Cover Picture: Electrophoresis 21'2011

Issue no. 21 is a regular issue consisting of one FAST TRACK article on “Blinded study determination of high sensitivity and specificity microchip electrophoresis‐SSCP/HA to detect mutations in the p53 gene” and 19 other contributions distributed over 5 distinct parts. Part I is on proteins and proteomics containing 5 contributions describing on‐line combination of multiple chromatographic modes for multicomponent separation of proteomics and glycoproteomics, the heterogeneity of plasma‐derived clotting factor VIII, rapid species evaluation of seafood spoilage and pathogenic Gram‐positive bacteria by MALDI‐TOF mass fingerprinting, comparison of depletion and equalization strategies in proteomics, and a competent extraction method for 2‐D gel electrophoresis. Part II is on affinity capillary electrophoresis and has 2 contributions on the application of partial‐filling using lectins and glycosidases for the characterization of oligosaccharides in therapeutic antibodies, and on protonated diamines as anion‐binding agents and their utility in CE separations. 5 contributions on detection and sensitivity enhancement make up the body of Part III. DNA translocation and depurination constitute the content of the two contributions of Part IV. Finally, Part V assembles 5 papers on various fundamentals and methodologies including the influence of membrane layer properties on the electrophoretic behavior of a soft particle, evaluation of the separation mechanism of EKC with microemulsion and CDs using NMR and molecular modeling, linear polyalkylamines as fingerprinting agents in CE of low‐molecular weight heparins and glycosaminoglycans, use of CE‐SDS gel for the characterization of monoclonal antibody hinge region clipping due to copper and high pH stress, and electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor‐specific cytotoxicity of targeted toxins. In short, this regular issue has a myriad of topics, which make the issue a must to read. Featured articles include: FAST TRACK: Blinded study determination of high sensitivity and specificity microchip electrophoresis‐SSCP/HA to detect mutations in the p53 gene (( 10.1002/elps.201100396 )) Online combination of reversed‐phase/reversed‐phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples (( 10.1002/elps.201100092 )) Trace determination of perchlorate using electromembrane extraction and capillary electrophoresis with capacitively coupled contactless conductivity detection (( 10.1002/elps.201100279 )) Sensitivity enhancement in capillary electrophoresis‐mass spectrometry of anionic metabolites using a triethylamine‐containing background electrolyte and sheath liquid (( 10.1002/elps.201100271 )) Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling (( 10.1002/elps.201100263 ))     

Cover Picture: Electrophoresis 21'2009

Issue no. 21 is a regular issue with Emphasis on “Nucleic Acids”. The first part has 7 articles on nucleic acids covering various topics, e.g., sequencing, genotyping, PCR, insertion, mutation, etc. The remaining 11 articles are concerned with monoliths, pseudo‐phases, coating, and sample pretreatment such as derivatization and concentration. Selected articles are: Applications of MALDI‐TOF MS to large‐scale human mtDNA population‐based studies (( 10.1002/elps.200900294 )) Visual DNA as a diagnostic tool (( 10.1002/elps.200900273 )) Preliminary results for two‐dimensional separation with high performance thin‐layer chromatography and pressurized planar electrochromatography (( 10.1002/elps.200900471 ))     

Cover Picture: Electrophoresis 6'2010

Issue no. 6 is a regular issue consisting of 18 full research papers. The first paper is a “Fast Track” contribution involving microchip electrophoresis of Alu elements for gender determination and inference of human ethnic origin. The remaining 17 papers are distributed over 5 different parts: Part I is on some trends in CEC; Part II deals with enantioseparations; Part III describes some novel detection approaches; Part IV has investigations on proteomics and proteins; Part V tackles the subjects related to pathogens, bacteria and the binding of aptamers to small solutes.     

Cover Picture: Electrophoresis 4'2010

Issue no. 4 is a regular issue with Emphasis on “Bioanalysis”. Part I has 12 articles on bioanalysis featuring methodologies for proteomics, proteins, peptides and nucleic acids. Part II has 5 papers on interactive CE, e.g., MEEKC, MEKC and ACE. The remaining 2 articles make up Part III, and are concerned with the regulation of flow in microfluidics and sensitivity enhancement in CEC. Featured articles include: Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in gel electrophoresis. (( 10.1002/elps.200900441.R1 )) An effective SCAR‐PCR method derived from restriction site amplified polymorphism (RSAP) for the identification of female Schistosoma japonicum of zoonotic significance. (( 10.1002/elps.200900615.R1 )) Rapid and sensitive DNA targets detection using enzyme amplified electrochemical detection based on microchip. (( 10.1002/elps.200900538.R1 ))     

Cover Picture: Electrophoresis 12'2010

Issue no. 12 is a regular issue comprising 19 contributions distributed over five distinct parts. Part I has 7 articles describing novel methodologies pertaining to proteins and proteomics. Part II has 3 research papers on CEC stationary phases and CEC‐MS. Part III is on detection approaches including a review article on the advances and applications of chemiluminescence coupled to CE. Part IV has two papers on enantioseparations, and Part V has four contributions on aptamers, human genetic, preparative FFE and microchannels. Featured articles include: Simplified method for concentration of mitochondrial membrane protein complexes (( 10.1002/elps.201000019 )) Analysis of low‐molecular mass aldehydes in drinking waters through capillary electrophoresis with laser‐induced fluorescence detection (( 10.1002/elps.200900734 )) Selection of aptamers for signal transduction proteins by capillary electrophoresis (( 10.1002/elps.200900543 ))     

