Abietane lactones and iridoids from Goldfussia yunnanensis

Two new abietane diterpene lactones (1--2), three new abietane diterpene lactone glycosides (3--5) and a new iridoid glycoside (6), together with five known compounds, were isolated from the aerial parts of Goldfussia yunnanensis. The new compounds were determined to be 18-hydroxyhelioscopinolide A (1), 18-oxohelioscopinolide A (2), 18-hydroxy-3-O-beta-D-glucopyranosylhelioscopinolide A (3), 3-O-beta-D-glucopyranosylhelioscopinolide A (4), 3-O-beta-D-galactopyranosylhelioscopinolide A (5), and 6-O-trans-cinnamoyl E-harpagoside (6) on the basis of spectral data and chemical evidence.     

Norditerpenoid alkaloids from the processed tubers of Aconitum carmichaeli

Four new and five known norditerpenoid alkaloids were isolated from the processed tubers of Aconitum carmichaeli. The new alkaloids are 14-O-cinnamoylneoline (3), 14-O-anisoylneoline (4) 14-O-veratroylneoline (5), and lipo-14-O-anisoylbikhaconine (8). The known alkaloids are neoline (1), 14-O-acetylneoline (2), foresaconitine (6), crassicauline A (7), and lipohypaconitine (9). Alkaloids 2, 6, and 7 were isolated from this plant for the first time. The structures of the new alkaloids were established by spectroscopic and chemical methods.     

高乌头根中新的二萜生物碱

从高乌头根中分离得到3个新的冉乌头型的C₁₈-二萜生物碱高乌宁己(1)、高乌宁庚(3)、高乌宁辛(5)和一个新的牛扁碱型C₁₉-二萜生物碱高乌宁壬(7). 它们的结构通过IR, ¹H NMR, ¹³C NMR, MS予以确证.     

Terpenoids and coumarins isolated from the fruits of Poncirus trifoliata

Four new triterpenes, 21alpha-methylmelianodiol (1), 21beta-methylmelianodiol (2), hispidol A 25-methyl ether (3) and hispidol B 25-methyl ether (4), and a new coumarin, isoschininallylol (5), were isolated from the fruits of Poncirus trifoliata RAFINESQUE, along with seventeen known compounds. The structures of the new compounds (1 - 5) were elucidated by interpretation of their spectroscopic data.     

Cussosaponins A-E,triterpene saponins from the leaves of Cussonia racemosa,a Malagasy endemic plant

Five new triterpene saponins, cussosaponins A (2), B (3), C (4), D (5), and E (6), were isolated from the dried leaves of Cussonia racemosa BAKER. The structures of these new compounds were deduced on the basis of chemical and spectroscopic evidence.     

Diterpenes from Sideritis trojana

Six known ent-kaurene, a new ent-kaurane and a new pimarane diterpenes were isolated from Sideritis trojana. The structures of new compounds were determined as ent-7alpha-15beta,16beta-epoxykaurane (1), and ent-2alpha-hydroxy-8(14),15-pimaradiene (2) along with the known compounds siderol (3), sideridiol (4), 7-epicandicandiol (5), isocandol B (6), candol A acetate (7) ent-7alpha-acetoxykaur-15-ene (8) by IR, 1D and 2D NMR techniques and HRMS.     

Studies on the constituents of Swertia japonica Makino II. On the structures of new glycosides

Two new secoiridoid glycosides, swertiajaposide A (1) and swertiajaposide B (2), a new unsaturated alco-hol glycoside, 3-butenyl 6'-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside (3), and a new lignan glycoside, 7R,7'R,8S,8'S-(+)-neo-olivil-4-O-beta-D-glucopyranoside (4), were isolated together with six known compounds from the whole plants of Swertia japonica Makino. The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence.     

New Oligosaccharide Esters and Xanthone C‐Glucosides from Polygala telephioides

Three new oligosaccharide esters named telephioses D ( 4 ), E ( 5 ), and F ( 6 ), and two new xanthone C‐glucosides, telephioxanthones A ( 7 ) and B ( 8 ), together with five known oligosaccharide esters and mangiferin, were isolated from the whole plant of Polygala telephioides Willd . The structures of the new compounds were elucidated on the basis of spectral data.     

Four new terpenes from the pericarp of Platycladus orientalis

A new monoterpene, platydiol (1), and three new diterpenes, platyclolactonic acid (2), 14,15-bisnor-8(17)-labdene-16,19-dioic acid (3), and 6,7-dehydrosandaracopimaric acid (4), were isolated from the pericarp of Platycladus orientalis. Their structures were elucidated by spectral and chemical methods.     

Anthraquinones from Ophiorrhiza hayatana OHWI

Three new naturally occurring anthraquinones, ophiohayatone-A (1), -B (2), and -C (3), together with four known anthraquinones, were isolated from Ophiorrhiza hayatana OHWI (Rubiaceae). Structures of these new compounds were established by spectral methods.     

