共查询到20条相似文献,搜索用时 15 毫秒
1.
Sudhakar D. G. S. Rao A. Srinivasa Reddy Ch. Venkata Ramana 《Russian Journal of General Chemistry》2019,89(8):1696-1701
Russian Journal of General Chemistry - A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1H and 13C... 相似文献
2.
Pervaram S. Ashok D. Sarasija M. Reddy C. V. R. Sridhar G. 《Russian Journal of General Chemistry》2018,88(6):1219-1223
Russian Journal of General Chemistry - Ten 1,2,4-oxadiazole fused benzofuran derivatives 11a–11j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data.... 相似文献
3.
Synthesis and Anticancer Evaluation of Amide Derivatives of 1,3,4-Oxadiazole Linked with Benzoxazole
Ravinaik B. Ramachandran D. Rao M. V. Basaveswara 《Russian Journal of General Chemistry》2019,89(5):1003-1008
Russian Journal of General Chemistry - A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a–12j are synthesized and their anticancer activity is screened against four... 相似文献
4.
Badithapuram Vinitha Nukala Satheesh Kumar Thirukovela Narasimha Swamy Manchal Ravinder Dasari Gouthami Bandari Srinivas 《Russian Journal of General Chemistry》2022,92(1):117-124
Russian Journal of General Chemistry - Herein, synthesis of some new quinoxaline-1,2,4-oxadiazole derivatives is presented, and their in vitro anti-cancer activity against four human cancer cell... 相似文献
5.
芳基肟胺菊酯类化合物和1,2,4-噁二唑衍生物的合成及其生物活性研究 总被引:1,自引:0,他引:1
芳基肟胺化合物与取代环丙烷羧酸酰氯在Et_3N作用下室温反应得到芳基肟胺菊酯类化合物,在甲苯中回流反应则得到含取代环丙烷基的1,2,4- 二唑衍生物。前者在甲苯中回流,HOAc作催化剂时发生环化反应也生成1,2,4- 二唑衍生物.初步生物活性测试表明这些化合物具有的杀菌和除草活性. 相似文献
6.
LIU Wen-Rui HUA Xue-Wen ZHOU Sha YUAN Feng-Ying WANG Gui-Qing LIU Yi XING Xiao-Ran 《结构化学》2021,40(5):666-674
Fifteen novel N-sulfonyl aromatic amide derivatives were designed and synthesized,and the structures were characterized by 1H-and 13C-NMR,EA and HRMS.The crysta... 相似文献
7.
Shahinshavali S. Sreenivasulu R. Guttikonda V. R. Kolli D. Rao M. V. B. 《Russian Journal of General Chemistry》2019,89(2):324-329
Russian Journal of General Chemistry - A series of amide derivatives of 1,2-isoxazole combined with 1,2,4-thiadiazole are synthesized 11a–11j. Their chemical structures are confirmed by 1H... 相似文献
8.
1,3,4-Oxadiazole nucleus shows a broad spectrum of pharmaceutical applications. Thus, in recent years scientists have developed various new methods for the synthesis of its derivatives. Here we give a review of recent developments in the synthesis over the past decade (2004–2013). 相似文献
9.
新型1,3,4-噁二唑衍生物的合成与性质研究 总被引:3,自引:0,他引:3
研制高效载流子传输材料是提高有机电致发光器件性能的关键. 采用对酯对二酰氯(5)与含不同链长烷氧取代基的苯甲酰肼(2)缩合制备了一系列腰接羧基1,3,4-噁二唑衍生物, 即1,4-二[5-(4-烷氧基苯)-1,3,4-噁二唑基]-2,5-二羧基苯(7; 烷氧基=OCnH2n+1; n=8, 12, 16), 并采用UV-vis吸收和荧光光谱对合成物进行了表征. 结果表明: 7的分子结构中羧基的横向引入, 对化合物的光物理性质和能带结构产生较大影响. 这些噁二唑化合物的LUMO及HOMO值分别介于-3.62与-3.58 eV之间及-6.94与-6.90 eV之间, 说明它们可能具有良好的电子传输性. 相似文献
10.
11.
Kurma Srimathi Dasari Gouthami Nukala Satheesh Kumar Ravula Sharada Kandukuri Padma Bandari Srinivas 《Russian Journal of General Chemistry》2022,92(7):1326-1332
Russian Journal of General Chemistry - A series of new quinoxaline-1,2,4-thiadiazoles amide hybrids has been synthesized and evaluated for their anti-proliferative activity on four different human... 相似文献
12.
Ragha Suma V. Sreenivasulu R. Subramanyam M. Rao K. Ram Mohan 《Russian Journal of General Chemistry》2019,89(3):499-504
A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for their anticancer activity towards human cancer cell lines, MCF-7 (breast), A-549 (lung), Colo-205 (colon), and A-2780 (ovarian). The compounds 10b, 10c, and 10d demonstrate the most promising activity.
相似文献13.
双枝[1,3,4]-噁二唑衍生物的合成与荧光性质 总被引:4,自引:0,他引:4
通过Wittig反应和Heck反应合成了三个双枝噁二唑衍生物: N-{{{3,5-二-[5-(4-叔丁基苯基)-1,3,4-噁二唑-2]-苯基}-E-乙烯基}-4-苯基}二苯胺(BBOD-2), N,N-双{{{3,5-二-[5-(4-叔丁基苯基)-1,3,4-噁二唑-2]-苯基}-E-乙烯基}-4-苯基}苯胺(BBOD-3), N,N,N-三{4-{2-{3,5-二-[5-(4-叔丁基苯基)-1,3,4-噁二唑-2]-苯基}-E-乙烯基}苯基}胺(BBOD-4). 化合物结构经过红外光谱、核磁共振谱、质谱和熔点确证, 测定了它们在不同溶剂中的紫外光谱和单光子荧光光谱. BBOD-1, BBOD-2, BBOD-3, BBOD-4在二氯甲烷中的最大吸收峰分别位于295, 390, 398和408 nm; 最大发射峰分别为360, 486, 483和487 nm. 讨论了Stokes位移与溶剂极性的关系. 相似文献
14.
