A Novel Sesquiterpene Polyol Ester from Celastrus Angulatus and its Antitumor Activities

Chinesebittersweet(CelaslrusangulalusM.)iswidelydistributedinChina.IthasbeenusedastraditionalplantinsecticideandamedicinalherbformanyyearsinthefolkmedicineofChina'-'.Inpreviousstudies,P-dihydroagarofuransesquiterpenepolyolestersandsesquiterpenealkaloidswerefrequentlyfoundinthecelaslrusfamilyofplants'-',ItwasreportedthatmostofP-dihydroagarofuransesquiterpenepolyolestersfromChinesebit-tersweethaveinhibitoryeffectsonEBVandantitumoractivity'.,'.InourattempttofindnovelbioactivecompoundsintheCh…     

A New Sesquiterpene from Celastrus Angulatus

Inourpreviouspaper',wereportedthemethodologicstudiesonauthenticatingplantspeciesbyIHNMRfinger-printsofthecharacteristicgeneralextractsofplants.Incontinuationofourworkonthissubject,ourattentionwasdrawntotheassignmentsofthesignalsintheIHNMRfinger-printsofplants,thatwastheinvestigationoftheconstituents.Inthecourseofourresearch,anewsesquiterpenepolyolesternamedangulatinCwasisolatedfromtherootbarkofC.angulatusalongwithaknowncompound,angulatinB.Inadditiontoinsecticidalactivity,angulatinCalsosh…     

Two New Sesquiterpene Polyol Esters from Celastrus angulatus

Two novel sesquiterpene polyol esters with a dihydro‐β‐agarofuran (=(3R,5aS,9R,9aS)‐octahydro‐2,2,5a,9‐tetramethyl‐2H‐3,9a‐methano‐1‐benzoxepin) skeleton, (1α,2α,4β,8α,9α)‐1,2,8,12‐tetrakis(acetyloxy)‐9‐(furoyloxy)‐4‐hydroxydihydro‐β‐agarofuran ( 1 ) and (1α,2α,6β,8α,9α)‐1,2,6,8,12‐pentakis(acetyloxy)‐9‐(benzoyloxy)dihydro‐β‐agarofuran ( 2 ), and the three known compounds (1α,2α,4β,6β,8α,9β)‐1,2,6‐tris(acetyloxy)‐9‐(benzoyloxy)‐4‐hydroxy‐8,12‐bis(isobutyryloxy)dihydro‐β‐agarofuran ( 3 ), (1α, 2α,4β,6β,8α,9β)‐1,2,6,8‐tetrakis(acetyloxy)‐9‐(furoyloxy)‐4‐hydroxy‐12‐isobutyryloxy)dihydro‐β‐agarofuran ( 4 ), and (1α,2α,4β,6β,8α,9β)‐1,2,6‐tris(acetyloxy)‐9‐(benzoyloxy)‐4‐hydroxy‐8‐(isobutyryloxy)‐12‐[(2‐methylbutanoyl)oxy]dihydro‐β‐agarofuran ( 5 ) were isolated from the root bark of Celastrus angulatus. Their chemical structures were elucidated by analyses of their MS and NMR data.     

苦皮素的结构修饰研究

以苦皮藤中的有效杀虫成份苦皮素为原料合成了 8种衍生物 ,用元素分析、核磁共振波谱等数据对其进行了结构确证 .以 3龄虫 (mythimnaseparatawalker)为试虫 ,测定了它们的杀虫活性 .结果表明 ,苦皮素衍生物对粘虫表现程度不等的杀虫效果     

Sesquiterpene esters from the fruits of Celastrus orbiculatus

Three new beta-dihydroagarofuran sesquiterpene esters, 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-butanoyloxy-beta-dihydroagarofuran (1), 6 alpha-acetoxy-9 beta-benzoyloxy-1 beta-cinnamoyloxy-8 beta-(2-methylbutanoyloxy)-beta-dihydroagarofuran (2), and 6 alpha-acetoxy-1 beta,8 beta-dibenzoyloxy-9 beta-hydroxy-beta-dihydroagarofuran (6), together with three known compounds (3-5) were isolated from the fruits of Celastrus orbiculatus THUNB. Their structures were elucidated on the basis of spectroscopic methods. Compound 4 showed moderate activity in inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells with an IC(50) value of 43.7 microM.     

A New Sesquiterpene from Saussurea parviflora

A new sesquiterpene:11,12,13-trihydroxy-4(15),7(8)-eudesmdien-9-one was isolated from Saussurea parviflora. The structure was elucidated on the basis of spectral evidence.     

