Overview on the synthetic routes to nicotine nitriles

The biological and medicinal properties of nicotinonitrile and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocyclic. This review highlights the different synthetic routes to nicotine nitriles.     

Chalcone derived benzoheterodiazepines for medicinal applications: A Two-pot and one-pot synthetic approach

The production of effective drugs has continuously been a challenging process for researchers due to the occurrence of resistive diseases. Drugs derived from natural product-based compounds as an active scaffold have gained interest in drug development due to a wide range of biological properties. Benzoheterodiazepines, a natural product derivative of bicyclic chalcones have been widely reported with various therapeutic potentials. This review discusses current synthetic methods in the preparation of benzoheterodiazepine derivatives (i.e., homocyclic benzoheterodiazepine, heterocyclic benzoheterodiazepine, bis-benzoheterodiazepine, and fused benzoheterodiazepine) via two-pot and one-pot synthetic routes. Several reaction protocols following both synthetic routes have been developed for efficient and higher yields that offer access to different functionalization of benzoheterodiazepines are comprehensively described. This review is important in the heterocyclic chemistry of benzoheterodiazepines and pharmacological industries in drug development processes.     

Modular synthesis of optically active lactones by Ru-catalyzed asymmetric allylic carboxylation and ring-closing metathesis reaction

A new synthetic route to optically active unsaturated γ- and δ-lactones has been demonstrated via asymmetric allylic carboxylation with a planar-chiral Cp'Ru catalyst and ring-closing metathesis reaction with a Grubbs II catalyst, and successfully applied to the enantioselective synthesis of (R)-(-)-massoialactone.     

Revisiting the Chemistry of Vinylpyrazoles: Properties,Synthesis, and Reactivity

Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.     

Decades of synthesis and application of spiro cyclopropanes

This review demonstrates the synthesis and application of spirocyclopropane annelated to six- and five-member rings in recent decades. The aim of this review was to give ideas to researchers about organic chemistry and synthetic routes.     

The syntheses and catalytic applications of unsymmetrical ferrocene ligands

Interest in the chemistry of ferrocene remains intense, largely due to applications within catalysis. New synthetic routes to unsymmetrical ferrocene ligands have provided another facet to this area, as substituents can be designed to be electronically- and/or sterically-distinct in order to affect the environment around the catalytically-active metal centre. This critical review provides a concise summary of the synthetic routes that have been applied to the synthesis of unsymmetrical ferrocene ligands, along with a systematic survey of the applications of these ligands in homogeneous catalysis. The aim is to help the reader select a suitable ferrocenediyl ligand for a particular synthetic application, and in the synthesis of ligands that require particular structural and/or electronic features.     

Recent synthetic methodologies for pyrazolo[1,5-a]pyrimidine

The development of new synthetic routes towards pyrazolo[1,5-a]pyrimidines for their biological and medicinal exploration is an attractive area for researchers. This review focuses on various synthetic routes developed in the last decade for the synthesis of differently substituted pyrazolo[1,5-a]pyrimidines by a broad range of organic reactions by means of 5-aminopyrazole as a precursor.     

The synthesis of an enantiopure planar-chiral Lewis acid complex via kinetic resolution and its application in stereoselective additions to imines

This report describes the synthesis and an application of a new planar-chiral Lewis acid based on a 1,2-azaborolyl framework. The enantiopure complex is generated through an intriguing kinetic resolution by a chiral nucleophile. Imines bind in excellent yield to the planar-chiral 1,2-azaborolyl, furnishing crystallographically characterizable adducts that adopt the conformation that had been anticipated on the basis of steric considerations. Nucleophiles add with high stereoselectivity to these complexes, with the predicted sense of asymmetric induction.     

Synthetic Approaches to α-, β-, γ-, and δ-Lycoranes

Lycorane is a pentacyclic core presented in alkaloids isolated from the Amaryllidaceae family of herbaceous flowering plants. Members of this class of natural products have shown to display important biological properties including analgesic, antiviral, and antiproliferative activities. This review presents the known synthetic routes toward α-, β-, γ-, and δ-lycoranes. α-(19 routes), β-(10 routes), γ-(38 routes), and δ-(6 routes).     

