 8,C29H28CoN5O9S,Mr = 681.55,μ = 0.593 mm-1,Dc = 1.271 Kg/m3,F(000) = 2816,the final R = 0.0434 and wR = 0.1351. The title complex is a monomeric compound which is further assembled by intermolecular hydrogen bonds into a 3-D supramolecular network. Thermogravimetric analysis illustrates that this complex begins decomposing at 100 ℃ and decompounding completely at 560 ℃.     

Synthesis, Crystal Structure and Thermal Stability of the Coordination Polymer [Co（2-mpac）_2（py）·4H_2O）]_n

A new coordination polymer with the formula of [Co(2-mpac)2(py)·4H2O)]n (1, 2-mpac = 5-methyl-2-pyrazinecarboxylic acid, py = pyrazine) has been synthesized through hydrothermal synthesis and structurally characterized by X-ray single-crystal diffraction method. 1 exhibits a 3D supramolecular network. Crystal data: monoclinic, space group C2/m, a = 15.907(9), b = 7.104(3), c = 9.793(5), β = 95.232(8)o, V = 1102.0(10)3, Z = 2, S = 0.995, the final R = 0.0509, wR = 0.1626 for 1002 observed reflections with (I > 2σ(I)) and R = 0.0530, wR = 0.1667 for all data. In addition, elemental analysis, IR and thermalgravimetric analysis are presented.     

六钨酸盐为模板的三维网状超分子化合物[La2(DNBA)4(DMF)8][W6O19]的合成和晶体结构

0 Introduction polyoxometalates (POMs), in addition to their im- portance in catalysis, biochemical separation and medicinal chemistry, play an important role for the design of new materials with novel electronic, magnet- ic and topological properties[1￣…     

Synthesis and 2D H-bonded Cd（ Ⅱ ） Network Structure of [Cd（C10H15N3）Cl2]

1 INTRODUCTION Transition metal Schiff base complexes have been extensively studied in the past two decades for their various crystallographic features, enzymatic reactions, steric effects[1～4], catalysis and magnetic properties[5, 6] as well as their important role in organisms[7, 8]. Most of these first-row materials are biologically essential with a number of their complexes showing bioactivities[9, 10]. Herein we describe the synthesis and X-ray structure of the cadmium (Ⅱ) compl…     

超分子三维氢键网络：{[Cu(phen)3](SO4)(H3PCA)2(8H2O)}的晶体结构

A new complex， {[Cu(phen)₃](SO₄)(H₃PCA)₂(8H₂O)}， was synthesized and structurally characterized by single-crystal X-ray analysis. The complex is composed of copper cations， sulfate anions， 1，10-phenanthroline， protocatechuic acid and lattice water molecules. The structure of H₃PCA， SO₄^2- and waters comprises packing of anionic three-dimensional network by hydrogen bonds with cavities. The complex can be considered as a model of host/guest supramolecule. The three-dimensional hydrogen-bonding network is the host species. The Cu(phen)₃²⁺ cations， guest species， occupied the cavities of the host. And the results demonstrate that the form of protocatechuic acid at pH< 1 should be free ligand. CCDC： 191733.     

六钨酸盐为模板的三维网状超分子化合物[La2(DNBA)4(DMF)8][W6O19]的合成和晶体结构

A new three-dimensional (3D) lanthanide-aromatic monocarboxylate dimer supramolecular network [La₂(DNBA)₄(DMF)₈][W₆O₁₉] (DNBA=3,5-dinitrobenzoate, DMF=dimethylfomamide) was synthesized using hexatungstate anion (W₆O₁₉^2-) as template. The crystal structure of the title compound has been determined by single-crystal X-ray diffraction. It crystallizes in triclinic, space group P1 with a=1.334 54(18) nm, b=1.387 52(19) nm, c=1.426 06(19) nm, α=102.189(2)°, β=101.023(2)°, γ=116.349(2)°, V=2.187 2(5) nm³, D_c=2.364 g·cm^-3, Z=1, F(000)=1 453.40. The single crystal structure reveals that two La(Ⅲ) ions are bridged by four 3,5-dinitrobenzoate anions as asymmetrically bridging ligands, leading to dimeric cores, [La₂(DNBA)₄(DMF)₈]²⁺; [La₂(DNBA)₄(DMF)₈]²⁺ groups are joined together by π-π stacking interaction between the aromatic groups to form a two-dimensional grid-like network; the 2D supramolecular layers are further extended into 3D supramolecular network with a 1D box-like channels by hydrogen bonding interactions, in which hexatungstate polyanions reside. CCDC: 284694.     

