Eco-friendly methods of synthesis and preliminary biological evaluation of sulfonamide derivatives of cyclic arylguanidines

The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties. The methods of the synthesis presented in the literature are characterized with low selectivity and high environmental nuisance. In this publication, we present a developed alternative and earlier undescribed pathway C, for the synthesis of arylsulfonamide derivatives of cyclic arylguanidines (N-(1H-arylimidazol-2-yl)arylsulfonamides and N-(1,4-dihydroquinazolin-2-yl)arylsulfonamides), including reaction between 2-(methylsulfanyl)-benzimidazole or 2-(methylsulfanyl)-3,4-dihydroquinazoline with arylsulfonamides. We also optimized previously reported methods; A (reaction of 2-aminobenzimidazole or 2-amino-3,4-dihydroquinazoline with arylsulfonyl chlorides) and B (reaction of dimethyl-(arylsulfonyl)carbonodithioimidate with aryldiamines). The conducted research allowed achieving two independent ecological and quick methods of obtaining the desired products. We used ecological methods of ultrasound-assisted or microwave synthesis, solvent-free reactions and a “green” reaction environment. In both pathways, it has proven advantageous to use H₂O as the solvent and K₂CO₃ (1 or 3 equivalent) as the basic agent. In the sonochemical variant, the efficiency reached B: 37–89 %, C: 90 % in 60 min (P = 80 W and f = 40 kHz), while in the microwave synthesis it was B: 38–74 %, C: 63–85 % in 0.5–4 min (P = 50 W). Path A led to a complementary substitution product (i.e. 1-(arylsulfonyl)-1H-benzimidazol-2-amine or 1-(arylsulfonyl)-1,4-dihydroquinazolin-2-amine). We obtained a small group of compounds that were tested for cytotoxicity. The 10f (N-(1,4-dihydroquinazolin-2-yl)naphthalene-1-sulfonamide) showed cytotoxic activity towards human astrocytoma cell line 1321 N1. The calculated IC₅₀ value was 8.22 µM at 24 h timepoint (doxorubicin suppressed 1321 N1 cell viability with IC₅₀ of 1.1 µM). The viability of the cells exposed to 10f for 24 h dropped to 48.0 % compared to vehicle control, while the cells treated with doxorubicin experienced decline to 47.5 %. We assessed its potential usefulness in pharmacotherapy in the ADMET study, confirming its ability to cross the blood–brain barrier (Pe = 5.0 ± 1.5 × 10^-6 cm/s) and the safety of its potential use in terms of DDI and hepatotoxicity.     

Dynamic features of a laser-induced cavitation bubble near a solid boundary

This paper deals with detailed features of bubble dynamics near a solid boundary. The cavitation bubble was created by using a Q-switched Nd: YAG laser pulse and observed using a high-speed camera (up to 100,000 frames per second). A hydrophone system was employed to monitor the acoustic signals generated by the transient pressure impulses and estimate the bubble oscillation periods. Experimental observations were carried out for bubbles with various maximum expanded radius R_max (between 1.0 mm and 1.6 mm) and stand-off distances, ds (defined as the distance between the solid boundary and the bubble center at inception) of 0.4 ? γ ? 3.0, and γ = ds/R_max. The existence of a solid boundary created asymmetry in the flow field and forced the bubble to collapse non-spherically, which finally brought forth the jet impact phenomenon. The dimensionless first and second oscillation periods were dependent on γ. A series of expansion and collapse of the bubble with cascading loss of energy were observed after the bubble had been generated. This study revealed that most bubbles lost about two-thirds of the total energy from the first maximum expansion to the second maximum expansion.     

Ultrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84–96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dispolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. All the target compounds were characterized by HRMS, FT-IR, ¹H NMR and ¹³C NMR spectroscopy. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C₁₀-HSL as a positive control. The compounds 8a, 8c and 8f exhibited considerable levels of inhibitory activity against violacein production, and IC₅₀ values were 217 ± 19, 223 ± 20 and 42.8 ± 4.5 μM, respectively, which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.     

Unbinding of adhesive vesicles

We consider a vesicle, bound on one side to a pipette and sticking on the other side to a flat plate. When a pulling force f is applied to the pipette, the radius R_c of the contact patch decreases, and jumps to zero at a critical value of the force. We present here an extension of the Evans theory for these processes. Then we discuss the dynamics of separation for two distinct cases: (a) nonspecific adhesion; and (b) specific adhesion induced by mobile proteins. To cite this article: F. Brochard-Wyart, P.-G. de Gennes, C. R. Physique 4 (2003).     

