共查询到20条相似文献,搜索用时 468 毫秒
1.
The synthesis of two isotopomers of L-DOPA, the precursors for labeled dopamine is reported. The ring labeled with deuterium
or tritium [2′,5′,6-2H3]-L-DOPA, and [2′,5′,6-3H3]-L-DOPA were obtained using acid catalyzed isotopic exchange between L-DOPA and heavy or tritiated water, respectively. Their
derivatives, i.e., [2′,5′,6-2H3], and [2′,5′,6-3H3]-dopamine were obtained by enzymatic decarboxylation of deuterated or tritiated isotopomers of L-DOPA using enzyme tyrosine
decarboxylase (EC 4.1.1.25). 相似文献
2.
The enzymatic synthesis of three isotopomers of l-DOPA labeled with deuterium and tritium at α carbon atom was elaborated. These compounds were converted into [(1S)-2H]–, [(1S)-
3H]–, and doubly labeled [(1S)-2H/3H]-dopamines using enzyme tyrosine decarboxylase. Doubly labeled (1R) isotopologue, i.e., [(1R)-2H/3H]-dopamine, was afforded by enzymatic decarboxylation of authentic l-DOPA carried out in deuteriated and tritiated incubation medium. 相似文献
3.
The synthesis of selectively labeled [3-14C]-L-tryptophan and its derivative 5′-hydroxy-[3-14C]-L-tryptophan using chemical and multienzymatic methods is reported. The key intermediate for this synthesis, [3-14C]-DL-alanine was obtained from 14CH3I as a result of its condensation with N-(diphenylmethylene)glycine tert-butyl ester. Next, the mixture containing [3-14C]-DL-alanine, indole or 5-hydroxyindole has been converted to [3-14C]-L-tryptophan or 5′-hydroxy-[3-14C]-L-tryptophan, respectively, in a one-pot multienzymatic reaction using four enzymes: D-amino acid oxidase, catalase, glutamic-pyruvic
transaminase and tryptophanase. 相似文献
4.
A new chromone-substituted dihydrotriflavonol, (2S,3S)[6-{(3S) 3″,5″-dihydroxy-6″-methoxydihydrochromone}5,3′,4′,5′-tetrahydroxy-7-methoxy-3-O-8-dihydroflavone]2 3-O-8[6-{(3S) 3″,5″-dihydroxy-6″methoxydihydrochromone}3,5,3′,4′,5′-pentahydroxy-7-methoxydihydroflavonol] was isolated from the leaves
of Anogeissus pendula. The structure was determined by UV, 1H NMR, 13C NMR, HMBC, and CD data. 相似文献
5.
Sylwia Dragulska Marianna Kańska 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):759-763
Nine isotopomers of tryptamine and its halogen derivatives, labeled with deuterium, tritium in side chain, i.e., [(1R)-2H]-, [(1R)-3H]-, 5-F-[(1R)-2H]-, 5-F-[(1R)-3H]-, 5-Br-[(1R)-2H]-, double labeled [(1R)-2H/3H]-, 5-F-[(1R)-2H/3H]-, and ring labeled [4-2H]-, and [5-2H]-tryptamine, were obtained by enzymatic decarboxylation of l-Trp and its appropriate derivatives in deuteriated or tritiated media, respectively. Intermediates: [5′-2H]-l-Trp used for further decarboxylation was synthesized by enzymatic coupling of [5-2H]-indole with S-methyl-l-cysteine, and [4′-2H]-l-Trp was obtained by isotope exchange 1H/2H of the authentic l-Trp dissolved in heavy water induced by UV-irradiation. Doubly labeled [(1R)-2H/3H]- and 5-F-[(1R)-2H/3H]-tryptamine were obtain by decarboxylation of l-Trp or [5′-F]-l-Trp carried out in 2H3HO incubation medium. 相似文献
6.
E. S. Denislamova N. V. Bubnov A. N. Maslivets 《Russian Journal of Organic Chemistry》2011,47(6):933-936
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione to give methyl 11-aryl-12-benzoyl-9-hydroxy-4,6-dimethyl-3,5,10-trioxo-4,6,8,11-tetraazatricyclo[7.2.1.02,7]dodec-2(7)-ene-1-carboxylates which underwent thermal recyclization to 1-aryl-3-benzoyl-4-hydroxy-1′,3′-dimethylspiro[pyrrole-2,5′-pyrrolo[2,3-d]pyrimidine]-2′,4′,5,6′(1H,1′H,3′H,7′H)-tetraones. 相似文献
7.
