Reaction–Diffusion Equations in Immunology

Computational Mathematics and Mathematical Physics - The paper is devoted to the recent works on reaction–diffusion models of virus infection dynamics in human and animal organisms. Various...     

Existence and Uniqueness of Invariant Measures for Stochastic Reaction–Diffusion Equations in Unbounded Domains

In this paper, we investigate the long-time behavior of stochastic reaction–diffusion equations of the type \(\text {d}u = (Au + f(u))\text {d}t + \sigma (u) \text {d}W(t)\), where \(A\) is an elliptic operator, \(f\) and \(\sigma \) are nonlinear maps and \(W\) is an infinite-dimensional nuclear Wiener process. The emphasis is on unbounded domains. Under the assumption that the nonlinear function \(f\) possesses certain dissipative properties, this equation is known to have a solution with an expectation value which is uniformly bounded in time. Together with some compactness property, the existence of such a solution implies the existence of an invariant measure, which is an important step in establishing the ergodic behavior of the underlying physical system. In this paper, we expand the existing classes of nonlinear functions \(f\) and \(\sigma \) and elliptic operators \(A\) for which the invariant measure exists, in particular in unbounded domains. We also show the uniqueness of the invariant measure for an equation defined on the upper half space if \(A\) is the Shrödinger-type operator \(A = \frac{1}{\rho }(\text {div} \rho \nabla u)\) where \(\rho = \text {e}^{-|x|^2}\) is the Gaussian weight.     

Scaling Methods and Approximative Equations for Homogeneous Reaction—Diffusion Systems and Applications to Epidemics

Summary. We consider a reaction-diffusion equation that is homogeneous of degree one. This homogeneity is a symmetry. The dynamics is factorized into trivial evolution due to symmetry and nontrivial behavior by a projection to an appropriate hypermanifold. The resulting evolution equations are rather complex. We examine the bifurcation behavior of a stationary point of the projected system. For these purposes we develop techniques for dimension reduction similar to the Ginzburg-Landau (GL) approximation, the modulation equations. Since we are not in the classical GL situation, the remaining approximative equations have a quadratic nonlinearity and the amplitude does not scale with ε but with ε ² where ε ² denotes the bifurcation parameter. Moreover, the symmetry requires that not only one but two equations are necessary to describe the behavior of the system. We investigate traveling fronts for the modulation equations. This result is used to analyze an epidemic model. Received April 9, 1996; second revision received January 3, 1997; final revision received October 7, 1997; accepted January 19, 1998     

A Mesh Free Stochastic Algorithm for Solving Diffusion–Convection–Reaction Equations on Complicated Domains

A mesh free stochastic algorithm for solving transient diffusion–convection–reaction problems on domains with complicated structure is suggested. For the solutions of this kind of equations exact representations of the survival probabilities, the probability densities of the first passage time and position on a sphere are obtained. Based on these representations we construct a stochastic algorithm which is simple in implementaion for solving one- and three-dimensional diffusion–convection–reaction equations. The method is continuous both in space and time, and its advantages are particularly well manifested in solving problems on complicated domains, calculating fluxes to parts of the boundary, and other integral functionals, for instance, the total concentration of the particles which have been reacted to a time instant t.     

Localization on the Boundary of Blow-up for Reaction–Diffusion Equations with Nonlinear Boundary Conditions

Abstract

In this work we analyze the existence of solutions that blow-up in finite time for a reaction–diffusion equation u _t  ? Δu = f(x, u) in a smooth domain Ω with nonlinear boundary conditions ?u/?n = g(x, u). We show that, if locally around some point of the boundary, we have f(x, u) = ?βu ^p , β ≥ 0, and g(x, u) = u ^q then, blow-up in finite time occurs if 2q > p + 1 or if 2q = p + 1 and β < q. Moreover, if we denote by T _b the blow-up time, we show that a proper continuation of the blowing up solutions are pinned to the value infinity for some time interval [T, τ] with T _b  ≤ T < τ. On the other hand, for the case f(x, u) = ?βu ^p , for all x and u, with β > 0 and p > 1, we show that blow-up occurs only on the boundary.     