A comprehensive numerical analysis of heat and mass transfer phenomenons during cavitation sono-process

The present study treats the effects of mass transport, heat transfer and chemical reactions heat on the bubble dynamics by spanning a range of ambient bubble radii. The thermodynamic behavior of the acoustic bubble was shown for three wave frequencies, 355, 515 and 1000 kHz. The used acoustic amplitude ranges from 1 to 3 atm. It has been demonstrated that the ambient bubble radius, R₀, of the maximal response (i.e., maximal bubble temperature and pressure, T_max and P_max) is shifted toward lower values if the acoustic amplitude (at fixed frequency) or the ultrasonic frequency (at fixed amplitude) are increased. The range of the ambient bubble radius narrows as the ultrasonic frequency increases. Heat exchange at the bubble interface was found to be the most important mechanism within the bubble internal energy balance for acoustic amplitudes lower than 2.5 and 3 atm for ultrasonic frequencies of 355 and 515 kHz, respectively. For acoustic amplitudes greater or equal to 2.5 and 3 atm, corresponding to 355 and 515 kHz, respectively, mass transport mechanism (i.e., evaporation and condensation of water vapor) becomes dominant compared to the other mechanisms. At 1000 kHz, the mechanism of heat transfer persists to be dominant for all the used acoustic amplitudes (from 1 to 3 atm). Practically, all the above observations were maintained for bubbles at and around the optimum bubble radius, whereas no significant impact of the three energetic mechanisms was observed for bubbles of too lower and too higher values of R₀ (limits of the investigated ranges of R₀).     

Electronic band structure calculation of GaNAsBi alloys and effective mass study

Electronic band structures of GaN_xAs_1−x−yBi_y dilute nitrides–bismides have been determined theoretically within the framework of the band anticrossing (BAC) model and k ⋅ p method. We have developed computer codes based on our extended BAC model, denoted (16 × 16), in which the dimension of the used states basis was equal to 16. We have investigated the band gap and the spin orbit splitting as a function of Bi composition for alloys lattice matched to GaAs. We have found that the substitution of As element by N and Bi impurities leads to a significant reduction of band gap energy by roughly 198 meV/%Bi. Meanwhile, spin orbit splitting increases by 56 meV/%Bi regardless N content. There is an excellent agreement between the model predictions and experiment reported in the literature. In addition, alloys compositions and oscillator strengths of transition energies have been calculated for GaNAsBi alloys which represent active zone of temperature insensitive (1.55 μm and 1.3 μm) wavelength laser diodes intended for optical fiber communications. A crossover at about 0.6 eV has occurred between E_g and Δ_so of GaN_.039As_.893Bi_.068. When the quaternary is lattice mismatched to GaAs, resonance energy increases with Bi content if N content decreases. On the other hand, effective mass behavior of carriers at Γ point has been discussed with respect to alloy composition, k-directions and lattice mismatch.     

Études RMN haute résolution et RPE des composés Ba3C60 et Ba6C60

We report the results of ¹³C MAS NMR and EPR measurements on Ba₃C₆₀ and Ba₆C₆₀ fullerides. Using high resolution NMR, we were able to identify an isotropic line around 156 ppm for Ba₃C₆₀ and a broad isotropic one with three components at 132, 134.6, 139.9 ppm for Ba₆C₆₀ compound. The latter line is consistent with orientationally ordered C₆₀ molecules leading to three unequivalent carbon sites in agreement with X-ray studies. A strong diamagnetic shift was observed for the NMR line of Ba₆C₆₀ that is interpreted in terms of transition moment in an indirect gap system. EPR results confirm the insulating nature of both studied compounds. To cite this article: A. Rezzouk et al., C. R. Physique 4 (2003).     

