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1.
V. V. Baranov G. A. Gazieva Yu. V. Nelyubina A. N. Kravchenko N. N. Makhova 《Russian Journal of Organic Chemistry》2011,47(10):1564-1571
Acid-catalyzed reactions of N-(carboxyalkyl)ureas with 1,3-dialkyl-4,5-dihydroxy-4,5-diphenylimidazolidine-2-thiones in methanol or propan-2-ol led to
the formation of previously unknown ω-(4,6-dialkyl-2-oxo-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-1-yl)alkanoic acids and their methyl and isopropyl esters. The structure of some esters was proved by X-ray analysis.
Methyl (4,6-diethyl-2-oxo-3a,6adiphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-1-yl)acetate showed anxiolytic effect. 相似文献
2.
A. G. Mal''kina V. V. Nosyreva R. N. Kudyakova L. V. Sokolyanskaya B. A. Trofimov 《Russian Journal of Organic Chemistry》2001,37(5):649-654
The reaction of 4-alkyl-4-hydroxy-2-alkynenitriles with hydrogen halides (HCl and HI) in dioxane is accompanied by intramolecular cyclization with formation of 5,5-dialkyl-4-halo-2-imino-2,5-dihydrofuran hydrohalides. Treatment of the latter with K2CO3 in ethanol yields 5,5-dialkyl-4-halo-2-imino-2,5-dihydrofurans. 相似文献
3.
A. N. Kravchenko G. A. Gazieva A. S. Sigachev E. Yu. Maksareva K. A. Lyssenko N. N. Makhova 《Russian Chemical Bulletin》2007,56(1):148-153
Two-step α-ureidoalkylation of ureas with various 4,5-dihydroxyimidazolidin-2-ones gave novel 1,3-dialkyl-4,5-bis(3-alkylureido)-,
1,3-dialkyl-4,5-bis[3-(2-pyrimidyl)ureido]-, or 1,3-dialkyl-4,5-bis(3,3-dialkylureido)imidazolidin-2-ones and ensembles of
three imidazolidine rings. The structure of 4,5-bis(2-oxoimidazolidin-1-yl)imidazolidin-2-one was confirmed by X-ray diffraction
data.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 140–145, January, 2007. 相似文献
4.
The reaction of 5,6-dialkyl-2-halopyridine-3,4-dicarbonitriles with alcoholic ammonia under elevated pressure gave 5,6-dialkyl-2-aminopyridine-3,4-dicarbonitriles
as a result of nucleophilic replacement of the halogen atom by amino group. 6,7-Dialkyl-4-halo-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diimines were formed in analogous reaction at room temperature in the presence of potassium carbonate. 相似文献
5.
Gazieva G. A. Baranov V. V. Kravchenko A. N. Makhova N. N. 《Russian Journal of Organic Chemistry》2011,47(10):1572-1575
Reactions of N-(hydroxyalkyl)ureas with 4,5-dihydroxy-4,5-diphenylimidazolidine-2-thiones gave previously unknown 4,6-dialkyl-1-hydroxyalkyl-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-2-ones which may be regarded as thio analogs of N-(hydroxyalkyl)glycolurils. 相似文献
6.
Fumio Yoneda Masatsugu Higuchi Yoshihiro Nitta 《Journal of heterocyclic chemistry》1980,17(5):869-871
Treatment of 1,3-dialkyl-7-azalumazine derivatives with alcoholic sodium hydroxide caused a benzylic acid type rearrangement followed by decarboxylation and oxidation by air to give the corresponding 5,7-dialkyl-5H-imidazo[4,5-e]-as-triazin-6-(7H)ones (7,9-dialkyl-6-azapurin-8-ones). 相似文献
7.
G. A. Gazieva M. I. Struchkova N. G. Kolotyrkina 《Chemistry of Heterocyclic Compounds》2011,47(2):210-214
Previously unknown 1,3-dialkyl-4,5-bis[4-alkyl(phenyl)thiosemicarbazido]imidazolidine-2-thiones and 4,5,7-trialkylperhydroimidazo[4,5-e]-1,2,4-triazine-3,6-dithiones have been synthesized by the α-thio-ureidoalkylation of 4-alkyl(phenyl)thiosemicarbazides using
1,3-dialkyl-4,5-dihydroxyimidazolidine-2-thiones. 相似文献
8.
4(And 5)-cyclopropylamino-5(and 4)halo-3(2H)pyridazinones. Formation and characterization of isomers
The reactions of 4,5-dihalo-3(2H)pyridazinones with ammonia and amines gave mixtures of 5-amino-4-halo- and 4-amino-5-halo-3(2H)pyridazinones separated by chromatography. Structures were elucidated by means of retention values (Rf) and confirmed by independent synthesis. 相似文献
9.
