结合计算层析与光学相干层析测量折射率分布

通过将计算层析技术与光学相干层析技术相结合,测量散射介质非均匀折射率分布。该方法测量散射样品折射率分布时,通过光学相干层析技术测量散射样品折射率分布在多个方向上的投影,采用计算层析技术实现对样品折射率分布的层析重建,克服了传统折射率光学测量方法如单纯的基于光学相干层析原理的焦点追迹法和光程匹配法,不能测量散射介质非均匀折射率分布的缺点。采用该方法在实验中对梯度折射率棒的径向相对折射率分布进行层析重建,取得了较好的实验结果。     

基于受激辐射信号的谱域光学相干层析分子成像方法

鉴于不同生理病理状态下组织复折射率实部的变化不大,传统光学相干层析(OCT)成像技术在分子特异性识别上存在先天不足.为此,本文提出了基于受激辐射信号的OCT成像方法,可在实现传统散射成像的同时,实现基于受激辐射信号的分子成像.在超高分辨率谱域OCT系统的基础上,通过增设光谱分光与调制抽运光支路,建立了基于单宽谱光源的抽运探测谱域OCT系统,详细推导了调制抽运下受激辐射信号的获取与成像公式.利用搭建的抽运探测谱域OCT系统,实现了瞬态受激辐射信号的相干探测.基于同时获取的受激辐射OCT信号和传统OCT信号,成功重构了氮化物粉末构建样品的基于受激辐射信号的分子对比OCT图像.     

Non-Scanning Optical Coherence Tomography Using Off-Axis Interferometry with an Angular-Dispersion Imaging Scheme

We present a non-scanning approach for real-time optical coherence tomography (OCT). Our approach is based on an off-axis interferometer that laterally projects the time-of-flight or depth information of the sample onto an image sensor. To facilitate the use of an off-axis interferometer in OCT, an angular-dispersion imaging method has been developed. Theoretical analysis and experimental results are presented to demonstrate that this method is capable of demodulating the interferogram and thus permits a direct inspection of the depth-resolved image. Depth resolution and detection range of the present method are also studied.     

Fiber type of optical coherence tomography with an auto-focus device

Optical coherence tomography (OCT) is a novel technique for non-invasive imaging based on low coherence interferometer. In this study, we develop a new optical fiber type of OCT with a commercial auto-focus device to simultaneously measure the refractive index and thickness of a single-layer for demonstration. An auto-focus device can be easily implemented into the new OCT in order to diminish the measurement error resulting from the slight vibration of the sample and/or the sample stage. However, if the conventional OCT is implemented with an auto-focus device, it would be extremely difficult in locating and controlling the positions of the sample and scanning stages.From the experimental results, the error percentage from various frequency of the simulated noise is almost under 0.4%. Due to the resonance frequency of a DVD pickup head is around 40 Hz, the error percentage is apparently highest up to 1%; however still acceptable. It is concluded that the auto-focus device indeed works in an OCT system.     

OCT图像法测量折射率

基于光程匹配原理提出了一种用光学相干断层成像(OCT)系统获得的图像测量样品折射率的方法。通过分析光程匹配原理,给出用OCT图像法测量样品折射率的原理及过程。以玻璃载波片和黄瓜组织为样品进行实验。实验结果表明,用OCT图像法获得的载玻片和黄瓜组织的折射率测量值分别为1.499和1.353,与发表或已知的折射率结果相吻合,测试结果的随机误差可小于0.01。另外,使用OCT图像法通过短时间所采集的两幅图像可对横向扫描任意位置的折射率同时进行测量。该方法进一步简化了基于光程匹配原理的折射率测量法的过程,缩短了测量时间,是一种快速测量样品折射率的实用方法。     

Ultra-High Resolution Optical Coherence Tomography (OCT) Using a Halogen Lamp as the Light Source

The axial resolution of optical coherence tomography (OCT) is determined by the coherence length of the light source. We demonstrate for the first time high-resolution OCT of biological tissue using a halogen lamp as the light source for a low coherence interferometer. High-resolution OCT imaging with 3.5 μm resolution was performed successfully for onion and porcine skin, although the coherence light power for illumination of a sample is as small as 100 nW.     

Polarization Sensitive Spectral Interferometric Optical Coherence Tomography for Biological Samples

A spectral interferometric optical coherence tomography (OCT) system which has polarization sensitivity is developed. This system reduces the mechanical scanning dimension by employing the principle of spectral interferometry, and measures a two dimensional cross-sectional image of biological tissue with one dimensional mechanical scanning. Sixteen OCT images with different polarization conditions are measured, and two dimensional distributions of each element of the Müller matrix of a sample to be measured are calculated.     