Cover Picture: Electrophoresis 2'2010

Issue no. 2 has 19 contributions including one Fast Track contribution on “Thermophoresis of ssDNA”. The remaining 18 articles cover a wide variety of investigation involving nucleic acids, cells, viruses, interactive CE, detection methodologies in CE, enantioseparations, and studies on proteins and proteomics. Further selected articles include: Capillary electrophoresis of bone marrow stromal cells with uptake of heparin‐functionalized poly(lactide‐co‐glycolide) nanoparticles during differentiation towards neurons. (( 10.1002/elps.200900336 )) Ghrelin‐liposome interactions. Characterization of liposomal formulations of an acylated 28‐amino acid peptide using capillary electrophoresis. (( 10.1002/elps.200900394 ))     

Cover Picture: Electrophoresis 3'2010

Issue no. 3 is a regular issue with Emphasis on “Proteins and Proteomics”. The first part has 8 articles on proteins and proteomics covering various topics, e.g. preparative divergent flow IEF, multichannel gel electrophoresis, capillary gel electrophoresis, nanoparticle‐based CE of proteins, 2‐DE in a radial gel format, depletion of high abundance proteins, and proteomic investigation of fetal brain and lentil seed. The remaining 10 articles are concerned with nucleic acids, gene expression, methodologies and application. Featured articles include: Preparative divergent flow IEF without carrier ampholytes for separation of complex biological samples (( 10.1002/elps.200900484 )) SDS‐PAGE and two‐dimensional maps in a radial gel format (( 10.1002/elps.200900526 )) Analysis of Effect of Electrolyte Types on Electrokinetic Energy Conversion in Nanoscale Capillaries (( 10.1002/elps.200900409 )) A simple method to determine the surface charge in microfluidic channels (( 10.1002/elps.200900603 ))     

Cover Picture: Electrophoresis 20'2010

Issue no. 20 is a regular issue comprising 17 contributions distributed over 7 distinct parts. Part I has 3 research articles on particle analysis. Part II has 2 research articles dealing with hyphenated techniques such as CITP‐CZE and CE‐ESI‐MS. Part III reports a variety of methodologies and systems for proteins and proteomics that are described in 4 research articles. Gel DNA: theory and visualization are treated in 2 research articles making up part IV. Part V has 2 contributions that describe CE systems for water analysis. The following Part VI is on affinity and Immunoaffinity CE and has 2 research articles. The last 2 articles in this issue (Part VII) are on MEEKC and free flow electrophoresis. Featured articles include: Dielectrophoretically patterned carbon nanotubes to sort microparticles ((doi: 10.1002/elps.201000104 )) Analysis of 5‐methyltetrahydrofolate in human blood, serum and urine by on‐line coupling of capillary isotachophoresis and zone electrophoresis ((doi: 10.1002/elps.201000193 ))     

Cover Picture: Electrophoresis 15'09

Issue no. 15 is a regular issue consisting of 20 research papers distributed over 7 different parts dealing with various fundamental studies, analytical methodologies, various aspects of proteins and protein biomarkers, affinity studies, genetics, pathogens and toxins, and enantioseparations.     

Cover Picture: Electrophoresis 2'2012

Issue no. 2 is a regular issue consisting of 18 contributions distributed over 5 distinct parts. The issue has an “Emphasis on Proteins and Proteomics” with 7 contributions featured in Part I. This is followed by Part II that has 4 research articles on nanopore and nanoparticles based analyses. Part III has 2 contributions on agarose gel electrophoresis for the analysis of the structure fluidity of a phage T3 DNA packaging intermediate and analyzing RNA quality. Part IV has two research articles on microchip capillary electrophoresis with poly(ethylene glycol)‐coated microfluidic devices and poly(dimethylsiloxane) microchips using a mixture of ionic and zwitterionic surfactants. The last part (Part V) consists of 3 contributions on CE of some common controlled stimulants, CE test of a blood‐brain barrier model and the simultaneous determinations of nitrite and nitrate in human plasma by CE. This issue is populated by a collection of very important research articles. It is a must read. Featured articles include: The challenge to quantify proteins with charge trains due to isoforms or conformers (( 10.1002/elps.201100321 )) Electrophoretically‐driven SDS removal and protein fractionation in the shotgun analysis of membrane proteomes (( 10.1002/elps.201100364 )) Modeling and simulation of nanoparticle separation through a solid state nanopore (( 10.1002/elps.201100201 )) A novel open‐tubular capillary electrochromatography with magnetic nanoparticle coating as stationary phase (( 10.1002/elps.201100337 )) Direct visualization of electrophoretic mobility shift assays using nanoparticle‐aptamer conjugates (( 10.1002/elps.201100308 ))