爱博霉素B的全合成研究进展

爱博霉素B是16元环的大环内酯类化合物,以其独特的抗癌性能和复杂新颖的化学结构而受到越来越多的化学工作者的关注,从发现至今已有许多研究小组报道了相关的全合成研究成果.本文作者综述了其合成研究进展,分析了各合成路线的关键步骤,讨论了某些路线的优缺点,并对该药的研究前景进行了展望.     

Remarkably flexible quinazolinones—synthesis and biological applications

Even though several quinazolinone derivatives have been synthesized, still there is a constant demand for designing and synthesis of new quinazolinone derivatives by fine-tuning the electronic and steric properties of substituents due to their interesting structure-based biological utilities and the versatile chemistry. While many of the synthetic routes are useful as building blocks in synthetic organic chemistry, the drawbacks of some of these methods like unsatisfactory or variable yields, prolonged reaction times, inadequate tolerance to other substrates, including the use of costly catalysts/reagents. This review article is mainly focused on various synthetic routes for the preparation of quinazolinones, their important properties and applications.     

Synthesis and medicinal importance of oxicams and their analogues

The biological and medicinal properties of oxicams and its analogues are attracting attention of chemist aimed at developing synthetic routes to these heterocycles. This review focuses on the synthesis and medical importance of oxicams and their analogues.     

Overview of the synthetic routes to sildenafil and its analogues

The biological and medicinal properties of sildenafil and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocycles. This review focuses on the chemical properties associated with this system.     

铜N-杂环卡宾化合物的合成及其在有机合成中的应用

N-杂环卡宾铜化合物具有简便易得,价廉低毒,性质稳定,结构类型多样并易于修饰等诸多优点,在很多领域具有重要的应用价值,因此铜的N-杂环卡宾化学在过去十几年中得到了快速发展。本文结合我们的工作,总结铜N-杂环卡宾化合物的合成方法、结构特点、转移卡宾配体用于合成其它金属卡宾化合物以及催化应用。     

An overview of the synthetic routes to Faipiravir and their analogous

The biological and medicinal properties of Favipiravir and its analogs have prompted enormous research aimed at developing synthetic routes to these heterocycles. This review focuses on the chemical properties associated with this system.     

Overview of the synthetic routes to tadalafil and its analogues

The biological and medicinal properties of tadalafil and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocyclic analogues. This review focuses on the chemical properties associated with this system.     

Structure, bioactivity and synthesis of natural products with hexahydropyrrolo[2,3-b]indole

Research on natural products containing hexahydropyrrolo[2,3-b]indole (HPI) has dramatically increased during the past few years. Newly discovered natural products with complex structures and important biological activities have recently been isolated and synthesized. This review summarizes the structures, biological activities, and synthetic routes for natural compounds containing HPI, emphasizing the different strategies for assembling this motif. It covers a broad range of molecules, from small alkaloids to complex peptides.     

Stoichiometric and catalytic activation of P-H and P-P bonds

The abilities of transition metal species to activate P-H and P-P bonds are emerging. Such investigations provide novel M-P species, as well as stoichiometric and catalytic routes to P(III) compounds. The application of organometallic approaches and methodologies to phosphorus chemistry is providing emerging, stoichiometric and catalytic routes to phosphorus compounds and materials. This tutorial review surveys recent advances, with a focus on the activation of P-H and P-P bonds. The isolation of novel M-P species provides insight, while stoichiometric and catalytic reactivity expands the arsenal of synthetic strategies leading to P(III) compounds.     

A Review: Synthesis and Medicinal Importance of Nicotinonitriles and Their Analogous

The biological, therapeutic, and medicinal properties of nicotinonitriles (cyanopyridines) and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review presents a systematic and comprehensive survey of the method of preparation, the chemical reactivity, and biological properties associated with this system.     

Overview of the synthetic routes of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamides-1,1-dioxides (oxicams) and their analogues

The biological and medicinal properties of oxicams and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocycles. This review focuses on the chemical properties associated with this system.