共查询到16条相似文献,搜索用时 78 毫秒
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分子电子器件的化学研究 总被引:5,自引:0,他引:5
在电子工程技术领域中,经历了电子管、晶体管、集成电路、大规模集成电路和超大规模集成电路等五个阶段后,已能在指甲大小的芯片上制成几十万个元件。然而,计算和实验表明, 相似文献
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综述了超分子高分子化学近年来的进展,着重介绍固相聚合和毛杆高分子等方面的最新研究成果及应用展望,对超分子高分子化学的主要研究方法也作了扼要的介绍。 相似文献
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传统化学以研究变化,关注变化前后的结果而著称。化学与其他学科,特别是生命科学的相互渗透使得化学的动态特征更加突出,化学学科格局也因之发生了变化。因此,化学需要新认识。 相似文献
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高效液相色谱在生物医药研究中的应用(Ⅱ)肽化学研究中的高效液相色谱 总被引:3,自引:0,他引:3
七十年代中期以来.色谱学家逐步建立起包括反相HPLC的一整套色谱方法,并运用这些方法在肽的分离纯化,制备,定性定量分析,分子量测定,肽结构与其色谱保留值关系等方面进行了深入的研究。八十年代以来,HPLC在肽化学研究领域得到了广泛应用,取得突破性进展。主要表现在,人们利用HPLC并与其它方法相结合,发现了许多新的天然活性肽,特别是神经肽。如作者自83~88年不完全统计,已确定一级结构的新活性 相似文献
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An active pharmaceutical ingredient (API) is any substance in a pharmaceutical product that is biologically active. That means the specific molecular entity is capable of achieving a defined biological effect on the target. These ingredients need to meet very strict limits; chemical and optical purity are considered to be the most important ones. A continuous-flow synthetic methodology which utilizes a continuously flowing stream of reactive fluids can be easily combined with photochemistry, which works with the chemical effects of light. These methods can be useful tools to meet these strict limits. Both of these methods are unique and powerful tools for the preparation of natural products or active pharmaceutical ingredients and their precursors with high structural complexity under mild conditions. This review shows some main directions in the field of active pharmaceutical ingredients’ preparation using continuous-flow chemistry and photochemistry with numerous examples of industry and laboratory-scale applications. 相似文献
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Dr. Brice Sautier Dr. Carl F. Nising Dr. Lars Wortmann 《Angewandte Chemie (International ed. in English)》2016,55(52):15982-15988
Owing to their high occurrence rate across many human cancers and their lack of druggability so far, mutant forms of the signaling protein Ras are currently among the most attractive (and elusive) oncology targets. This strong appeal explains the sustained effort in the field, and the ensuing progress has rekindled optimism regarding the discovery of Ras inhibitors. In this Minireview, we discuss the most recent advances towards irreversible inhibitors, and highlight approaches to inhibitors of Ras–effector interactions that have been overshadowed by the current focus on direct Ras inhibition. At the same time, we provide a critical assessment from a medicinal chemistry perspective. 相似文献