Saraeva T. A. Khoroshilov G. E. Brovarets V. S. Zubatyuk R. I. Shishkin O. V. 《Russian Journal of General Chemistry》2011,81(10):2172-2175
An attempt to effect exhaustive alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl) indolizine with alkyl iodides
in boiling acetone led to the formation of 6,6-dimethyl-8-(4-methoxybenzoyl)-6,7-dihydrobenzo[4′,5′]imidazo[1′,2′: 1,6]pyrimido[5,4-a]indolizine instead of expected N-alkyl derivatives. The product structure was proved by X-ray analysis. 相似文献
8.
M. A. Kukaniev S. Sh. Shukurov U. Norov Yu. Khodzhiboev 《Russian Chemical Bulletin》1999,48(2):364-366
2-R-5-Imino-6H-1,3,4-thiadiazolo[3,2-a]pyrimidin-7-ones react with aromatic and heterocyclic aldehydes in the presence of Et3N to give condensation products on the methylene group, which react with carbon disulfide to yield the corresponding 2,6-disubstituted
8-thioxo-9,9a-dihydro-1,3,4-thiadiazolo[3′,2′∶1,2]pyrimidino[5,6-d]1,3-thiazin-5-ones.
Deceased.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 366–368, February, 1999. 相似文献
9.
Abolghasem Davoodnia Mehdi Bakavoli Sharare Mohseni Niloofar Tavakoli-Hoseini 《Monatshefte für Chemie / Chemical Monthly》2008,139(8):963-965
Some new pyrido[3′,2′:4,5]thieno[2,3-e]-[1,2,4]triazolo[4,3-a] pyrimidin-5(4H)-ones were prepared through heterocyclization of ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate with phenyl or ethyl isothiocyanate followed by nucleophilic displacement with hydrazine, and finally
cyclocondensation with orthoesters.
Correspondence: Abolghasem Davoodnia, Department of Chemistry, School of Sciences, Islamic Azad University, Mashhad Branch,
Mashhad 91735-413, Iran. 相似文献
10.
T. P. Glushchenko A. V Aksenov V. I. Goncharov 《Chemistry of Heterocyclic Compounds》2009,45(3):351-356
A method has been developed for the synthesis of 4-(2-quinolinyl)-1,2,3,3a-tetrahydropyrrolo-[1,2-a]quinolines based on the 1,3-dipolar cycloaddition reaction of α,β-unsaturated carbonyl compounds to 2,3′-biquinolinium salts.
Oxidation in benzene using MnO2 gave 4-(2-quinolinyl)-pyrrolo[1,2-a]quinolines. It was found that a side product of the 1,3-dipolar cycloaddition is 7,14-di-benzoyl-6,13-di(2-quinolyl)-6a,7,13a,14-tetrahydro-7a,14a-diazadibenzo[a,h]anthracene. Reaction of 1′-phenacyl-2,3′-biquinolinium salts with hydroxylamine in acetic acid gave 4-(2-quinolyl)imidazo-[1,2-a]quinolines.
*For Communication 24 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 433–439, March, 2009. 相似文献
11.
Wael A. El-Sayed Mohamed I. Hegab Hala E. M. Tolan Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2008,139(9):1055-1060
A series of new N- and S-substituted 1,3,4-oxadiazole derivatives were synthesized. 5-Pyridin-3-yl-3-[2-(5-thioxo-4,5-dihydro-l,3,4-thiadiazol-2-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione and 5-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)methyl]-N-phenyl-1,3,4-thiadiazol-2-amine were formed by cyclization of 3-(5-pyridin-3-yl-2-thioxo-1,3,4-oxadiazol-3(2H)-ylpropanimidohydrazide and 2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)thio]thiosemicarbazide with CS2 and H2SO4. On the other hand, a number of new bicyclic 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were synthesized. 6-Pyridin-3-ylbis[1,2,4]‐triazolo[3,4-b:4′,3′-d][1,3,4]thiadiazole-3(2H)-thione was synthesized by reaction of 6-(hydrazino)-3-pyridine-3-yl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole with CS2/KOH/EtOH. The structures of the newly synthesized compounds were elucidated by the spectral and analytical data IR, Mass, and 1H NMR spectra.
Correspondence: Adel A.-H. Abdel-Rahman, Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam,
Egypt; Wael A. El-Sayed, National Research Centre, Department of Photochemistry, Cairo, Egypt. 相似文献
12.