On Attractors of Reaction–Diffusion Equations in a Porous Orthotropic Medium

Doklady Mathematics - A system of reaction–diffusion equations in a perforated domain with rapidly oscillating terms in the equation and in the boundary conditions is studied. A nonlinear...     

A Nonlinear Singularly Perturbed Problem for Reaction Diffusion Equations with Boundary Perturbation

A nonlinear singularly perturbed problems for reaction diffusion equation with boundary perturbation is considered. Under suitable conditions, the asymptotic behavior of solution for the initial boundary value problems of reaction diffusion equations is studied using the theory of differential inequalities.     

The Singularly Perturbed Nonlinear Nonlocal Initial Boundary Value Problems for Reaction Diffusion Equations

The singularly perturbed nonlinear nonlocal initial boundary value problem for reaction diffusion equations is discussed. Under suitable conditions, the outer solution of the original problem is obtained. By using the stretched variable, the composing expansion method and the expanding theory of power series the initial layer is constructed. By using the theory of differential inequalities the asymptotic behavior of solution for the initial boundary value problems are studied, and by educing some relational inequalities the existence and uniqueness of solution for the original problem and the uniformly valid asymptotic estimation are considered.     

Sharp Estimates for the Global Attractor of Scalar Reaction–Diffusion Equations with a Wentzell Boundary Condition

In this paper, we derive optimal upper and lower bounds on the dimension of the attractor A_W\mathcal{A}_{\mathrm{W}} for scalar reaction–diffusion equations with a Wentzell (dynamic) boundary condition. We are also interested in obtaining explicit bounds on the constants involved in our asymptotic estimates, and to compare these bounds to previously known estimates for the dimension of the global attractor A_K\mathcal{A}_{K}, K∈{D,N,P}, of reaction–diffusion equations subject to Dirichlet, Neumann and periodic boundary conditions. The explicit estimates we obtain show that the dimension of the global attractor A_W\mathcal {A}_{\mathrm{W}} is of different order than the dimension of A_K\mathcal{A}_{K}, for each K∈{D,N,P}, in all space dimensions that are greater than or equal to three.     

On Exact Multidimensional Solutions of a Nonlinear System of Reaction–Diffusion Equations

We study a nonlinear reaction–diffusion system modeled by a system of two parabolic-type equations with power-law nonlinearities. Such systems describe the processes of nonlinear diffusion in reacting two-component media. We construct multiparameter families of exact solutions and distinguish the cases of blow-up solutions and exact solutions periodic in time and anisotropic in spatial variables that can be represented in elementary functions.     

Spreading Speeds and Traveling Waves for Non-cooperative Reaction�CDiffusion Systems

Much has been studied on the spreading speed and traveling wave solutions for cooperative reaction–diffusion systems. In this paper, we shall establish the spreading speed for a large class of non-cooperative reaction–diffusion systems and characterize the spreading speed as the slowest speed of a family of non-constant traveling wave solutions. Our results are applied to a partially cooperative system describing interactions between ungulates and grass.     

Optimal Control Problem for Cancer Invasion Reaction–Diffusion System

Abstract

An optimal control problem constrained by a reaction–diffusion mathematical model which incorporates the cancer invasion and its treatment is considered. The state equations consisting of three unknown variables namely tumor cell density, normal cell density, and drug concentration. The main goal of the considered optimal control problem is to minimize the density of cancer cells and decreasing the side effects of treatment. Moreover, existence of a weak solution of brain tumor reaction–diffusion system and the corresponding adjoint system of optimal control problem is also investigated. Further, existence of minimizer for the optimal control problem is established and also the first-order optimality conditions are derived.     

Boundary Control Problem for a Nonlinear Convection–Diffusion–Reaction Equation

Computational Mathematics and Mathematical Physics - The solvability of boundary-value and extremum problems for a nonlinear convection–diffusion–reaction equation with mixed boundary...     

