新型异戊烯并环黄酮化合物的合成

以间苯三酚和3,3-二甲基烯丙酸为起始原料,通过苄基保护、甲基化、脱保护基、Clemmenson还原、乙酰化、Fries重排、Baker-Venkataraman重排和成环等10步反应, 以18.2%的总收率合成了1个新型异戊烯并环黄酮化合物BE-1C,其结构经¹H NMR, ¹³C NMR和HR-MS(ESI-TOF)表征。     

新型多氢键双功能手性酰胺类化合物的高效合成

以BINOL-3,3′-二羧酸为原料,经外消旋化合物的拆分和缩合反应,合成了7个新型的联二萘骨架手性酰胺类化合物,收率51%~70%,其结构经¹H NMR, ¹³C NMR, FT-IR, HR-MS（ESI）和元素分析表征。     

铜催化的苯并恶唑、五氟苯与O-苯甲酰羟胺的C-H键胺化反应

以四氢呋喃为溶剂，在碘化亚铜催化下，苯并恶唑和五氟苯等缺电子芳烃体系与O-苯甲酰羟胺发生C-H键亲电胺化反应，分别以42%~92%和20%~84%的收率合成了多种2-氨基苯并恶唑和五氟苯胺衍生物，其结构经¹H NMR和¹³C NMR表征。      

新型3-哌啶/吡咯烷氧化吲哚的合成

以3-卤氧化吲哚、哌啶或吡咯烷为起始原料,碳酸钠为催化剂,于65 ℃经3-叔胺基化反应,合成了15个新型的3-哌啶/吡咯烷氧化吲哚,收率84%~93%,其结构经¹H NMR, ¹³C NMR和HR-MS（ESI-TOF）表征。     

吲哚与含CF3氮杂对亚甲基苯醌的1,6-共轭加成反应合成含CF3的吲哚衍生物

以5 mol%布朗斯特酸(±)-BNPA为催化剂，含CF₃氮杂对亚甲基苯醌与吲哚为原料，通过1,6-共轭加成反应合成了7个结构新颖的含CF₃的吲哚类化合物，收率80%~87%，其结构经¹H NMR， ¹³C NMR， ¹⁹F NMR和HR-MS(ESI)表征，并对反应机理进行了探讨。     

5-炔基噁唑啉-2-酮的合成

以廉价易得的取代酸为原料,经取代、硝基还原、氨基磺酰化、炔基格氏试剂加成和羰基化环化反应合成了13个5-炔基噁唑啉-2-酮类化合物,收率为10.6%~71.8%。产物结构经¹H NMR和¹³C NMR确证。      

手性方酰胺催化巴比妥酸和硝基烯的不对称Michael加成反应

用手性环己二胺衍生的方酰胺催化1,3-二甲基巴比妥酸和硝基烯的不对称Michael加成反应,合成了一系列新型巴比妥衍生物,其结构经¹H NMR和¹³C NMR表征。并考察了底物结构对反应收率和立体选择性的影响。结果表明：该反应可获得较高的收率(80%~100%)和中等至良好的对映选择性(ee 43%~90%)。     

甲基对硫磷-D6的合成

报道了一种合成甲基对硫磷-D₆的新方法。以三氯硫磷、氘代甲醇和对硝基苯酚为起始原料,经三次酯化反应合成了目标产物甲基对硫磷-D₆,总收率47.6%,其结构经¹H NMR、 ¹³C NMR、 ³¹P NMR和HR-MS(ESI)确证。     

新型甘油拼接3-四取代氧化吲哚的无催化剂无溶剂合成

以3-氯氧化吲哚为原料，在无催化剂、无溶剂条件下于80 ℃发生亲核取代反应，合成了10个新型的甘油拼接3-四取代氧化吲哚，收率54%~72%， dr值10/9~>10/7, 其结构经¹H NMR, ¹³C NMR和HR-MS（ESI-TOF）表征。     

硫化镉量子点催化的光诱导肉桂酸脱羧二氟烷基化反应

以硫化镉量子点为催化剂，在光照条件下以二氟溴乙酸乙酯为二氟烷基化试剂，高效地实现肉桂酸脱羧二氟烷基化反应,共合成了18个含有烯丙基二氟模块的化合物（3a~3r），收率53%~80%，其结构经¹H NMR，¹³C NMR，¹⁹F NMR确证。该反应条件温和，底物适用范围广，官能团耐受性好。自由基抑制实验结果表明：反应经过自由基途径。      

Furyl- and thienyl-silatranes and germatranes

We review our research on the synthesis and study of the physical and biological properties of furyl- and thienylgermatranes and -silatranes.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 725–732, June, 1992.     

