共查询到20条相似文献,搜索用时 93 毫秒
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标题化合物C1 5H1 6NO3由苯甲醛、醋酸铵、乙酰乙酸乙酯、麦氏酸在微波辐射下干反应而得。结构通过单晶X 射线衍射法测定 ,其晶体属单斜晶系 ,空间群P1 ,a =7.870 (1 ) ,b =9 2 90 (1 ) ,c=1 0 .640 (2 ) ,α =1 0 2 .76(3) ,β =1 1 0 .42 (3) ,γ =96.92 (3)°,V =694.2 (2 ) 3,Z =2 ,Mr=2 59.30 ,Dc=1 .2 4 0 g/cm3,μ(MoKα) =0 .0 86mm- 1 ,F(0 0 0 )=2 76。晶体结构用直接法解出 ,经用全矩阵最小二乘法对原子参数进行修正 ,最终的偏离因子为R =0 0 4 2 3,wR =0 .1 2 57。在晶体结构中 ,吡啶酮环与苯环之间的二面角为 87.31°。 相似文献
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1,4-二氢吡啶的微波合成新方法 总被引:5,自引:0,他引:5
研究了微波作用下1,4-二氢吡啶-3,5-二甲酸乙酯(3)的合成,结果表明,在微波的作用下,用简单易得的原料如(HCHO)n,HCHO/H2O,(CH2)6N4,NH4OAc,NH3/H2O,NH4HCO3,(NH4)2CO3等就可以得到3,收率在50%左右。微波可以很容易地由甲醛水溶液和氨水为反应物得到3,传统方法根本得不到。反应中只使用少量乙醇,而用甲醛水溶液的反应是无溶剂合成。 相似文献
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立体选择合成是当今有机合成中一个较新的,极其活跃的研究领域。而利用手性模板进行不对称诱导反应,则是立体选择合成的一种重要方法。近年来,国外报道了许多利用手性模板获得高光学纯度的氨基酸的事例。1981年,Schoellkopf 等用环烯状的双内酰亚胺作手性模板获得了高光学纯度的α-氨基酸。1986年,Williams 用亲电性的甘氨酸内酯作为手性模板进行不对称诱导反应,得到了光学纯度96.5~99.5%的一系列α-取代氨基酸。因此,选择一个好的手性模板是获得高光学纯度产物的关键。较理想的手性模板必须满足以下条 相似文献
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以取代苯甲醛、乙酰乙酸乙酯和尿素为原料,以溶胶凝胶法制备二氧化硅负载的磷钨酸(H3PW12O40/SiO2)为催化剂,催化合成3,4-二氢嘧啶-2(1H)-酮,考察了三组分摩尔比、反应温度、催化剂用量及反应时间对反应收率的影响。 研究表明,H3PW12O40/SiO2是合成3,4-二氢嘧啶-2(1H)-酮的良性催化剂,在取代苯甲醛的用量为0.04 mol,反应温度为90 ℃的条件下,收率可达73.1%~88.4%。 催化剂和产品结构分别经IR、XRD、SEM和1H NMR、IR、MS等技术手段表征。 相似文献
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Wei Sun Linjie Tian Hui Qi Dan Jiang Ying Wang Song Li Junhai Xiao Xiaohong Yang 《中国化学》2013,(9):1144-1152
A series of tri-substituted chiral pyrrolidin-2-one derivatives have been designed and synthesized as CC chemokine receptor 4 (CCR4) antagonists. The structure of CCR4 was built by homology modeling. Asymmetric synthesis was applied to synthesize the R,R configuration chiral pyrrolidin-2-one scaffold. The stereoisomeric con- figurations of the compounds were identified by 2D I H-~H COSY spectroscopy and 1D NOESY spectroscopy. This method was more economical and convenient than traditional X-ray single crystal diffraction. In addition, the inter- actions between these compounds and the N-terminal extracellular tail of CCR4 were studied using capillary zone electrophoresis. The CCR4 chemotaxis inhibition effect was tested in CCR4-transfected HEK293 cells. Several compounds showed potent activities as CCR4 antagonists. Among these compounds, lc is the most active one. Its apparent binding constant of CZE experiment result is (1.569±0.11)× 10s L·mol ^-1, and its percentage inhibition of the HEK293/CCR4 cells migration with the concentration of I gmol·L ^-1 in DMSO is 59%. And compound If has slightly higher affinity to N-terminal of CCR4 according to its apparent binding constant than lb because of the in- troduced ester linkage. Further studies on the mechanism of these compounds are in progress. 相似文献
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The attempted Baylis-Hillman reactions of sulfonyl aldimines or aryl aldehydes with 3-methylpenta-3,4-dien-2-one or 3-benzylpenta-3,4-dien-2-one gave the corresponding Baylis-Hillman adducts in moderate yields in DMSO under the catalysis of DBU or PMe3, respectively. Moderate diastereoselectivities were observed in the reaction of 3-benzylpenta-3,4-dien-2-one with N-arylmethylidene-1-naphthalenesulfonamides catalyzed by chiral catalyst cinchona alkaloid derivative TQO {4-(3-ethyl-4-oxa-1-azatricyclo[4.4.0.0^3,8]dec-5-yl)quinolin-6-ol}. 相似文献
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Gade Srinivas Reddy Kadaboina Rajasekhar Cherukupally Praveen Kaga Mukkanti 《合成通讯》2013,43(22):3884-3893
3,4-Dihydro-1,4,4a,6a-tetraaza-benzo[a]fluoren-2-one, a new tetracyclic heterocyclic framework, is designed through a simple and convenient synthetic sequence. Its 6-aryl derivatives are synthesized starting from 1H-indole-2-carboxylic acid. The reaction of differently substituted phenacyl bromides with 1H-indole-2-carboxylic acid and POCl3-mediated cyclization of the resultant 1H-indole-2-carboxylic acid phenacyl ester provided 2-oxa-4a-aza-fluoren-1-one, and its sequential reaction with hydrazine and 2-chloro-acetamide furnished the desired new heterocyclic compounds 7a–f. 相似文献