A. S. Sigachev A. N. Kravchenko P. A. Belyakov O. V. Lebedev N. N. Makhova 《Russian Chemical Bulletin》2006,55(5):865-872
azo[4,5-e][1,2,4]triazin-6-ones, 4,5-bis(3-thiosemicarbazido(guanidinoamino))imidazolidin-2-ones, and 1,3-dialkyl-4-(guanidinoimino)imidazolidin-2-ones
by α-ureidoalkylation of thiosemicarbazide or aminoguanidine were found. A novel conglomerate in the series of imidazolidin-2-one
derivatives was detected: 4,5-bis(guanidinoamino)-1,3-dimethylimid-azolidin-2-one dihydrochloride dihydrate.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 836–843, May, 2006. 相似文献
10.
Su-Dong Cho Deok-Heon Kweon Young-Jin Kang Hyun-A Chung Yong-Jin Yoon 《Journal of heterocyclic chemistry》1998,35(3):601-605
Novel pyridazino[4,5-b][1,4]oxazine-3,5-diones were synthesized from N-[2-(3,4-dimethoxyphenyl)-ethyl]-2-chloroacetamide (or 2-chloropropanamide) and 1-alkyl-5-halo-4-hydroxypyridazin-6-ones in good yield. 相似文献
11.
Hyun-A Chung Young-Jin Kang Deok-Heon Kweon Yong-Jin Yoon 《Journal of heterocyclic chemistry》1999,36(2):413-421
Functionalization of 1-acetyloxymethyl-4,5-dihalopyridazin-6-ones via retro-ene reaction with some nucleophiles gave regioselectively only 5-halo-4-substitutedpyridazin-6-ones. 相似文献
12.
Hyun-A Chung Young-Jin Kang Joo-Wha Chung Su-Dong Cho Yong-Jin Yoon 《Journal of heterocyclic chemistry》1999,36(1):277-281
Functionalization of 1-hydroxymethyl-4,5-dihalopyridazin-6-ones via a retro-ene reaction with some nucleophiles gave regioselectively only 5-halo-4-substitutedpyridazin-6-ones. 相似文献
13.
G. A. Gazieva P. V. Lozhkin V. V. Baranov Yu. V. Nelyubina A. N. Kravchenko N. N. Makhova 《Russian Chemical Bulletin》2009,58(12):2488-2493
α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea with 1,3-unsubstituted, 1,3-dialkyl-, and 1,3-dimethyl-4,5-diphenyl-4,5-dihydroxyimidazolidin-2-ones(thiones)
was systematically studied. Hitherto unknown N-[2-(dimethylamino)ethyl]glycolurils and their hydrochlorides were synthesized. The yields of the target glycoluril hydrochlorides
decreased on going from 1,3-H2- to 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-ones and increased with the introduction of phenyl groups at the positions 4
and 5 of the starting 4,5-dihydroxyimidazolidin-2-one. X-ray diffraction study showed that 2-[2-(dimethylamino)ethyl]glycoluril
crystallizes in the form of a conglomerate. 相似文献
14.
O. V. Khilya T. A. Volovnenko A. V. Turov Yu. M. Volovenko 《Chemistry of Heterocyclic Compounds》2004,40(8):1063-1069
The interaction of 4-oxo-3,4-dihydroquinazolinyl- and benzimidazolylacetonitriles with 2,6-dihalobenzaldehydes leads to 3-(2,6-dihalophenyl)-2-(4-oxo-3,4-dihydro-2-quinazolinyl)acrylonitriles and 2-(1H-benzo[d]imidazol-2-yl)-3-(2,6-dihalophenyl)acrylonitriles respectively. As a result of intramolecular cyclization of these nitriles 4-halo-12-oxo-12H-quino[2,1-b]quinazoline-6-carbonitriles and 4-halobenzo[4,5]imidazo[1,2-a]quinoline-6-carbonitriles respectively are formed. 相似文献
15.
Gazieva G._A. Nelyubina Yu. V. Kravchenko A. N. Sigachev A. S. Glukhov I. V. Struchkova M. I. Lyssenko K. A. Makhova N. N. 《Russian Chemical Bulletin》2009,58(9):1945-1954
α-Thioureidoalkylation of urea heteroanalogs such as thiosemicarbazide, amino-guanidine, sulfamide, and sulfonamides with
4,5-dihydroxyimidazolidine-2-thiones has been studied. Previously unknown 4,5-bis[thiosemicarbazido(guanidinoamino)]imidazolidine-2-thiones,
5,7-dialkylperhydroimidazo[4,5- e][1,2,4]triazine-3,6-dithiones, 4,6-diethyl-5(3H)-thioxotetrahydro-1 H-imidazo[4,5- c][1,2,5]thiadiazole 2,2-dioxide, and 1,3-dialkyl-4-[guanidinoimino(arylsulfonylimino)]imidazolidine-2-thiones have been synthesized. 相似文献
16.