Short Note: A Note on Nonstandard Finite Difference Schemes for Reaction–Diffusion Equations Having Linear Advection

Nonstandard modified upwind difference scheme for one dimensional nonlinear reaction–diffusion equation with linear advection is given in this note. The use of a positivity condition allows the determination of a functional relation between the time and space step sizes, and it is weaker than that of the corresponding simple upwind difference scheme. Error estimate in the discrete l ^∞ norm is provided under suitable assumptions.     

A Class of Nonlinear Singularly Perturbed Problems for Reaction Diffusion Equations with Boundary Perturbation

A class of nonlinear singularly perturbed problems for reaction diffusion equations with boundary perturbation are considered. Under suitable conditions, the asymptotic behavior of solution for the initial boundary value problems is studied using the theory of differential inequalities.     

Application of p-Adic Wavelets to Model Reaction–Diffusion Dynamics in Random Porous Media

Fourier and more generally wavelet analysis over the fields of p-adic numbers are widely used in physics, biology and cognitive science, and recently in geophysics. In this note we present a model of the reaction–diffusion dynamics in random porous media, e.g., flow of fluid (oil, water or emulsion) in a a complex network of pores with known topology. Anomalous diffusion in the model is represented by the system of two equations of reaction–diffusion type, for the part of fluid not bound to solid’s interface (e.g., free oil) and for the part bound to solid’s interface (e.g., solids–bound oil). Our model is based on the p-adic (treelike) representation of pore-networks. We present the system of two p-adic reaction–diffusion equations describing propagation of fluid in networks of pores in random media and find its stationary solutions by using theory of p-adic wavelets. The use of p-adic wavelets (generalizing classical wavelet theory) gives a possibility to find the stationary solution in the analytic form which is typically impossible for anomalous diffusion in the standard representation based on the real numbers.     

Existence and Stability of Traveling Waves for Degenerate Reaction–Diffusion Equation with Time Delay

This paper deals with the existence and stability of traveling wave solutions for a degenerate reaction–diffusion equation with time delay. The degeneracy of spatial diffusion together with the effect of time delay causes us the essential difficulty for the existence of the traveling waves and their stabilities. In order to treat this case, we first show the existence of smooth- and sharp-type traveling wave solutions in the case of \(c\ge c^*\) for the degenerate reaction–diffusion equation without delay, where \(c^*>0\) is the critical wave speed of smooth traveling waves. Then, as a small perturbation, we obtain the existence of the smooth non-critical traveling waves for the degenerate diffusion equation with small time delay \(\tau >0\). Furthermore, we prove the global existence and uniqueness of \(C^{\alpha ,\beta }\)-solution to the time-delayed degenerate reaction–diffusion equation via compactness analysis. Finally, by the weighted energy method, we prove that the smooth non-critical traveling wave is globally stable in the weighted \(L^1\)-space. The exponential convergence rate is also derived.     

The Envelope Attractor of Non-strict Multivalued Dynamical Systems with Application to the 3D Navier–Stokes and Reaction–Diffusion Equations

Multivalued semiflows generated by evolution equations without uniqueness sometimes satisfy a semigroup set inclusion rather than equality because, for example, the concatentation of solutions satisfying an energy inequality almost everywhere may not satisfy the energy inequality at the joining time. Such multivalued semiflows are said to be non-strict and their attractors need only be negatively semi-invariant. In this paper the problem of enveloping a non-strict multivalued dynamical system in a strict one is analyzed and their attactors are compared. Two constructions are proposed. In the first, the attainability set mapping is extending successively to be strict at the dyadic numbers, which essentially means (in the case of the Navier–Stokes system) that the energy inequality is satisfied piecewise on successively finer dyadic subintervals. The other deals directly with trajectories and their concatenations, which are then used to define a strict multivalued dynamical system. The first is shown to be applicable to the three-dimensional Navier–Stokes equations and the second to a reaction–diffusion problem without unique solutions.