O. B. Smirnova T. V. Golovko L. M. Alekseeva V. V. Chernyshev V. G. Granik 《Russian Chemical Bulletin》2010,59(1):177-185
The reactions of 2-dicyanomethylidene-3-ethoxymethylidene-2,3-dihydroindole with hydrazine hydrate and phenylhydrazine afforded
2,3-diamino-4-cyanopyrido[4,3-b]indole and 3-amino-2-anilino-4-cyanopyrido[4,3-b]indole, respectively, and the reactions of the latter compounds with dimethylformamide diethyl acetal were studied. The reactions
of 2,3-diamino-4-cyanopyrido[4,3-b]indole with benzaldehyde, ethyl acetoacetate, and acetylacetone were investigated. First representatives of new heterocyclic
systems, viz., [1,2,4]triazolo[1’,5’:1,6]-pyrido[4,3-b]indole and pyrazolo[1’,5’:1,2]pyrido[4,3-b]indole, were synthesized. The structure of ethyl 6-cyano-5-[(E)-(dimethylamino)methylideneamino]-2-methyl-7H-pyrazolo-[1’,5’:1,2]pyrido[4,3-b]indole-1-carboxylate was established by X-ray diffraction. 相似文献
13.
A. V. Velikorodov N. M. Imasheva A. K. Kuanchalieva O. Yu. Poddubnyi 《Russian Journal of Organic Chemistry》2010,46(7):971-975
Condensation of methyl 4-acetylphenylcarbamate with isatin in the presence of diethylamine afforded methyl 4-[(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetyl]phenylcarbamate which was converted into the corresponding chalcone on heating in glacial acetic acid in
the presence of hydrochloric acid. 1,3-Dipolar cycloaddition to that chalcone of azomethine ylide generated from 2-phenacylisoquinolinium
bromide by the action of triethylamine gave methyl 4-(3′-benzoyl-2-oxo-1′,2,2′,3,3′,10b′-hexahydro-1H-spiro-[indole-3,1′-pyrrolo[1,2-a]isoquinolin]-2′-ylcarbonyl)phenylcarbamate. Condensation of 2-hydroxy- and 2,4-dihydroxybenzaldehydes with methyl 4-acetylphenylcarbamate
in the presence of gaseous hydrogen chloride resulted in the formation of chromenium salts with a methoxycarbonylaminophenyl
fragment on the C2 atom in the heteroring. 相似文献
14.
E. O. Chukhajian A. A. Khachatryan A. R. Gevorkyan H. A. Panosyan 《Chemistry of Heterocyclic Compounds》2009,45(4):426-429
In aqueous base medium p-bis{3-[N-(3-chlorobuten-2-yl)pyrrolidinio (piperidinio or morpholinio)]-propyn-1-yl}benzene dichlorides undergo a two-way
dehydrochlorination-cyclization reaction to form benzo[5,6-a:5′,6′-c]bis(2,2-tetramethylene- or -2,2-pentamethylene-4-methylisoindolinium) and benzo-[5,6-a:5′,6′-c]bisspiro(4-methylisoindoline-2,4′-morpholinium) dichlorides.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 546–549, April, 2009. 相似文献
15.
Adrian B. Chaplin Zoltán Béni Christian G. Hartinger Hisham Ben Hamidane Andrew D. Phillips Rosario Scopelliti Paul J. Dyson 《Journal of Cluster Science》2008,19(1):295-309
The new mixed-metal complex {anti-[(p-cymene)RuCl]-μ-[κ
2-P,P′;κ
1-P′′-(PPh2CH2)3CMe]-[AuCl]}PF6 and its cluster derivative {anti-[(p-cymene)RuCl]-μ-[κ
2-P,P′;κ
1-P′′-(PPh2CH2)3CMe]-[AuPt3(CO)3(PCy3)3]}(PF6)2 have been prepared and characterized. Notably, NMR spectroscopy and high resolution FT-ICR mass spectrometry, including a
tandem mass spectrometric analysis, demonstrated the formation of these compounds that was also confirmed by single crystal
X-ray diffraction analysis. 相似文献
16.
Lichitsky B. V. Komogortsev A. N. Dudinov A. A. Krayushkin M. M. 《Russian Chemical Bulletin》2009,58(7):1504-1508
A new method for the synthesis of hitherto unknown substituted 1,7-dihydrospiro-[pyrazolo[3,4-b]pyridine-4,3′-indole]-2′,6(1′H,5H)-diones based on three-component condensation of 5-aminopyrazoles with Meldrum’s acid and isatins is developed. 相似文献
17.
