2-(Trimethylsilyl)ethyl chloroformate: A convenient reagent for protection of hydroxyl function

2-(Trimethylsilyl)ethyl chloroformate reacts with alcohols to give carbonates in high yield. n-Bu₄NF in THF(0.2M) solution for 10 min or ZnBr₂ or ZnCl₂ in CH₃NO₂ for 10 min regenerate the alcohol at 20°C.     

Trimethylsilyl trichloroacetate: a new reagent for salt-free silylations

Trimethylsilyl trichloroacetate ($\text{1}$) is a convenient reagent for the silylation of phenols, carboxylic acids, mercaptans, amides, acetylenes, and β-keto esters, while the reaction of $\text{1}$ with aldehydes and ketones affords silylated trichloromethyl carbinols ($\text{5}$).     

Trimethylsilyl polyphosphate (PPSE), a useful reagent for the beckmamn rearrangement

Various oximes were rearranged smoothly to the corresponding amides in trimethylsilyl polyphosphate (PPSE) which was conveniently prepared from phosphorus pentoxide and hexamethyldisiloxane.     

Methoxyphenylthiotrimethylsilylmethyllithium a convenient reagent for the homologation of carbonyl compounds

A facile homologation procedure for the conversion of carbonyl compounds into ketene-O,S-acetals is described. These intermediates are readily converted into ketene-O-silyl,S-acetals, thioesters, and carboxamides.     

A convenient reagent for aldehyde to alkyne homologation

A convenient reagent for the one-carbon homologation of an aldehyde to the corresponding alkyne is reported. This reagent allows this conversion to conveniently be carried out on a large scale under ambient conditions.     

N,N'-ditosylhydrazine: a convenient reagent for facile synthesis of diazoacetates

A novel entry to the synthesis of diazoacetates is disclosed. A variety of diazoacetates were synthesized from the corresponding bromoacetates by treatment with N,N'-ditosylhydrazine in moderate to high yields. Ease of operation with the stable crystalline reagent as well as a short reaction time offer a useful alternative to the conventional methods.     

TLC plates as a convenient platform for solvent-free reactions

Solvent-free oxidative couplings of naphthols have been optimized by co-spotting catalysts and substrates directly on silica TLC plates and heating, followed by chromatography, staining, and qualitative visualization.     

Linear free energy relationships and solvolysis reactions

The validity of Grunwald-Winstein m values in relation to mechanistic designation of solvolysis reactions is examined. Stability-selectivity relationships in this area are shown to form examples of LFER's and not to emanate from correlations between selectivity and reactivity.     

Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent

TFDA is readily prepared from the reaction of fluorosulfonyldifluoroacetic acid with trimethylsilyl chloride, and it is a very effective and efficient source of difluorocarbene for use in addition reactions to alkenes of a broad scope of reactivities. Acid-sensitive substrates may require an additional purification step involving treatment of the distilled TFDA with sufficient Et₃N to remove the acid impurity. Other trialkylsilyl fluorosulfonyldifluoroacetates can also be prepared, and they have been found to have reactivities similar to TFDA. The triethyl derivative, TEFDA is more convenient to prepare in a pure state and has similar reactivity to TFDA. Thus, it may prove to be a superior reagent.     

Synthesis of ferrocenylcarbodiimide as a convenient electrochemically active labeling reagent for nucleic acids

Ferrocenylcarbodiimides carrying different redox potentials, 1 and 2, were designed and synthesized as convenient electrochemically active labeling reagents for nucleic acids, which may be used as dually labeling reagents of nucleic acids like Cy3 and Cy5 dyes. These reagents could react with the imino unit of thymine or guanine base on DNA or of uracil base on RNA under a basic buffer condition to yield a labeled product quantitatively in a short period of time. The current responses of the labeled DNAs in square wave voltammetric (SWV) measurement showed a good linear correlation with the amount of the hybridized ones. DNAs labeled with the two different reagents, 1 and 2, could be detected electrochemically at different potentials after hybridization with a DNA probe-immobilized gold electrode.     

Polystyrene-supported N-methylthiourea: a convenient new reagent for the hydrogenolysis of bicyclic endoperoxides

The single-step preparation of a polystyrene-bound N-methylthiourea and its use for the hydrogenolysis of bicyclic endoperoxides is described.     

Facile preparation and reactivity of bifunctional ionic liquid-supported hypervalent iodine reagent: a convenient recyclable reagent for catalytic oxidation

Novel, efficient, and recyclable bifunctional catalysts bearing ionic liquid supported (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) and iodoarene moieties were developed and used for environmentally benign catalytic oxidation of alcohols. The reactions using peracetic acid as a green and practical co-oxidant afforded the corresponding carbonyl compounds in high yields under mild conditions and convenient work-up. Furthermore, these ionic liquid supported bifunctional catalysts could be simply recovered and reused.     

Lithium diselenide in aprotic medium - a convenient reagent for synthesis of organic diselenides

The reduction of selenium with lithium in THF in the presence of diphenylacetylene as a catalyst afforded lithium diselenide, which reacted with electrophiles giving alkyl or aryl diselenides 1 - 3 and selenides 4, as by-products. The useful method for preparation of diselenides based on this reaction was elaborated.     

Palladium complex in a room temperature ionic liquid: a convenient recyclable reagent for catalytic oxidation

Palladium (Pd)-catalyzed carbonylation of alcohols proceeds in ionic liquid (IL) media (1-ethyl-3-methylimidazolium hexafluorophosphate). Carbonylation of primary/secondary alcohols to aldehydes/ketones was greatly accelerated by the use of a Pd-based catalyst in the presence of NaOCl as an oxidant. The catalyst was more easier to recycle in the IL [Emim]PF₆ with an equal-proportioned CH₂Cl₂ than in the single CH₂Cl₂ or IL.     

二(芳砜基)甲烷作极性逆转试剂:醛的一个简便合成法

二(芳砜基)甲烷的亚甲基被两个砜基活化,它的酸性大于硫代缩醛.使用较弱的碱性试剂即可使它形成相应的α-碳阴离子,发生烃化反应,继而还原,水解,从而提供醛的简便合成方法.