Enhanced mangnetoelectric voltage in multiferroic particulate Ni0.83Co0.15Cu0.02Fe1.9O4−δ/PbZr0.52Ti0.48O3 composites – dielectric,piezoelectric and magnetic properties

Multiferroic particulate composites of Ni_0.83Co_0.15Cu_0.02Fe_1.9O_4−δ– NCCF and lead zirconate titanate (PZT) were prepared conventional ceramic method. The generic formulae x NCCF + (1−x) PZT where x = 0.1, 0.2, 0.3, 0.4, 0.5 and 0.6 mole fractions. The presence of two phases in multiferroic was confirmed with XRD technique. The dielectric constant and loss tangent were studied as a function of frequency (100 Hz to 1 M Hz) and temperature (30–500 °C). The piezoelectric coefficient d₃₃ were also studied on these particulate composites. The hysteresis behaviour was studied to understand the magnetic properties such as saturation magnetization (Ms) and magnetic moment (μ_B). The static magnetoelectric (ME) voltage coefficient was measured as a function of dc magnetic bias field. A high value of ME output (3151 mV/Oe.cm) was obtained in the composite containing 50% highly magnetostrictive ferrite component NCCF – 50% highly piezoelectric ferroelectric component PZT. These multiferroic particulate composites are used as phase shifters, magnetic sensors, cables etc.     

High-efficiency degradation catalytic performance of a novel Angelica sinensis polysaccharide-silver nanomaterial for dyes by ultrasonic cavitation

Currently, the polluted wastewater discharged by industry accounts for the major part of polluted bodies of water. As one of the industrial wastewaters, dye wastewater is characterized by high toxicity, wide pollution, and difficulty in decolorization degradation. In this paper, a novel composite nanomaterial catalyst of silver was prepared by using Angelica sinensis polysaccharide (ASP) as a reducing and stabilizing agent. And the optimum reaction conditions explored are V_AgNO3 = 5 mL (300 mM) and v_ASP = 7% (w/v) for 6 h at 90 °C. In addition, the ASP-Ag nanocatalyst was characterized by several techniques. The results demonstrated that ASP-Ag nanoparticles were successfully synthesized. Degradation rate, which provides a numerical visualization of the percentage reduction in pollutant concentration. With the wrapping of ASP, the ultrasonic catalytic degradation rates of different organic dyes including rhodamine B (RB), methylene blue (MB), and methyl orange (MO) were from 88.2%, 88.7%, and 85.2% to 96.1%, 95.2% and 93.5% at room temperature, respectively. After the experiments, when c_dyes = 10 mg/L, the highest degradation rate can be observed under c_APS-AgNPs = 10 mg/L with the most powerful cavitation frequency f = 59 kHz. The effect of ultrasonic frequency on the acoustic pressure distribution in the reactor was investigated by using COMSOL Multiphysis^@ software to propose the mechanism of ultrasonic degradation and the mechanism was confirmed by OH radical trapping experiments. It indicates that OH produced by the ultrasonic cavitation effect plays a determinant role in the degradation. And then, the intermediate products of the dye degradation process were analyzed by gas chromatography and mass spectrometry (GC–MS), and the possible degradation processes of dyes were proposed. The resulting products of degradation are SO₄²⁻, NH₄⁺, NO₃⁻, N₂, CO₂ and H₂O. Finally, the recycling degradation experiments showed that catalyst maintains a high degradation rate within reusing 5 cycles. Thus, this catalyst is highly efficient and recyclable.     

Ultrasound-assisted synthesis of water-soluble monosubstituted diruthenium compounds

The elusive monosubstituted diruthenium complexes [Ru₂Cl(DAniF)(O₂CMe)₃] (1), [Ru₂Cl(DPhF)(O₂CMe)₃] (2), [Ru₂Cl(D-p-CNPhF)(O₂CMe)₃] (3), [Ru₂Cl(D-o-TolF)(O₂CMe)₃] (4), [Ru₂Cl(D-m-TolF)(O₂CMe)₃] (5), [Ru₂Cl(D-p-TolF)(O₂CMe)₃] (6) and [Ru₂Cl(p-TolA)(O₂CMe)₃] (7) have been synthesized using for the first time ultrasound-assisted synthesis to carry out a substitution reaction in metal–metal bonded dinuclear compounds (DAniF⁻ = N,N′-bis(4-anisyl)formamidinate; DPhF⁻ = N,N′-diphenylformamidinate; D-p-CNPhF⁻ = N,N′-bis(4-cyanophenyl)formamidinate; D-o/m/p-TolF⁻ = N,N′-bis(2/3/4-tolyl)formamidinate; p-TolA⁻ = N-4-tolylamidate). This is a simpler and greener method than the tedious procedures described in the literature, and it has permitted to obtain water-soluble complexes with good yields in a short period of time. A synthetic study has been implemented to find the best experimental conditions to prepare compounds 1–7. Two different types of ligands, formamidinate and amidate, have been used to check the generality of the method for the preparation of monosubstituted complexes. Five new compounds (2–6) have been obtained using a formamidinate ligand, the synthesis of the previously described compound 1 has been improved, and an unprecedented monoamidate complex has been achieved (7). The crystal structures of compounds 3 and 7 have been solved by single crystal X-ray diffraction. These compounds show the typical paddlewheel structure with three acetate ligands and one formamidinate (3) or amidate (7) bridging ligand at the equatorial positions. The axial positions are occupied by the chloride ligand giving rise to one-dimensional polymer structures that were previously unknown for monosubstituted compounds.     