Constituents of the Vietnamese medicinal plant Orthosiphon stamineus

From the MeOH extract of the aerial part of Vietnamese Orthosiphon stamineus, five new isopimarane-type diterpenes [orthosiphols F-J (1-5)] and two new diterpenes [staminols A (6) and B (7)] with a novel carbon-framework, to which we proposed the name "staminane", and three new highly-oxygenated staminane-type diterpenes [staminolactones A (8) and B (9) and norstaminol A (10)1 were isolated. Moreover, staminolactone A (8) is 8,14-secostaminane-type and staminolactone B (9) is 13,14-secostaminane-type, while norstaminol A (10) is 14-norstaminen-type. Together with these new diterpenes, sixteen known compounds were also isolated and identified to be: 7,3',4'-tri-O-methylluteolin (11), eupatorin (12), sinensetin (13), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (14), salvigenin (15), ladanein (16), tetramethylscutellarein (17), 6-hydroxy-5,7,4'-trimethoxyflavone (18), vomifoliol (19), aurantiamide acetate (20), rosmarinic acid (21), caffeic acid (22), oleanolic acid (23), ursolic acid (24), betulinic acid (25), and beta-sitosterol (26). All the isolated compounds were tested for their cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, and the new diterpenes, except for 4, and flavonoids (11, 12, 16, 18) showed cytotoxicity with an ED50 value between 10 and 90 microg/ml.     

Cadinane-type sesquiterpenes from the roots of Taiwania cryptomerioides Hayata

Five new cadinane-type sesquiterpenes, 15-acetoxy-T-muurolol (1), isokhusinodiol (2), cadin-10(14)-ene-4beta,5alpha-diol (3), cadinane-4beta,5alpha,10beta-triol (4), and muurolane-4beta,5beta,10beta-triol (5), together with five known compounds, T-cadinol (6), T-muurolol (7), alpha-cadinol (8), delta-cadinol (9), and khusinodiol (10), were isolated from the roots of Taiwania cryptomerioides. The structure of the new constituents were elucidated through chemical and spectral studies.     

Constituents of the pollen of Crocus sativus L. and their tyrosinase inhibitory activity

Five new naturally occurring monoterpenoids, crocusatins-A (1), -B (2a), -C (3), -D (4a) -E (5), a new lactate, sodium (2S)-(O-hydroxyphenyl)lactate (6), and eighteen known compounds were isolated and characterized from the pollen of Crocus sativus L. The tyrosinase inhibitory activities of these compounds were also discussed.     

New C18-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri

Five new C18-diterpenoid alkaloids, anthriscifolcines A (1), B (2), C (3), D (4), and E (5), together with a known C19-diterpenoid alkaloid delcorine (6), were isolated from the whole herb of Delphinium anthriscifolium var. savatieri. The structures of these new alkaloids were established on the basis of spectral data (1D- and 2D-NMR, HR-ESI-MS).     

Three new quassinoids,ailantinol E,F, and G,from Ailanthus altissima

Three new quassinoids, ailantinol E (1), ailantinol F (2), and ailantinol G (3), and related compounds were isolated from Ailanthus altissima grown in Taiwan. Their structures were elucidated from spectral evidence. Each new quassinoid was evaluated for its antitumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The new quassinoids were found to show potent activity without showing any cytotoxicity. The screening for inhibitors against nitric oxide donor action was also conducted using the new quassinoids and some standard samples.     

Alkoxy Derivatives of Diantipyrylphenylmethane As New Analytical Reagent For The Spectrophotometric Determination of Vanadium(V)

Five new alkoxy derivatives of diantipyrylphenylmethane were synthesized and identified. They are diantipyryl-(o-methoxy)-phenylmethane(DAoMM), diantipyryl-(p-methoxy)-pheny-hlmethane (DApMM), diantipyryl-(o-ethoxy)-phenylmethane(DAoEM), diantipyryl-(m-ethoxy)-phe-nylmethane (DAmEM), diantipyryl-(p-ethoxy)-phenylmethane(DApEM). Their color reactions with Vanadium(V) were studied and five new supersensitive spectrophotometries for the determination of Vanadium(V) were established.     

Three new Anthraquinones,one new Benzochromene and one new Furfural glycoside from Lasianthus acuminatissimus

Three new anthraquinones, lasianthurin B (1), C (2), lasianthuoside D (3), a new benzochromene, lasianthurin D (4), and a new furfural glycoside, lasianthuoside E (5), together with one known compound 4- hydroxymethyl-2-furaldehyde (6) were isolated from an alcohol extract of the root of Lasianthus acuminatissimus. Their structures were elucidated on the basis of extensive spectroscopic data analysis (including 1D, 2D NMR, X-ray, and MS experiments) and comparsion to literature data.     

Pentacyclic triterpenoids from the aerial parts of Lantana camara

Three new pentacyclic triterpenoids, camaryolic acid (1), methylcamaralate (2) and camangeloyl acid (3) and six known compounds beta-sitosterol 3-O-beta-D-glucopyranoside (4), octadecanoic acid (5), docosanoic acid (6), palmitic acid (7), camaric acid (8) and lantanolic acid (9) were isolated from the aerial parts of Lantana camara. Structures of the new compounds were elucidated by spectroscopic and chemical methods.     

Three New Terpenoids from Pinus yunnanensis

A new abietatrienoid, 15‐methoxydidehydroabietic acid ( 1 ), a new ring B‐seco abietatrienoid, 10‐hydroxy‐9,10‐secoabieta‐8,11,13‐trien‐18‐oic acid ( 2 ), and a new tetracyclic triterpenoid, pinusyunnanol ( 3 ), together with five known compounds, were obtained from the twigs and needles of Pinus yunnanensis. The structures of the new compounds were elucidated by means of extensive spectroscopic analyses.     

A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

A new triterpenoid saponin with novel sugar moiety (1), a new trisaccharide derivative (2), as well as a known monosaccharide derivative (3), were isolated from the dried stem of Epigyhum aurilum. The structures of compounds 1 and 2 were determined by MS and NMR spectram analyses.