低相干光断层扫描系统的噪声分析与研究

低相干光断层扫描,是近十几年来发展起来集多种前沿科学和技术为一体的超高精度成像技术。介绍了该技术的理论原理及本实验室建立的基于时域线性调制和光纤迈克耳孙干涉仪的低相干光断层扫描系统并给出了初步的实验结果。重点对光源谱型和参考臂扫描速度不均匀性对系统输出信噪比的影响进行了理论模拟计算和实验研究。通过运用傅里叶频谱的分析方法,从工程设计的角度出发给出了基于实验结果的参量特性分析以及这些特性将会给实际光学相干层析系统测量结果带来的影响,从而获得了低相干光断层扫描系统改进的方法。     

The application of optical coherence tomography to problems in polymer matrix composites

The Composites Group at the National Institute of Standards and Technology has found optical coherence tomography (OCT) to be a powerful tool for non-destructive characterization of polymer matrix composites. Composites often exhibit superior properties to traditional materials such as wood and metal. However, the barrier to their widespread infiltration into consumer markets is cost. Composites can be made more cost competitive by improved composite design, process optimization, and quality control. OCT provides a means of evaluating the three aforementioned areas. OCT is a very versatile technique that can be applied to a variety of problems in polymer composites such as: microstructure determination for permeability and mechanical property prediction, void, dry spot, and defect detection, and damage evaluation. Briefly, OCT uses a low coherence source such as a superluminescent diode laser with a fiber optic based Michelson interferometer. In this configuration, the composite is the fixed arm of the interferometer. Reflections from heterogeneities within the sample are mapped as a function of thickness for any one position. Volume information is generated by translating the sample on a motorized stage. Information about the location and size of a feature within the composite is obtained. In this work, the power of OCT for imaging composite microstructure and damage is presented. An example of permeability prediction using the composite microstructure imaged from OCT is demonstrated. The effect of image processing on the value of permeability is discussed. Using the same sample, OCT imaging of composite impact damage is compared to more traditional techniques, X-ray computed tomography and confocal microscopy.     

适合于内窥成像的共路型光学相干层析成像系统

提出了一种采用光纤型迈克耳孙干涉仪进行光程补偿的菲佐型光学相干层析成像(OCT)系统.该系统的传感探头为共路干涉结构,以解决现有内窥光学相干层析成像系统中存在的探头运动导致图像失真、以及更换使用不同探头时需进行色散和偏振态调节等问题.光程补偿和振动干扰实验结果表明,光程补偿方法正确可行,系统对环境干扰不敏感.利用研制的系统对反射镜和近红外卡进行了成像实验,验证了系统的有效性.提出的方法非常适合于内窥成像,并给出了把系统扩展为内窥光学相干层析成像系统的具体实现过程.     

Range Technique in Scattering Medium Using a Needle-Fiber Optical Coherence Tomography System

A needle-fiber optical coherence tomography (OCT) system designed for guiding epidural anesthesia to a target is presented. In the preliminary experiment, a desired target in tofu as a strong scattering medium can be monitored over a sufficient range of several millimeters within a short measuring time. The axial resolution is 21 μm. In order to investigate the ranging performance, the relation between background noise levels and focus-scattering properties in a confocal optical system is numerically studied by use of Monte Carlo technique. Numerical results indicate that an appropriate focal length of the lens attached to the fiber should be used to separate the OCT signal from strong noise in strongly scattered medium.     

System for measuring optical admittance of a thin film stack

A new method based on the polarization interferometer structure has been applied to measure the optical admittance, the refractive index and thickness of a thin film. The structure is a vibration insensitive optical system. There is one Twyman-Green interferometer part to induce a phase difference and one Fizeau interferometer part to induce the interference in the system. The intensities coming from four different polarizers were measured at the same time to prevent mechanical vibration influence. Using the polarization interferometer, the optical admittance, the refractive index and thickness of a single layer of Ta₂O₅ thin film has been measured. The measurement results were compared with the results obtained by ellipsometer. The results meet reasonable values in both refractive index and thickness.     