A new symmetrical vicinal dioxime, N,N′-bis-{4-[[(2-hydroxyphenyl)methylene]hydrazinecarbonyl]phenyl}diaminoglyoxime (LH4), was prepared by reacting anti-dichloroglyoxime with salicylaldehyde 4-aminobenzoylhydrazone. The reaction of ligand with Ni2+ salts gave mono-and homopentanuclear complexes, [Ni(LH3)2] and [Ni5(LH)2X2]. Furthermore, heteropentanuclear complexes of dioxime ligand, [Cu4Ni(LH)2X4], were prepared by the reaction of [Ni(LH3)2)] with Cu2+ salt and a monodentate ligand (X = SCN−, CN−, or N
3
−
). The structures of both the new symmetrical vicinal dioxime and its complexes were identified by elemental analyses, IR,
1H NMR, UV-VIS spectra, and magnetic susceptibility. The elemental analyses and spectral data indicate that the hydrazone side
of ligand acts as a O,N,O′ tridentate and the fourth position is occupied with monodentate anion such as SCN−, CN−, N
3
−
. 相似文献
18.
Simonov A. Yu. Lakatosh S. A. Luzikov Yu. N. Reznikova M. I. Preobrazhenskaya M. N. 《Russian Chemical Bulletin》2010,59(7):1442-1450
A dialkylaminomethylation reaction (the Mannich reaction) of 3,4-bis(indol-l-yl)-maleimides and 3-(indol-l-yl)-4-(indolin-l-yl)maleimides
leads to mono- and di(dimethyl-amino) derivatives at position 3 of one or two indole rings. A series of 3,4-bis(indol-l-yl)-maleimides
and 3-(indol-l-yl)-4-(indolin-l-yl)maleimides containing ω-hydroxyalkyloxy-methyl substituents at position 3 of the indole
ring was obtained by the reaction of iodomethyl-ates of these compounds with ethylene glycol and other 6h,ω-alkanediols. The
reaction of quaternary salts of bis(3-dimethylaminomethylindol-l-yl)maleimides with 6h,ω-alkanediols resulted in the isolation
of 3,4-bis(3-ω-hydroxyalkyloxymethylindol-l-yl)maleimides. Upon heating iodomethylate of 3-(3-dimethylaminoindol-l-yl)-4-(indolin-l-yl)maleimide
in pyridine, 5,6-dihydro-10-methyl-H-indolo[l′,7a′,7′:4,5,6]pyrrolo[3′,4′:2,3]-[l,4]diazepino[l,7-a]-indole-l,3(2H)-dione was obtained due to the intramolecular alkylation and formation of the bond between position 2 of the
indole and position 7 of the indoline rings. 相似文献
19.
Deuterium-induced 13C isotope shifts were measured in the 13C {1H} NMR spectra of monodeuteriated cyclododecanones formed upon oxidation of [1-2H1] cyclododecanol with lead tetraacetate. These shifts, when used in conjunction with 13C NMR data of specifically labelled analogues, [2, 2, 12, 12-2H4]- and [2-2H1] cyclododecanone, enabled the ketone formed with lead tetraacetate to be identified as a mixture of [5-2H1]- and [6-2H1] isotopomers. 相似文献
20.
V. V. Dotsenko S. G. Krivokolysko A. N. Chernega V. P. Litvinov 《Russian Chemical Bulletin》2007,56(5):1053-1062
Treatment of N-methylmorpholinium 4-R-6-amino-3,5-dicyano-1,4-dihydropyridine-2-thiolates (R = 2-ClC6H4 and 2-MeOC6H4) with primary amines in the presence of an excess of formaldehyde gave 13-R-8-thioxo-3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitrile derivatives in high yields (66–95%). In a similar way, aminomethylation of 3-R-10-amino-7,11-dicyano-9-aza-3-azoniaspiro[5.5]undeca-7,10-diene-8-thiolates
(R = Me and Et) afforded 1′-alkyl-8-thioxospiro[3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-13,4′-piperidine]-1,9-dicarbonitriles in 43–91% yields. Alternatively, these compounds were obtained by multicomponent
cyclocondensation of N-alkylpiperidin-4-ones, cyanothioacetamide, primary amines, and aqueous formaldehyde. The starting 3-R-10-amino-7,11-dicyano-9-aza-3-azoniaspiro[5.5]undeca-7,10-diene-8-thiolates
were prepared by a new method from N-alkylpiperidin-4-ones and cyanothioacetamide. The structure of 5,11-bis(4-ethoxyphenyl)-13-(2-methoxyphenyl)-8-thioxo-3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitrile was examined by X-ray diffraction analysis.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1014–1022, May, 2007. 相似文献