SPOC教学模式在学科教学(化学)教育硕士培养中的应用——以教育技术在中学化学教学中的应用为例

以师范院校面向学科教学(化学)专业教育硕士开设的"教育技术在中学化学教学中的应用"课程为例,研究了SPOC课程教学资源建设的内容、方法,分析了采用翻转课堂的SPOC教学流程的教学设计策略,比较了应用SPOC教学模式前后的学生学习效果。     

翻转课堂在医学院校卫生化学实验教学中的应用

将翻转课堂教学模式引入到预防医学专业卫生化学实验课中,以“高效液相色谱法测定饮料中的山梨酸与苯甲酸”为例分析翻转课堂设计过程,包括任务单设计、教学视频制作、课堂组织、课后评价等诸多环节。实践表明,翻转课堂的应用,激发了非化学专业学生对卫生化学实验的学习兴趣,调动了学习主动性和积极性,使学生由被动接受者变为主动探究者,而教师则由知识传授者转变为学习促进者和指导者,有利于培养学生自主学习能力和创新合作精神。     

后MOOC时期高职分析化学混合式教学模式构建

为了全面提高后MOOC时期的高职院校分析化学课程教学质量，提出了基于SPOC的分析化学课程混合式教学模式。首先分析了高职学生的特点和分析化学课程教学中的主要问题；然后根据基于SPOC的混合式教学模式构建流程，依次阐述了课程分析、整体设计、资源开发、教学过程和评价考核设计的原则与思路；最后探讨了基于翻转课堂的分析化学课程混合式教学环境与实施过程。     

基于多维任务驱动下的物理化学实验课程探索*

设计不同维度的课程任务学习单,并将自主探究、协作交流等学习模式引入物理化学实验的实践教学,深入探讨了物理化学实验课程实施翻转课堂的教学模式的研究。整个教学环节包括:课前资源导学、课内知识拓展、课后成效评价。实践表明,翻转课堂有利于提高学生的知识内化能力、分析解决问题能力、合作交流能力以及自学能力,尤其是文献调研的能力有显著提升,该模式取得了较好的教学效果。     

翻转课堂模式在旋光度测定实验教学中的应用

以糖类物质旋光度的测定为例,探索了翻转教学在医学院校基础有机化学实验教学中的应用。包括设计任务书、制作教学视频及文档、查找相关文献、课堂活动、教学总结及反思等多个环节。实践表明,翻转课堂在实验教学中的应用,改善了课前预习流于形式的状况,培养了学生主动学习的能力,激发了医学专业学生对基础有机化学实验的学习兴趣。     

线上线下混合式教学结合翻转课堂进行酯缩合反应的教学*

采用“线上线下混合式教学”开展有机化学课程的教学工作,利用APP “学习通”将在线课堂教学和线下讲授相结合。以知识点酯缩合反应的教学为例,介绍了该教学模式的实施过程和教学效果。实践结果表明,线上线下混合式教学与翻转课堂相结合的教学模式,能够拓展化学专业学生知识面,提升学生的自主学习能力和学习的积极性,取得了较好的教学效果。     

翻转课堂教学模式在普通化学教学中的应用与评价

首次探讨了在普通化学民族班教学中应用"翻转课堂"的教学模式,并就教学效果进行了评估。翻转课堂教学模式充分调动了民族班学生的学习积极性和主动性,同时提高了教师的教学水平,取得了较好的教学效果。为在对母语为非汉语的学生开设的普通化学课程教学中逐步采用"翻转课堂"教学模式替代传统教学模式提供了成功的经验。     

信息化网络环境下高职应用型课程翻转课堂的教学设计与实施——以“中药制剂检验技术”为例

以"中药制剂检验技术"课程为例,在课前、课内、课后3个阶段,从理论和实践的角度探讨了如何利用N-CLASS网络平台构建和实施高职药品检验类课程的翻转课堂。结果表明,在药品检测类课程中,利用信息技术构建的翻转课堂不仅能够激发学生学习的主动性和学习兴趣,同时也培养了独立学习和协作学习的能力,明显提升了教学效果。     

大学无机化学“原电池”翻转课堂教学研究

通过翻转课堂与传统课堂在学习目标与教学流程上的对比,详细阐述了"原电池"翻转课堂的教学设计特点与实践研究过程,即课前利用微视频和学习单自主学习形成基本概念,课堂上通过解决问题实现重要概念内化,课后通过开放性问题体验原电池的价值。实践结果显示,"原电池"翻转课堂教学设计与实践能够更好地促进学生的发展,并在一定程度上优于传统课堂教学。     

基于教育游戏的翻转课堂教学设计——以“原电池的设计”为例

在国内外翻转课堂相关文献对比和教育游戏特点分析基础上,尝试进行了基于教育游戏的高中化学“原电池的设计”的翻转课堂教学设计,利用教学游戏,充分调动学生的学习兴趣,提高翻转课堂课前学习效率。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Microwave-assisted copper-catalyzed stereoselective ring expansion of three-membered heterocycles with α-diazo-β-dicarbonyl compounds

Microwave-assisted copper-catalyzed ring expansions of three-membered heterocycles with α-diazo-β-dicarbonyl compounds were investigated. Thiiranes generated 3-acyl-5,6-dihydro-1,4-oxathiines in the presence of copper sulfate and trans-3-acyl-5,6-dihydro-1,4-oxathiines as stereospecific products for 1,2-disubstituted cis-thiiranes through an intramolecular S_N2 process. Oxiranes gave rise to 2-acyl-5,6-dihydro-1,4-dioxines under the catalysis of copper hexafluoroacetylacetonate and cis-3-acyl-5,6-dihydro-1,4-dioxines as stereospecific products for 1,2-disubstituted cis-oxiranes via an intimate ion-pair mechanism. The current method provides a direct and simple strategy in efficient preparation of 3-acyl-5,6-dihydro-1,4-oxathiines and 2-acyl-5,6-dihydro-1,4-dioxines, important agents in medicinal and agricultural chemistry, from readily available thiiranes and oxiranes, respectively.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.