Synthesis and Structure of Bis[2,6-bis(2-pyridylamino)pyridinium] Tetrachlorocadmiumate(II)

1 INTRODUTION The d10 configuration of Cd(II) permits a wide variety of coordination numbers and geometries[1~3]. In recent years, one-, two- and three-dimensional infinite supramolecular coordination assemblies of Cd(II) have been the subject of great interest owing to their potential applications in catalysis, optical properties, clathration, etc[4~8]. In fabricating the coordination assemblies, organic ligands as well as inorganic anions have been observed to control the structural di…     

Crystal Structure of[La(NO_3)_3(12-crown-4)-(H_2O)](12-crown-4)

ＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆ［Ｌａ（ＮＯ_３）_３（１２－ｃｒｏｗｎ－４）－（Ｈ_２Ｏ）］（１２－ｃｒｏｗｎ－４）ＭａｏＪｉａｎｇ－Ｇａｏ；ＪｉｎＺｈｏｎｇ－Ｓｈｅｎｇ；ＹｕＦｅｎｇ－Ｌａｎ（ＬａｂｏｒａｔｏｒｙｏｆＲａｒｅＥａｒｔｈＣｈｅｍｉ?..     

一个锰(Ⅲ)Schiff碱配合物[Mn(napn)(CH_3OH)_2]ClO_4的合成与晶体结构

合成了一个新配合物[Mn(napn)(CH3OH)2]ClO4 (C26H26 Cl N2O8Mn,Mr = 584.88,H2napn = 双a-萘酚醛缩乙二胺),并测定了其晶体结构。晶体属于三斜晶系,空间群P ,a = 7.813(1),b = 13.025(2),c = 14.089(2) ? = 64.89(3), = 83.98(3), = 78.11(3)海琕 = 1270.16 ?,Z = 2, Dc = 1.529 g/cm3, F(000) = 604, R = 0.0837, wR = 0.1636。锰(Ⅲ)离子的配位构型为拉长的八面体。Schiff碱配体napn2-中的N2O2在赤道平面与锰(Ⅲ)形成四配位,2个CH3OH中的O原子分别在赤道平面两侧轴向位置与锰(Ⅲ)配位。由于Jahn-Teller效应,轴向上的MnO平均键长为2.52 拧A硗猓О写嬖诜肿幽诤头肿蛹淝饧?     

A Novel 3D Supramolecular Network Constructed from [Cu(4,4'-bipyridine)(O_2CMe)_2]_2 Molecular Ladders by Hydrogen Bonding

1 INTRODUCTION In recent years, the assembly of extended supra- molecular architectures from molecular building units has yielded a new generation of materials with diverse network topologies[1～3]. A number of such frameworks have been found to exhibit fascinating physical and chemical properties. The investigation of hydrogen bonding is important for many practical applications, such as the design of antibiotics and development of new materials with programmed properties[4]. A great va…     

Synthese und Kristallstrukturen von (PPh4)2[In(S4)(S6)Cl] und (PPh4)2[In(S4)Cl3]

Synthesis and Crystal Structures of (PPh₄)₂[In(S₄)(S₆)Cl] and (PPh₄)₂[In(S₄)Cl₃] InCl and PPh₄Cl yield (PPh₄)₂[In₂Cl₆] in acetonitrile. This reacts with Na₂S₄ in presence of PPh₄Cl, forming (PPh₄)₂[In(S₄)(S₆)Cl]. Its crystal structure was determined by X-ray diffraction (R = 0.075, 2 282 observed reflexions). It is isotypic with (PPh₄)₂[In(S₄)(S₆)Br] and contains anions with trigonal-bipyramidal coordination of In, Cl occupying an axial position, and the S₄ and S₆ groups being bonded in a chelate manner. The reaction of (PPh₄)₂[In₂Cl₆] and sulfur in acetonitrile yielded (PPh₄)₂[InCl₅] and (PPh₄)₂[In(S₄)Cl₃]. The crystal structure analysis of the latter (R = 0.072, 4 080 reflexions) revealed an anion with distorted trigonal-bipyramidal coordination of In, the S₄ group occupying one axial and one equatorial position; the S₄ group shows positional disorder.     

D,L-1,2,2-三甲基环戊烷-1,3-二胺硝酸镍配合物的合成、结构及其和手性D-(+)-1,2,2-三甲基环戊烷-1,3-二胺氯化镍配合物的对比分析

0IntroductionAsweknow,camphoricderivativespossessingtwochiralcarbonatomsintheirmoleculesoccupyalargebranchoforganiccompoundsandhavebeenusedwidelyinorganicsynthesis.D鄄,L鄄andD,L鄄1,2,2鄄trimethylcyclopentane鄄1,3鄄diaminesareveryusefulintermediatesinorgan