Sonochemical synthesis of nano-scale mixed-ligands lead(II) coordination polymers as precursors for preparation of PbO and PbBr(OH) nano-structures; thermal,structural and X-ray powder diffraction studies

Nano-structures of two new lead(II) two-dimensional coordination polymers, [Pb₂(2-pyc)₂(I)₂]_n (1) and [Pb₂(2-pyc)₂(Br)₂]_n (2), {2-Hpyc = 2-pyridinecarboxilic acid } were synthesized by a sonochemical method that produce the coordination polymers at nano-size. The new nano-structures were characterized by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy and elemental analyses. Compounds 1 and 2 were structurally characterized by single crystal X-ray diffraction and consist of two-dimensional polymeric units. The thermal stability of compounds 1 and 2 were studied by thermal gravimetric and differential thermal analyses. PbO and PbBr(OH) nano-structures were obtained by calcination of the nano-structures of compounds 1 and 2 at 400 °C, respectively.     

Sonochemical synthesis of nanoscale mixed-ligands lead(II) coordination polymers as precursors for preparation of Pb2(SO4)O and PbO nanoparticles; thermal,structural and X-ray powder diffraction studies

Nano-structures of two new Pb(II) two-dimensional coordination polymers, [Pb(μ-4-pyc)(μ-NCS)(μ-H₂O)]_n (1) and [Pb(μ-4-pyc)(μ-N₃)(μ-H₂O)]_n (2), 4-Hpyc = 4-pyridinecarboxylic acid were synthesized by a sonochemical method. The new nano-structures were characterized by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy and elemental analyses. Compounds 1 and 2 were structurally characterized by single crystal X-ray diffraction and consist of two-dimensional polymeric units. The thermal stability of compounds 1 and 2 were studied by thermal gravimetric and differential thermal analyses and compared. Pb₂(SO₄)O and PbO nanoparticles were obtained by calcination of the nano-structures of compounds 1 and 2 at 600 °C, respectively.     

UV–Vis and NMR spectroscopic investigations on effective and selective non-covalent interactions between fullerenes and calix[6]arene

Ground state non-covalent interactions between a macro cyclic calixarene receptor, namely, 4-tert-butylcalix[6]arene (1), and fullerenes (C₆₀ and C₇₀) were studied in toluene medium by absorption spectrophotometric method. Absorption band due to the charge transfer (CT) transition have been observed in the visible region between fullerenes and 1. Utilizing the CT absorption bands, various important physicochemical parameters like oscillator strength, resonance energy, transition dipole strength of the fullerene-1 complexes and ionization potential of 1 is determined in present investigations. From Jobs method of continuous variation, it is observed that both C₆₀ and C₇₀ form stable 1:1 complexes with 1. The most fascinating feature of the present study is that 1 binds selectively C₇₀ compared to C₆₀ as obtained from binding constant (K) data of C₆₀–1 (K_C60–1) and C₇₀–1 (K_C70–1) complexes, i.e., K_C60–1 = 32,400 dm³·mol^? 1 and K_C70–1 = 110,000 dm³.mol^? 1 and selectivity (K_C70–1/K_C60–1) = 3.4. ¹H NMR analysis provides very good support in favor of strong binding between C₇₀ and 1.     