Review and patents and literature

The use of the insect cell/baculovirus expression system for producing recombinant proteins of bacterial, plant, insect, and mammalian origin has become widespread. The popularity of this eukaryotic expression system is due to many factors, including (1) potentially high protein expression levels, (2) ease and speed of genetic engineering, (3) ability to accommodate large DNA inserts, (4) protein processing similar to higher eukaryotic cells (e.g., mammalian cells), and (5) ease of insect cell growth (e.g., suspension growth). The following review of the literature discusses two engineering aspects of recombinant protein synthesis by insect cell cultures: bioreactor scale-up and insect cell line selection. Following this review patent abstracts and additional literature pertaining to expression of recombinant proteins in insect cell culture are listed.     

多环芳二酐型聚酯亚胺膜的透气性能

多环芳二酐型聚酯亚胺膜的透气性能李悦生，丁孟贤，徐纪平（浙江大学高分子科学与工程研究所，杭州，３１００２７）（中国科学院长春应用化学研究所）关键词聚醚酰亚胺，聚酯酰亚胺，膜，透气性通常的聚酰亚胺加工性能较差，在芳环二酐的苯环间引入醚键等柔性基团后，其...     

微量元素与疾病诊断治疗的研究现状及展望

对国内外微量元素与疾病的关系及其诊断治疗的研究现状及研究动向进行了综述，包括：微量元素与地方病、癌肿、心血管病、糖尿病、眼病、神经系统病等。参考文献72篇。     

Preparation and photolysis of poly-p-ethylacrylophenone and poly-p-chloroacrylophenone and their copolymers with styrene and methyl methacrylate

Poly-p-ethylacrylophenone (PPEtAP) and poly-p-chloroacrylophenone (PPClAP) and their copolymers with styrene (PEtAP/S) and (PClAP/S) and with methyl methacrylate (PEtAP/MMA) and (PClAP/MMA) were prepared. Quantum yields of main-chain scissions at 366 nm at room temperature in benzene solution are of the same order as those of the unsubstituted polyacrylophenone and its copolymers. Substitution with chlorine and ethyl group in the para position compared to the unsubstituted polyacrylophenone and its copolymers leads to an increase of the lifetime for the n–π^* excited triplet state, as is evident from the measured quenching constants of photolysis. The low-temperature emission spectra of the copolymers are similar to the spectra of the model compounds in a polymer film. For the homopolymer, however, the character of the emission spectrum changes considerably.     

Concentrations and distributions of trace and minor elements in Chinese and Canadian coals and ashes

A total of 35 trace and minor elements including some of environmental significance were determined in each of a selection of 15 Chinese and 6 Canadian thermal coals and their ashes by using the SLOWPOKE-2 nuclear reactor facility of the University of Toronto. The concentrations and distributions of these constituents among the coals and their combustion products (viz. ash and volatile matter) are presented together with an interpretation of their significance in relation to the large scale combustion of these coals as thermal fuels in industrialized countries such as China and Canada. The detailed results showed wide variations in trace impurity concentrations (up to a factor of 100 and more) among the coals studied with few large differences between those of Chinese and Canadian origin except that the rare earths, Sc, Th, U, I, and Se were much higher in the former, other halogens, As and Na were lower. Values for elemental enrichment factors (EF) relative to normal crustal abundances indicated that only As(EF=13), Br(5.7), I(16), S(230), Sb(11) and Se(320) were appreciably enriched in coal. During static ashing at 750°C most of the halogens, S and Se were volatilized whereas most other inorganic constituents were highly retained and concentrated in the ash by factors of 6 to 11.