牛尾蒿中—新倍半萜结构的确定

牛尾蒿中—新倍半萜结构的确定李瑜，杨立，师彦平（兰州大学应用有机化学国家重点实验室，兰州，７３００００）关键词牛尾蒿，倍半萜，牛尾蒿酮牛尾蒿（ＡｒｔｅｍｉｓｉａＳｕｂｄｉｇｉｔａｔａ）是菊科蒿属的一种多年生草本植物，广布于华北、东北、西北和西南等地区...     

A New Sesquiterpene from Michelia yunnanensis

MicheliayunnanensisFr.exFin.etGagnisaChinesetraditionalmedicinefortreatmentofinflammation.Weobtainedanewsesquiterpene1,throughinvestigationoftheplant,togetherwithtwoknowncompoundsPhydroxyarbusculinAZIandparthenolide32.Compound1,needlecrystal,mp146"C,[a];z-2.56(c0.391,CHC13),displayedstrongabsorptionsforhydroxylandestergroups(3339cm-',3298cm',1750..-i,1742cm')inIR.HRFAB MSmlz:389.2168[(M l) ,Cafe.forC19H33OS:389.21751agreedwithmolecularformulaC19H32O8.Fourunsaturations,twoofwhichwer…     

A New Sesquiterpene from Ligularia Songarica

ThechemicalstudiesofLigulariasongaricahavenotbeenreportedtillnow.Inourpreliminarystudyontherootsofthisplant,anewbisabolanesesquiterpenewasobtainedanditsstructurewasidentifiedasSp-acetoxy-40,8-diangeloyloxy-26,3p,;10,Ildiepoxy-bisabola-7(14)-ene1.,Com...     

A New Bisabolane Sesquiterpene from Cremanthodium Discoideum

ThegenusCremanthodium(ComPositae)isaTibetan-traditionalmedicineusedforanti-inflanunation,painreliefandcuringaPoplexy'.Incontinuationofourstudies0nCremanthodiumplantS',wenowreport0ntheisolahonandstrUctUreelucidationofanewbisabolanesesquiterpenefromCremanth0diumdiscotheum.ComPound1,gum,[a]io53.3(cl.0,CHCl3),TheFABmassspectrUmsh0wedaquasim0lecularionpeak559[M H] anditSisotopicpeakofll3intensityatInlz56l,whichsuggestedthemolecularformulatobeC28ffi3O9Clinagreementwiththe13CNMRandDEPTsp…     

A New Sesquiterpene Lactone from Ainsliaea bonatii

A new sesquiterpene lactone, Ainsliaolide A, was isolated from Ainsliaea bonatii. The structure was determined on the basis of spectral data.     

A New Eremophilanoid Sesquiterpene from Senecio oldhamianus

A new Eremophilanoid sesquiterpene(1) was isolated from the whole plant of Senecio oldhaminus. Its structure was elucidated as 7β,11-epoxy-9α,10α-epoxy-8-oxoeremophilane using spectroscopic methords and X-ray analysis.     

A New Sesquiterpene Lactone from Scorzonera austriaca

A new guaianolide was isolated from the roots of Scorzonera austriaca. The structurewas elucidated on the basis of spectral methods including 2D NMR.     

A New Phytotoxic Sesquiterpene from Inula japonica

Chemistry of Natural Compounds - A new eudesmane sesquiterpene, 12-acetoxy-1β,2α-dihydroxyeudesma-4(15),11(13)-diene (1), was isolated from Inula japonica. The chemical structure of...     

A New Nortriterpene from the Root of Celastrus hypoleucus

A new nortriterpene, 2‐hydroxy‐3‐methyl‐21‐oxo‐12,24‐dinor‐D : B‐friedooleana‐1,3,5(10),7‐tetraen‐29‐oic acid ( 1 ), was isolated from the root of Celastrus hypoleucus, together with the two known compounds, celastorol ( 2 ) and pristimerine ( 3 ). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1 – 3 exhibited in vitro significant antioxidant (against lipid peroxidation; by the TBARS method) and antitumor activities (against cancer cell lines P‐388, A‐549, HL‐60, and BEL‐7402).     

A New Irregular Trihydroxy Sesquiterpene from Teucrium mascatense

A new trihydroxy sesquiterpene, rel‐(1R,4aR,5S,6S,7S,8aR)‐decahydro‐6,8a‐dimethyl‐5‐(propan‐2‐yl)naphthalene‐1,6,7‐triol ( 1 ), has been isolated as a result of the phytochemical investigation on the CH₂Cl₂ extract of Teucrium mascatense. The structure elucidation of the new constituent was carried out by the combined use of 1D‐ (¹H‐ and ¹³C‐NMR) and 2D‐NMR (HMBC and HSQC) spectroscopic analysis, along with mass spectrometric techniques. In addition to the new constituent 1 , the known metabolite 2 , previously isolated from Crataegus pinnatifida, was also identified.