STM spectroscopy of an organic superconductor

Electron tunneling spectroscopy of the organic superconductor κ-(BEDT-TTF)₂Cu(NCS)₂using low temperature scanning tunneling microscope (STM) is reported. The tunneling differential conductance in the superconducting phase was obtained in theb–cplane of a single crystal, by varying the tip position on the sample surface. The differential conductance is reduced near zero bias voltage and enhanced at the gap edge, associated with the superconducting gap structure below[formula] K. The gap width differs slightly from sample to sample, while the overall functional shape of the conductance is sample-independent. The tunneling conductance is reduced to almost zero near zero bias voltage, while it is finite inside the gap edge. The curve obtained cannot be fit to the BCS density of states withs-wave pairing symmetry, even if the life-time broadening of one-electron levels is taken into account. Finite conductance inside the gap edge suggests anisotropy of the gap. However, the conductance curve obtained is not explained by a simpled-wave symmetry for Δ(k). The reduced conductance near zero bias voltage suggests a finite gap. An anisotropic model with a finite gap, in which Δ(k) varies depending on the direction ink-space, is examined. The tunneling conductance in the low-energy region is almost fit by the model with Δ_min = 2 meV and Δ_max = 6 meV. The finite conductance is explained by introducing a small effect of life time broadening. We conclude that the gap is anisotropic and is finite (at least Δ_min = 2 meV) on the entire Fermi surface.     

Sonochemical synthesis and characterization of nano-sized lead(II) 3D coordination polymer: Precursor for the synthesis of lead(II) oxybromide nanoparticles

Nanoparticles of a three-dimensional coordination polymer, [Pb(L)(μ₂-Br)(H₂O)]_n (1), (L^? = 1H-1,2,4-triazole-3-carboxylate), have been synthesized by an ultrasonic method and characterized by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy and elemental analyses. The thermal stability of compound 1 both its bulk and nano-size has been studied by thermal gravimetric (TG) and differential thermal (DTA) analyses and compared each other. Concentration of initial reagents effects and the role of power ultrasound irradiation on size and morphology of nano-structured compound 1, have been studied. Calcination of the compound 1 at 500 °C under air atmosphere yields Pb₃O₂Br₂ nanoparticles.     

Synthesis,characterization and luminescence study of dimethyl[N-arylmethylenethiobenzahydrazonato]indium

Five dimethylindium complexes of type Me₂InL [L = N-(4-methoxy)benzylidenethiobenzahydrazonato (1), N-(3,4-dimethoxy)benzylidenethiobenzahydrazonato (2), N-(4-N,N-dimethylamino)benzylidenethiobenzahydrazonato (3), N-(2-naphthyl)methylene thiobenzahydrazonato (4) and N-(9-anthryl)methylenethiobenzahydrazonato (5)] have been synthesized by reaction of trimethylindium with appropriate N-arylmethylenethiobenzahydrozones. The complexes obtained have been characterized by elemental analysis, ¹H NMR, IR and mass spectroscopy. Compounds 1–5 emit blue colors at λ_max = 432–479 nm when irradiated by UV light. The electroluminescent (EL) properties of 1–5 were examined by fabricating EL devices using 1–5 as emitter, respectively. The EL bands are located in the green region (513–578 nm).     

Sonochemical synthesis of a new nano-sized cerium(III) supramolecular compound; Precursor for nanoceria

Using a sonochemical method, nanoparticles of a new Ce(III) supramolecular compound, (NAMH⁺)₂[Ce₄(pydc)₆(pydcH)₂(H₂O)₈]·8H₂O (1), (H₂pydc = 2,6-pyridinedicarboxylic acid, NAM = nicotinamide), have been synthesized. Compound 1 was characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), FT-IR spectroscopy and elemental analyses, and its structure was determined by X-ray crystallography. It has been revealed that its structure consists of tetra-nuclear building units that extend to a 3D supramolecular network via non-covalent interactions mainly hydrogen bonding. The thermal stability of complex 1 both for its crystals and nanostructures has been studied by the thermal gravimetric (TG) method and compared with each other. The role of ultrasound irradiation power and the concentration of initial reactants on the size and morphology of the nano-structured complex 1, has been investigated. Ceria nanoparticles were obtained upon the calcination of complex 1 at 800 °C under atmospheric air. Furthermore, the fluorescent properties of complex 1 at room temperature were studied.     