1,3-Dialkyl-5-amino-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones reacted with acetylacetone to give the corresponding 4-(1,3-dialkyl-2-oxo-1,3-dihydro-2H-imidazo[4,5-b]pyridin-5-ylamino)pent-3-en-2-ones which underwent intramolecular cyclization to 1,3-dialkyl-5,7-dimethyl-1,3-dihydro-2H-imidazo[4,5-b]-[1,8]naphthyridin-2-ones on heating in polyphosphoric acid or diphenyl ether. Analogous reaction of 1,3-dialkyl-5-amino-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones with ethyl acetoacetate led to the formation of ethyl 3-(1,3-dialkyl-2-oxo-1,3-dihydro-2H-imidazo[4,5-b]pyridin-5-ylamino)but-2-enoates whose cyclization afforded 1,3-dialkyl-8-hydroxy-7-methyl-1,3-dihydro-2H-imidazo[5,4-b][1,8]naphthyridin-2-ones. 相似文献
17.
Hyun-A Chung Deok-Heon Kweon Young-Jin Kang Jung-Won Park Yong-Jin Yoon 《Journal of heterocyclic chemistry》1999,36(4):905-910
Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo-4-substituted-pyridazin-6-ones as main product. Reaction of 4,5-dichloropyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)pyridazin-6-one as the main product. 相似文献
18.
Young-Jin Kang Hyun-A Chung Deok-Heon Kweon Su-Dong Cho Sang-Gyeong Lee Sung-Kyu Kim Yong-Jin Yoon 《Journal of heterocyclic chemistry》1998,35(3):595-600
Functionalization of 4,5-dihalopyridazin-6-ones using 1-(1,1-dibromo-2-oxopropyl)-4,5-dihalopyridazin-6-ones with some nucleophiles gave regioselectively only 5-halo-4-substituted-pyridazin-6-ones. 相似文献
19.
Photolysis of 5-benzyl-2-methoxy-2,5-dimethyl-3-1, 3,4-oxadiazoline and of the 5,5-dibenzyl analogue with 300-nm light afforded 1-phenyl-2-diazopropane and 1,3-diphenyl-2-diazopropane, respectively. The diazoalkanes were intercepted, in situ, with dimethyl acetylenedicarboxylate to afford 3-benzyl-4,5-bis(methoxycarbonyl)-3-methyl-3H-pyrazole and 3,3-dibenzyl-4,5-bis(methoxycarbonyl)-3H-pyrazole, respectively. Those pyrazoles are short-lived under the reaction conditions and undergo two major reactions. Photolysis prior to rearrangement affords the corresponding 3,3-dialkyI-1,2-bis(methoxycarbonyl)-cyclopropenes. Thermal 1,5-benzyl migration converts the two 3H-pyrazoles in part into the corresponding 4H-pyrazoles, which undergo photolysis to 2,3-dialkyl-1,3-bis(methoxycarbonyl)cyclopropenes.Thermolysis of the 3,3-dialkyl-1,2-bis(methoxycarbonyl) cyclopropenes affords conjugated dienes, presumably through the sequence cyclopropene vinyl carbene diene. The stereochemistry of the dienes was determined and a mechanism consistent with that stereochemistry is proposed.The 2,3-dialkyl-1,3-bis(methoxycarbonyl)cyclopropanes are very stable under conditions that convert isomeric 3,3-dialkyl-1,2-bis(methoxycarbonyl)cyclopropenes to conjugated dienes. It is proposed that the effect of substitution pattern on the thermolysis rate constants is the result of combined ground state and transition state factors. 相似文献
20.
D. A. Lomov 《Russian Journal of Organic Chemistry》2016,52(1):51-53
Treatment of 5-amino-1,3-dialkyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-2-ones with sodium nitrite in aqueous HCl gave 1,3-dialkyl-1H-imidazo[4,5-b]pyridine-2,5(3H,4H)-diones which were nitrated with potassium nitrate in sulfuric acid to 6-nitro derivatives, and the latter underwent recyclization into 4-amino-1,3-dialkyl-5-(1H-pyrazol-5-yl)-2,3-dihydro-1H-imidazol-2-ones by the action of hydrazine hydrate. 相似文献