从迈克耳孙干涉仪到光学相干层析术

介绍了迈克耳孙干涉仪在物理学发展史上的重要作用及生物医学成像技术的发展状况．从迈克耳孙干涉仪的发展过程出发,讨论了光学相干层析术的原理、特性及其在生物医学成像、物理学、材料科学中的应用,并将频谱光学相干层析术与傅里叶变换光谱术作了比较,最后讨论了它在教学上的意义．     

光纤型光学相干层析成像系统的研制

光学相干层析(OCT)成像技术是一新近发展的高分辨力生物医学成像手段,能非侵入性地对活体内部的结构与生理功能进行可视化观察。采用宽带近红外光源,基于迈克耳孙干涉原理和外差探测方法,建立了单模光纤型光学相干层析成像系统,相干地提取从生物体内部返回的深度分辨的弹性散射光信息,并依此构筑了自然状态下活体组织的二维光学相干层析成像图像和三维光学相干层析成像图像。光纤化设计的光学相干层析成像系统紧凑、灵活,便于与光纤导管、内窥镜和其它成像装置的有机结合,以拓展其观察范围和应用领域。     

Measurement of gradient refractive index profile of crystalline lens of fisheye in vivo using optical coherence tomography

We report the use of optical coherence tomography (OCT) for noninvasive measurement of the refractive index profile of a crystalline lens of a fisheye. The approach exploits the fact that OCT provides a direct measurement of the optical path of the light traveled through the medium. The gradient refractive index profile for the crystalline lens was retrieved by iterative fitting of the optical path calculated by the ray tracing method with that experimentally measured using OCT. The estimated error in refractive index is approximately 1%. The measured gradient refractive index and Matthiessen’s ratio (ratio of focal length to lens radius) are in good agreement with the previously reported values. PACS 42.62.Be; 42.30.-d; 42.30.Wb; 07.60.Vg     

双光栅快速扫描光学延迟线的色散补偿

光学相干层析成像(OCT)系统的纵向分辨力不仅与光源的带宽有关,而且与系统中两干涉臂间的色散匹配有关。如果色散没有得到精确匹配,将使光学相干层析成像系统的纵向分辨力达不到所预期的理论值。色散问题在超高分辨光学相干层析成像系统中尤为突出。提出了一种基于双光栅快速扫描光学延迟线(RSOD),用于光学相干层析成像系统的色散补偿。该方法中新增的光栅引入了光栅间距这一独立变量,其与常规单光栅快速扫描光学延迟线机构中的光栅离焦量一起,可使光学相干层析成像系统中的群速度色散(GVD)和三阶色散(TOD)同时得到补偿。分析了双光栅快速扫描光学延迟线的色散特性和色散调节原则,并提供了一个典型光学相干层析成像系统中的色散补偿实例。     

光学相干层析成像的图像重建

层析成像技术－光学相干层析术是基于光学低相干反射测量发展而来的。介绍了用图像恢复的基本原理在光学相干层析术图像增强方面的工作。通过实验测量行到了解卷积所必需的点扩展函数。重建后的膜层结构图像的深度分辨率提高了一个数量级,图像也取得了了的锐化、去噪的效果。     

光学相干断层扫描成像新技术OCT

光学相干层析成像技术（optical coherence tomography,简称OCT）是一种新型成像方法,在生物医学和材料等许多领域有广泛的应用。本文介绍了OCT的基本原理,并给出了用该装置对生物组织样品的成像结果。此外还用计算机图像处理的方法,使得图像分辨率得到了进一步提高。     

Quantitative assessment of touch-screen panel by nondestructive inspection with three-dimensional real-time display optical coherence tomography

We investigated the use of optical coherence tomography (OCT) to measure several materials immersed in optical adhesives. The effects of variations in the concentration, physical characteristics, and thickness of the materials were studied, and these parameters were found to significantly affect the OCT measurement. The materials were selected for their distinct spectral properties in the infrared region. To ensure reliability, we acquired images using a scanning electron microscope after performing the semiconductor production process. We verified the feasibility of the application of OCT for defect inspection and product verification of touch-screen panels.     

光学相干层析成像色散补偿研究

针对通过增加光源谱宽度来提高光学相干层析成像系统分辨率时样品色散特性的限制作用,分析了色散与光学相干层析成像系统纵向光程分辨率的约束关系.根据物质色散特性,采用数值变换方法对光学相干层析成像相干成像信号进行了色散补偿.实验使用了中心波长1 550 nm 自激发辐射光源和光纤迈克尓逊干涉结构,对水和光学快速扫描延迟线引入的二阶和三阶色散进行了数值补偿并通过相位修正因子来改善补偿效果.确定了一种普适的、快速的数值色散补偿方法.在对水中盖玻片和生物组织和的光学相干层析成像图像的色散补偿实验中取得了良好的效果,证明了方法的可行性.