New sonochemiluminescence involving solvated electron in Ce(III)/Ce(IV) solutions

The moving single-bubble sonoluminescence of Ce³⁺ in water and ethylene glycol solutions of CeCl₃ and (NH₄)₂Ce(NO₃)₆ was studied. As found, a significant part of intensity of the luminescence (100% with cerium concentration less than 10^–4 M) is due to the sonochemiluminescence. A key reaction of sonochemiluminescence is the Ce⁴⁺ reduction by a solvated (or hydrated in water) electron: Ce⁴⁺ + e_s (e_aq) → *Ce³⁺. Solvated electrons are formed in a solution via electrons ejection from a low-temperature plasma periodically generated in deformable moving bubble at acoustic vibrations. Reactions of heterolytic dissociation of solvents make up the source of electrons in the plasma. In aqueous CeCl₃ solutions, the Ce⁴⁺ ion is formed at the oxidation of Ce³⁺ by OH radical. The latter species originates from homolytic dissociation of water in the plasma of the bubble, also penetrating from the moving bubble into the solution. The sonochemiluminescence in cerium trichloride solutions are quenched by the Br⁻ (acceptor of OH) and H⁺ ions (acceptor of e_aq). In water and ethylene glycol solutions of (NH₄)₂Ce(NO₃)₆, the sonochemiluminescence also quenched by the H⁺ ion. The sonochemiluminescence in CeCl₃ solutions is registered at [Ce³⁺] ≥ 10^–5 M. Then the sonochemiluminescence intensity increases with the cerium ion concentration and reaches the saturation plateau at 10^–2 M. It was shown that sonophotoluminescence (re-emission of light of bubble plasma emitters by cerium ions) also contributes to the luminescence of Ce³⁺ in solutions with [Ce³⁺] ≥ 10^–4 M. If the cerium concentration is more than 10^–2 M, a third source contributes to luminescence, viz., the collisional excitation of Ce³⁺ ions penetrating into the moving bubble.     

Magnetoresistance hysteresis of bulk textured Bi1.8Pb0.3Sr1.9Ca2Cu3Ox + Ag ceramics and its anisotropy

Magnetoresistance of bulk textured Bi_1.8Pb_0.3Sr_1.9Ca₂Cu₃O_x + Ag ceramics has been studied in the magnetic fields applied parallel and perpendicular to a–b planes of Bi2223 crystallites. Besides well known anisotropy of magnetoresistance of textured superconductors (R_H || c > R_H || a–b), anisotropic hysteresis of R(H) dependences was investigated. Parameters characterizing hysteretic R(H) curves differ for the cases H || c and H || a–b. This behavior is explained within the model of a granular superconductor where the total magnetic induction in the intercrystallite boundaries is superposition of the external field and the magnetic field induced by dipole magnetic moments of neighbor crystallites.     

Sonochemical effect on two new Ruthenium(II) complexes with ligand (E)-N-((6-bromopyridin-2-yl)methylene)-4-(methylthio)aniline precursors for synthesis of RuO2 nanoparticles

Two novel Ru(II) complexes [(η⁶-p-cymene)RuCl(L2)]PF₆ (R2) and [(η⁶-C₆H₆)RuCl(L2)]PF₆ (R4), with ligand (E)-N-((6-bromopyridin-2-yl)methylene)-4-(methylthio)aniline (L2), were synthesized and characterized by elemental analysis, ¹H NMR, ¹³C NMR and IR spectroscopy. Based on X-ray crystallography studies, complexes R2 and R4 have coordination environments with formulated (η⁶-p-cymene)Ru(N₂Cl) and (η⁶-C₆H₆)Ru(N₂Cl), respectively. The thermal stabilities of compounds R2 and R4 were studied by thermal gravimetric (TG) and differential scanning calorimetry (DSC). Thermal decomposition of these complexes was at 280 °C and 260 °C under air atmosphere respectively. The interaction of these complexes with calf thymus DNA (CT-DNA) was explored through electronic absorption spectra, fluorescence and redox behavior studies. The results showed that the complexes bind to CT-DNA with electrostatic interactions. Nanoparticles of RuO₂ were prepared by calcination of R2 and R4. Also the role of the ultrasound waves on the characteristics of the RuO₂ nanoparticles was studied. The nanoparticles were characterized by IR spectroscopy and X-ray diffraction (XRD). Also size and morphology of nanoparticles were studied by scanning electron microscopy (SEM).