含吡啶环的1,3,4-噁二唑衍生物的合成及生物活性研究 总被引:22,自引:0,他引:22
依据生物电子等排原理,在分子中同时引入吡啶环和1,3,4-噁二唑杂环合成了5-(3-吡啶基或4-吡啶基)-1,3,4-噁二唑2-硫乙酸胺类化合物,用1HNMR,IR,质谱和元素分析对其结构进行了表征.离体试验表明,化合物B1-5小麦赤霉病菌和苹果轮纹病菌的抑制率分别为30%和42%,化合物B1-6对苹果轮纹病菌的抑制率为38%.除草活性实验结果表明,化合物B1-6对油菜和稗草具有较高的抑制作用. 相似文献
15.
A. G. Tyrkov N. A. Solov'ev T. D. Ladyzhnikova K.V. Altukhov 《Russian Journal of Organic Chemistry》2004,40(8):1151-1155
Mass spectra were investigated of a series of 3-aryl-5-(nitromethyl)-1,2,4-oxadiazole derivatives and of N-methylated (benzylated) isomeric 4-(dinitromethyl)-1,2,3-triazoles. The principal fragmentation processes of these compounds involve the heterocycle opening and/or liberation of nitrogen-containing fragments followed by formation of the most stable fragment ions. 相似文献
16.
大黄素衍生物的合成及细胞毒性研究 总被引:7,自引:0,他引:7
以天然大黄素为母体, 经化学修饰得到一系列新的含氮衍生物6~14. 通过1H NMR, IR, MS和元素分析确定了结构. 选择口腔底癌(KB)和乳腺癌(MFC-7)两种人癌细胞株, 采用标准MTT法测定了这类大黄素衍生物的细胞毒性. 研究表明大多数衍生物都有较强的抗癌活性, 其中位置异构体7a和7b的混合物表现出最强的活性, 与母体大黄素相比较, 活性分别提高了174倍(KB)和133倍(MFC-7). 相似文献
17.
Min-Ting Tu Ying-Ying Shao Sen Yang Bin-Long Sun Ying-Ying Wang Cheng-Xia Tan Xue-Dong Wang 《Molecules (Basel, Switzerland)》2022,27(15)
In order to discover pesticidal lead compounds with high activity and low toxicity, a series of novel benzamides substituted with pyrazole-linked 1,2,4-oxadiazole were designed via bioisosterism. The chemical structures of the target compounds were confirmed via 1H NMR, 13C NMR and HRMS analysis. The preliminary bioassay showed that most compounds exhibited good lethal activities against Mythimna separate, Helicoverpa armigera, Ostrinia nubilalis and Spodoptera frugiperda at 500 mg/L. Particularly in the case of Mythimna separate, compound 14q (70%) exhibited obvious insecticidal activity. In addition, compound 14h demonstrated good fungicidal activity against Pyricularia oryae with an inhibition rate of 77.8%, and compounds 14e, 14k, 14n and 14r also showed certain antifungal activities (55.6–66.7%). The zebrafish toxicity test showed that the LC50 of compound 14h was 14.01 mg/L, which indicated that it may be used as a potential leading compound for further structural optimization. 相似文献
18.
Russian Journal of Organic Chemistry - A tetraazacrown ether, 4,9-di(prop-2-yn-1-yl)-1,4,9,12-tetraazacyclohexadecane-2,11-dione, bearing propargyl groups on two nitrogens was synthesized starting... 相似文献
19.
Lukasz Banach Lukasz Janczewski Jakub Kajdanek Katarzyna Milowska Joanna Kolodziejczyk-Czepas Grzegorz Galita Wioletta Rozpedek-Kaminska Ewa Kucharska Ireneusz Majsterek Beata Kolesinska 《Molecules (Basel, Switzerland)》2022,27(7)
Eight dipeptides containing antifibrinolytic agents (tranexamic acid, aminocaproic acid, 4-(aminomethyl)benzoic acid, and glycine—natural amino acids) were synthesized in a three-step process with good or very good yields. DMT/NMM/TsO− (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate) was used as a coupling reagent. Hemolysis tests were used to study the effects of the dipeptides on blood components. Blood plasma clotting tests were used to examine their effects on thrombin time (TT), prothrombin time (PT), and the activated partial thromboplastin time (aPTT). The level of hemolysis did not exceed 1%. In clotting tests, TT, PT, and aPTT did not differentiate any of the compounds. The prothrombin times for all amides 1–8 were similar. The obtained results in the presence of amides 1–4 and 8 were slightly lower than for the other compounds and the positive control, and they were similar to the results obtained for TA. In the case of amide 3, a significantly decreased aPTT was observed. The aPTTs observed for plasma treated with amide 3 and TA were comparable. In the case of amide 6 and 8, TT values significantly lower than for the other compounds were found. The clot formation and fibrinolysis (CFF) assay was used to assess the influence of the dipeptides on the blood plasma coagulation cascade and the fibrinolytic efficiency of the blood plasma. In the clot formation and fibrinolysis assay, amides 5 and 7 were among the most active compounds. The cytotoxicity and genotoxicity of the synthesized dipeptides were evaluated on the monocyte/macrophage peripheral blood cell line. The dipeptides did not cause hemolysis at any concentrations. They exhibited no significant cytotoxic effect on SC cells and did not induce significant DNA damage. 相似文献